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Q96LU7

- MRFL_HUMAN

UniProt

Q96LU7 - MRFL_HUMAN

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Protein
Myelin regulatory factor-like protein
Gene
MYRFL, C12orf15, C12orf28
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi142 – 405264NDT80
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin regulatory factor-like protein
Gene namesi
Name:MYRFL
Synonyms:C12orf15, C12orf28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:26316. MYRFL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei628 – 64821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Myelin regulatory factor-like protein
PRO_0000252150Add
BLAST

Proteomic databases

PaxDbiQ96LU7.
PRIDEiQ96LU7.

PTM databases

PhosphoSiteiQ96LU7.

Expressioni

Gene expression databases

ArrayExpressiQ96LU7.
BgeeiQ96LU7.
CleanExiHS_C12orf28.
GenevestigatoriQ96LU7.

Organism-specific databases

HPAiHPA049340.

Structurei

3D structure databases

ProteinModelPortaliQ96LU7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini451 – 559109Peptidase S74
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili543 – 57533 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the MRF family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322996.
HOGENOMiHOG000169651.
HOVERGENiHBG081231.
InParanoidiQ96LU7.
OMAiLKWQPYQ.

Family and domain databases

Gene3Di2.60.40.1390. 1 hit.
InterProiIPR026932. MRF_C1.
IPR025719. MRF_C2.
IPR024061. NDT80_DNA-bd_dom.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF13887. MRF_C1. 1 hit.
PF13888. MRF_C2. 1 hit.
PF05224. NDT80_PhoG. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS51688. ICA. 1 hit.
PS51517. NDT80. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LU7-1 [UniParc]FASTAAdd to Basket

« Hide

MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL    50
PDTPPYSASD SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP 100
LQSTSGMGDS CQIHGGFHSC HSNASHLATP LDQSVSSHLG IGCSYPQQPL 150
CHSPGASLPP TKKRKCTQAL EDSGECRVWA CHCRPMTSRS RSSEVQDPDS 200
EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG YRVVTDKGFN 250
FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT 300
KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA 350
NNMRKKGKPN PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ 400
FENDSDALWQ RGQVPESIVC HGRVGINTDA PDEALVVCGN MKVMGTIMHP 450
SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD YKPEFASAMG INTAHQTGMI 500
AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME NVGAVKQLCK 550
LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP 600
RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS 650
LKDQDRRVPN LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT 700
FCEILPCQET YCCPIRGMKE VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA 750
RNALSGPDWE SDWIDTTISS IQIMEIQQII DHQYCIQSLQ CGSGNYNYNI 800
PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR GTKGLESHRE 850
ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD 900
YFFYFYRRCA 910
Length:910
Mass (Da):101,670
Last modified:February 6, 2013 - v2
Checksum:i18444DB071F0B57E
GO

Sequence cautioni

The sequence BAB71571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti723 – 7231S → L.
Corresponds to variant rs35051828 [ dbSNP | Ensembl ].
VAR_033742
Natural varianti753 – 7531A → S.
Corresponds to variant rs11177991 [ dbSNP | Ensembl ].
VAR_027780
Natural varianti845 – 8451L → M.2 Publications
Corresponds to variant rs10879065 [ dbSNP | Ensembl ].
VAR_069018

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC025263 Genomic DNA. No translation available.
AC078922 Genomic DNA. No translation available.
AK057785 mRNA. Translation: BAB71571.1. Different initiation.
BC101820 mRNA. Translation: AAI01821.2.
UniGeneiHs.253773.

Genome annotation databases

EnsembliENST00000552032; ENSP00000448753; ENSG00000166268.

Polymorphism databases

DMDMi449081266.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC025263 Genomic DNA. No translation available.
AC078922 Genomic DNA. No translation available.
AK057785 mRNA. Translation: BAB71571.1 . Different initiation.
BC101820 mRNA. Translation: AAI01821.2 .
UniGenei Hs.253773.

3D structure databases

ProteinModelPortali Q96LU7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q96LU7.

Polymorphism databases

DMDMi 449081266.

Proteomic databases

PaxDbi Q96LU7.
PRIDEi Q96LU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000552032 ; ENSP00000448753 ; ENSG00000166268 .

Organism-specific databases

GeneCardsi GC12P070221.
HGNCi HGNC:26316. MYRFL.
HPAi HPA049340.
neXtProti NX_Q96LU7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322996.
HOGENOMi HOG000169651.
HOVERGENi HBG081231.
InParanoidi Q96LU7.
OMAi LKWQPYQ.

Gene expression databases

ArrayExpressi Q96LU7.
Bgeei Q96LU7.
CleanExi HS_C12orf28.
Genevestigatori Q96LU7.

Family and domain databases

Gene3Di 2.60.40.1390. 1 hit.
InterProi IPR026932. MRF_C1.
IPR025719. MRF_C2.
IPR024061. NDT80_DNA-bd_dom.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view ]
Pfami PF13887. MRF_C1. 1 hit.
PF13888. MRF_C2. 1 hit.
PF05224. NDT80_PhoG. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS51688. ICA. 1 hit.
PS51517. NDT80. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-910, VARIANT MET-845.
    Tissue: Cerebellum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-910, VARIANT MET-845.
    Tissue: Brain.

Entry informationi

Entry nameiMRFL_HUMAN
AccessioniPrimary (citable) accession number: Q96LU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 6, 2013
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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