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Protein

Mitochondrial inner membrane protease subunit 1

Gene

IMMP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401By similarity
Active sitei83 – 831By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.A05.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 1 (EC:3.4.21.-)
Alternative name(s):
IMP1-like protein
Gene namesi
Name:IMMP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26317. IMMP1L.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671655.

Polymorphism and mutation databases

BioMutaiIMMP1L.
DMDMi74752020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Mitochondrial inner membrane protease subunit 1PRO_0000259573Add
BLAST

Proteomic databases

MaxQBiQ96LU5.
PaxDbiQ96LU5.
PRIDEiQ96LU5.

Expressioni

Gene expression databases

BgeeiQ96LU5.
CleanExiHS_IMMP1L.
ExpressionAtlasiQ96LU5. baseline and differential.
GenevestigatoriQ96LU5.

Organism-specific databases

HPAiHPA038372.

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

BioGridi128195. 1 interaction.
STRINGi9606.ENSP00000278200.

Structurei

3D structure databases

ProteinModelPortaliQ96LU5.
SMRiQ96LU5. Positions 40-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0681.
GeneTreeiENSGT00550000075025.
HOGENOMiHOG000003673.
HOVERGENiHBG080010.
InParanoidiQ96LU5.
KOiK09647.
OMAiRCYGPVP.
PhylomeDBiQ96LU5.
TreeFamiTF315083.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR026730. Mitochondrial_IMP1.
IPR000223. Pept_S26A_signal_pept_1.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PTHR12383:SF14. PTHR12383:SF14. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGVLGKTF RLVGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI
60 70 80 90 100
VFAENLSRHF YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILTTSPSD
110 120 130 140 150
FFKSHSYVPM GHVWLEGDNL QNSTDSRCYG PIPYGLIRGR IFFKIWPLSD
160
FGFLRASPNG HRFSDD
Length:166
Mass (Da):18,504
Last modified:December 1, 2001 - v1
Checksum:i53E4EB65757BA71A
GO

Sequence cautioni

The sequence CAC39221.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057788 mRNA. Translation: BAB71573.1.
AL133295 Genomic DNA. Translation: CAC39221.1. Sequence problems.
CH471064 Genomic DNA. Translation: EAW68239.1.
CH471064 Genomic DNA. Translation: EAW68240.1.
BC023595 mRNA. Translation: AAH23595.1.
CCDSiCCDS7874.1.
RefSeqiNP_659418.1. NM_144981.2.
XP_005252869.1. XM_005252812.2.
UniGeneiHs.502223.

Genome annotation databases

EnsembliENST00000278200; ENSP00000278200; ENSG00000148950.
ENST00000532287; ENSP00000435576; ENSG00000148950.
GeneIDi196294.
KEGGihsa:196294.
UCSCiuc001msy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057788 mRNA. Translation: BAB71573.1.
AL133295 Genomic DNA. Translation: CAC39221.1. Sequence problems.
CH471064 Genomic DNA. Translation: EAW68239.1.
CH471064 Genomic DNA. Translation: EAW68240.1.
BC023595 mRNA. Translation: AAH23595.1.
CCDSiCCDS7874.1.
RefSeqiNP_659418.1. NM_144981.2.
XP_005252869.1. XM_005252812.2.
UniGeneiHs.502223.

3D structure databases

ProteinModelPortaliQ96LU5.
SMRiQ96LU5. Positions 40-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128195. 1 interaction.
STRINGi9606.ENSP00000278200.

Protein family/group databases

MEROPSiS26.A05.

Polymorphism and mutation databases

BioMutaiIMMP1L.
DMDMi74752020.

Proteomic databases

MaxQBiQ96LU5.
PaxDbiQ96LU5.
PRIDEiQ96LU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278200; ENSP00000278200; ENSG00000148950.
ENST00000532287; ENSP00000435576; ENSG00000148950.
GeneIDi196294.
KEGGihsa:196294.
UCSCiuc001msy.1. human.

Organism-specific databases

CTDi196294.
GeneCardsiGC11M031411.
HGNCiHGNC:26317. IMMP1L.
HPAiHPA038372.
MIMi612323. gene.
neXtProtiNX_Q96LU5.
PharmGKBiPA142671655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0681.
GeneTreeiENSGT00550000075025.
HOGENOMiHOG000003673.
HOVERGENiHBG080010.
InParanoidiQ96LU5.
KOiK09647.
OMAiRCYGPVP.
PhylomeDBiQ96LU5.
TreeFamiTF315083.

Miscellaneous databases

ChiTaRSiIMMP1L. human.
GenomeRNAii196294.
NextBioi89429.
PROiQ96LU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LU5.
CleanExiHS_IMMP1L.
ExpressionAtlasiQ96LU5. baseline and differential.
GenevestigatoriQ96LU5.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR026730. Mitochondrial_IMP1.
IPR000223. Pept_S26A_signal_pept_1.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PTHR12383:SF14. PTHR12383:SF14. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane."
    Burri L., Strahm Y., Hawkins C.J., Gentle I.E., Puryer M.A., Verhagen A., Callus B., Vaux D., Lithgow T.
    Mol. Biol. Cell 16:2926-2933(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIMP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96LU5
Secondary accession number(s): D3DQZ7, Q96SH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.