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Protein

Protein FAM81B

Gene

FAM81B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM81B
Gene namesi
Name:FAM81B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26335. FAM81B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671847.

Polymorphism and mutation databases

BioMutaiFAM81B.
DMDMi296439348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Protein FAM81BPRO_0000265122Add
BLAST

Proteomic databases

EPDiQ96LP2.
PaxDbiQ96LP2.
PeptideAtlasiQ96LP2.
PRIDEiQ96LP2.

PTM databases

iPTMnetiQ96LP2.
PhosphoSiteiQ96LP2.

Expressioni

Gene expression databases

BgeeiENSG00000153347.
CleanExiHS_FAM81B.
ExpressionAtlasiQ96LP2. baseline and differential.
GenevisibleiQ96LP2. HS.

Organism-specific databases

HPAiHPA072554.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RINT1Q6NUQ13EBI-10290827,EBI-726876

Protein-protein interaction databases

BioGridi127508. 4 interactions.
IntActiQ96LP2. 1 interaction.
STRINGi9606.ENSP00000283357.

Structurei

3D structure databases

ProteinModelPortaliQ96LP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 19229Sequence analysisAdd
BLAST
Coiled coili329 – 452124Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM81 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG0A. Eukaryota.
ENOG4111JK9. LUCA.
HOGENOMiHOG000112481.
HOVERGENiHBG107904.
InParanoidiQ96LP2.
OrthoDBiEOG091G0CNY.
PhylomeDBiQ96LP2.
TreeFamiTF335682.

Family and domain databases

InterProiIPR029619. FAM81.
IPR029620. FAM81B.
[Graphical view]
PANTHERiPTHR22420. PTHR22420. 1 hit.
PTHR22420:SF5. PTHR22420:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQFLGTLA SSEKRKKSQR LFFKNIKSTK NKAGKASIMS SDTNVNKSAS
60 70 80 90 100
PTATAEEQPV EPDGPLPGSD NNQEKKVRLS PAKMSTKNST DLVEYVDKSH
110 120 130 140 150
AFLPIIPNTQ RGQLEDRLNN QARTIAFLLE QAFRIKEDIS ACLQGTHGFR
160 170 180 190 200
KEESLARKLL ESHIQTITSI VKKLSQNIEI LEDQIRARDQ AATGTNFAVH
210 220 230 240 250
EINIKHLQGV GDLRGRVARC DSSIVKLSGD IHLFRQEHRQ IEKAIQEFVP
260 270 280 290 300
ALETLSKNLD MKVMQLLGKI ETASPEQTSN LKMVQGDYRH EMNLLEFKFH
310 320 330 340 350
SLSSNLYEEV ENNKKWTENQ FLKYRKDHLG HINECLKVLQ EKLEKSENKM
360 370 380 390 400
EEKLLQLSSK VENFINTQKQ ETQLSKVKHM ENKLSKKMEQ MEKQIWGELE
410 420 430 440 450
TMQNEYQSGF KSIHDSLSSL QQIQKTKMDL EKYKVQKDLK KLQRKIVELQ

EV
Length:452
Mass (Da):52,032
Last modified:May 18, 2010 - v3
Checksum:iD22DE065641966A8
GO

Sequence cautioni

The sequence AAH34772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71646 differs from that shown. Reason: Frameshift at position 24. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501R → G.
Corresponds to variant rs10042271 [ dbSNP | Ensembl ].
VAR_057968
Natural varianti187 – 1871A → V.
Corresponds to variant rs11555275 [ dbSNP | Ensembl ].
VAR_057969
Natural varianti239 – 2391R → Q.
Corresponds to variant rs1541797 [ dbSNP | Ensembl ].
VAR_057970
Natural varianti275 – 2751P → S.2 Publications
Corresponds to variant rs6878669 [ dbSNP | Ensembl ].
VAR_057971

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058062 mRNA. Translation: BAB71646.1. Frameshift.
AC008573 Genomic DNA. No translation available.
AC090071 Genomic DNA. No translation available.
BC034772 mRNA. Translation: AAH34772.1. Different initiation.
CCDSiCCDS43341.1.
RefSeqiNP_689761.2. NM_152548.2.
UniGeneiHs.276287.

Genome annotation databases

EnsembliENST00000283357; ENSP00000283357; ENSG00000153347.
GeneIDi153643.
KEGGihsa:153643.
UCSCiuc003kla.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058062 mRNA. Translation: BAB71646.1. Frameshift.
AC008573 Genomic DNA. No translation available.
AC090071 Genomic DNA. No translation available.
BC034772 mRNA. Translation: AAH34772.1. Different initiation.
CCDSiCCDS43341.1.
RefSeqiNP_689761.2. NM_152548.2.
UniGeneiHs.276287.

3D structure databases

ProteinModelPortaliQ96LP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127508. 4 interactions.
IntActiQ96LP2. 1 interaction.
STRINGi9606.ENSP00000283357.

PTM databases

iPTMnetiQ96LP2.
PhosphoSiteiQ96LP2.

Polymorphism and mutation databases

BioMutaiFAM81B.
DMDMi296439348.

Proteomic databases

EPDiQ96LP2.
PaxDbiQ96LP2.
PeptideAtlasiQ96LP2.
PRIDEiQ96LP2.

Protocols and materials databases

DNASUi153643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283357; ENSP00000283357; ENSG00000153347.
GeneIDi153643.
KEGGihsa:153643.
UCSCiuc003kla.2. human.

Organism-specific databases

CTDi153643.
GeneCardsiFAM81B.
HGNCiHGNC:26335. FAM81B.
HPAiHPA072554.
neXtProtiNX_Q96LP2.
PharmGKBiPA142671847.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG0A. Eukaryota.
ENOG4111JK9. LUCA.
HOGENOMiHOG000112481.
HOVERGENiHBG107904.
InParanoidiQ96LP2.
OrthoDBiEOG091G0CNY.
PhylomeDBiQ96LP2.
TreeFamiTF335682.

Miscellaneous databases

ChiTaRSiFAM81B. human.
GenomeRNAii153643.
PROiQ96LP2.

Gene expression databases

BgeeiENSG00000153347.
CleanExiHS_FAM81B.
ExpressionAtlasiQ96LP2. baseline and differential.
GenevisibleiQ96LP2. HS.

Family and domain databases

InterProiIPR029619. FAM81.
IPR029620. FAM81B.
[Graphical view]
PANTHERiPTHR22420. PTHR22420. 1 hit.
PTHR22420:SF5. PTHR22420:SF5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFA81B_HUMAN
AccessioniPrimary (citable) accession number: Q96LP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-39 is the initiator. Met-1 does not seem to exist in orthologs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.