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Protein

Mitochondrial inner membrane protease subunit 1

Gene

IMMP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40By similarity1
Active sitei83By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 1 (EC:3.4.21.-)
Alternative name(s):
IMP1-like protein
Gene namesi
Name:IMMP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000148950.9.
HGNCiHGNC:26317. IMMP1L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi196294.
OpenTargetsiENSG00000148950.
PharmGKBiPA142671655.

Polymorphism and mutation databases

BioMutaiIMMP1L.
DMDMi74752020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595731 – 166Mitochondrial inner membrane protease subunit 1Add BLAST166

Proteomic databases

EPDiQ96LU5.
MaxQBiQ96LU5.
PaxDbiQ96LU5.
PeptideAtlasiQ96LU5.
PRIDEiQ96LU5.

PTM databases

iPTMnetiQ96LU5.
PhosphoSitePlusiQ96LU5.

Expressioni

Gene expression databases

BgeeiENSG00000148950.
CleanExiHS_IMMP1L.
ExpressionAtlasiQ96LU5. baseline and differential.
GenevisibleiQ96LU5. HS.

Interactioni

Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.By similarity

Protein-protein interaction databases

BioGridi128195. 4 interactors.
STRINGi9606.ENSP00000278200.

Structurei

3D structure databases

ProteinModelPortaliQ96LU5.
SMRiQ96LU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family. IMP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0171. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00550000075025.
HOGENOMiHOG000003673.
HOVERGENiHBG080010.
InParanoidiQ96LU5.
KOiK09647.
OMAiCKGPSME.
OrthoDBiEOG091G0TXV.
PhylomeDBiQ96LU5.
TreeFamiTF315083.

Family and domain databases

InterProiView protein in InterPro
IPR026730. Mitochondrial_IMP1.
IPR000223. Pept_S26A_signal_pept_1.
IPR015927. Peptidase_S24_S26A/B/C.
PANTHERiPTHR12383:SF31. PTHR12383:SF31. 1 hit.
PfamiView protein in Pfam
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGVLGKTF RLVGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI
60 70 80 90 100
VFAENLSRHF YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILTTSPSD
110 120 130 140 150
FFKSHSYVPM GHVWLEGDNL QNSTDSRCYG PIPYGLIRGR IFFKIWPLSD
160
FGFLRASPNG HRFSDD
Length:166
Mass (Da):18,504
Last modified:December 1, 2001 - v1
Checksum:i53E4EB65757BA71A
GO

Sequence cautioni

The sequence CAC39221 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057788 mRNA. Translation: BAB71573.1.
AL133295 Genomic DNA. Translation: CAC39221.1. Sequence problems.
CH471064 Genomic DNA. Translation: EAW68239.1.
CH471064 Genomic DNA. Translation: EAW68240.1.
BC023595 mRNA. Translation: AAH23595.1.
CCDSiCCDS7874.1.
RefSeqiNP_001291203.1. NM_001304274.1.
NP_659418.1. NM_144981.2.
XP_005252869.1. XM_005252812.3.
XP_011518244.1. XM_011519942.1.
XP_011518245.1. XM_011519943.2.
XP_011518246.1. XM_011519944.2.
XP_011518247.1. XM_011519945.2.
XP_011518248.1. XM_011519946.2.
XP_011518249.1. XM_011519947.2.
XP_016872794.1. XM_017017305.1.
UniGeneiHs.502223.

Genome annotation databases

EnsembliENST00000278200; ENSP00000278200; ENSG00000148950.
ENST00000532287; ENSP00000435576; ENSG00000148950.
GeneIDi196294.
KEGGihsa:196294.
UCSCiuc001msy.1. human.

Similar proteinsi

Entry informationi

Entry nameiIMP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96LU5
Secondary accession number(s): D3DQZ7, Q96SH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families