Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM81B

Gene

FAM81B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-39 is the initiator. Met-1 does not seem to exist in orthologs.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM81B
Gene namesi
Name:FAM81B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153347.9
HGNCiHGNC:26335 FAM81B
neXtProtiNX_Q96LP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi153643
PharmGKBiPA142671847

Polymorphism and mutation databases

BioMutaiFAM81B
DMDMi296439348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002651221 – 452Protein FAM81BAdd BLAST452

Proteomic databases

MaxQBiQ96LP2
PaxDbiQ96LP2
PeptideAtlasiQ96LP2
PRIDEiQ96LP2

PTM databases

iPTMnetiQ96LP2
PhosphoSitePlusiQ96LP2

Expressioni

Gene expression databases

BgeeiENSG00000153347
CleanExiHS_FAM81B
ExpressionAtlasiQ96LP2 baseline and differential
GenevisibleiQ96LP2 HS

Organism-specific databases

HPAiHPA072554

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127508, 4 interactors
IntActiQ96LP2, 4 interactors
STRINGi9606.ENSP00000283357

Structurei

3D structure databases

ProteinModelPortaliQ96LP2
SMRiQ96LP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 192Sequence analysisAdd BLAST29
Coiled coili329 – 452Sequence analysisAdd BLAST124

Sequence similaritiesi

Belongs to the FAM81 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG0A Eukaryota
ENOG4111JK9 LUCA
HOGENOMiHOG000112481
HOVERGENiHBG107904
InParanoidiQ96LP2
OrthoDBiEOG091G0CNY
PhylomeDBiQ96LP2
TreeFamiTF335682

Family and domain databases

InterProiView protein in InterPro
IPR029619 FAM81
IPR029620 FAM81B
PANTHERiPTHR22420 PTHR22420, 1 hit
PTHR22420:SF5 PTHR22420:SF5, 1 hit

Sequencei

Sequence statusi: Complete.

Q96LP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQFLGTLA SSEKRKKSQR LFFKNIKSTK NKAGKASIMS SDTNVNKSAS
60 70 80 90 100
PTATAEEQPV EPDGPLPGSD NNQEKKVRLS PAKMSTKNST DLVEYVDKSH
110 120 130 140 150
AFLPIIPNTQ RGQLEDRLNN QARTIAFLLE QAFRIKEDIS ACLQGTHGFR
160 170 180 190 200
KEESLARKLL ESHIQTITSI VKKLSQNIEI LEDQIRARDQ AATGTNFAVH
210 220 230 240 250
EINIKHLQGV GDLRGRVARC DSSIVKLSGD IHLFRQEHRQ IEKAIQEFVP
260 270 280 290 300
ALETLSKNLD MKVMQLLGKI ETASPEQTSN LKMVQGDYRH EMNLLEFKFH
310 320 330 340 350
SLSSNLYEEV ENNKKWTENQ FLKYRKDHLG HINECLKVLQ EKLEKSENKM
360 370 380 390 400
EEKLLQLSSK VENFINTQKQ ETQLSKVKHM ENKLSKKMEQ MEKQIWGELE
410 420 430 440 450
TMQNEYQSGF KSIHDSLSSL QQIQKTKMDL EKYKVQKDLK KLQRKIVELQ

EV
Length:452
Mass (Da):52,032
Last modified:May 18, 2010 - v3
Checksum:iD22DE065641966A8
GO

Sequence cautioni

The sequence AAH34772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB71646 differs from that shown. Reason: Frameshift at position 24.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057968150R → G. Corresponds to variant dbSNP:rs10042271Ensembl.1
Natural variantiVAR_057969187A → V. Corresponds to variant dbSNP:rs11555275Ensembl.1
Natural variantiVAR_057970239R → Q. Corresponds to variant dbSNP:rs1541797Ensembl.1
Natural variantiVAR_057971275P → S2 PublicationsCorresponds to variant dbSNP:rs6878669Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058062 mRNA Translation: BAB71646.1 Frameshift.
AC008573 Genomic DNA No translation available.
AC090071 Genomic DNA No translation available.
BC034772 mRNA Translation: AAH34772.1 Different initiation.
CCDSiCCDS43341.1
RefSeqiNP_689761.2, NM_152548.2
UniGeneiHs.276287

Genome annotation databases

EnsembliENST00000283357; ENSP00000283357; ENSG00000153347
GeneIDi153643
KEGGihsa:153643
UCSCiuc003kla.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA81B_HUMAN
AccessioniPrimary (citable) accession number: Q96LP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health