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Protein

Cyclic nucleotide-binding domain-containing protein 2

Gene

CNBD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 239cNMPAdd BLAST124

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-binding domain-containing protein 2
Gene namesi
Name:CNBD2
Synonyms:C20orf152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16145. CNBD2.

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149646.
PharmGKBiPA25694.

Polymorphism and mutation databases

BioMutaiCNBD2.
DMDMi25089999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794711 – 576Cyclic nucleotide-binding domain-containing protein 2Add BLAST576

Proteomic databases

PaxDbiQ96M20.
PRIDEiQ96M20.

PTM databases

iPTMnetiQ96M20.
PhosphoSitePlusiQ96M20.

Expressioni

Gene expression databases

BgeeiENSG00000149646.
CleanExiHS_C20orf152.
ExpressionAtlasiQ96M20. baseline and differential.
GenevisibleiQ96M20. HS.

Organism-specific databases

HPAiHPA043182.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340954.

Structurei

3D structure databases

ProteinModelPortaliQ96M20.
SMRiQ96M20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
GeneTreeiENSGT00390000003964.
HOGENOMiHOG000231998.
HOVERGENiHBG051202.
InParanoidiQ96M20.
OMAiPMINTKY.
OrthoDBiEOG091G031R.
PhylomeDBiQ96M20.
TreeFamiTF326269.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96M20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRHMVTYAW QLLKKELGLY QLAMDIIIMI RVCKMFRQGL RGFREYQIIE
60 70 80 90 100
TAHWKHPIFS FWDKKMQSRV TFDTMDFIAE EGHFPPKAIQ IMQKKPSWRT
110 120 130 140 150
EDEIQAVCNI LQVLDSYRNY AEPLQLLLAK VMRFERFGRR RVIIKKGQKG
160 170 180 190 200
NSFYFIYLGT VAITKDEDGS SAFLDPHPKL LHKGSCFGEM DVLHASVRRS
210 220 230 240 250
TIVCMEETEF LVVDREDFFA NKLDQEVQKD AQYRFEFFRK MELFASWSDE
260 270 280 290 300
KLWQLVAMAK IERFSYGQLI SKDFGESPFI MFISKGSCEV LRLLDLGASP
310 320 330 340 350
SYRRWIWQHL ELIDGRPLKT HLSEYSPMER FKEFQIKSYP LQDFSSLKLP
360 370 380 390 400
HLKKAWGLQG TSFSRKIRTS GDTLPKMLGP KIQSRPAQSI KCAMINIKPG
410 420 430 440 450
ELPKEAAVGA YVKVHTVEQG EILGLHQAFL PEGECDTRPL ILMSLGNELI
460 470 480 490 500
RIRKEIFYEL IDNDDEMIKK LLKLNIAFPS DEDMCQKFLQ QNSWNIFRKD
510 520 530 540 550
LLQLLVEPCQ SQLFTPNRPK KREIYNPKSV VLDLCSINKT TKPRYPIFMA
560 570
PQKYLPPLRI VQAIKAPRYK IRELLA
Length:576
Mass (Da):67,512
Last modified:November 15, 2002 - v2
Checksum:iB38592A8233A9354
GO
Isoform 2 (identifier: Q96M20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-427: Missing.

Show »
Length:572
Mass (Da):67,077
Checksum:i374D76208E0E3E4E
GO
Isoform 3 (identifier: Q96M20-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-576: Missing.

Show »
Length:423
Mass (Da):49,514
Checksum:i33B41D839E080317
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05685337R → H.Corresponds to variant rs17347958dbSNPEnsembl.1
Natural variantiVAR_056854208T → A.Corresponds to variant rs6142471dbSNPEnsembl.1
Natural variantiVAR_056855375P → S.1 PublicationCorresponds to variant rs6060750dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043858424 – 576Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_039149424 – 427Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057454 mRNA. Translation: BAB71494.1.
AL109965, AL359828 Genomic DNA. Translation: CAI19248.1.
AL109965, AL359828 Genomic DNA. Translation: CAI19249.1.
AL359828, AL109965 Genomic DNA. Translation: CAI23441.1.
AL359828, AL109965 Genomic DNA. Translation: CAI23442.1.
CH471077 Genomic DNA. Translation: EAW76149.1.
BC114945 mRNA. Translation: AAI14946.1.
CCDSiCCDS13270.1. [Q96M20-2]
CCDS56189.1. [Q96M20-3]
RefSeqiNP_001194005.1. NM_001207076.2. [Q96M20-3]
NP_543024.2. NM_080834.3. [Q96M20-2]
XP_005260352.1. XM_005260295.2. [Q96M20-1]
UniGeneiHs.732697.

Genome annotation databases

EnsembliENST00000349339; ENSP00000340954; ENSG00000149646. [Q96M20-2]
ENST00000373973; ENSP00000363084; ENSG00000149646. [Q96M20-1]
ENST00000538900; ENSP00000442729; ENSG00000149646. [Q96M20-3]
GeneIDi140894.
KEGGihsa:140894.
UCSCiuc002xer.1. human. [Q96M20-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057454 mRNA. Translation: BAB71494.1.
AL109965, AL359828 Genomic DNA. Translation: CAI19248.1.
AL109965, AL359828 Genomic DNA. Translation: CAI19249.1.
AL359828, AL109965 Genomic DNA. Translation: CAI23441.1.
AL359828, AL109965 Genomic DNA. Translation: CAI23442.1.
CH471077 Genomic DNA. Translation: EAW76149.1.
BC114945 mRNA. Translation: AAI14946.1.
CCDSiCCDS13270.1. [Q96M20-2]
CCDS56189.1. [Q96M20-3]
RefSeqiNP_001194005.1. NM_001207076.2. [Q96M20-3]
NP_543024.2. NM_080834.3. [Q96M20-2]
XP_005260352.1. XM_005260295.2. [Q96M20-1]
UniGeneiHs.732697.

3D structure databases

ProteinModelPortaliQ96M20.
SMRiQ96M20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340954.

PTM databases

iPTMnetiQ96M20.
PhosphoSitePlusiQ96M20.

Polymorphism and mutation databases

BioMutaiCNBD2.
DMDMi25089999.

Proteomic databases

PaxDbiQ96M20.
PRIDEiQ96M20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349339; ENSP00000340954; ENSG00000149646. [Q96M20-2]
ENST00000373973; ENSP00000363084; ENSG00000149646. [Q96M20-1]
ENST00000538900; ENSP00000442729; ENSG00000149646. [Q96M20-3]
GeneIDi140894.
KEGGihsa:140894.
UCSCiuc002xer.1. human. [Q96M20-1]

Organism-specific databases

CTDi140894.
GeneCardsiCNBD2.
HGNCiHGNC:16145. CNBD2.
HPAiHPA043182.
neXtProtiNX_Q96M20.
OpenTargetsiENSG00000149646.
PharmGKBiPA25694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
GeneTreeiENSGT00390000003964.
HOGENOMiHOG000231998.
HOVERGENiHBG051202.
InParanoidiQ96M20.
OMAiPMINTKY.
OrthoDBiEOG091G031R.
PhylomeDBiQ96M20.
TreeFamiTF326269.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149646-MONOMER.

Miscellaneous databases

GenomeRNAii140894.
PROiQ96M20.

Gene expression databases

BgeeiENSG00000149646.
CleanExiHS_C20orf152.
ExpressionAtlasiQ96M20. baseline and differential.
GenevisibleiQ96M20. HS.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNBD2_HUMAN
AccessioniPrimary (citable) accession number: Q96M20
Secondary accession number(s): Q14C79
, Q5JWY7, Q5T3S1, Q9BR36, Q9BWY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.