Reviewed, UniProtKB/Swiss-Prot Q96M32 (KAD7_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative adenylate kinase 7
    EC=2.7.4.3

Gene names

Name:

AK7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + AMP = 2 ADP.
Sequence similarities	In the central section; belongs to the adenylate kinase family. In the C-terminal section; belongs to the dpy-30 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Putative adenylate kinase 7		PRO_0000158952
Regions
	Nucleotide binding	374 – 381	8	ATP Potential
	Region	366 – 502	137	Adenylate kinase
	Region	679 – 723	45	DPY-30
	Coiled coil	46 – 458	413	Potential
	Coiled coil	609 – 677	69	Potential
	Compositional bias	3 – 6	4	Poly-Glu
	Compositional bias	51 – 58	8	Poly-Glu
	Compositional bias	420 – 432	13	Poly-Glu
	Compositional bias	497 – 502	6	Poly-Glu
	Compositional bias	616 – 674	59	Glu-rich
Natural variations
	Natural variant	102	1	R → Q: dbSNP rs2275554.		VAR_017059
	Natural variant	389	1	K → N: dbSNP rs2369679.		VAR_057950
Experimental info
	Sequence conflict	272	1	P → L in BAB71480. Ref.1
	Sequence conflict	410	1	E → G in BAB71480. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96M32-1 [UniParc]. Last modified October 3, 2003. Version 2. Checksum: 8E5FE865A9DA0AFB	FASTA	723	82,673
	10 20 30 40 50 60 MAEEEETAAL TEKVIRTQRV FINLLDSYSS GNIGKFLSNC VVGASLEEIT EEEEEEDENK 70 80 90 100 110 120 SAMLEASSTK VKEGTFQIVG TLSKPDSPRP DFAVETYSAI SREDLLMRLL ECDVIIYNIT 130 140 150 160 170 180 ESSQQMEEAI WAVSALSEEV SHFEKRKLFI LLSTVMTWAR SKALDPEDSE VPFTEEDYRR 190 200 210 220 230 240 RKSHPNFLDH INAEKMVLKF GKKARKFAAY VVAAGLQYGA EGGMLHTFFK MAWLGEIPAL 250 260 270 280 290 300 PVFGDGTNVI PTIHVLDLAG VIQNVIDHVP KPHYLVAVDE SVHTLEDIVK CISKNTGPGK 310 320 330 340 350 360 IQKIPRENAY LTKDLTQDCL DHLLVNLRME ALFVKENFNI RWAAQTGFVE NINTILKEYK 370 380 390 400 410 420 QSRGLMPIKI CILGPPAVGK SSIAKELAKY YKLHHIQLKD VISEAIAKLE AIVAPNDVGE 430 440 450 460 470 480 GEEEVEEEEE EENVEDAQEL LDGIKESMEQ NAGQLDDQYI IRFMKEKLKS MPCRNQGYIL 490 500 510 520 530 540 DGFPKTYDQA KDLFNQEDEE EEDDVRGRMF PFDKLIIPEF VCALDASDEF LKERVINLPE 550 560 570 580 590 600 SIVAGTHYSQ DRFLRALSNY RDINIDDETV FNYFDELEIH PIHIDVGKLE DAQNRLAIKQ 610 620 630 640 650 660 LIKEIGEPRN YGLTDEEKAE EERKAAEERL AREAAEEAER EHQEAVEMAE KIARWEEWNK 670 680 690 700 710 720 RLEEVKREER ELLEAQSIPL RNYLMTYVMP TLIQGLNECC NVRPEDPVDF LAEYLFKNNP EAQ

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-102. Tissue: Testis.

[2]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK057426 mRNA. Translation: BAB71480.1. AL163051 Genomic DNA. No translation available. AL359240 Genomic DNA. No translation available.
IPI	IPI00065250.
RefSeq	NP_689540.2.
UniGene	Hs.667462
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q96M32.
Proteomic databases
PRIDE	Q96M32.
Genome annotation databases
Ensembl	ENSG00000140057. Homo sapiens. [Contig view]
GeneID	122481.
KEGG	hsa:122481.
Organism-specific databases
GeneCards	GC14P095928.
HGNC	HGNC:20091. AK7.
HPA	HPA003543.
PharmGKB	PA134963502.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96M32.
HOVERGEN	Q96M32.
Enzyme and pathway databases
BRENDA	2.7.4.3. 247.
Gene expression databases
ArrayExpress	Q96M32.
Bgee	Q96M32.
CleanEx	HS_AK7.
GermOnline	ENSG00000140057. Homo sapiens.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR007858. Dpy-30_CS. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF05186. Dpy-30. 1 hit. [Graphical view]
PROSITE	PS00113. ADENYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	80898.

Entry information

Entry name

KAD7_HUMAN

Accession

Primary (citable) accession number: Q96M32
Secondary accession number(s): Q8IYP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	October 3, 2003
Last modified:	June 16, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)