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Protein

Apolipoprotein L domain-containing protein 1

Gene

APOLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L domain-containing protein 1
Alternative name(s):
Vascular early response gene protein
Gene namesi
Name:APOLD1
Synonyms:VERGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000178878.12.
HGNCiHGNC:25268. APOLD1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 105HelicalSequence analysisAdd BLAST23
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81575.
OpenTargetsiENSG00000178878.
PharmGKBiPA143485306.

Polymorphism and mutation databases

BioMutaiAPOLD1.
DMDMi110832749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472751 – 279Apolipoprotein L domain-containing protein 1Add BLAST279

Proteomic databases

PaxDbiQ96LR9.
PRIDEiQ96LR9.

Expressioni

Tissue specificityi

Expressed in neonatal dermal microvascular endothelial cells.1 Publication

Inductioni

In neonatal dermal microvascular endothelial cells, by hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000178878.
ExpressionAtlasiQ96LR9. baseline and differential.
GenevisibleiQ96LR9. HS.

Organism-specific databases

HPAiHPA052462.
HPA058882.

Interactioni

Protein-protein interaction databases

BioGridi123535. 4 interactors.
STRINGi9606.ENSP00000324277.

Structurei

3D structure databases

ProteinModelPortaliQ96LR9.
SMRiQ96LR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili226 – 253Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 82Arg-richAdd BLAST80

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWGQ. Eukaryota.
ENOG410YM8A. LUCA.
GeneTreeiENSGT00710000106780.
HOGENOMiHOG000092978.
HOVERGENiHBG079426.
InParanoidiQ96LR9.
OMAiCNSREVR.
OrthoDBiEOG091G0L8F.
PhylomeDBiQ96LR9.
TreeFamiTF334681.

Family and domain databases

InterProiView protein in InterPro
IPR008405. ApoL.
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiView protein in Pfam
PF05461. ApoL. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR
60 70 80 90 100
FQGLLLDRRG RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA
110 120 130 140 150
AIVGLSLSPV TLGTSLLVSA VGLGVATAGG AVTITSDLSL IFCNSRELRR
160 170 180 190 200
VQEIAATCQD QMREILSCLE FFCRWQGCGD RQLLQCGRNA SIALYNSVYF
210 220 230 240 250
IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC TGALDELSEQ
260 270
LESRVQLCTK SSRGHDLKIS ADQRAGLFF
Note: No experimental confirmation available.
Length:279
Mass (Da):30,546
Last modified:July 25, 2006 - v2
Checksum:iE2CDA210C1FD80C3
GO
Isoform 2 (identifier: Q96LR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-32: Missing.

Show »
Length:248
Mass (Da):27,063
Checksum:i291DE656CDC04338
GO

Sequence cautioni

The sequence AAH42478 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64G → R in CAB66717 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199602 – 32Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136783 mRNA. Translation: CAB66717.1.
AK057867 mRNA. Translation: BAB71601.1.
BC042478 mRNA. Translation: AAH42478.1. Different initiation.
CCDSiCCDS44833.1. [Q96LR9-1]
CCDS8654.1. [Q96LR9-2]
RefSeqiNP_001123887.1. NM_001130415.1. [Q96LR9-1]
NP_110444.3. NM_030817.2. [Q96LR9-2]
UniGeneiHs.23388.
Hs.719938.

Genome annotation databases

EnsembliENST00000326765; ENSP00000324277; ENSG00000178878. [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878. [Q96LR9-2]
GeneIDi81575.
KEGGihsa:81575.
UCSCiuc001rau.5. human. [Q96LR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPLD1_HUMAN
AccessioniPrimary (citable) accession number: Q96LR9
Secondary accession number(s): Q8IVR2, Q9H0I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: September 27, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families