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Protein

Zinc finger protein 354B

Gene

ZNF354B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178338-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354B
Gene namesi
Name:ZNF354B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17197. ZNF354B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178338.
PharmGKBiPA38210.

Polymorphism and mutation databases

BioMutaiZNF354B.
DMDMi74762673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804061 – 612Zinc finger protein 354BAdd BLAST612

Proteomic databases

EPDiQ96LW1.
MaxQBiQ96LW1.
PaxDbiQ96LW1.
PeptideAtlasiQ96LW1.
PRIDEiQ96LW1.

PTM databases

iPTMnetiQ96LW1.
PhosphoSitePlusiQ96LW1.

Expressioni

Gene expression databases

BgeeiENSG00000178338.
CleanExiHS_ZNF354B.
ExpressionAtlasiQ96LW1. baseline and differential.
GenevisibleiQ96LW1. HS.

Organism-specific databases

HPAiHPA029056.

Interactioni

Protein-protein interaction databases

IntActiQ96LW1. 2 interactors.
STRINGi9606.ENSP00000327143.

Structurei

3D structure databases

ProteinModelPortaliQ96LW1.
SMRiQ96LW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133790.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96LW1.
KOiK09228.
OMAiCEIQRNS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96LW1.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF16622. zf-C2H2_11. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGQREARP QVSLTFEDVA VLFTWDEWRK LAPSQRNLYR DVMLENYRNL
60 70 80 90 100
VSLGLSFTKP KVISLLQQGE DPWEVEKDSS GVSSLGCKST PKMTKSTQTQ
110 120 130 140 150
DSFQEQIRKR LKRDEPWNFI SERSCIYEEK LKKQQDKNEN LQIISVAHTK
160 170 180 190 200
ILTVDRSHKN VEFGQNFYLK SVFIKQQRFA KEKTPSKCEI QRNSFKQNSN
210 220 230 240 250
LLNQSKIKTA EKRYKCSTCE KAFIHNSSLR KHQKNHTGEK LFKCKECLKA
260 270 280 290 300
FSQSSALIQH QRTHTGEKPY ICKECGKAFS HSASLCKHLR THTVEKCYRC
310 320 330 340 350
KECGKSFSRR SGLFIHQKIH AQENPHKYNP GRKASSYSTS LSGSQKIHLR
360 370 380 390 400
KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH
410 420 430 440 450
ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKLYNC NECGKALSSH
460 470 480 490 500
STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECD
510 520 530 540 550
KTFRCNSSLS NHQRIHTGEK PYRCLECGMS FGQSAALIQH QRIHTGEKPF
560 570 580 590 600
KCNTCGKTFR QSSSLIAHQR IHTGEKPYEC NACGKLFSQR SSLTNHYKIH
610
IEEDSLKADL HV
Length:612
Mass (Da):70,529
Last modified:December 1, 2001 - v1
Checksum:iD1E94FD6B22305B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057737 mRNA. Translation: BAB71556.1.
AK289667 mRNA. Translation: BAF82356.1.
BC104777 mRNA. Translation: AAI04778.1.
BC112111 mRNA. Translation: AAI12112.1.
CCDSiCCDS4439.1.
RefSeqiNP_478137.1. NM_058230.2.
UniGeneiHs.724051.

Genome annotation databases

EnsembliENST00000322434; ENSP00000327143; ENSG00000178338.
GeneIDi117608.
KEGGihsa:117608.
UCSCiuc003mjl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057737 mRNA. Translation: BAB71556.1.
AK289667 mRNA. Translation: BAF82356.1.
BC104777 mRNA. Translation: AAI04778.1.
BC112111 mRNA. Translation: AAI12112.1.
CCDSiCCDS4439.1.
RefSeqiNP_478137.1. NM_058230.2.
UniGeneiHs.724051.

3D structure databases

ProteinModelPortaliQ96LW1.
SMRiQ96LW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96LW1. 2 interactors.
STRINGi9606.ENSP00000327143.

PTM databases

iPTMnetiQ96LW1.
PhosphoSitePlusiQ96LW1.

Polymorphism and mutation databases

BioMutaiZNF354B.
DMDMi74762673.

Proteomic databases

EPDiQ96LW1.
MaxQBiQ96LW1.
PaxDbiQ96LW1.
PeptideAtlasiQ96LW1.
PRIDEiQ96LW1.

Protocols and materials databases

DNASUi117608.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322434; ENSP00000327143; ENSG00000178338.
GeneIDi117608.
KEGGihsa:117608.
UCSCiuc003mjl.4. human.

Organism-specific databases

CTDi117608.
GeneCardsiZNF354B.
HGNCiHGNC:17197. ZNF354B.
HPAiHPA029056.
neXtProtiNX_Q96LW1.
OpenTargetsiENSG00000178338.
PharmGKBiPA38210.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133790.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96LW1.
KOiK09228.
OMAiCEIQRNS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96LW1.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178338-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF354B. human.
GenomeRNAii117608.
PROiQ96LW1.

Gene expression databases

BgeeiENSG00000178338.
CleanExiHS_ZNF354B.
ExpressionAtlasiQ96LW1. baseline and differential.
GenevisibleiQ96LW1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF16622. zf-C2H2_11. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ354B_HUMAN
AccessioniPrimary (citable) accession number: Q96LW1
Secondary accession number(s): A8K0V2, Q5U5Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.