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Protein

Tektin-5

Gene

TEKT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a structural component of the sperm flagellum.By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153060-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-5
Gene namesi
Name:TEKT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26554. TEKT5.

Subcellular locationi

  • Cell projectionciliumflagellum By similarity

  • Note: Appears to be associated with flagellar accessory structures and not the axoneme.By similarity

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • sperm flagellum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

DisGeNETi146279.
OpenTargetsiENSG00000153060.
PharmGKBiPA162405603.

Polymorphism and mutation databases

BioMutaiTEKT5.
DMDMi74732290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611711 – 485Tektin-5Add BLAST485

Proteomic databases

EPDiQ96M29.
PaxDbiQ96M29.
PeptideAtlasiQ96M29.
PRIDEiQ96M29.

PTM databases

iPTMnetiQ96M29.
PhosphoSitePlusiQ96M29.

Expressioni

Gene expression databases

BgeeiENSG00000153060.
CleanExiHS_TEKT5.
ExpressionAtlasiQ96M29. baseline and differential.
GenevisibleiQ96M29. HS.

Organism-specific databases

HPAiHPA043578.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLHL38Q2WGJ63EBI-10239812,EBI-6426443
TNS2Q63HR25EBI-10239812,EBI-949753

Protein-protein interaction databases

BioGridi126976. 2 interactors.
IntActiQ96M29. 7 interactors.
STRINGi9606.ENSP00000283025.

Structurei

3D structure databases

ProteinModelPortaliQ96M29.
SMRiQ96M29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 185Sequence analysisAdd BLAST72
Coiled coili225 – 247Sequence analysisAdd BLAST23
Coiled coili307 – 385Sequence analysisAdd BLAST79
Coiled coili421 – 444Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ96M29.
KOiK18632.
OMAiNEVFTID.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ96M29.
TreeFamiTF320754.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.

Sequencei

Sequence statusi: Complete.

Q96M29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLGTTQTA SYCGPKKCCG LTSLPAVQAP VIQECYQPYY LPGYRYLNSW
60 70 80 90 100
RPSLFYKIAN VQTCPDESTS TLRPPTILPT LRSALFSRYS PHDWDQSNQL
110 120 130 140 150
QVRGAEASRL WASRLTDDSM RLLQDKDQLT HQMQEGTCRN LGQRLSDIGF
160 170 180 190 200
WKSELSYELD RLLTENQNLE TVKRRLECAA NEVNCPLQVA LECLYHREKR
210 220 230 240 250
IGIDLVHDNV EKNLIREVDL LKCCQEQMRK LAQRIDIQMR DNRDAQHVLE
260 270 280 290 300
RDLEDKSSAQ CIDEKCFNLR NTSDCISFFH GMEKIDGTIS VPETWAKFSN
310 320 330 340 350
DNIKHSQNMR ANSIQLREEA EHLFETLSDQ MWRQFTDTNL AFNARISEVT
360 370 380 390 400
DVKNKLQTQL AKTLQEIFQA ENTIMLLERS IMAKEGPLKV AQTRLECRTR
410 420 430 440 450
RPNMELCRDI PQLKLVNEVF TIDDTLQTLK LRLRETQDTL QLLVMTKCRL
460 470 480
EHELAIKANT LCIDKEKCMG MRKTFPCTPR LVGHT
Length:485
Mass (Da):56,294
Last modified:December 1, 2001 - v1
Checksum:i615A98D46699B876
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05372259A → T.Corresponds to variant rs16957557dbSNPEnsembl.1
Natural variantiVAR_053723196H → R.Corresponds to variant rs16957546dbSNPEnsembl.1
Natural variantiVAR_053724239M → T.Corresponds to variant rs17684500dbSNPEnsembl.1
Natural variantiVAR_053725315Q → R.Corresponds to variant rs2719710dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057433 mRNA. Translation: BAB71484.1.
BC130336 mRNA. Translation: AAI30337.1.
BC130338 mRNA. Translation: AAI30339.1.
CCDSiCCDS10542.1.
RefSeqiNP_653275.1. NM_144674.1.
UniGeneiHs.143519.

Genome annotation databases

EnsembliENST00000283025; ENSP00000283025; ENSG00000153060.
GeneIDi146279.
KEGGihsa:146279.
UCSCiuc002czz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057433 mRNA. Translation: BAB71484.1.
BC130336 mRNA. Translation: AAI30337.1.
BC130338 mRNA. Translation: AAI30339.1.
CCDSiCCDS10542.1.
RefSeqiNP_653275.1. NM_144674.1.
UniGeneiHs.143519.

3D structure databases

ProteinModelPortaliQ96M29.
SMRiQ96M29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126976. 2 interactors.
IntActiQ96M29. 7 interactors.
STRINGi9606.ENSP00000283025.

PTM databases

iPTMnetiQ96M29.
PhosphoSitePlusiQ96M29.

Polymorphism and mutation databases

BioMutaiTEKT5.
DMDMi74732290.

Proteomic databases

EPDiQ96M29.
PaxDbiQ96M29.
PeptideAtlasiQ96M29.
PRIDEiQ96M29.

Protocols and materials databases

DNASUi146279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283025; ENSP00000283025; ENSG00000153060.
GeneIDi146279.
KEGGihsa:146279.
UCSCiuc002czz.2. human.

Organism-specific databases

CTDi146279.
DisGeNETi146279.
GeneCardsiTEKT5.
HGNCiHGNC:26554. TEKT5.
HPAiHPA043578.
neXtProtiNX_Q96M29.
OpenTargetsiENSG00000153060.
PharmGKBiPA162405603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685. Eukaryota.
ENOG410XSCN. LUCA.
GeneTreeiENSGT00390000016344.
HOGENOMiHOG000246943.
HOVERGENiHBG056503.
InParanoidiQ96M29.
KOiK18632.
OMAiNEVFTID.
OrthoDBiEOG091G0AJL.
PhylomeDBiQ96M29.
TreeFamiTF320754.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153060-MONOMER.

Miscellaneous databases

GenomeRNAii146279.
PROiQ96M29.

Gene expression databases

BgeeiENSG00000153060.
CleanExiHS_TEKT5.
ExpressionAtlasiQ96M29. baseline and differential.
GenevisibleiQ96M29. HS.

Family and domain databases

InterProiIPR000435. Tektin.
[Graphical view]
PANTHERiPTHR19960. PTHR19960. 1 hit.
PRINTSiPR00511. TEKTIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTEKT5_HUMAN
AccessioniPrimary (citable) accession number: Q96M29
Secondary accession number(s): A1L3Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.