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Protein

Centrosomal protein C10orf90

Gene

C10orf90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein C10orf90
Alternative name(s):
Fragile-site associated tumor suppressor homolog
Gene namesi
Name:C10orf90
Synonyms:FATS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26563. C10orf90.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134895930.

Polymorphism and mutation databases

BioMutaiC10orf90.
DMDMi143377520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Centrosomal protein C10orf90PRO_0000279492Add
BLAST

Proteomic databases

EPDiQ96M02.
MaxQBiQ96M02.
PaxDbiQ96M02.
PeptideAtlasiQ96M02.
PRIDEiQ96M02.

PTM databases

iPTMnetiQ96M02.
PhosphoSiteiQ96M02.

Expressioni

Gene expression databases

BgeeiENSG00000154493.
CleanExiHS_C10orf90.
ExpressionAtlasiQ96M02. baseline and differential.
GenevisibleiQ96M02. HS.

Organism-specific databases

HPAiHPA038648.
HPA057599.

Interactioni

Subunit structurei

Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21.By similarity

Protein-protein interaction databases

BioGridi125615. 2 interactions.
IntActiQ96M02. 2 interactions.
STRINGi9606.ENSP00000284694.

Structurei

3D structure databases

ProteinModelPortaliQ96M02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 224109Required for interaction with HDAC1By similarityAdd
BLAST
Regioni571 – 699129ALMS motifBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi663 – 6664Poly-Lys

Phylogenomic databases

eggNOGiENOG410IEBN. Eukaryota.
ENOG410Y0PQ. LUCA.
GeneTreeiENSGT00550000074751.
HOVERGENiHBG058161.
InParanoidiQ96M02.
KOiK16773.
OMAiCSSHRLT.
OrthoDBiEOG091G0HCJ.
PhylomeDBiQ96M02.

Family and domain databases

InterProiIPR029299. ALMS_motif.
IPR029561. C10orf90.
[Graphical view]
PANTHERiPTHR21553:SF24. PTHR21553:SF24. 1 hit.
PfamiPF15309. ALMS_motif. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96M02-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKLSGEGLR DSYHSRRDQI ALKNLQSDVT EAKSDFTKET LASQNTKMIS
60 70 80 90 100
SIVISQMIDE NKSRENRASL PLPCAIAQSR AHHAKQSLAN RSGVNIHRAF
110 120 130 140 150
ALLPGRLGIP APSDERGPEA ELPPKEERPC GGPRRGFASI TITARRVGPP
160 170 180 190 200
ARALVWGTAG DSLCPKCRAE DTLFQAPPAL ANGAHPGRHQ RSFACTEFSR
210 220 230 240 250
NSSVVRLKVP EAHTGLCERR KYWVTHADDK ETSFSPDTPL SGKSPLVFSS
260 270 280 290 300
CVHLRVSQQC PDSIYYVDKS LSVPIEPPQI ASPKMHRSVL SLNLNCSSHR
310 320 330 340 350
LTADGVDGLV NREPISEALK QELLEGDQDL VGQRWNPGLQ ESHLKETPSL
360 370 380 390 400
RRVHLGTGAC PWSGSFPLEN TELANVGANQ VTVRKGEKDH TTHCHASDHA
410 420 430 440 450
NQLSIHIPGW SYRAVHTKVF SGSSKRQQGE VCMTVSAPPV EQKPTRHFLP
460 470 480 490 500
IGDSSPSDDC LSRDLSEPTE RRHQSFLKPR ILFPGFLCPL QDVCASLQED
510 520 530 540 550
NGVQIESKFP KGDYTCCDLV VKIKECKKSE DPTTPEPSPA APSPAPRDGA
560 570 580 590 600
GSPGLSEDCS ESQQTPARSL TLQEALEVRK PQFISRSQER LKKLEHMVQQ
610 620 630 640 650
RKAQRKEDLR QKQSLLPIRT SKKQFTIPHP LSDNLFKPKE RCISEKEMHM
660 670 680 690
RSKRIYDNLP EVKKKKEEQR KRVILQSNRL RAEVFKKQLL DQLLQRNAV
Length:699
Mass (Da):77,910
Last modified:March 6, 2007 - v2
Checksum:i099E8CEF3C910F1E
GO
Isoform 2 (identifier: Q96M02-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-511: Missing.

Show »
Length:602
Mass (Da):67,103
Checksum:iD645C12B669E5F3C
GO

Sequence cautioni

The sequence AAM20911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI12409 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40680 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti654 – 6541R → G in BAB71512 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571M → I.
Corresponds to variant rs11558415 [ dbSNP | Ensembl ].
VAR_050855
Natural varianti134 – 1341R → H.
Corresponds to variant rs11245008 [ dbSNP | Ensembl ].
VAR_030908
Natural varianti262 – 2621D → N.1 Publication
Corresponds to variant rs11245007 [ dbSNP | Ensembl ].
VAR_030909
Natural varianti531 – 5311D → E.
Corresponds to variant rs12412320 [ dbSNP | Ensembl ].
VAR_050856

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei415 – 51197Missing in isoform 2. 1 PublicationVSP_023458Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583860, AL589787 Genomic DNA. Translation: CAI12409.1. Sequence problems.
AL589787, AL583860 Genomic DNA. Translation: CAI40680.1. Sequence problems.
AL589787 Genomic DNA. Translation: CAI40684.1.
BC021140 mRNA. Translation: AAH21140.1.
BC140898 mRNA. Translation: AAI40899.1.
BC146869 mRNA. Translation: AAI46870.1.
AK057500 mRNA. Translation: BAB71512.1.
AF435960 mRNA. Translation: AAM20911.1. Different initiation.
CCDSiCCDS31310.1. [Q96M02-1]
RefSeqiNP_001004298.2. NM_001004298.2. [Q96M02-1]
UniGeneiHs.587663.

Genome annotation databases

EnsembliENST00000284694; ENSP00000284694; ENSG00000154493. [Q96M02-1]
GeneIDi118611.
KEGGihsa:118611.
UCSCiuc001ljq.4. human. [Q96M02-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583860, AL589787 Genomic DNA. Translation: CAI12409.1. Sequence problems.
AL589787, AL583860 Genomic DNA. Translation: CAI40680.1. Sequence problems.
AL589787 Genomic DNA. Translation: CAI40684.1.
BC021140 mRNA. Translation: AAH21140.1.
BC140898 mRNA. Translation: AAI40899.1.
BC146869 mRNA. Translation: AAI46870.1.
AK057500 mRNA. Translation: BAB71512.1.
AF435960 mRNA. Translation: AAM20911.1. Different initiation.
CCDSiCCDS31310.1. [Q96M02-1]
RefSeqiNP_001004298.2. NM_001004298.2. [Q96M02-1]
UniGeneiHs.587663.

3D structure databases

ProteinModelPortaliQ96M02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125615. 2 interactions.
IntActiQ96M02. 2 interactions.
STRINGi9606.ENSP00000284694.

PTM databases

iPTMnetiQ96M02.
PhosphoSiteiQ96M02.

Polymorphism and mutation databases

BioMutaiC10orf90.
DMDMi143377520.

Proteomic databases

EPDiQ96M02.
MaxQBiQ96M02.
PaxDbiQ96M02.
PeptideAtlasiQ96M02.
PRIDEiQ96M02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284694; ENSP00000284694; ENSG00000154493. [Q96M02-1]
GeneIDi118611.
KEGGihsa:118611.
UCSCiuc001ljq.4. human. [Q96M02-1]

Organism-specific databases

CTDi118611.
GeneCardsiC10orf90.
HGNCiHGNC:26563. C10orf90.
HPAiHPA038648.
HPA057599.
neXtProtiNX_Q96M02.
PharmGKBiPA134895930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEBN. Eukaryota.
ENOG410Y0PQ. LUCA.
GeneTreeiENSGT00550000074751.
HOVERGENiHBG058161.
InParanoidiQ96M02.
KOiK16773.
OMAiCSSHRLT.
OrthoDBiEOG091G0HCJ.
PhylomeDBiQ96M02.

Miscellaneous databases

GenomeRNAii118611.
PROiQ96M02.

Gene expression databases

BgeeiENSG00000154493.
CleanExiHS_C10orf90.
ExpressionAtlasiQ96M02. baseline and differential.
GenevisibleiQ96M02. HS.

Family and domain databases

InterProiIPR029299. ALMS_motif.
IPR029561. C10orf90.
[Graphical view]
PANTHERiPTHR21553:SF24. PTHR21553:SF24. 1 hit.
PfamiPF15309. ALMS_motif. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCJ090_HUMAN
AccessioniPrimary (citable) accession number: Q96M02
Secondary accession number(s): B9EIQ9
, Q5JRP6, Q5T023, Q8NCV5, Q8WU75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.