Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin regulatory factor-like protein

Gene

MYRFL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi142 – 405NDT80PROSITE-ProRule annotationAdd BLAST264

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin regulatory factor-like protein
Gene namesi
Name:MYRFL
Synonyms:C12orf15, C12orf28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166268.10
HGNCiHGNC:26316 MYRFL
neXtProtiNX_Q96LU7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166268

Polymorphism and mutation databases

DMDMi449081266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521501 – 910Myelin regulatory factor-like proteinAdd BLAST910

Proteomic databases

PaxDbiQ96LU7
PRIDEiQ96LU7

PTM databases

iPTMnetiQ96LU7
PhosphoSitePlusiQ96LU7

Expressioni

Gene expression databases

BgeeiENSG00000166268
CleanExiHS_C12orf28
ExpressionAtlasiQ96LU7 baseline and differential
GenevisibleiQ96LU7 HS

Organism-specific databases

HPAiHPA049340

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000449598

Structurei

3D structure databases

ProteinModelPortaliQ96LU7
SMRiQ96LU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini451 – 559Peptidase S74PROSITE-ProRule annotationAdd BLAST109

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili543 – 575Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the MRF family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3661 Eukaryota
ENOG410XPRK LUCA
GeneTreeiENSGT00530000063626
HOGENOMiHOG000169651
HOVERGENiHBG081231
InParanoidiQ96LU7
OMAiLKWQPYQ
OrthoDBiEOG091G0213

Family and domain databases

InterProiView protein in InterPro
IPR026932 MRF_C1
IPR025719 MRF_C2
IPR024061 NDT80_DNA-bd_dom
IPR008967 p53-like_TF_DNA-bd
IPR030392 S74_ICA
PfamiView protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit
PF05224 NDT80_PhoG, 1 hit
PF13884 Peptidase_S74, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51688 ICA, 1 hit
PS51517 NDT80, 1 hit

Sequencei

Sequence statusi: Complete.

Q96LU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL
60 70 80 90 100
PDTPPYSASD SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP
110 120 130 140 150
LQSTSGMGDS CQIHGGFHSC HSNASHLATP LDQSVSSHLG IGCSYPQQPL
160 170 180 190 200
CHSPGASLPP TKKRKCTQAL EDSGECRVWA CHCRPMTSRS RSSEVQDPDS
210 220 230 240 250
EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG YRVVTDKGFN
260 270 280 290 300
FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT
310 320 330 340 350
KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA
360 370 380 390 400
NNMRKKGKPN PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ
410 420 430 440 450
FENDSDALWQ RGQVPESIVC HGRVGINTDA PDEALVVCGN MKVMGTIMHP
460 470 480 490 500
SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD YKPEFASAMG INTAHQTGMI
510 520 530 540 550
AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME NVGAVKQLCK
560 570 580 590 600
LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP
610 620 630 640 650
RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS
660 670 680 690 700
LKDQDRRVPN LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT
710 720 730 740 750
FCEILPCQET YCCPIRGMKE VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA
760 770 780 790 800
RNALSGPDWE SDWIDTTISS IQIMEIQQII DHQYCIQSLQ CGSGNYNYNI
810 820 830 840 850
PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR GTKGLESHRE
860 870 880 890 900
ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD
910
YFFYFYRRCA
Length:910
Mass (Da):101,670
Last modified:February 6, 2013 - v2
Checksum:i18444DB071F0B57E
GO

Sequence cautioni

The sequence BAB71571 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033742723S → L. Corresponds to variant dbSNP:rs35051828Ensembl.1
Natural variantiVAR_027780753A → S. Corresponds to variant dbSNP:rs11177991Ensembl.1
Natural variantiVAR_069018845L → M2 PublicationsCorresponds to variant dbSNP:rs10879065Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025263 Genomic DNA No translation available.
AC078922 Genomic DNA No translation available.
AK057785 mRNA Translation: BAB71571.1 Different initiation.
BC101820 mRNA Translation: AAI01821.2
CCDSiCCDS76577.1
RefSeqiNP_872336.2, NM_182530.2
UniGeneiHs.253773
Hs.740075

Genome annotation databases

EnsembliENST00000552032; ENSP00000448753; ENSG00000166268
GeneIDi196446
KEGGihsa:196446
UCSCiuc001svu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRFL_HUMAN
AccessioniPrimary (citable) accession number: Q96LU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 6, 2013
Last modified: April 25, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome