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Protein

Zinc finger protein 354B

Gene

ZNF354B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354B
Gene namesi
Name:ZNF354B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000178338.10
HGNCiHGNC:17197 ZNF354B
neXtProtiNX_Q96LW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178338
PharmGKBiPA38210

Polymorphism and mutation databases

BioMutaiZNF354B
DMDMi74762673

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804061 – 612Zinc finger protein 354BAdd BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96LW1
MaxQBiQ96LW1
PaxDbiQ96LW1
PeptideAtlasiQ96LW1
PRIDEiQ96LW1

PTM databases

iPTMnetiQ96LW1
PhosphoSitePlusiQ96LW1

Expressioni

Gene expression databases

BgeeiENSG00000178338
CleanExiHS_ZNF354B
ExpressionAtlasiQ96LW1 baseline and differential
GenevisibleiQ96LW1 HS

Organism-specific databases

HPAiHPA029056

Interactioni

Protein-protein interaction databases

BioGridi125594, 1 interactor
IntActiQ96LW1, 2 interactors
STRINGi9606.ENSP00000327143

Structurei

3D structure databases

ProteinModelPortaliQ96LW1
SMRiQ96LW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144148
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96LW1
KOiK09228
OMAiCEIQRNS
OrthoDBiEOG091G02KC
PhylomeDBiQ96LW1
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q96LW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTWDEWRK LAPSQRNLYR DVMLENYRNL
60 70 80 90 100
VSLGLSFTKP KVISLLQQGE DPWEVEKDSS GVSSLGCKST PKMTKSTQTQ
110 120 130 140 150
DSFQEQIRKR LKRDEPWNFI SERSCIYEEK LKKQQDKNEN LQIISVAHTK
160 170 180 190 200
ILTVDRSHKN VEFGQNFYLK SVFIKQQRFA KEKTPSKCEI QRNSFKQNSN
210 220 230 240 250
LLNQSKIKTA EKRYKCSTCE KAFIHNSSLR KHQKNHTGEK LFKCKECLKA
260 270 280 290 300
FSQSSALIQH QRTHTGEKPY ICKECGKAFS HSASLCKHLR THTVEKCYRC
310 320 330 340 350
KECGKSFSRR SGLFIHQKIH AQENPHKYNP GRKASSYSTS LSGSQKIHLR
360 370 380 390 400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH
410 420 430 440 450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKLYNC NECGKALSSH
460 470 480 490 500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECD
510 520 530 540 550
KTFRCNSSLS NHQRIHTGEK PYRCLECGMS FGQSAALIQH QRIHTGEKPF
560 570 580 590 600
KCNTCGKTFR QSSSLIAHQR IHTGEKPYEC NACGKLFSQR SSLTNHYKIH
610
IEEDSLKADL HV
Length:612
Mass (Da):70,529
Last modified:December 1, 2001 - v1
Checksum:iD1E94FD6B22305B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057737 mRNA Translation: BAB71556.1
AK289667 mRNA Translation: BAF82356.1
BC104777 mRNA Translation: AAI04778.1
BC112111 mRNA Translation: AAI12112.1
CCDSiCCDS4439.1
RefSeqiNP_478137.1, NM_058230.2
UniGeneiHs.724051

Genome annotation databases

EnsembliENST00000322434; ENSP00000327143; ENSG00000178338
GeneIDi117608
KEGGihsa:117608
UCSCiuc003mjl.4 human

Similar proteinsi

Entry informationi

Entry nameiZ354B_HUMAN
AccessioniPrimary (citable) accession number: Q96LW1
Secondary accession number(s): A8K0V2, Q5U5Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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