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Q96LU7 (MRFL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin regulatory factor-like protein
Gene names
Name:MYRFL
Synonyms:C12orf15, C12orf28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the MRF family.

Contains 1 NDT80 DNA-binding domain.

Contains 1 peptidase S74 domain.

Sequence caution

The sequence BAB71571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Myelin regulatory factor-like protein
PRO_0000252150

Regions

Transmembrane628 – 64821Helical; Potential
Domain451 – 559109Peptidase S74
DNA binding142 – 405264NDT80
Coiled coil543 – 57533 Potential

Natural variations

Natural variant7231S → L.
Corresponds to variant rs35051828 [ dbSNP | Ensembl ].
VAR_033742
Natural variant7531A → S.
Corresponds to variant rs11177991 [ dbSNP | Ensembl ].
VAR_027780
Natural variant8451L → M. Ref.2 Ref.3
Corresponds to variant rs10879065 [ dbSNP | Ensembl ].
VAR_069018

Sequences

Sequence LengthMass (Da)Tools
Q96LU7 [UniParc].

Last modified February 6, 2013. Version 2.
Checksum: 18444DB071F0B57E

FASTA910101,670
        10         20         30         40         50         60 
MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL PDTPPYSASD 

        70         80         90        100        110        120 
SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP LQSTSGMGDS CQIHGGFHSC 

       130        140        150        160        170        180 
HSNASHLATP LDQSVSSHLG IGCSYPQQPL CHSPGASLPP TKKRKCTQAL EDSGECRVWA 

       190        200        210        220        230        240 
CHCRPMTSRS RSSEVQDPDS EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG 

       250        260        270        280        290        300 
YRVVTDKGFN FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT 

       310        320        330        340        350        360 
KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA NNMRKKGKPN 

       370        380        390        400        410        420 
PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ FENDSDALWQ RGQVPESIVC 

       430        440        450        460        470        480 
HGRVGINTDA PDEALVVCGN MKVMGTIMHP SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD 

       490        500        510        520        530        540 
YKPEFASAMG INTAHQTGMI AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME 

       550        560        570        580        590        600 
NVGAVKQLCK LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP 

       610        620        630        640        650        660 
RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS LKDQDRRVPN 

       670        680        690        700        710        720 
LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT FCEILPCQET YCCPIRGMKE 

       730        740        750        760        770        780 
VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA RNALSGPDWE SDWIDTTISS IQIMEIQQII 

       790        800        810        820        830        840 
DHQYCIQSLQ CGSGNYNYNI PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR 

       850        860        870        880        890        900 
GTKGLESHRE ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD 

       910 
YFFYFYRRCA 

« Hide

References

[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-910, VARIANT MET-845.
Tissue: Cerebellum.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-910, VARIANT MET-845.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC025263 Genomic DNA. No translation available.
AC078922 Genomic DNA. No translation available.
AK057785 mRNA. Translation: BAB71571.1. Different initiation.
BC101820 mRNA. Translation: AAI01821.2.
UniGeneHs.253773.

3D structure databases

ProteinModelPortalQ96LU7.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ96LU7.

Polymorphism databases

DMDM449081266.

Proteomic databases

PaxDbQ96LU7.
PRIDEQ96LU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000552032; ENSP00000448753; ENSG00000166268.

Organism-specific databases

GeneCardsGC12P070221.
HGNCHGNC:26316. MYRFL.
HPAHPA049340.
neXtProtNX_Q96LU7.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322996.
HOGENOMHOG000169651.
HOVERGENHBG081231.
InParanoidQ96LU7.

Gene expression databases

ArrayExpressQ96LU7.
BgeeQ96LU7.
CleanExHS_C12orf28.
GenevestigatorQ96LU7.

Family and domain databases

Gene3D2.60.40.1390. 1 hit.
InterProIPR026932. MRF_C1.
IPR025719. MRF_C2.
IPR024061. NDT80_DNA-bd_dom.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamPF13887. MRF_C1. 1 hit.
PF13888. MRF_C2. 1 hit.
PF05224. NDT80_PhoG. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS51688. ICA. 1 hit.
PS51517. NDT80. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRFL_HUMAN
AccessionPrimary (citable) accession number: Q96LU7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 6, 2013
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM