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Protein

Melanoma-associated antigen B10

Gene

MAGEB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B10
Alternative name(s):
MAGE-B10 antigen
Gene namesi
Name:MAGEB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25377. MAGEB10.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177689.
PharmGKBiPA134952121.

Polymorphism and mutation databases

BioMutaiMAGEB10.
DMDMi224471901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567181 – 347Melanoma-associated antigen B10Add BLAST347

Proteomic databases

MaxQBiQ96LZ2.
PaxDbiQ96LZ2.
PeptideAtlasiQ96LZ2.
PRIDEiQ96LZ2.

PTM databases

iPTMnetiQ96LZ2.
PhosphoSitePlusiQ96LZ2.

Expressioni

Gene expression databases

BgeeiENSG00000177689.
CleanExiHS_MAGEB10.

Organism-specific databases

HPAiHPA000611.

Interactioni

Protein-protein interaction databases

BioGridi126566. 49 interactors.
IntActiQ96LZ2. 1 interactor.
STRINGi9606.ENSP00000368304.

Structurei

3D structure databases

ProteinModelPortaliQ96LZ2.
SMRiQ96LZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 310MAGEPROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96LZ2.
OMAiLYDGIEH.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ96LZ2.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRQARG GLEDLIDALD ILEEEEESPP SASACLKDVF
60 70 80 90 100
QSSLDGASNN PHGLREAQST STSATAASHT RHPEGVNDQM EERPICTQDL
110 120 130 140 150
EATDSFPRGP VDEKVIILVH YLLYKYQMKE PITKADMLRN VTQMSKSQFP
160 170 180 190 200
VILSRASEHL ELIFGLDLKE VEPNKHIYVL VNKLDLGCDA KLSDETGVPK
210 220 230 240 250
TGLLMTVLGI IFTNGNCVAE EEVWKVFNTM GLYDGIEHFM FGEPRKLLTK
260 270 280 290 300
DLVKENYLEY QQVPNSDPPR YQFLWGPRAH AETSKMKVLE FLAKVNDTAP
310 320 330 340
SEFSNWYTEA LQDEEERARA RVAAKARVSA TAGARSKVKS SKSSQLQ
Length:347
Mass (Da):38,971
Last modified:March 3, 2009 - v4
Checksum:i26BA1493CF566A39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6K → E in BAB71522 (PubMed:14702039).Curated1
Sequence conflicti68Q → R in BAB71522 (PubMed:14702039).Curated1
Sequence conflicti164F → L in BAB71522 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05450050F → S.2 PublicationsCorresponds to variant rs1368769dbSNPEnsembl.1
Natural variantiVAR_02677365R → Q.2 PublicationsCorresponds to variant rs12557898dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057527 mRNA. Translation: BAB71522.1.
AC107613 Genomic DNA. No translation available.
AC112492 Genomic DNA. No translation available.
BC101307 mRNA. Translation: AAI01308.1.
BC101308 mRNA. Translation: AAI01309.1.
BC101309 mRNA. Translation: AAI01310.1.
BC101310 mRNA. Translation: AAI01311.1.
AF333708 Genomic DNA. Translation: AAK00360.1.
CCDSiCCDS35221.1.
RefSeqiNP_872312.2. NM_182506.3.
UniGeneiHs.447363.

Genome annotation databases

EnsembliENST00000356790; ENSP00000368304; ENSG00000177689.
ENST00000614159; ENSP00000480889; ENSG00000177689.
GeneIDi139422.
KEGGihsa:139422.
UCSCiuc004dbw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057527 mRNA. Translation: BAB71522.1.
AC107613 Genomic DNA. No translation available.
AC112492 Genomic DNA. No translation available.
BC101307 mRNA. Translation: AAI01308.1.
BC101308 mRNA. Translation: AAI01309.1.
BC101309 mRNA. Translation: AAI01310.1.
BC101310 mRNA. Translation: AAI01311.1.
AF333708 Genomic DNA. Translation: AAK00360.1.
CCDSiCCDS35221.1.
RefSeqiNP_872312.2. NM_182506.3.
UniGeneiHs.447363.

3D structure databases

ProteinModelPortaliQ96LZ2.
SMRiQ96LZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126566. 49 interactors.
IntActiQ96LZ2. 1 interactor.
STRINGi9606.ENSP00000368304.

PTM databases

iPTMnetiQ96LZ2.
PhosphoSitePlusiQ96LZ2.

Polymorphism and mutation databases

BioMutaiMAGEB10.
DMDMi224471901.

Proteomic databases

MaxQBiQ96LZ2.
PaxDbiQ96LZ2.
PeptideAtlasiQ96LZ2.
PRIDEiQ96LZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356790; ENSP00000368304; ENSG00000177689.
ENST00000614159; ENSP00000480889; ENSG00000177689.
GeneIDi139422.
KEGGihsa:139422.
UCSCiuc004dbw.3. human.

Organism-specific databases

CTDi139422.
GeneCardsiMAGEB10.
HGNCiHGNC:25377. MAGEB10.
HPAiHPA000611.
MIMi300761. gene.
neXtProtiNX_Q96LZ2.
OpenTargetsiENSG00000177689.
PharmGKBiPA134952121.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96LZ2.
OMAiLYDGIEH.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ96LZ2.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii139422.
PROiQ96LZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177689.
CleanExiHS_MAGEB10.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGBA_HUMAN
AccessioniPrimary (citable) accession number: Q96LZ2
Secondary accession number(s): Q494Y6, Q494Y7, Q9BZ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.