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Q96LU7

- MRFL_HUMAN

UniProt

Q96LU7 - MRFL_HUMAN

Protein

Myelin regulatory factor-like protein

Gene

MYRFL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (06 Feb 2013)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi142 – 405264NDT80PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin regulatory factor-like protein
    Gene namesi
    Name:MYRFL
    Synonyms:C12orf15, C12orf28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:26316. MYRFL.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 910910Myelin regulatory factor-like proteinPRO_0000252150Add
    BLAST

    Proteomic databases

    PaxDbiQ96LU7.
    PRIDEiQ96LU7.

    PTM databases

    PhosphoSiteiQ96LU7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96LU7.
    BgeeiQ96LU7.
    CleanExiHS_C12orf28.
    GenevestigatoriQ96LU7.

    Organism-specific databases

    HPAiHPA049340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96LU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei628 – 64821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini451 – 559109Peptidase S74Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili543 – 57533Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MRF family.Curated
    Contains 1 NDT80 DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 peptidase S74 domain.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322996.
    HOGENOMiHOG000169651.
    HOVERGENiHBG081231.
    InParanoidiQ96LU7.
    OMAiLKWQPYQ.

    Family and domain databases

    Gene3Di2.60.40.1390. 1 hit.
    InterProiIPR026932. MRF_C1.
    IPR025719. MRF_C2.
    IPR024061. NDT80_DNA-bd_dom.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view]
    PfamiPF13887. MRF_C1. 1 hit.
    PF13888. MRF_C2. 1 hit.
    PF05224. NDT80_PhoG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS51688. ICA. 1 hit.
    PS51517. NDT80. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96LU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL    50
    PDTPPYSASD SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP 100
    LQSTSGMGDS CQIHGGFHSC HSNASHLATP LDQSVSSHLG IGCSYPQQPL 150
    CHSPGASLPP TKKRKCTQAL EDSGECRVWA CHCRPMTSRS RSSEVQDPDS 200
    EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG YRVVTDKGFN 250
    FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT 300
    KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA 350
    NNMRKKGKPN PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ 400
    FENDSDALWQ RGQVPESIVC HGRVGINTDA PDEALVVCGN MKVMGTIMHP 450
    SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD YKPEFASAMG INTAHQTGMI 500
    AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME NVGAVKQLCK 550
    LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP 600
    RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS 650
    LKDQDRRVPN LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT 700
    FCEILPCQET YCCPIRGMKE VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA 750
    RNALSGPDWE SDWIDTTISS IQIMEIQQII DHQYCIQSLQ CGSGNYNYNI 800
    PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR GTKGLESHRE 850
    ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD 900
    YFFYFYRRCA 910
    Length:910
    Mass (Da):101,670
    Last modified:February 6, 2013 - v2
    Checksum:i18444DB071F0B57E
    GO

    Sequence cautioni

    The sequence BAB71571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti723 – 7231S → L.
    Corresponds to variant rs35051828 [ dbSNP | Ensembl ].
    VAR_033742
    Natural varianti753 – 7531A → S.
    Corresponds to variant rs11177991 [ dbSNP | Ensembl ].
    VAR_027780
    Natural varianti845 – 8451L → M.2 Publications
    Corresponds to variant rs10879065 [ dbSNP | Ensembl ].
    VAR_069018

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025263 Genomic DNA. No translation available.
    AC078922 Genomic DNA. No translation available.
    AK057785 mRNA. Translation: BAB71571.1. Different initiation.
    BC101820 mRNA. Translation: AAI01821.2.
    UniGeneiHs.253773.

    Genome annotation databases

    EnsembliENST00000552032; ENSP00000448753; ENSG00000166268.

    Polymorphism databases

    DMDMi449081266.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025263 Genomic DNA. No translation available.
    AC078922 Genomic DNA. No translation available.
    AK057785 mRNA. Translation: BAB71571.1 . Different initiation.
    BC101820 mRNA. Translation: AAI01821.2 .
    UniGenei Hs.253773.

    3D structure databases

    ProteinModelPortali Q96LU7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q96LU7.

    Polymorphism databases

    DMDMi 449081266.

    Proteomic databases

    PaxDbi Q96LU7.
    PRIDEi Q96LU7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000552032 ; ENSP00000448753 ; ENSG00000166268 .

    Organism-specific databases

    GeneCardsi GC12P070221.
    HGNCi HGNC:26316. MYRFL.
    HPAi HPA049340.
    neXtProti NX_Q96LU7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322996.
    HOGENOMi HOG000169651.
    HOVERGENi HBG081231.
    InParanoidi Q96LU7.
    OMAi LKWQPYQ.

    Gene expression databases

    ArrayExpressi Q96LU7.
    Bgeei Q96LU7.
    CleanExi HS_C12orf28.
    Genevestigatori Q96LU7.

    Family and domain databases

    Gene3Di 2.60.40.1390. 1 hit.
    InterProi IPR026932. MRF_C1.
    IPR025719. MRF_C2.
    IPR024061. NDT80_DNA-bd_dom.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view ]
    Pfami PF13887. MRF_C1. 1 hit.
    PF13888. MRF_C2. 1 hit.
    PF05224. NDT80_PhoG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS51688. ICA. 1 hit.
    PS51517. NDT80. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-910, VARIANT MET-845.
      Tissue: Cerebellum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-910, VARIANT MET-845.
      Tissue: Brain.

    Entry informationi

    Entry nameiMRFL_HUMAN
    AccessioniPrimary (citable) accession number: Q96LU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: February 6, 2013
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3