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Protein

Coiled-coil domain-containing protein 17

Gene

CCDC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 17
Gene namesi
Name:CCDC17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159588.14
HGNCiHGNC:26574 CCDC17
neXtProtiNX_Q96LX7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159588

Polymorphism and mutation databases

BioMutaiCCDC17
DMDMi302393684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028521 – 622Coiled-coil domain-containing protein 17Add BLAST622

Proteomic databases

EPDiQ96LX7
PaxDbiQ96LX7
PeptideAtlasiQ96LX7
PRIDEiQ96LX7

PTM databases

CarbonylDBiQ96LX7
iPTMnetiQ96LX7
PhosphoSitePlusiQ96LX7

Expressioni

Gene expression databases

BgeeiENSG00000159588
CleanExiHS_CCDC17
ExpressionAtlasiQ96LX7 baseline and differential
GenevisibleiQ96LX7 HS

Organism-specific databases

HPAiHPA028338

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127219, 4 interactors
IntActiQ96LX7, 11 interactors
STRINGi9606.ENSP00000432172

Structurei

3D structure databases

ProteinModelPortaliQ96LX7
SMRiQ96LX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili81 – 102Sequence analysisAdd BLAST22
Coiled coili146 – 207Sequence analysisAdd BLAST62
Coiled coili294 – 320Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 366Pro-richAdd BLAST24

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXRK Eukaryota
ENOG4111MM2 LUCA
GeneTreeiENSGT00390000006459
HOVERGENiHBG106753
InParanoidiQ96LX7
OMAiWITEVPR
OrthoDBiEOG091G03D0
PhylomeDBiQ96LX7
TreeFamiTF335390

Family and domain databases

InterProiView protein in InterPro
IPR038800 CCDC17
PANTHERiPTHR33820 PTHR33820, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LX7-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSHSGEPAL LPCGTCDMVF RSSALLATHT QRFCIGHPTQ EMTFGAQASV
60 70 80 90 100
ATEPQRAAVV PQEHQGVPQE PQGLPDQQAS RSALKRLTEE VQWLRLSLQE
110 120 130 140 150
MRPWITEVPR VFAGPWTRSE ARPQSPMSEA VGSPSERLRA LFRTRARRVA
160 170 180 190 200
EMEAQSRALQ LRGEELSRRL QVVACTRGGM SRLFGLEQEI RELQAEAGRT
210 220 230 240 250
RGALEVLGAR IQELQAEPGN PLSSRREAEL YSPVQKANPG TLAAEIRALR
260 270 280 290 300
EAYIRDGGRD PGVLGQIWQL QVEASALELQ RSQTRRGRAG ATSGELPVVE
310 320 330 340 350
AENRRLEAEI LALQMQRGRA PLGPQDLRLL GDASLQPKGR RDPPLLPPPV
360 370 380 390 400
APPLPPLPGF SEPQLPGTMT RNLGLDSHFL LPTSDMLGPA PYDPGAGLVI
410 420 430 440 450
FYDFLRGLEA SWIWVQLRTG LARDGRDTGR TTALPPALCL PPPPAPGPMG
460 470 480 490 500
NCAILASRQP VPRLPPSSSV SLVCELQVWQ GLAWARAPQP KAWVSLGLFD
510 520 530 540 550
QDQRVLSGRW RLPLRALPLD PSLSLGQLNG IPQAGQAELF LRLVNARDAA
560 570 580 590 600
VQTLAEINPA SVHEYQYPPP VSSTSSLEAS FLTPAVGFAD PPPRTEEPLS
610 620
GVKDRDEGLG PHHSSDLPPV SF
Note: No experimental confirmation available.
Length:622
Mass (Da):67,721
Last modified:August 10, 2010 - v2
Checksum:iA48A40C2229C37E0
GO
Isoform 2 (identifier: Q96LX7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-99: Missing.

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):66,597
Checksum:i145B9AF19DCB937D
GO
Isoform 3 (identifier: Q96LX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:443
Mass (Da):47,827
Checksum:iDF68100E53A5CCC4
GO
Isoform 4 (identifier: Q96LX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-571: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):11,565
Checksum:i1A40F6416B9DE091
GO

Sequence cautioni

The sequence BAB71539 differs from that shown. Incompletely spliced mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41E → V in BAB71539 (PubMed:14702039).Curated1
Sequence conflicti74L → P in BAG64867 (PubMed:14702039).Curated1
Sequence conflicti417L → E in AAH29888 (PubMed:15489334).Curated1
Sequence conflicti420 – 421GL → AS in AAH29888 (PubMed:15489334).Curated2
Sequence conflicti423 – 425RDG → HAA in AAH29888 (PubMed:15489334).Curated3
Sequence conflicti439C → F in AAH29888 (PubMed:15489334).Curated1
Sequence conflicti450G → S in AAH29888 (PubMed:15489334).Curated1
Sequence conflicti615S → F in AAH29888 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034976353P → L1 PublicationCorresponds to variant dbSNP:rs3014242Ensembl.1
Natural variantiVAR_059599470V → I. Corresponds to variant dbSNP:rs17410855Ensembl.1
Natural variantiVAR_034977557I → V. Corresponds to variant dbSNP:rs2297654Ensembl.1
Natural variantiVAR_063516580S → N2 PublicationsCorresponds to variant dbSNP:rs3014246Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0396511 – 179Missing in isoform 3. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_03965260 – 571Missing in isoform 4. 1 PublicationAdd BLAST512
Alternative sequenceiVSP_03965391 – 99Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057646 mRNA Translation: BAB71539.1 Sequence problems.
AK298104 mRNA Translation: BAG60389.1
AK303939 mRNA Translation: BAG64867.1
AL355480 Genomic DNA No translation available.
BC029888 mRNA Translation: AAH29888.1
BC128177 mRNA Translation: AAI28178.1
BC128178 mRNA Translation: AAI28179.2
CCDSiCCDS44131.2 [Q96LX7-4]
CCDS53314.1 [Q96LX7-5]
RefSeqiNP_001108410.2, NM_001114938.2 [Q96LX7-4]
NP_001177111.1, NM_001190182.1 [Q96LX7-5]
UniGeneiHs.18912

Genome annotation databases

EnsembliENST00000421127; ENSP00000389415; ENSG00000159588 [Q96LX7-5]
ENST00000445048; ENSP00000411335; ENSG00000159588 [Q96LX7-3]
ENST00000528266; ENSP00000432172; ENSG00000159588 [Q96LX7-4]
GeneIDi149483
KEGGihsa:149483
UCSCiuc009vxz.4 human [Q96LX7-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD17_HUMAN
AccessioniPrimary (citable) accession number: Q96LX7
Secondary accession number(s): A1A4Y7
, B4DNX7, B4E1Q5, C9J8L2, Q0P683, Q5T629
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health