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Protein

Melanoma-associated antigen B10

Gene

MAGEB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B10
Alternative name(s):
MAGE-B10 antigen
Gene namesi
Name:MAGEB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25377. MAGEB10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952121.

Polymorphism and mutation databases

BioMutaiMAGEB10.
DMDMi224471901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Melanoma-associated antigen B10PRO_0000156718Add
BLAST

Proteomic databases

EPDiQ96LZ2.
PaxDbiQ96LZ2.
PRIDEiQ96LZ2.

PTM databases

iPTMnetiQ96LZ2.
PhosphoSiteiQ96LZ2.

Expressioni

Gene expression databases

BgeeiQ96LZ2.
CleanExiHS_MAGEB10.

Organism-specific databases

HPAiHPA000611.

Interactioni

Protein-protein interaction databases

BioGridi126566. 49 interactions.
IntActiQ96LZ2. 1 interaction.
STRINGi9606.ENSP00000368304.

Structurei

3D structure databases

ProteinModelPortaliQ96LZ2.
SMRiQ96LZ2. Positions 98-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 310200MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96LZ2.
OMAiLYDGIEH.
OrthoDBiEOG75F4GM.
PhylomeDBiQ96LZ2.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRQARG GLEDLIDALD ILEEEEESPP SASACLKDVF
60 70 80 90 100
QSSLDGASNN PHGLREAQST STSATAASHT RHPEGVNDQM EERPICTQDL
110 120 130 140 150
EATDSFPRGP VDEKVIILVH YLLYKYQMKE PITKADMLRN VTQMSKSQFP
160 170 180 190 200
VILSRASEHL ELIFGLDLKE VEPNKHIYVL VNKLDLGCDA KLSDETGVPK
210 220 230 240 250
TGLLMTVLGI IFTNGNCVAE EEVWKVFNTM GLYDGIEHFM FGEPRKLLTK
260 270 280 290 300
DLVKENYLEY QQVPNSDPPR YQFLWGPRAH AETSKMKVLE FLAKVNDTAP
310 320 330 340
SEFSNWYTEA LQDEEERARA RVAAKARVSA TAGARSKVKS SKSSQLQ
Length:347
Mass (Da):38,971
Last modified:March 3, 2009 - v4
Checksum:i26BA1493CF566A39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61K → E in BAB71522 (PubMed:14702039).Curated
Sequence conflicti68 – 681Q → R in BAB71522 (PubMed:14702039).Curated
Sequence conflicti164 – 1641F → L in BAB71522 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501F → S.2 Publications
Corresponds to variant rs1368769 [ dbSNP | Ensembl ].
VAR_054500
Natural varianti65 – 651R → Q.2 Publications
Corresponds to variant rs12557898 [ dbSNP | Ensembl ].
VAR_026773

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057527 mRNA. Translation: BAB71522.1.
AC107613 Genomic DNA. No translation available.
AC112492 Genomic DNA. No translation available.
BC101307 mRNA. Translation: AAI01308.1.
BC101308 mRNA. Translation: AAI01309.1.
BC101309 mRNA. Translation: AAI01310.1.
BC101310 mRNA. Translation: AAI01311.1.
AF333708 Genomic DNA. Translation: AAK00360.1.
CCDSiCCDS35221.1.
RefSeqiNP_872312.2. NM_182506.3.
XP_011543752.1. XM_011545450.1.
XP_011543753.1. XM_011545451.1.
XP_011543754.1. XM_011545452.1.
UniGeneiHs.447363.

Genome annotation databases

EnsembliENST00000356790; ENSP00000368304; ENSG00000177689.
ENST00000614159; ENSP00000480889; ENSG00000177689.
GeneIDi139422.
KEGGihsa:139422.
UCSCiuc004dbw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057527 mRNA. Translation: BAB71522.1.
AC107613 Genomic DNA. No translation available.
AC112492 Genomic DNA. No translation available.
BC101307 mRNA. Translation: AAI01308.1.
BC101308 mRNA. Translation: AAI01309.1.
BC101309 mRNA. Translation: AAI01310.1.
BC101310 mRNA. Translation: AAI01311.1.
AF333708 Genomic DNA. Translation: AAK00360.1.
CCDSiCCDS35221.1.
RefSeqiNP_872312.2. NM_182506.3.
XP_011543752.1. XM_011545450.1.
XP_011543753.1. XM_011545451.1.
XP_011543754.1. XM_011545452.1.
UniGeneiHs.447363.

3D structure databases

ProteinModelPortaliQ96LZ2.
SMRiQ96LZ2. Positions 98-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126566. 49 interactions.
IntActiQ96LZ2. 1 interaction.
STRINGi9606.ENSP00000368304.

PTM databases

iPTMnetiQ96LZ2.
PhosphoSiteiQ96LZ2.

Polymorphism and mutation databases

BioMutaiMAGEB10.
DMDMi224471901.

Proteomic databases

EPDiQ96LZ2.
PaxDbiQ96LZ2.
PRIDEiQ96LZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356790; ENSP00000368304; ENSG00000177689.
ENST00000614159; ENSP00000480889; ENSG00000177689.
GeneIDi139422.
KEGGihsa:139422.
UCSCiuc004dbw.3. human.

Organism-specific databases

CTDi139422.
GeneCardsiMAGEB10.
HGNCiHGNC:25377. MAGEB10.
HPAiHPA000611.
MIMi300761. gene.
neXtProtiNX_Q96LZ2.
PharmGKBiPA134952121.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ96LZ2.
OMAiLYDGIEH.
OrthoDBiEOG75F4GM.
PhylomeDBiQ96LZ2.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii139422.
PROiQ96LZ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LZ2.
CleanExiHS_MAGEB10.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-50 AND GLN-65.
    Tissue: Testis.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-50 AND GLN-65.
  4. "Identification of new members of the MAGE gene family."
    Lucas S., Boon T.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-222.
    Tissue: Blood.

Entry informationi

Entry nameiMAGBA_HUMAN
AccessioniPrimary (citable) accession number: Q96LZ2
Secondary accession number(s): Q494Y6, Q494Y7, Q9BZ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.