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Protein

Leucine rich adaptor protein 1

Gene

LURAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine rich adaptor protein 1
Alternative name(s):
Leucine repeat adapter protein 35A
Gene namesi
Name:LURAP1
Synonyms:C1orf190, LRAP35A, LRP35A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32327. LURAP1.

Subcellular locationi

GO - Cellular componenti

  • actomyosin Source: Ensembl
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672401.

Polymorphism and mutation databases

BioMutaiLURAP1.
DMDMi74752014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Leucine rich adaptor protein 1PRO_0000271078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei213 – 2131PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96LR2.
PaxDbiQ96LR2.
PeptideAtlasiQ96LR2.
PRIDEiQ96LR2.

PTM databases

iPTMnetiQ96LR2.
PhosphoSiteiQ96LR2.

Expressioni

Gene expression databases

BgeeiENSG00000171357.
CleanExiHS_C1orf190.
GenevisibleiQ96LR2. HS.

Organism-specific databases

HPAiHPA030060.
HPA030061.

Interactioni

Subunit structurei

Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation.

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTQ4VCS5-23EBI-741355,EBI-3891843
CSNK1DP487304EBI-741355,EBI-751621
DKFZp451B226Q5HYH73EBI-741355,EBI-10173842
HAUS1Q96CS23EBI-741355,EBI-2514791
PRPF31F1T0A53EBI-741355,EBI-10177194
TPM3P067533EBI-741355,EBI-355607
ZNF417Q8TAU33EBI-741355,EBI-740727

Protein-protein interaction databases

BioGridi139071. 18 interactions.
IntActiQ96LR2. 17 interactions.
STRINGi9606.ENSP00000361048.

Structurei

3D structure databases

ProteinModelPortaliQ96LR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati55 – 8329LRR 1Add
BLAST
Repeati93 – 11422LRR 2Add
BLAST

Sequence similaritiesi

Contains 2 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJRV. Eukaryota.
ENOG4111FFM. LUCA.
GeneTreeiENSGT00530000063790.
HOGENOMiHOG000231120.
HOVERGENiHBG099631.
InParanoidiQ96LR2.
OMAiMEGTAES.
OrthoDBiEOG091G0OGC.
PhylomeDBiQ96LR2.
TreeFamiTF332089.

Sequencei

Sequence statusi: Complete.

Q96LR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTVESQTP DLRDVEGKVG RKTPEGLLRG LRGECELGTS GALLLPGASS
60 70 80 90 100
TGHDLGDKIM ALKMELAYLR AIDVKILQQL VTLNEGIEAV RWLLEERGTL
110 120 130 140 150
TSHCSSLTSS QYSLTGGSPG RSRRGSWDSL PDTSTTDRLD SVSIGSFLDT
160 170 180 190 200
VAPSELDEQG PPGAPRSEMD WAKVIAGGER ARTEVDVAAT RLGSLRAVWK
210 220 230
PPGERLQGGP PESPEDESAK LGFEAHWFWE QCQDDVTFL
Length:239
Mass (Da):25,806
Last modified:December 1, 2001 - v1
Checksum:iE6D06F384B5448C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057892 mRNA. Translation: BAB71608.1.
AL672043 Genomic DNA. Translation: CAH72471.1.
BC034422 mRNA. Translation: AAH34422.1.
CCDSiCCDS30703.1.
RefSeqiNP_001013633.1. NM_001013615.2.
UniGeneiHs.568642.

Genome annotation databases

EnsembliENST00000371980; ENSP00000361048; ENSG00000171357.
GeneIDi541468.
KEGGihsa:541468.
UCSCiuc010oma.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057892 mRNA. Translation: BAB71608.1.
AL672043 Genomic DNA. Translation: CAH72471.1.
BC034422 mRNA. Translation: AAH34422.1.
CCDSiCCDS30703.1.
RefSeqiNP_001013633.1. NM_001013615.2.
UniGeneiHs.568642.

3D structure databases

ProteinModelPortaliQ96LR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139071. 18 interactions.
IntActiQ96LR2. 17 interactions.
STRINGi9606.ENSP00000361048.

PTM databases

iPTMnetiQ96LR2.
PhosphoSiteiQ96LR2.

Polymorphism and mutation databases

BioMutaiLURAP1.
DMDMi74752014.

Proteomic databases

EPDiQ96LR2.
PaxDbiQ96LR2.
PeptideAtlasiQ96LR2.
PRIDEiQ96LR2.

Protocols and materials databases

DNASUi541468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371980; ENSP00000361048; ENSG00000171357.
GeneIDi541468.
KEGGihsa:541468.
UCSCiuc010oma.3. human.

Organism-specific databases

CTDi541468.
GeneCardsiLURAP1.
H-InvDBHIX0000545.
HGNCiHGNC:32327. LURAP1.
HPAiHPA030060.
HPA030061.
MIMi616129. gene.
neXtProtiNX_Q96LR2.
PharmGKBiPA142672401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJRV. Eukaryota.
ENOG4111FFM. LUCA.
GeneTreeiENSGT00530000063790.
HOGENOMiHOG000231120.
HOVERGENiHBG099631.
InParanoidiQ96LR2.
OMAiMEGTAES.
OrthoDBiEOG091G0OGC.
PhylomeDBiQ96LR2.
TreeFamiTF332089.

Miscellaneous databases

GenomeRNAii541468.
PROiQ96LR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171357.
CleanExiHS_C1orf190.
GenevisibleiQ96LR2. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLURA1_HUMAN
AccessioniPrimary (citable) accession number: Q96LR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.