Q96LU7 (MRFL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin regulatory factor-like protein

Gene names

Name:	MYRFL
Synonyms:	C12orf15, C12orf28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the MRF family. Contains 1 NDT80 DNA-binding domain.
Sequence caution	The sequence BAB71571.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 910	910	Myelin regulatory factor-like protein		PRO_0000252150
Regions
	Transmembrane	628 – 648	21	Helical; Potential
	DNA binding	142 – 405	264	NDT80
	Coiled coil	543 – 575	33	Potential
Natural variations
	Natural variant	723	1	S → L. Corresponds to variant rs35051828 [ dbSNP | Ensembl ].		VAR_033742
	Natural variant	753	1	A → S. Corresponds to variant rs11177991 [ dbSNP | Ensembl ].		VAR_027780
	Natural variant	845	1	L → M. Ref.2 Ref.3 Corresponds to variant rs10879065 [ dbSNP | Ensembl ].		VAR_069018

Sequences

	Sequence		Length	Mass (Da)
	Q96LU7 [UniParc]. Last modified February 6, 2013. Version 2. Checksum: 18444DB071F0B57E	FASTA	910	101,670
	10 20 30 40 50 60 MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL PDTPPYSASD 70 80 90 100 110 120 SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP LQSTSGMGDS CQIHGGFHSC 130 140 150 160 170 180 HSNASHLATP LDQSVSSHLG IGCSYPQQPL CHSPGASLPP TKKRKCTQAL EDSGECRVWA 190 200 210 220 230 240 CHCRPMTSRS RSSEVQDPDS EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG 250 260 270 280 290 300 YRVVTDKGFN FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT 310 320 330 340 350 360 KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA NNMRKKGKPN 370 380 390 400 410 420 PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ FENDSDALWQ RGQVPESIVC 430 440 450 460 470 480 HGRVGINTDA PDEALVVCGN MKVMGTIMHP SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD 490 500 510 520 530 540 YKPEFASAMG INTAHQTGMI AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME 550 560 570 580 590 600 NVGAVKQLCK LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP 610 620 630 640 650 660 RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS LKDQDRRVPN 670 680 690 700 710 720 LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT FCEILPCQET YCCPIRGMKE 730 740 750 760 770 780 VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA RNALSGPDWE SDWIDTTISS IQIMEIQQII 790 800 810 820 830 840 DHQYCIQSLQ CGSGNYNYNI PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR 850 860 870 880 890 900 GTKGLESHRE ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD 910 YFFYFYRRCA

References

[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-910, VARIANT MET-845. Tissue: Cerebellum.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-910, VARIANT MET-845. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC025263 Genomic DNA. No translation available. AC078922 Genomic DNA. No translation available. AK057785 mRNA. Translation: BAB71571.1. Different initiation. BC101820 mRNA. Translation: AAI01821.2.
IPI	IPI00888646.
UniGene	Hs.253773.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q96LU7.
Polymorphism databases
DMDM	74717031.
Proteomic databases
PaxDb	Q96LU7.
PRIDE	Q96LU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299350; ENSP00000299350; ENSG00000166268.
UCSC	uc001svu.1. human.
Organism-specific databases
GeneCards	GC12P070219.
HGNC	HGNC:26316. MYRFL.
HPA	HPA049340.
neXtProt	NX_Q96LU7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322996.
HOGENOM	HOG000169651.
HOVERGEN	HBG081231.
InParanoid	Q96LU7.
OrthoDB	EOG4NZTV7.
Gene expression databases
ArrayExpress	Q96LU7.
Bgee	Q96LU7.
CleanEx	HS_C12orf28.
Genevestigator	Q96LU7.
GermOnline	ENSG00000166268. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.1390. 1 hit.
InterPro	IPR026932. MRF_C1. IPR025719. MRF_C2. IPR024061. NDT80_DNA-bd_dom. IPR008967. p53-like_TF_DNA-bd. [Graphical view]
Pfam	PF13887. MRF_C1. 1 hit. PF13888. MRF_C2. 1 hit. PF05224. NDT80_PhoG. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS51517. NDT80. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRFL_HUMAN

Accession

Primary (citable) accession number: Q96LU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	February 6, 2013
Last modified:	April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.