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Q96LW7

- BINCA_HUMAN

UniProt

Q96LW7 - BINCA_HUMAN

Protein

Bcl10-interacting CARD protein

Gene

C9orf89

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.1 Publication

    GO - Molecular functioni

    1. CARD domain binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl10-interacting CARD protein
    Short name:
    BinCARD
    Gene namesi
    Name:C9orf89
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28148. C9orf89.

    Subcellular locationi

    Isoform 1 : Nucleus 1 Publication
    Note: Coexpression with BCL10 induced translocation from nucleus to cytosol.
    Isoform 2 : Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication. Mitochondrion membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi apparatus Source: HPA
    4. integral component of membrane Source: UniProtKB-KW
    5. mitochondrial membrane Source: UniProtKB-SubCell
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi17 – 171L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication
    Mutagenesisi65 – 651L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134909664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Bcl10-interacting CARD proteinPRO_0000064927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 77Redox-active1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ96LW7.
    PaxDbiQ96LW7.
    PeptideAtlasiQ96LW7.
    PRIDEiQ96LW7.

    PTM databases

    PhosphoSiteiQ96LW7.

    Expressioni

    Tissue specificityi

    Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.1 Publication

    Gene expression databases

    BgeeiQ96LW7.
    CleanExiHS_C9orf89.
    GenevestigatoriQ96LW7.

    Organism-specific databases

    HPAiHPA010921.
    HPA038297.

    Interactioni

    Subunit structurei

    Associates with BCL10 by CARD-CARD interaction.

    Protein-protein interaction databases

    BioGridi123997. 1 interaction.
    MINTiMINT-1215062.

    Structurei

    Secondary structure

    1
    228
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1712
    Helixi25 – 3612
    Beta strandi37 – 404
    Helixi45 – 517
    Helixi58 – 7215
    Helixi74 – 8714
    Helixi89 – 946
    Helixi96 – 983

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DWNX-ray1.58A/B3-99[»]
    4FH0X-ray1.40A/B3-101[»]
    ProteinModelPortaliQ96LW7.
    SMRiQ96LW7. Positions 3-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 9992CARDAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68992.
    OMAiDRHVSRF.
    OrthoDBiEOG7KM5V8.
    PhylomeDBiQ96LW7.
    TreeFamiTF335747.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96LW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK    50
    FRNPKASLRV RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA 100
    LRKFHITNHA CLVLARGGHP SLPLMAWMSS MTTQVCCSPG LASPLASAPP 150
    QRPPSGPEGR VWQAQAVQML VSVSHFLPLP PSLSHGSFHT AWGILYVHSC 200
    PSFSNLIPRG SLHVCVDSNL VPTAAWRS 228
    Length:228
    Mass (Da):25,589
    Last modified:December 1, 2001 - v1
    Checksum:i7A58F5AB69882CF8
    GO
    Isoform 2 (identifier: Q96LW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-228: RKFHITNHAC...NLVPTAAWRS → QNSDCTELDS...AFLADDLGGL

    Note: Appears to be the dominant isoform in peripheral blood cell fractions. Contain a transmembrane helix.

    Show »
    Length:183
    Mass (Da):20,626
    Checksum:i9F0FB9192B11D0EF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei102 – 228127RKFHI…AAWRS → QNSDCTELDSGSQSGELSNR GPMSFLAGLGLAVGLALLLY CYPPDPKGLPGTRRVLGFSP VIIDRHVSRYLLAFLADDLG GL in isoform 2. 1 PublicationVSP_014723Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057716 mRNA. Translation: BAB71550.1.
    AL451065 Genomic DNA. Translation: CAI95110.1.
    BC004500 mRNA. Translation: AAH04500.1.
    BC038856 mRNA. Translation: AAH38856.1.
    CCDSiCCDS6702.2. [Q96LW7-2]
    RefSeqiNP_115686.3. NM_032310.3. [Q96LW7-2]
    UniGeneiHs.434213.

    Genome annotation databases

    EnsembliENST00000375464; ENSP00000364613; ENSG00000165233. [Q96LW7-2]
    ENST00000466409; ENSP00000437237; ENSG00000165233. [Q96LW7-1]
    GeneIDi84270.
    KEGGihsa:84270.
    UCSCiuc004atd.3. human. [Q96LW7-2]

    Polymorphism databases

    DMDMi71658794.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057716 mRNA. Translation: BAB71550.1 .
    AL451065 Genomic DNA. Translation: CAI95110.1 .
    BC004500 mRNA. Translation: AAH04500.1 .
    BC038856 mRNA. Translation: AAH38856.1 .
    CCDSi CCDS6702.2. [Q96LW7-2 ]
    RefSeqi NP_115686.3. NM_032310.3. [Q96LW7-2 ]
    UniGenei Hs.434213.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DWN X-ray 1.58 A/B 3-99 [» ]
    4FH0 X-ray 1.40 A/B 3-101 [» ]
    ProteinModelPortali Q96LW7.
    SMRi Q96LW7. Positions 3-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123997. 1 interaction.
    MINTi MINT-1215062.

    PTM databases

    PhosphoSitei Q96LW7.

    Polymorphism databases

    DMDMi 71658794.

    Proteomic databases

    MaxQBi Q96LW7.
    PaxDbi Q96LW7.
    PeptideAtlasi Q96LW7.
    PRIDEi Q96LW7.

    Protocols and materials databases

    DNASUi 84270.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375464 ; ENSP00000364613 ; ENSG00000165233 . [Q96LW7-2 ]
    ENST00000466409 ; ENSP00000437237 ; ENSG00000165233 . [Q96LW7-1 ]
    GeneIDi 84270.
    KEGGi hsa:84270.
    UCSCi uc004atd.3. human. [Q96LW7-2 ]

    Organism-specific databases

    CTDi 84270.
    GeneCardsi GC09P095858.
    HGNCi HGNC:28148. C9orf89.
    HPAi HPA010921.
    HPA038297.
    neXtProti NX_Q96LW7.
    PharmGKBi PA134909664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68992.
    OMAi DRHVSRF.
    OrthoDBi EOG7KM5V8.
    PhylomeDBi Q96LW7.
    TreeFami TF335747.

    Miscellaneous databases

    GenomeRNAii 84270.
    NextBioi 73828.

    Gene expression databases

    Bgeei Q96LW7.
    CleanExi HS_C9orf89.
    Genevestigatori Q96LW7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Leukocyte and Skin.
    4. "Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein."
      Woo H.-N., Hong G.-S., Jun J.-I., Cho D.-H., Choi H.-W., Lee H.-J., Chung C.-W., Kim I.-K., Jo D.-G., Pyo J.-O., Bertin J., Jung Y.-K.
      FEBS Lett. 578:239-244(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCL10, MUTAGENESIS OF LEU-17 AND LEU-65.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. "The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized."
      Chen K.E., Richards A.A., Caradoc-Davies T.T., Vajjhala P.R., Robin G., Lua L.H., Hill J.M., Schroder K., Sweet M.J., Kellie S., Kobe B., Martin J.
      Acta Crystallogr. D 69:774-784(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 3-101 OF MUTANT MET-16 AND MET-66, ALTERNATIVE SPLICING, DISULFIDE BOND, SUBCELLULAR LOCATION (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiBINCA_HUMAN
    AccessioniPrimary (citable) accession number: Q96LW7
    Secondary accession number(s): Q5BJH8, Q9BSY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3