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Q96LR9 (APLD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein L domain-containing protein 1
Alternative name(s):
Vascular early response gene protein
Gene names
Name:APOLD1
Synonyms:VERGE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Probable Ref.4.

Tissue specificity

Expressed in neonatal dermal microvascular endothelial cells. Ref.4

Induction

In neonatal dermal microvascular endothelial cells, by hypoxia. Ref.4

Sequence similarities

Belongs to the apolipoprotein L family.

Sequence caution

The sequence AAH42478.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96LR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96LR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-32: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Apolipoprotein L domain-containing protein 1
PRO_0000247275

Regions

Transmembrane83 – 10523Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane192 – 21221Helical; Potential
Coiled coil226 – 25328 Potential
Compositional bias3 – 8280Arg-rich

Natural variations

Alternative sequence2 – 3231Missing in isoform 2.
VSP_019960

Experimental info

Sequence conflict641G → R in CAB66717. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: E2CDA210C1FD80C3

FASTA27930,546
        10         20         30         40         50         60 
MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR FQGLLLDRRG 

        70         80         90        100        110        120 
RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA AIVGLSLSPV TLGTSLLVSA 

       130        140        150        160        170        180 
VGLGVATAGG AVTITSDLSL IFCNSRELRR VQEIAATCQD QMREILSCLE FFCRWQGCGD 

       190        200        210        220        230        240 
RQLLQCGRNA SIALYNSVYF IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC 

       250        260        270 
TGALDELSEQ LESRVQLCTK SSRGHDLKIS ADQRAGLFF 

« Hide

Isoform 2 [UniParc].

Checksum: 291DE656CDC04338
Show »

FASTA24827,063

References

« Hide 'large scale' references
[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[4]"Verge: a novel vascular early response gene."
Regard J.B., Scheek S., Borbiev T., Lanahan A.A., Schneider A., Demetriades A.-M., Hiemisch H., Barnes C.A., Verin A.D., Worley P.F.
J. Neurosci. 24:4092-4103(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136783 mRNA. Translation: CAB66717.1.
AK057867 mRNA. Translation: BAB71601.1.
BC042478 mRNA. Translation: AAH42478.1. Different initiation.
RefSeqNP_001123887.1. NM_001130415.1.
NP_110444.3. NM_030817.2.
UniGeneHs.23388.
Hs.719938.

3D structure databases

ProteinModelPortalQ96LR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123535. 2 interactions.
STRING9606.ENSP00000324277.

Polymorphism databases

DMDM110832749.

Proteomic databases

PaxDbQ96LR9.
PRIDEQ96LR9.

Protocols and materials databases

DNASU81575.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326765; ENSP00000324277; ENSG00000178878. [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878. [Q96LR9-2]
GeneID81575.
KEGGhsa:81575.
UCSCuc001rau.4. human. [Q96LR9-1]

Organism-specific databases

CTD81575.
GeneCardsGC12P012880.
HGNCHGNC:25268. APOLD1.
HPAHPA052462.
MIM612456. gene.
neXtProtNX_Q96LR9.
PharmGKBPA143485306.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40567.
HOGENOMHOG000092978.
HOVERGENHBG079426.
InParanoidQ96LR9.
OMAKSSRGHD.
OrthoDBEOG7W41D2.
PhylomeDBQ96LR9.
TreeFamTF334681.

Gene expression databases

ArrayExpressQ96LR9.
BgeeQ96LR9.
GenevestigatorQ96LR9.

Family and domain databases

InterProIPR008405. ApoL.
[Graphical view]
PANTHERPTHR14096. PTHR14096. 1 hit.
PfamPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOLD1. human.
GeneWikiAPOLD1_(gene).
GenomeRNAi81575.
NextBio71884.
PROQ96LR9.
SOURCESearch...

Entry information

Entry nameAPLD1_HUMAN
AccessionPrimary (citable) accession number: Q96LR9
Secondary accession number(s): Q8IVR2, Q9H0I5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM