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Protein

Calcineurin subunit B type 2

Gene

PPP3R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi31 – 42121Add
BLAST
Calcium bindingi63 – 74122Add
BLAST
Calcium bindingi100 – 111123Add
BLAST
Calcium bindingi141 – 152124Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Calcineurin B-like protein
Short name:
CBLP
Calcineurin BII
Short name:
CNBII
PPP3R1-like
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:PPP3R2
Synonyms:CBLP, PPP3RL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9318. PPP3R2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 170169Calcineurin subunit B type 2PRO_0000073499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ96LZ3.
PaxDbiQ96LZ3.
PRIDEiQ96LZ3.

PTM databases

PhosphoSiteiQ96LZ3.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiQ96LZ3.
CleanExiHS_PPP3R2.
GenevestigatoriQ96LZ3.

Organism-specific databases

HPAiHPA047157.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

BioGridi111527. 2 interactions.
IntActiQ96LZ3. 13 interactions.
STRINGi9606.ENSP00000363939.

Structurei

3D structure databases

ProteinModelPortaliQ96LZ3.
SMRiQ96LZ3. Positions 16-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5134EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini87 – 12236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 16336EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiQ96LZ3.
KOiK06268.
OrthoDBiEOG75QR5D.
PhylomeDBiQ96LZ3.
TreeFamiTF105558.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR
60 70 80 90 100
HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD
110 120 130 140 150
MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF
160 170
EEFSAVVRDL EIHKKLVLIV
Length:170
Mass (Da):19,533
Last modified:January 23, 2007 - v3
Checksum:i322F9CA4123BA2C3
GO

Sequence cautioni

The sequence AAH30595.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH66299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP57772.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH69961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW58961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161D → N in AAL40395 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145026 mRNA. Translation: AAP97278.1.
AF400667 mRNA. Translation: AAP57772.1. Different initiation.
AF085237 mRNA. Translation: AAL40395.1.
AK057524 mRNA. Translation: BAB71521.1. Different initiation.
AL591377 Genomic DNA. Translation: CAH69961.1. Different initiation.
CH471105 Genomic DNA. Translation: EAW58961.1. Different initiation.
BC030595 mRNA. Translation: AAH30595.1. Different initiation.
BC066299 mRNA. Translation: AAH66299.1. Different initiation.
RefSeqiNP_671709.1. NM_147180.3.
UniGeneiHs.151167.

Genome annotation databases

EnsembliENST00000374806; ENSP00000363939; ENSG00000188386.
GeneIDi5535.
KEGGihsa:5535.
UCSCiuc004bbr.3. human.

Polymorphism databases

DMDMi52000731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145026 mRNA. Translation: AAP97278.1.
AF400667 mRNA. Translation: AAP57772.1. Different initiation.
AF085237 mRNA. Translation: AAL40395.1.
AK057524 mRNA. Translation: BAB71521.1. Different initiation.
AL591377 Genomic DNA. Translation: CAH69961.1. Different initiation.
CH471105 Genomic DNA. Translation: EAW58961.1. Different initiation.
BC030595 mRNA. Translation: AAH30595.1. Different initiation.
BC066299 mRNA. Translation: AAH66299.1. Different initiation.
RefSeqiNP_671709.1. NM_147180.3.
UniGeneiHs.151167.

3D structure databases

ProteinModelPortaliQ96LZ3.
SMRiQ96LZ3. Positions 16-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111527. 2 interactions.
IntActiQ96LZ3. 13 interactions.
STRINGi9606.ENSP00000363939.

Chemistry

DrugBankiDB00091. Cyclosporine.

PTM databases

PhosphoSiteiQ96LZ3.

Polymorphism databases

DMDMi52000731.

Proteomic databases

MaxQBiQ96LZ3.
PaxDbiQ96LZ3.
PRIDEiQ96LZ3.

Protocols and materials databases

DNASUi5535.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374806; ENSP00000363939; ENSG00000188386.
GeneIDi5535.
KEGGihsa:5535.
UCSCiuc004bbr.3. human.

Organism-specific databases

CTDi5535.
GeneCardsiGC09M104353.
HGNCiHGNC:9318. PPP3R2.
HPAiHPA047157.
MIMi613821. gene.
neXtProtiNX_Q96LZ3.
PharmGKBiPA33682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiQ96LZ3.
KOiK06268.
OrthoDBiEOG75QR5D.
PhylomeDBiQ96LZ3.
TreeFamiTF105558.

Enzyme and pathway databases

BRENDAi3.1.3.16. 2681.

Miscellaneous databases

GeneWikiiPPP3R2.
GenomeRNAii5535.
NextBioi21442.
PROiQ96LZ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LZ3.
CleanExiHS_PPP3R2.
GenevestigatoriQ96LZ3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis."
    Liu L., Zhang J., Yuan J., Dang Y., Yang C., Chen X., Xu J., Yu L.
    Mol. Biol. Rep. 32:41-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "cDNA cloning of a novel calcineurin B-like protein (CBLP)."
    Guo J.H., She X.Y., Dai F.Y., Yu L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of a novel human cDNA, CNBII, whose product shows significant homology to calcineurin B."
    Tu Q., Yu L., Bi A., Zhang H., He W., Zhao S.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCANB2_HUMAN
AccessioniPrimary (citable) accession number: Q96LZ3
Secondary accession number(s): Q5VTR4, Q7Z4V8, Q8WYJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.