Q96LW2 (SG494_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized serine/threonine-protein kinase SgK494
EC=2.7.11.1

Alternative name(s):
Sugen kinase 494

Gene names

Name:

SGK494

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96LW2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96LW2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     160-171: RQINHPFVHSLG → VISMTWASCIEM
     172-274: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Uncharacterized serine/threonine-protein kinase SgK494		PRO_0000250646
Regions
	Domain	107 – 274	168	Protein kinase
	Nucleotide binding	113 – 121	9	ATP By similarity
Sites
	Active site	229	1	Proton acceptor By similarity
	Binding site	136	1	ATP By similarity
Natural variations
	Alternative sequence	160 – 171	12	RQINH…VHSLG → VISMTWASCIEM in isoform 2.		VSP_020678
	Alternative sequence	172 – 274	103	Missing in isoform 2.		VSP_020679

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 078726BA9DE13670	FASTA	274	31,044
	10 20 30 40 50 60 MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG 70 80 90 100 110 120 HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT 130 140 150 160 170 180 VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQR QINHPFVHSL GDSWQGKRHL 190 200 210 220 230 240 FIMCSYCSTD LYSLWSAVGC FPEASIRLFA AELVLVLCYL HDLGIMHRDV KMENILLDER 250 260 270 GHLKLTDFGL SRHVPQGAQA YTICGTLQYM GERG
	Isoform 2 [UniParc]. Checksum: 8D125411B846D917	FASTA	171	19,316
	10 20 30 40 50 60 MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG 70 80 90 100 110 120 HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT 130 140 150 160 170 VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQV ISMTWASCIE M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Amygdala and Cerebellum.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The protein kinase complement of the human genome." Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057735 mRNA. Translation: BAB71555.1. AK294189 mRNA. Translation: BAG57505.1. BC045622 mRNA. Translation: AAH45622.1.
IPI	IPI00641744. IPI00956412.
UniGene	Hs.514033. Hs.729077.
3D structure databases
ProteinModelPortal	Q96LW2.
ModBase	Search...
Polymorphism databases
DMDM	74724242.
Proteomic databases
PaxDb	Q96LW2.
PRIDE	Q96LW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010crq.2. human.
Organism-specific databases
GeneCards	GC17M026907.
HPA	HPA046590.
neXtProt	NX_Q96LW2.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000154304.
HOVERGEN	HBG093948.
InParanoid	Q96LW2.
OrthoDB	EOG4XKV7R.
PhylomeDB	Q96LW2.
Gene expression databases
Genevestigator	Q96LW2.
GermOnline	ENSG00000167524. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13646348.

Entry information

Entry name

SG494_HUMAN

Accession

Primary (citable) accession number: Q96LW2
Secondary accession number(s): B4DFP4, Q49A48

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.