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Protein

Leucine rich adaptor protein 1

Gene

LURAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine rich adaptor protein 1
Alternative name(s):
Leucine repeat adapter protein 35A
Gene namesi
Name:LURAP1
Synonyms:C1orf190, LRAP35A, LRP35A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171357.5
HGNCiHGNC:32327 LURAP1
MIMi616129 gene
neXtProtiNX_Q96LR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi541468
OpenTargetsiENSG00000171357
PharmGKBiPA142672401

Polymorphism and mutation databases

BioMutaiLURAP1
DMDMi74752014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710781 – 239Leucine rich adaptor protein 1Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96LR2
PeptideAtlasiQ96LR2
PRIDEiQ96LR2

PTM databases

iPTMnetiQ96LR2
PhosphoSitePlusiQ96LR2

Expressioni

Gene expression databases

BgeeiENSG00000171357
CleanExiHS_C1orf190
GenevisibleiQ96LR2 HS

Organism-specific databases

HPAiHPA030060
HPA030061

Interactioni

Subunit structurei

Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation. Interacts with CDC42BPA and CDC42BPB.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi139071, 18 interactors
IntActiQ96LR2, 22 interactors
STRINGi9606.ENSP00000361048

Structurei

3D structure databases

ProteinModelPortaliQ96LR2
SMRiQ96LR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 83LRR 1Add BLAST29
Repeati93 – 114LRR 2Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJRV Eukaryota
ENOG4111FFM LUCA
GeneTreeiENSGT00530000063790
HOGENOMiHOG000231120
HOVERGENiHBG099631
InParanoidiQ96LR2
OMAiLRAVWKP
OrthoDBiEOG091G0OGC
PhylomeDBiQ96LR2
TreeFamiTF332089

Family and domain databases

InterProiView protein in InterPro
IPR037443 LURAP
PANTHERiPTHR33767 PTHR33767, 1 hit

Sequencei

Sequence statusi: Complete.

Q96LR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTVESQTP DLRDVEGKVG RKTPEGLLRG LRGECELGTS GALLLPGASS
60 70 80 90 100
TGHDLGDKIM ALKMELAYLR AIDVKILQQL VTLNEGIEAV RWLLEERGTL
110 120 130 140 150
TSHCSSLTSS QYSLTGGSPG RSRRGSWDSL PDTSTTDRLD SVSIGSFLDT
160 170 180 190 200
VAPSELDEQG PPGAPRSEMD WAKVIAGGER ARTEVDVAAT RLGSLRAVWK
210 220 230
PPGERLQGGP PESPEDESAK LGFEAHWFWE QCQDDVTFL
Length:239
Mass (Da):25,806
Last modified:December 1, 2001 - v1
Checksum:iE6D06F384B5448C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057892 mRNA Translation: BAB71608.1
AL672043 Genomic DNA No translation available.
BC034422 mRNA Translation: AAH34422.1
CCDSiCCDS30703.1
RefSeqiNP_001013633.1, NM_001013615.2
UniGeneiHs.568642

Genome annotation databases

EnsembliENST00000371980; ENSP00000361048; ENSG00000171357
GeneIDi541468
KEGGihsa:541468
UCSCiuc010oma.3 human

Similar proteinsi

Entry informationi

Entry nameiLURA1_HUMAN
AccessioniPrimary (citable) accession number: Q96LR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health