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Q96M32

- KAD7_HUMAN

UniProt

Q96M32 - KAD7_HUMAN

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Protein

Adenylate kinase 7

Gene

AK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.2 Publications

Catalytic activityi

ATP + AMP = 2 ADP.
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Kineticsi

  1. KM=1.0 µM for AMP1 Publication
  2. KM=28 µM for dAMP1 Publication
  3. KM=1.2 µM for CMP1 Publication

Vmax=1130 pmol/min/µg enzyme with AMP as substrate1 Publication

Vmax=860 pmol/min/µg enzyme with dAMP as substrate1 Publication

Vmax=150 pmol/min/µg enzyme with CMP as substrate1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei489 – 4891AMPBy similarity
Binding sitei555 – 5551AMPBy similarity
Binding sitei587 – 5871ATP; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi377 – 3826ATPBy similarity
Nucleotide bindingi432 – 45524AMPBy similarityAdd
BLAST
Nucleotide bindingi482 – 4854AMPBy similarity

GO - Molecular functioni

  1. adenylate kinase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. cytidylate kinase activity Source: UniProtKB
  4. nucleoside diphosphate kinase activity Source: UniProtKB

GO - Biological processi

  1. axoneme assembly Source: Ensembl
  2. brain development Source: Ensembl
  3. epithelial cilium movement Source: Ensembl
  4. inflammatory response to antigenic stimulus Source: Ensembl
  5. nucleoside diphosphate phosphorylation Source: UniProtKB
  6. nucleoside triphosphate biosynthetic process Source: UniProtKB
  7. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase 7 (EC:2.7.4.3, EC:2.7.4.6)
Short name:
AK 7
Alternative name(s):
ATP-AMP transphosphorylase 7
Gene namesi
Name:AK7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20091. AK7.

Subcellular locationi

Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Adenylate kinase 7PRO_0000158952Add
BLAST

Proteomic databases

PaxDbiQ96M32.
PRIDEiQ96M32.

PTM databases

PhosphoSiteiQ96M32.

Expressioni

Gene expression databases

BgeeiQ96M32.
CleanExiHS_AK7.
ExpressionAtlasiQ96M32. baseline and differential.
GenevestigatoriQ96M32.

Organism-specific databases

HPAiHPA003543.

Interactioni

Protein-protein interaction databases

BioGridi125773. 1 interaction.
STRINGi9606.ENSP00000267584.

Structurei

3D structure databases

ProteinModelPortaliQ96M32.
SMRiQ96M32. Positions 367-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 612246Adenylate kinaseAdd
BLAST
Regioni397 – 45559NMPbindBy similarityAdd
BLAST
Regioni537 – 54711LIDBy similarityAdd
BLAST
Regioni679 – 72345DPY-30Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili46 – 458413Sequence AnalysisAdd
BLAST
Coiled coili609 – 67769Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Glu
Compositional biasi51 – 588Poly-Glu
Compositional biasi420 – 43213Poly-GluAdd
BLAST
Compositional biasi497 – 5026Poly-Glu
Compositional biasi616 – 67459Glu-richAdd
BLAST

Sequence similaritiesi

In the central section; belongs to the adenylate kinase family.Curated
In the C-terminal section; belongs to the dpy-30 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG267062.
GeneTreeiENSGT00390000015102.
HOGENOMiHOG000007764.
HOVERGENiHBG045568.
InParanoidiQ96M32.
KOiK00939.
OMAiKMAWLGE.
OrthoDBiEOG786H2R.
PhylomeDBiQ96M32.
TreeFamiTF313982.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR007858. Dpy-30_motif.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PfamiPF05186. Dpy-30. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96M32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEEEETAAL TEKVIRTQRV FINLLDSYSS GNIGKFLSNC VVGASLEEIT
60 70 80 90 100
EEEEEEDENK SAMLEASSTK VKEGTFQIVG TLSKPDSPRP DFAVETYSAI
110 120 130 140 150
SREDLLMRLL ECDVIIYNIT ESSQQMEEAI WAVSALSEEV SHFEKRKLFI
160 170 180 190 200
LLSTVMTWAR SKALDPEDSE VPFTEEDYRR RKSHPNFLDH INAEKMVLKF
210 220 230 240 250
GKKARKFAAY VVAAGLQYGA EGGMLHTFFK MAWLGEIPAL PVFGDGTNVI
260 270 280 290 300
PTIHVLDLAG VIQNVIDHVP KPHYLVAVDE SVHTLEDIVK CISKNTGPGK
310 320 330 340 350
IQKIPRENAY LTKDLTQDCL DHLLVNLRME ALFVKENFNI RWAAQTGFVE
360 370 380 390 400
NINTILKEYK QSRGLMPIKI CILGPPAVGK SSIAKELANY YKLHHIQLKD
410 420 430 440 450
VISEAIAKLE AIVAPNDVGE GEEEVEEEEE EENVEDAQEL LDGIKESMEQ
460 470 480 490 500
NAGQLDDQYI IRFMKEKLKS MPCRNQGYIL DGFPKTYDQA KDLFNQEDEE
510 520 530 540 550
EEDDVRGRMF PFDKLIIPEF VCALDASDEF LKERVINLPE SIVAGTHYSQ
560 570 580 590 600
DRFLRALSNY RDINIDDETV FNYFDELEIH PIHIDVGKLE DAQNRLAIKQ
610 620 630 640 650
LIKEIGEPRN YGLTDEEKAE EERKAAEERL AREAAEEAER EHQEAVEMAE
660 670 680 690 700
KIARWEEWNK RLEEVKREER ELLEAQSIPL RNYLMTYVMP TLIQGLNECC
710 720
NVRPEDPVDF LAEYLFKNNP EAQ
Length:723
Mass (Da):82,658
Last modified:November 24, 2009 - v3
Checksum:i7A9E2BF11A4CEEF8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721P → L in BAB71480. (PubMed:14702039)Curated
Sequence conflicti410 – 4101E → G in BAB71480. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021R → Q.1 Publication
Corresponds to variant rs2275554 [ dbSNP | Ensembl ].
VAR_017059
Natural varianti389 – 3891N → K.1 Publication
Corresponds to variant rs2369679 [ dbSNP | Ensembl ].
VAR_057950

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057426 mRNA. Translation: BAB71480.1.
AL163051 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
CCDSiCCDS9945.1.
RefSeqiNP_689540.2. NM_152327.3.
UniGeneiHs.667462.

Genome annotation databases

EnsembliENST00000267584; ENSP00000267584; ENSG00000140057.
GeneIDi122481.
KEGGihsa:122481.
UCSCiuc001yfn.3. human.

Polymorphism databases

DMDMi269849674.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057426 mRNA. Translation: BAB71480.1 .
AL163051 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
CCDSi CCDS9945.1.
RefSeqi NP_689540.2. NM_152327.3.
UniGenei Hs.667462.

3D structure databases

ProteinModelPortali Q96M32.
SMRi Q96M32. Positions 367-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125773. 1 interaction.
STRINGi 9606.ENSP00000267584.

PTM databases

PhosphoSitei Q96M32.

Polymorphism databases

DMDMi 269849674.

Proteomic databases

PaxDbi Q96M32.
PRIDEi Q96M32.

Protocols and materials databases

DNASUi 122481.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267584 ; ENSP00000267584 ; ENSG00000140057 .
GeneIDi 122481.
KEGGi hsa:122481.
UCSCi uc001yfn.3. human.

Organism-specific databases

CTDi 122481.
GeneCardsi GC14P096858.
H-InvDB HIX0011951.
HGNCi HGNC:20091. AK7.
HPAi HPA003543.
MIMi 615364. gene.
neXtProti NX_Q96M32.
PharmGKBi PA134963502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267062.
GeneTreei ENSGT00390000015102.
HOGENOMi HOG000007764.
HOVERGENi HBG045568.
InParanoidi Q96M32.
KOi K00939.
OMAi KMAWLGE.
OrthoDBi EOG786H2R.
PhylomeDBi Q96M32.
TreeFami TF313982.

Miscellaneous databases

ChiTaRSi AK7. human.
GenomeRNAii 122481.
NextBioi 80898.
PROi Q96M32.
SOURCEi Search...

Gene expression databases

Bgeei Q96M32.
CleanExi HS_AK7.
ExpressionAtlasi Q96M32. baseline and differential.
Genevestigatori Q96M32.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR000850. Adenylat/UMP-CMP_kin.
IPR007858. Dpy-30_motif.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23359. PTHR23359. 1 hit.
Pfami PF05186. Dpy-30. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-102 AND LYS-389.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes."
    Panayiotou C., Solaroli N., Xu Y., Johansson M., Karlsson A.
    Biochem. J. 433:527-534(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, CATALYTIC ACTIVITY.
  4. "The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase."
    Amiri M., Conserva F., Panayiotou C., Karlsson A., Solaroli N.
    Int. J. Biochem. Cell Biol. 45:925-931(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiKAD7_HUMAN
AccessioniPrimary (citable) accession number: Q96M32
Secondary accession number(s): Q8IYP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3