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Protein

Caspase recruitment domain-containing protein 19

Gene

CARD19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.1 Publication

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB

GO - Biological processi

  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 19
Alternative name(s):
Bcl10-interacting CARD protein
Short name:
BinCARD
Gene namesi
Name:CARD19
Synonyms:C9orf89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28148. CARD19.

Subcellular locationi

Isoform 1 :
Isoform 2 :

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication1
Mutagenesisi65L → A: Abolishes the NF-kappa-B inhibitory activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000165233.
PharmGKBiPA134909664.

Polymorphism and mutation databases

BioMutaiC9orf89.
DMDMi71658794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649271 – 228Caspase recruitment domain-containing protein 19Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 77Redox-active1 Publication
Isoform 2 (identifier: Q96LW7-2)
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ96LW7.
PeptideAtlasiQ96LW7.
PRIDEiQ96LW7.

PTM databases

iPTMnetiQ96LW7.
PhosphoSitePlusiQ96LW7.

Expressioni

Tissue specificityi

Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.1 Publication

Gene expression databases

BgeeiENSG00000165233.
CleanExiHS_C9orf89.
ExpressionAtlasiQ96LW7. baseline and differential.
GenevisibleiQ96LW7. HS.

Organism-specific databases

HPAiHPA010921.
HPA010990.
HPA038297.

Interactioni

Subunit structurei

Associates with BCL10 by CARD-CARD interaction (PubMed:15637807).1 Publication

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123997. 9 interactors.
IntActiQ96LW7. 1 interactor.
MINTiMINT-1215062.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Helixi25 – 36Combined sources12
Beta strandi37 – 40Combined sources4
Helixi45 – 51Combined sources7
Helixi58 – 72Combined sources15
Helixi74 – 87Combined sources14
Helixi89 – 94Combined sources6
Helixi96 – 98Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DWNX-ray1.58A/B3-99[»]
4FH0X-ray1.40A/B3-101[»]
ProteinModelPortaliQ96LW7.
SMRiQ96LW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 99CARDAdd BLAST92

Sequence similaritiesi

Contains 1 CARD domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000016408.
InParanoidiQ96LW7.
OMAiCCPPDPK.
PhylomeDBiQ96LW7.
TreeFamiTF335747.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK
60 70 80 90 100
FRNPKASLRV RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA
110 120 130 140 150
LRKFHITNHA CLVLARGGHP SLPLMAWMSS MTTQVCCSPG LASPLASAPP
160 170 180 190 200
QRPPSGPEGR VWQAQAVQML VSVSHFLPLP PSLSHGSFHT AWGILYVHSC
210 220
PSFSNLIPRG SLHVCVDSNL VPTAAWRS
Length:228
Mass (Da):25,589
Last modified:December 1, 2001 - v1
Checksum:i7A58F5AB69882CF8
GO
Isoform 2 (identifier: Q96LW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-228: RKFHITNHAC...NLVPTAAWRS → QNSDCTELDS...AFLADDLGGL

Note: Appears to be the dominant isoform in peripheral blood cell fractions. Contain a transmembrane helix.Combined sources
Show »
Length:183
Mass (Da):20,626
Checksum:i9F0FB9192B11D0EF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014723102 – 228RKFHI…AAWRS → QNSDCTELDSGSQSGELSNR GPMSFLAGLGLAVGLALLLY CYPPDPKGLPGTRRVLGFSP VIIDRHVSRYLLAFLADDLG GL in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057716 mRNA. Translation: BAB71550.1.
AL451065 Genomic DNA. Translation: CAI95110.1.
BC004500 mRNA. Translation: AAH04500.1.
BC038856 mRNA. Translation: AAH38856.1.
CCDSiCCDS6702.2. [Q96LW7-2]
RefSeqiNP_115686.3. NM_032310.4. [Q96LW7-2]
UniGeneiHs.434213.

Genome annotation databases

EnsembliENST00000375464; ENSP00000364613; ENSG00000165233. [Q96LW7-2]
ENST00000466409; ENSP00000437237; ENSG00000165233. [Q96LW7-1]
GeneIDi84270.
KEGGihsa:84270.
UCSCiuc004atd.4. human. [Q96LW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057716 mRNA. Translation: BAB71550.1.
AL451065 Genomic DNA. Translation: CAI95110.1.
BC004500 mRNA. Translation: AAH04500.1.
BC038856 mRNA. Translation: AAH38856.1.
CCDSiCCDS6702.2. [Q96LW7-2]
RefSeqiNP_115686.3. NM_032310.4. [Q96LW7-2]
UniGeneiHs.434213.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DWNX-ray1.58A/B3-99[»]
4FH0X-ray1.40A/B3-101[»]
ProteinModelPortaliQ96LW7.
SMRiQ96LW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123997. 9 interactors.
IntActiQ96LW7. 1 interactor.
MINTiMINT-1215062.

PTM databases

iPTMnetiQ96LW7.
PhosphoSitePlusiQ96LW7.

Polymorphism and mutation databases

BioMutaiC9orf89.
DMDMi71658794.

Proteomic databases

MaxQBiQ96LW7.
PeptideAtlasiQ96LW7.
PRIDEiQ96LW7.

Protocols and materials databases

DNASUi84270.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375464; ENSP00000364613; ENSG00000165233. [Q96LW7-2]
ENST00000466409; ENSP00000437237; ENSG00000165233. [Q96LW7-1]
GeneIDi84270.
KEGGihsa:84270.
UCSCiuc004atd.4. human. [Q96LW7-1]

Organism-specific databases

CTDi84270.
GeneCardsiC9orf89.
HGNCiHGNC:28148. CARD19.
HPAiHPA010921.
HPA010990.
HPA038297.
neXtProtiNX_Q96LW7.
OpenTargetsiENSG00000165233.
PharmGKBiPA134909664.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000016408.
InParanoidiQ96LW7.
OMAiCCPPDPK.
PhylomeDBiQ96LW7.
TreeFamiTF335747.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165233-MONOMER.

Miscellaneous databases

ChiTaRSiC9orf89. human.
GenomeRNAii84270.
PROiQ96LW7.

Gene expression databases

BgeeiENSG00000165233.
CleanExiHS_C9orf89.
ExpressionAtlasiQ96LW7. baseline and differential.
GenevisibleiQ96LW7. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAR19_HUMAN
AccessioniPrimary (citable) accession number: Q96LW7
Secondary accession number(s): Q5BJH8, Q9BSY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.