Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1 regulatory subunit 36

Gene

PPP1R36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 36
Gene namesi
Name:PPP1R36
Synonyms:C14orf50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20097. PPP1R36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955014.

Polymorphism and mutation databases

BioMutaiPPP1R36.
DMDMi71153015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Protein phosphatase 1 regulatory subunit 36PRO_0000089893Add
BLAST

Proteomic databases

PaxDbiQ96LQ0.
PRIDEiQ96LQ0.

PTM databases

iPTMnetiQ96LQ0.
PhosphoSiteiQ96LQ0.

Expressioni

Gene expression databases

BgeeiENSG00000165807.
CleanExiHS_C14orf50.
ExpressionAtlasiQ96LQ0. baseline and differential.
GenevisibleiQ96LQ0. HS.

Organism-specific databases

HPAiHPA036801.

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126908. 1 interaction.
IntActiQ96LQ0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96LQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IECE. Eukaryota.
ENOG4111MKX. LUCA.
GeneTreeiENSGT00390000012412.
HOGENOMiHOG000111819.
HOVERGENiHBG060894.
InParanoidiQ96LQ0.
KOiK17575.
OMAiTLDSVPM.
OrthoDBiEOG091G0BX9.
PhylomeDBiQ96LQ0.
TreeFamiTF329463.

Family and domain databases

InterProiIPR026142. Pro_pase_1_reg_su_36.
[Graphical view]
PANTHERiPTHR21055. PTHR21055. 1 hit.
PfamiPF14895. PPPI_inhib. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRVPEFYAR RKRLGGQTPY LMDQLGLRLG MWYWKDETRT LEFRRFAAED
60 70 80 90 100
SVQWLLKHHP HFTPAAEVKE KGKKGKAVHF AETDGPASDR LTDKRLAAKD
110 120 130 140 150
DKSAKAVEKR GQQGTITLDD VKFVTLLLLQ DTEMQRICSF TTFMRNKNLD
160 170 180 190 200
NFLMALLYYL SHYLEKNSLE KKPKSYMVGL VEKKEMELVL SELEAAQRYL
210 220 230 240 250
AQKYCILVLG LAVPDKHHMC CGKEKISDTQ KDWKFFESFY TFCTYVAWIV
260 270 280 290 300
FRRQHLTEIE EEVGRLFRTN MFNIPRRRRE DEESGGEKKR MTFVQFRRMM
310 320 330 340 350
AKRPAIKKAI NMRSPVMSTL LPSLREKAQN VFEKKYHQVD VRFPAEMQKH
360 370 380 390 400
VGTLDSVPMP VVGILGEPRC LFNPHTLHPL DPEENTKSFG RYPSLMENNN
410 420
MRIQDTLDLV MKTLSSHTSC PK
Length:422
Mass (Da):49,440
Last modified:December 1, 2001 - v1
Checksum:i82DF1D7AB2BC8C44
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831T → I.1 Publication
Corresponds to variant rs6573560 [ dbSNP | Ensembl ].
VAR_022999
Natural varianti267 – 2671F → L.
Corresponds to variant rs45482504 [ dbSNP | Ensembl ].
VAR_061612

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058044 mRNA. Translation: BAB71637.1.
BC068989 mRNA. Translation: AAH68989.1.
CCDSiCCDS9767.1.
RefSeqiNP_758953.1. NM_172365.2.
UniGeneiHs.144696.

Genome annotation databases

EnsembliENST00000298705; ENSP00000298705; ENSG00000165807.
GeneIDi145376.
KEGGihsa:145376.
UCSCiuc001xhl.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058044 mRNA. Translation: BAB71637.1.
BC068989 mRNA. Translation: AAH68989.1.
CCDSiCCDS9767.1.
RefSeqiNP_758953.1. NM_172365.2.
UniGeneiHs.144696.

3D structure databases

ProteinModelPortaliQ96LQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126908. 1 interaction.
IntActiQ96LQ0. 1 interaction.

PTM databases

iPTMnetiQ96LQ0.
PhosphoSiteiQ96LQ0.

Polymorphism and mutation databases

BioMutaiPPP1R36.
DMDMi71153015.

Proteomic databases

PaxDbiQ96LQ0.
PRIDEiQ96LQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298705; ENSP00000298705; ENSG00000165807.
GeneIDi145376.
KEGGihsa:145376.
UCSCiuc001xhl.1. human.

Organism-specific databases

CTDi145376.
GeneCardsiPPP1R36.
H-InvDBHIX0202065.
HGNCiHGNC:20097. PPP1R36.
HPAiHPA036801.
neXtProtiNX_Q96LQ0.
PharmGKBiPA134955014.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IECE. Eukaryota.
ENOG4111MKX. LUCA.
GeneTreeiENSGT00390000012412.
HOGENOMiHOG000111819.
HOVERGENiHBG060894.
InParanoidiQ96LQ0.
KOiK17575.
OMAiTLDSVPM.
OrthoDBiEOG091G0BX9.
PhylomeDBiQ96LQ0.
TreeFamiTF329463.

Miscellaneous databases

GenomeRNAii145376.
PROiQ96LQ0.

Gene expression databases

BgeeiENSG00000165807.
CleanExiHS_C14orf50.
ExpressionAtlasiQ96LQ0. baseline and differential.
GenevisibleiQ96LQ0. HS.

Family and domain databases

InterProiIPR026142. Pro_pase_1_reg_su_36.
[Graphical view]
PANTHERiPTHR21055. PTHR21055. 1 hit.
PfamiPF14895. PPPI_inhib. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR36_HUMAN
AccessioniPrimary (citable) accession number: Q96LQ0
Secondary accession number(s): Q6NTH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.