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Protein

Apolipoprotein L domain-containing protein 1

Gene

APOLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L domain-containing protein 1
Alternative name(s):
Vascular early response gene protein
Gene namesi
Name:APOLD1
Synonyms:VERGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25268. APOLD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei83 – 10523HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485306.

Polymorphism and mutation databases

BioMutaiAPOLD1.
DMDMi110832749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Apolipoprotein L domain-containing protein 1PRO_0000247275Add
BLAST

Proteomic databases

PaxDbiQ96LR9.
PRIDEiQ96LR9.

Expressioni

Tissue specificityi

Expressed in neonatal dermal microvascular endothelial cells.1 Publication

Inductioni

In neonatal dermal microvascular endothelial cells, by hypoxia.1 Publication

Gene expression databases

BgeeiQ96LR9.
ExpressionAtlasiQ96LR9. baseline and differential.
GenevestigatoriQ96LR9.

Organism-specific databases

HPAiHPA052462.

Interactioni

Protein-protein interaction databases

BioGridi123535. 1 interaction.
STRINGi9606.ENSP00000324277.

Structurei

3D structure databases

ProteinModelPortaliQ96LR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili226 – 25328Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 8280Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40567.
GeneTreeiENSGT00710000106780.
HOGENOMiHOG000092978.
HOVERGENiHBG079426.
InParanoidiQ96LR9.
OMAiKISADQR.
OrthoDBiEOG7W41D2.
PhylomeDBiQ96LR9.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR
60 70 80 90 100
FQGLLLDRRG RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA
110 120 130 140 150
AIVGLSLSPV TLGTSLLVSA VGLGVATAGG AVTITSDLSL IFCNSRELRR
160 170 180 190 200
VQEIAATCQD QMREILSCLE FFCRWQGCGD RQLLQCGRNA SIALYNSVYF
210 220 230 240 250
IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC TGALDELSEQ
260 270
LESRVQLCTK SSRGHDLKIS ADQRAGLFF

Note: No experimental confirmation available.

Length:279
Mass (Da):30,546
Last modified:July 25, 2006 - v2
Checksum:iE2CDA210C1FD80C3
GO
Isoform 2 (identifier: Q96LR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-32: Missing.

Show »
Length:248
Mass (Da):27,063
Checksum:i291DE656CDC04338
GO

Sequence cautioni

The sequence AAH42478.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641G → R in CAB66717 (PubMed:11230166).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 3231Missing in isoform 2. 2 PublicationsVSP_019960Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136783 mRNA. Translation: CAB66717.1.
AK057867 mRNA. Translation: BAB71601.1.
BC042478 mRNA. Translation: AAH42478.1. Different initiation.
CCDSiCCDS44833.1. [Q96LR9-1]
CCDS8654.1. [Q96LR9-2]
RefSeqiNP_001123887.1. NM_001130415.1. [Q96LR9-1]
NP_110444.3. NM_030817.2. [Q96LR9-2]
UniGeneiHs.23388.
Hs.719938.

Genome annotation databases

EnsembliENST00000326765; ENSP00000324277; ENSG00000178878. [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878. [Q96LR9-2]
GeneIDi81575.
KEGGihsa:81575.
UCSCiuc001rau.4. human. [Q96LR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136783 mRNA. Translation: CAB66717.1.
AK057867 mRNA. Translation: BAB71601.1.
BC042478 mRNA. Translation: AAH42478.1. Different initiation.
CCDSiCCDS44833.1. [Q96LR9-1]
CCDS8654.1. [Q96LR9-2]
RefSeqiNP_001123887.1. NM_001130415.1. [Q96LR9-1]
NP_110444.3. NM_030817.2. [Q96LR9-2]
UniGeneiHs.23388.
Hs.719938.

3D structure databases

ProteinModelPortaliQ96LR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123535. 1 interaction.
STRINGi9606.ENSP00000324277.

Polymorphism and mutation databases

BioMutaiAPOLD1.
DMDMi110832749.

Proteomic databases

PaxDbiQ96LR9.
PRIDEiQ96LR9.

Protocols and materials databases

DNASUi81575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326765; ENSP00000324277; ENSG00000178878. [Q96LR9-1]
ENST00000356591; ENSP00000348998; ENSG00000178878. [Q96LR9-2]
GeneIDi81575.
KEGGihsa:81575.
UCSCiuc001rau.4. human. [Q96LR9-1]

Organism-specific databases

CTDi81575.
GeneCardsiGC12P012885.
HGNCiHGNC:25268. APOLD1.
HPAiHPA052462.
MIMi612456. gene.
neXtProtiNX_Q96LR9.
PharmGKBiPA143485306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40567.
GeneTreeiENSGT00710000106780.
HOGENOMiHOG000092978.
HOVERGENiHBG079426.
InParanoidiQ96LR9.
OMAiKISADQR.
OrthoDBiEOG7W41D2.
PhylomeDBiQ96LR9.
TreeFamiTF334681.

Miscellaneous databases

ChiTaRSiAPOLD1. human.
GeneWikiiAPOLD1_(gene).
GenomeRNAii81575.
NextBioi71884.
PROiQ96LR9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LR9.
ExpressionAtlasiQ96LR9. baseline and differential.
GenevestigatoriQ96LR9.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  4. Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAPLD1_HUMAN
AccessioniPrimary (citable) accession number: Q96LR9
Secondary accession number(s): Q8IVR2, Q9H0I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 29, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.