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Protein

UPF0739 protein C1orf74

Gene

C1orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0739 protein C1orf74
Gene namesi
Name:C1orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162757.4.
HGNCiHGNC:26319. C1orf74.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162757.
PharmGKBiPA142672523.

Polymorphism and mutation databases

BioMutaiC1orf74.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710921 – 269UPF0739 protein C1orf74Add BLAST269

Proteomic databases

EPDiQ96LT6.
PaxDbiQ96LT6.
PeptideAtlasiQ96LT6.
PRIDEiQ96LT6.

Expressioni

Gene expression databases

BgeeiENSG00000162757.
CleanExiHS_C1orf74.
ExpressionAtlasiQ96LT6. baseline and differential.
GenevisibleiQ96LT6. HS.

Organism-specific databases

HPAiHPA028496.

Interactioni

Protein-protein interaction databases

BioGridi127141. 6 interactors.
IntActiQ96LT6. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96LT6.
SMRiQ96LT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0739 family.Curated

Phylogenomic databases

eggNOGiENOG410IVPG. Eukaryota.
ENOG4112A34. LUCA.
GeneTreeiENSGT00390000002240.
HOGENOMiHOG000111227.
HOVERGENiHBG080000.
InParanoidiQ96LT6.
OMAiHILEIGE.
OrthoDBiEOG091G0N3X.
PhylomeDBiQ96LT6.
TreeFamiTF328609.

Family and domain databases

InterProiView protein in InterPro
IPR027850. DUF4504.
PANTHERiPTHR31366. PTHR31366. 1 hit.
PfamiView protein in Pfam
PF14953. DUF4504. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLDLMSSP SPQLLVAAAQ QTLGMGKRRS PPQAICLHLA GEVLAVARGL
60 70 80 90 100
KPAVLYDCNC AGASELQSYL EELKGLGFLT FGLHILEIGE NSLIVSPEHV
110 120 130 140 150
CQHLEQVLLG TIAFVDVSSC QRHPSVCSLD QLQDLKALVA EIITHLQGLQ
160 170 180 190 200
RDLSLAVSYS RLHSSDWNLC TVFGILLGYP VPYTFHLNQG DDNCLALTPL
210 220 230 240 250
RVFTARISWL LGQPPILLYS FSVPESLFPG LRDILNTWEK DLRTRFRTQN
260
DFADLSISSE IVTLPAVAL
Length:269
Mass (Da):29,561
Last modified:December 1, 2001 - v1
Checksum:i12E2D58AA1E2F617
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050701146L → F. Corresponds to variant dbSNP:rs7550857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057807 mRNA. Translation: BAB71584.1.
AL022398 Genomic DNA. No translation available.
BC039719 mRNA. Translation: AAH39719.1.
CCDSiCCDS1491.1.
RefSeqiNP_689698.1. NM_152485.3.
UniGeneiHs.497642.
Hs.634602.

Genome annotation databases

EnsembliENST00000294811; ENSP00000294811; ENSG00000162757.
GeneIDi148304.
KEGGihsa:148304.
UCSCiuc001hhp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCA074_HUMAN
AccessioniPrimary (citable) accession number: Q96LT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries