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Q96LR9

- APLD1_HUMAN

UniProt

Q96LR9 - APLD1_HUMAN

Protein

Apolipoprotein L domain-containing protein 1

Gene

APOLD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.1 Publication

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. endothelial cell activation Source: Ensembl
    4. lipid transport Source: InterPro
    5. lipoprotein metabolic process Source: InterPro
    6. regulation of endothelial cell differentiation Source: Ensembl
    7. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein L domain-containing protein 1
    Alternative name(s):
    Vascular early response gene protein
    Gene namesi
    Name:APOLD1
    Synonyms:VERGE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25268. APOLD1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485306.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Apolipoprotein L domain-containing protein 1PRO_0000247275Add
    BLAST

    Proteomic databases

    PaxDbiQ96LR9.
    PRIDEiQ96LR9.

    Expressioni

    Tissue specificityi

    Expressed in neonatal dermal microvascular endothelial cells.1 Publication

    Inductioni

    In neonatal dermal microvascular endothelial cells, by hypoxia.1 Publication

    Gene expression databases

    ArrayExpressiQ96LR9.
    BgeeiQ96LR9.
    GenevestigatoriQ96LR9.

    Organism-specific databases

    HPAiHPA052462.

    Interactioni

    Protein-protein interaction databases

    BioGridi123535. 2 interactions.
    STRINGi9606.ENSP00000324277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96LR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei83 – 10523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili226 – 25328Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 8280Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein L family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40567.
    HOGENOMiHOG000092978.
    HOVERGENiHBG079426.
    InParanoidiQ96LR9.
    OMAiKSSRGHD.
    OrthoDBiEOG7W41D2.
    PhylomeDBiQ96LR9.
    TreeFamiTF334681.

    Family and domain databases

    InterProiIPR008405. ApoL.
    [Graphical view]
    PANTHERiPTHR14096. PTHR14096. 1 hit.
    PfamiPF05461. ApoL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96LR9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR    50
    FQGLLLDRRG RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA 100
    AIVGLSLSPV TLGTSLLVSA VGLGVATAGG AVTITSDLSL IFCNSRELRR 150
    VQEIAATCQD QMREILSCLE FFCRWQGCGD RQLLQCGRNA SIALYNSVYF 200
    IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC TGALDELSEQ 250
    LESRVQLCTK SSRGHDLKIS ADQRAGLFF 279

    Note: No experimental confirmation available.

    Length:279
    Mass (Da):30,546
    Last modified:July 25, 2006 - v2
    Checksum:iE2CDA210C1FD80C3
    GO
    Isoform 2 (identifier: Q96LR9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-32: Missing.

    Show »
    Length:248
    Mass (Da):27,063
    Checksum:i291DE656CDC04338
    GO

    Sequence cautioni

    The sequence AAH42478.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641G → R in CAB66717. (PubMed:11230166)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 3231Missing in isoform 2. 2 PublicationsVSP_019960Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136783 mRNA. Translation: CAB66717.1.
    AK057867 mRNA. Translation: BAB71601.1.
    BC042478 mRNA. Translation: AAH42478.1. Different initiation.
    CCDSiCCDS44833.1. [Q96LR9-1]
    CCDS8654.1. [Q96LR9-2]
    RefSeqiNP_001123887.1. NM_001130415.1. [Q96LR9-1]
    NP_110444.3. NM_030817.2. [Q96LR9-2]
    UniGeneiHs.23388.
    Hs.719938.

    Genome annotation databases

    EnsembliENST00000326765; ENSP00000324277; ENSG00000178878. [Q96LR9-1]
    ENST00000356591; ENSP00000348998; ENSG00000178878. [Q96LR9-2]
    GeneIDi81575.
    KEGGihsa:81575.
    UCSCiuc001rau.4. human. [Q96LR9-1]

    Polymorphism databases

    DMDMi110832749.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136783 mRNA. Translation: CAB66717.1 .
    AK057867 mRNA. Translation: BAB71601.1 .
    BC042478 mRNA. Translation: AAH42478.1 . Different initiation.
    CCDSi CCDS44833.1. [Q96LR9-1 ]
    CCDS8654.1. [Q96LR9-2 ]
    RefSeqi NP_001123887.1. NM_001130415.1. [Q96LR9-1 ]
    NP_110444.3. NM_030817.2. [Q96LR9-2 ]
    UniGenei Hs.23388.
    Hs.719938.

    3D structure databases

    ProteinModelPortali Q96LR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123535. 2 interactions.
    STRINGi 9606.ENSP00000324277.

    Polymorphism databases

    DMDMi 110832749.

    Proteomic databases

    PaxDbi Q96LR9.
    PRIDEi Q96LR9.

    Protocols and materials databases

    DNASUi 81575.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326765 ; ENSP00000324277 ; ENSG00000178878 . [Q96LR9-1 ]
    ENST00000356591 ; ENSP00000348998 ; ENSG00000178878 . [Q96LR9-2 ]
    GeneIDi 81575.
    KEGGi hsa:81575.
    UCSCi uc001rau.4. human. [Q96LR9-1 ]

    Organism-specific databases

    CTDi 81575.
    GeneCardsi GC12P012880.
    HGNCi HGNC:25268. APOLD1.
    HPAi HPA052462.
    MIMi 612456. gene.
    neXtProti NX_Q96LR9.
    PharmGKBi PA143485306.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40567.
    HOGENOMi HOG000092978.
    HOVERGENi HBG079426.
    InParanoidi Q96LR9.
    OMAi KSSRGHD.
    OrthoDBi EOG7W41D2.
    PhylomeDBi Q96LR9.
    TreeFami TF334681.

    Miscellaneous databases

    ChiTaRSi APOLD1. human.
    GeneWikii APOLD1_(gene).
    GenomeRNAii 81575.
    NextBioi 71884.
    PROi Q96LR9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96LR9.
    Bgeei Q96LR9.
    Genevestigatori Q96LR9.

    Family and domain databases

    InterProi IPR008405. ApoL.
    [Graphical view ]
    PANTHERi PTHR14096. PTHR14096. 1 hit.
    Pfami PF05461. ApoL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    4. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAPLD1_HUMAN
    AccessioniPrimary (citable) accession number: Q96LR9
    Secondary accession number(s): Q8IVR2, Q9H0I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3