Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 597

Gene

ZNF597

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 597
Gene namesi
Name:ZNF597
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26573. ZNF597.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935893.

Polymorphism and mutation databases

BioMutaiZNF597.
DMDMi71153482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Zinc finger protein 597PRO_0000047687Add
BLAST

Proteomic databases

EPDiQ96LX8.
MaxQBiQ96LX8.
PaxDbiQ96LX8.
PRIDEiQ96LX8.

PTM databases

iPTMnetiQ96LX8.
PhosphoSiteiQ96LX8.

Expressioni

Inductioni

Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in leukocytes.2 Publications

Gene expression databases

BgeeiQ96LX8.
CleanExiHS_ZNF597.
GenevisibleiQ96LX8. HS.

Organism-specific databases

HPAiHPA001556.

Interactioni

Protein-protein interaction databases

BioGridi126986. 11 interactions.
IntActiQ96LX8. 1 interaction.
STRINGi9606.ENSP00000301744.

Structurei

3D structure databases

ProteinModelPortaliQ96LX8.
SMRiQ96LX8. Positions 156-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8875KRABAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00630000089880.
HOGENOMiHOG000234617.
HOVERGENiHBG108383.
InParanoidiQ96LX8.
KOiK09228.
OMAiSFRQHSH.
OrthoDBiEOG70KGPP.
PhylomeDBiQ96LX8.
TreeFamiTF342316.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMPPTPEA QGPILFEDLA VYFSQEECVT LHPAQRSLSK DGTKESLEDA
60 70 80 90 100
ALMGEEGKPE INQQLSLESM ELDELALEKY PIAAPLVPYP EKSSEDGVGN
110 120 130 140 150
PEAKILSGTP TYKRRVISLL VTIENHTPLV ELSEYLGTNT LSEILDSPWE
160 170 180 190 200
GAKNVYKCPE CDQNFSDHSY LVLHQKIHSG EKKHKCGDCG KIFNHRANLR
210 220 230 240 250
THRRIHTGEK PYKCAKCSAS FRQHSHLSRH MNSHVKEKPY TCSICGRGFM
260 270 280 290 300
WLPGLAQHQK SHSAENTYES TNCDKHFNEK PNLALPEETF VSGPQYQHTK
310 320 330 340 350
CMKSFRQSLY PALSEKSHDE DSERCSDDGD NFFSFSKFKP LQCPDCDMTF
360 370 380 390 400
PCFSELISHQ NIHTEERPHK CKTCEESFAL DSELACHQKS HMLAEPFKCT
410 420
VCGKTFKSNL HLITHKRTHI KNTT
Length:424
Mass (Da):48,076
Last modified:December 1, 2001 - v1
Checksum:i8A47D19087AA8645
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301T → S.
Corresponds to variant rs2270493 [ dbSNP | Ensembl ].
VAR_033581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057633 mRNA. Translation: BAB71538.1.
BC029899 mRNA. Translation: AAH29899.1.
CCDSiCCDS10505.1.
RefSeqiNP_689670.1. NM_152457.2.
UniGeneiHs.133338.
Hs.88630.

Genome annotation databases

EnsembliENST00000301744; ENSP00000301744; ENSG00000167981.
GeneIDi146434.
KEGGihsa:146434.
UCSCiuc002cvd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057633 mRNA. Translation: BAB71538.1.
BC029899 mRNA. Translation: AAH29899.1.
CCDSiCCDS10505.1.
RefSeqiNP_689670.1. NM_152457.2.
UniGeneiHs.133338.
Hs.88630.

3D structure databases

ProteinModelPortaliQ96LX8.
SMRiQ96LX8. Positions 156-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126986. 11 interactions.
IntActiQ96LX8. 1 interaction.
STRINGi9606.ENSP00000301744.

PTM databases

iPTMnetiQ96LX8.
PhosphoSiteiQ96LX8.

Polymorphism and mutation databases

BioMutaiZNF597.
DMDMi71153482.

Proteomic databases

EPDiQ96LX8.
MaxQBiQ96LX8.
PaxDbiQ96LX8.
PRIDEiQ96LX8.

Protocols and materials databases

DNASUi146434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301744; ENSP00000301744; ENSG00000167981.
GeneIDi146434.
KEGGihsa:146434.
UCSCiuc002cvd.4. human.

Organism-specific databases

CTDi146434.
GeneCardsiZNF597.
HGNCiHGNC:26573. ZNF597.
HPAiHPA001556.
MIMi614685. gene.
neXtProtiNX_Q96LX8.
PharmGKBiPA134935893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00630000089880.
HOGENOMiHOG000234617.
HOVERGENiHBG108383.
InParanoidiQ96LX8.
KOiK09228.
OMAiSFRQHSH.
OrthoDBiEOG70KGPP.
PhylomeDBiQ96LX8.
TreeFamiTF342316.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF597. human.
GenomeRNAii146434.
NextBioi85359.
PROiQ96LX8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LX8.
CleanExiHS_ZNF597.
GenevisibleiQ96LX8. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Analysis of allelic differential expression in human white blood cells."
    Pant P.V., Tao H., Beilharz E.J., Ballinger D.G., Cox D.R., Frazer K.A.
    Genome Res. 16:331-339(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPRINTING, INDUCTION.
  4. "Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes."
    Nakabayashi K., Trujillo A.M., Tayama C., Camprubi C., Yoshida W., Lapunzina P., Sanchez A., Soejima H., Aburatani H., Nagae G., Ogata T., Hata K., Monk D.
    Hum. Mol. Genet. 20:3188-3197(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPRINTING, INDUCTION.

Entry informationi

Entry nameiZN597_HUMAN
AccessioniPrimary (citable) accession number: Q96LX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.