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Q96LW2 (SG494_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized serine/threonine-protein kinase SgK494

EC=2.7.11.1
Alternative name(s):
Sugen kinase 494
Gene names
Name:SGK494
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96LW2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96LW2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     160-171: RQINHPFVHSLG → VISMTWASCIEM
     172-274: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Uncharacterized serine/threonine-protein kinase SgK494
PRO_0000250646

Regions

Domain107 – 274168Protein kinase
Nucleotide binding113 – 1219ATP By similarity

Sites

Active site2291Proton acceptor By similarity
Binding site1361ATP By similarity

Natural variations

Alternative sequence160 – 17112RQINH…VHSLG → VISMTWASCIEM in isoform 2.
VSP_020678
Alternative sequence172 – 274103Missing in isoform 2.
VSP_020679

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 078726BA9DE13670

FASTA27431,044
        10         20         30         40         50         60 
MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG 

        70         80         90        100        110        120 
HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT 

       130        140        150        160        170        180 
VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQR QINHPFVHSL GDSWQGKRHL 

       190        200        210        220        230        240 
FIMCSYCSTD LYSLWSAVGC FPEASIRLFA AELVLVLCYL HDLGIMHRDV KMENILLDER 

       250        260        270 
GHLKLTDFGL SRHVPQGAQA YTICGTLQYM GERG 

« Hide

Isoform 2 [UniParc].

Checksum: 8D125411B846D917
Show »

FASTA17119,316

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Amygdala and Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The protein kinase complement of the human genome."
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.
Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057735 mRNA. Translation: BAB71555.1.
AK294189 mRNA. Translation: BAG57505.1.
BC045622 mRNA. Translation: AAH45622.1.
UniGeneHs.729077.

3D structure databases

ProteinModelPortalQ96LW2.
SMRQ96LW2. Positions 106-271.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74724242.

Proteomic databases

PaxDbQ96LW2.
PRIDEQ96LW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGhsa:124923.
UCSCuc021ttt.1. human. [Q96LW2-1]

Organism-specific databases

CTD124923.
GeneCardsGC17M026992.
HPAHPA046590.
neXtProtNX_Q96LW2.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000154304.
HOVERGENHBG093948.
InParanoidQ96LW2.
KOK17529.
PhylomeDBQ96LW2.

Enzyme and pathway databases

SignaLinkQ96LW2.

Gene expression databases

GenevestigatorQ96LW2.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13646348.
PROQ96LW2.

Entry information

Entry nameSG494_HUMAN
AccessionPrimary (citable) accession number: Q96LW2
Secondary accession number(s): B4DFP4, Q49A48
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM