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Q96LZ3

- CANB2_HUMAN

UniProt

Q96LZ3 - CANB2_HUMAN

Protein

Calcineurin subunit B type 2

Gene

PPP3R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi31 – 42121Add
    BLAST
    Calcium bindingi63 – 74122Add
    BLAST
    Calcium bindingi100 – 111123Add
    BLAST
    Calcium bindingi141 – 152124Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    BRENDAi3.1.3.16. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcineurin subunit B type 2
    Alternative name(s):
    Calcineurin B-like protein
    Short name:
    CBLP
    Calcineurin BII
    Short name:
    CNBII
    PPP3R1-like
    Protein phosphatase 2B regulatory subunit 2
    Protein phosphatase 3 regulatory subunit B beta isoform
    Gene namesi
    Name:PPP3R2
    Synonyms:CBLP, PPP3RL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:9318. PPP3R2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33682.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 170169Calcineurin subunit B type 2PRO_0000073499Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PaxDbiQ96LZ3.
    PRIDEiQ96LZ3.

    PTM databases

    PhosphoSiteiQ96LZ3.

    Expressioni

    Tissue specificityi

    Testis-specific.1 Publication

    Gene expression databases

    BgeeiQ96LZ3.
    CleanExiHS_PPP3R2.
    GenevestigatoriQ96LZ3.

    Interactioni

    Subunit structurei

    Composed of a catalytic subunit (A) and a regulatory subunit (B).

    Protein-protein interaction databases

    BioGridi111527. 1 interaction.
    IntActiQ96LZ3. 1 interaction.
    STRINGi9606.ENSP00000363939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96LZ3.
    SMRiQ96LZ3. Positions 6-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 5134EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 12236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 16336EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG105307.
    InParanoidiQ96LZ3.
    KOiK06268.
    OrthoDBiEOG75QR5D.
    PhylomeDBiQ96LZ3.
    TreeFamiTF105558.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96LZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR    50
    HNPLVRRVID VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD 100
    MDKDGYISNG ELFQVLKMMV GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF 150
    EEFSAVVRDL EIHKKLVLIV 170
    Length:170
    Mass (Da):19,533
    Last modified:January 23, 2007 - v3
    Checksum:i322F9CA4123BA2C3
    GO

    Sequence cautioni

    The sequence AAH30595.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH66299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAP57772.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB71521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAH69961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence EAW58961.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161D → N in AAL40395. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145026 mRNA. Translation: AAP97278.1.
    AF400667 mRNA. Translation: AAP57772.1. Different initiation.
    AF085237 mRNA. Translation: AAL40395.1.
    AK057524 mRNA. Translation: BAB71521.1. Different initiation.
    AL591377 Genomic DNA. Translation: CAH69961.1. Different initiation.
    CH471105 Genomic DNA. Translation: EAW58961.1. Different initiation.
    BC030595 mRNA. Translation: AAH30595.1. Different initiation.
    BC066299 mRNA. Translation: AAH66299.1. Different initiation.
    RefSeqiNP_671709.1. NM_147180.2.
    UniGeneiHs.151167.

    Genome annotation databases

    EnsembliENST00000374806; ENSP00000363939; ENSG00000188386.
    GeneIDi5535.
    KEGGihsa:5535.
    UCSCiuc004bbr.3. human.

    Polymorphism databases

    DMDMi52000731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145026 mRNA. Translation: AAP97278.1 .
    AF400667 mRNA. Translation: AAP57772.1 . Different initiation.
    AF085237 mRNA. Translation: AAL40395.1 .
    AK057524 mRNA. Translation: BAB71521.1 . Different initiation.
    AL591377 Genomic DNA. Translation: CAH69961.1 . Different initiation.
    CH471105 Genomic DNA. Translation: EAW58961.1 . Different initiation.
    BC030595 mRNA. Translation: AAH30595.1 . Different initiation.
    BC066299 mRNA. Translation: AAH66299.1 . Different initiation.
    RefSeqi NP_671709.1. NM_147180.2.
    UniGenei Hs.151167.

    3D structure databases

    ProteinModelPortali Q96LZ3.
    SMRi Q96LZ3. Positions 6-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111527. 1 interaction.
    IntActi Q96LZ3. 1 interaction.
    STRINGi 9606.ENSP00000363939.

    Chemistry

    BindingDBi Q96LZ3.
    DrugBanki DB00091. Cyclosporine.

    PTM databases

    PhosphoSitei Q96LZ3.

    Polymorphism databases

    DMDMi 52000731.

    Proteomic databases

    PaxDbi Q96LZ3.
    PRIDEi Q96LZ3.

    Protocols and materials databases

    DNASUi 5535.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374806 ; ENSP00000363939 ; ENSG00000188386 .
    GeneIDi 5535.
    KEGGi hsa:5535.
    UCSCi uc004bbr.3. human.

    Organism-specific databases

    CTDi 5535.
    GeneCardsi GC09M104353.
    HGNCi HGNC:9318. PPP3R2.
    MIMi 613821. gene.
    neXtProti NX_Q96LZ3.
    PharmGKBi PA33682.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG105307.
    InParanoidi Q96LZ3.
    KOi K06268.
    OrthoDBi EOG75QR5D.
    PhylomeDBi Q96LZ3.
    TreeFami TF105558.

    Enzyme and pathway databases

    BRENDAi 3.1.3.16. 2681.

    Miscellaneous databases

    GeneWikii PPP3R2.
    GenomeRNAii 5535.
    NextBioi 21442.
    PROi Q96LZ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96LZ3.
    CleanExi HS_PPP3R2.
    Genevestigatori Q96LZ3.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis."
      Liu L., Zhang J., Yuan J., Dang Y., Yang C., Chen X., Xu J., Yu L.
      Mol. Biol. Rep. 32:41-45(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "cDNA cloning of a novel calcineurin B-like protein (CBLP)."
      Guo J.H., She X.Y., Dai F.Y., Yu L.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of a novel human cDNA, CNBII, whose product shows significant homology to calcineurin B."
      Tu Q., Yu L., Bi A., Zhang H., He W., Zhao S.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCANB2_HUMAN
    AccessioniPrimary (citable) accession number: Q96LZ3
    Secondary accession number(s): Q5VTR4, Q7Z4V8, Q8WYJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein has four functional calcium-binding sites.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3