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Protein

Protein FAM19A4

Gene

FAM19A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A4
Alternative name(s):
Chemokine-like protein TAFA-4
Gene namesi
Name:FAM19A4
Synonyms:TAFA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21591. FAM19A4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873006.

Polymorphism and mutation databases

BioMutaiFAM19A4.
DMDMi74732248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 140105Protein FAM19A4PRO_0000042728Add
BLAST

Proteomic databases

MaxQBiQ96LR4.
PaxDbiQ96LR4.
PRIDEiQ96LR4.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiQ96LR4.
CleanExiHS_FAM19A4.
ExpressionAtlasiQ96LR4. baseline and differential.
GenevisibleiQ96LR4. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-10290841,EBI-743771

Protein-protein interaction databases

BioGridi127394. 52 interactions.
IntActiQ96LR4. 1 interaction.
STRINGi9606.ENSP00000295569.

Structurei

3D structure databases

ProteinModelPortaliQ96LR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW83. Eukaryota.
ENOG410YMNB. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ96LR4.
OMAiMRFCAKS.
OrthoDBiEOG7K9K4X.
PhylomeDBiQ96LR4.
TreeFamiTF331749.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPRMRVCA KSVLLSHWLF LAYVLMVCCK LMSASSQHLR GHAGHHQIKQ
60 70 80 90 100
GTCEVVAVHR CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI
110 120 130 140
QKWWCHMNPC LEGEDCKVLP DYSGWSCSSG NKVKTTKVTR
Length:140
Mass (Da):15,682
Last modified:December 1, 2001 - v1
Checksum:i173254FBBB526009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325117 mRNA. Translation: AAP92409.1.
AK057890 mRNA. Translation: BAB71606.1.
AC096922 Genomic DNA. No translation available.
AC104166 Genomic DNA. No translation available.
AC109587 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65463.1.
BC031566 mRNA. Translation: AAH31566.1.
CCDSiCCDS2907.1.
RefSeqiNP_001005527.1. NM_001005527.2.
NP_872328.1. NM_182522.4.
UniGeneiHs.187873.
Hs.736925.

Genome annotation databases

EnsembliENST00000295569; ENSP00000295569; ENSG00000163377.
GeneIDi151647.
KEGGihsa:151647.
UCSCiuc021xag.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325117 mRNA. Translation: AAP92409.1.
AK057890 mRNA. Translation: BAB71606.1.
AC096922 Genomic DNA. No translation available.
AC104166 Genomic DNA. No translation available.
AC109587 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65463.1.
BC031566 mRNA. Translation: AAH31566.1.
CCDSiCCDS2907.1.
RefSeqiNP_001005527.1. NM_001005527.2.
NP_872328.1. NM_182522.4.
UniGeneiHs.187873.
Hs.736925.

3D structure databases

ProteinModelPortaliQ96LR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127394. 52 interactions.
IntActiQ96LR4. 1 interaction.
STRINGi9606.ENSP00000295569.

Polymorphism and mutation databases

BioMutaiFAM19A4.
DMDMi74732248.

Proteomic databases

MaxQBiQ96LR4.
PaxDbiQ96LR4.
PRIDEiQ96LR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295569; ENSP00000295569; ENSG00000163377.
GeneIDi151647.
KEGGihsa:151647.
UCSCiuc021xag.2. human.

Organism-specific databases

CTDi151647.
GeneCardsiFAM19A4.
HGNCiHGNC:21591. FAM19A4.
neXtProtiNX_Q96LR4.
PharmGKBiPA134873006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW83. Eukaryota.
ENOG410YMNB. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ96LR4.
OMAiMRFCAKS.
OrthoDBiEOG7K9K4X.
PhylomeDBiQ96LR4.
TreeFamiTF331749.

Miscellaneous databases

GenomeRNAii151647.
PROiQ96LR4.

Gene expression databases

BgeeiQ96LR4.
CleanExiHS_FAM19A4.
ExpressionAtlasiQ96LR4. baseline and differential.
GenevisibleiQ96LR4. HS.

Family and domain databases

InterProiIPR020350. Chemokine-like_FAM19A2.
[Graphical view]
PfamiPF12020. TAFA. 1 hit.
[Graphical view]
ProDomiPD298472. Chemokine-like_2FAM19A2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain."
    Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.
    Genomics 83:727-734(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiF19A4_HUMAN
AccessioniPrimary (citable) accession number: Q96LR4
Secondary accession number(s): A8MVT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.