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Protein

Testis-expressed sequence 37 protein

Gene

TEX37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 37 protein
Alternative name(s):
Testis-specific conserved protein of 21 kDa
Gene namesi
Name:TEX37
Synonyms:C2orf51, TSC21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26341. TEX37.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379191.

Polymorphism and mutation databases

BioMutaiTEX37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Testis-expressed sequence 37 proteinPRO_0000304989Add
BLAST

Proteomic databases

PaxDbiQ96LM6.
PRIDEiQ96LM6.

PTM databases

PhosphoSiteiQ96LM6.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiQ96LM6.
CleanExiHS_C2orf51.
GenevestigatoriQ96LM6.

Organism-specific databases

HPAiHPA043987.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-743976,EBI-724310
KPNA3Q8IYQ93EBI-743976,EBI-742146
RBPMSQ930624EBI-743976,EBI-740322
TRIP13Q156454EBI-743976,EBI-358993

Protein-protein interaction databases

BioGridi128332. 6 interactions.
IntActiQ96LM6. 5 interactions.
MINTiMINT-1456070.
STRINGi9606.ENSP00000307142.

Structurei

3D structure databases

ProteinModelPortaliQ96LM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41061.
GeneTreeiENSGT00390000012177.
HOGENOMiHOG000154692.
HOVERGENiHBG108602.
InParanoidiQ96LM6.
OMAiRWGPLMP.
OrthoDBiEOG7RZ5RG.
PhylomeDBiQ96LM6.
TreeFamiTF337872.

Family and domain databases

InterProiIPR029361. TEX37.
[Graphical view]
PfamiPF15217. TSC21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVKYPGQD PVDLDIYQSS HMVDYQPYRK HKYSRVTPQE QAKLDAQLRD
60 70 80 90 100
KEFYRPIPNP NPKLTDGYPA FKRPHMTAKD LGLPGFFPSQ EHEATREDER
110 120 130 140 150
KFTSTCHFTY PASHDLHLAQ GDPNQVLQSA DFPCLVDPKH QPAAEMAKGY
160 170 180
LLLPGCPCLH CHIVKVPILN RWGPLMPFYQ
Length:180
Mass (Da):20,615
Last modified:December 1, 2001 - v1
Checksum:iAB9BC8BFE2850E92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241D → N.
Corresponds to variant rs35750657 [ dbSNP | Ensembl ].
VAR_035142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058098 mRNA. Translation: BAB71663.1.
AC104134 Genomic DNA. Translation: AAY24330.1.
CH471215 Genomic DNA. Translation: EAW77070.1.
BC029522 mRNA. Translation: AAH29522.1.
CCDSiCCDS2003.1.
RefSeqiNP_689883.1. NM_152670.2.
XP_005264245.2. XM_005264188.2.
UniGeneiHs.132104.

Genome annotation databases

EnsembliENST00000303254; ENSP00000307142; ENSG00000172073.
GeneIDi200523.
KEGGihsa:200523.
UCSCiuc002stb.2. human.

Polymorphism and mutation databases

BioMutaiTEX37.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058098 mRNA. Translation: BAB71663.1.
AC104134 Genomic DNA. Translation: AAY24330.1.
CH471215 Genomic DNA. Translation: EAW77070.1.
BC029522 mRNA. Translation: AAH29522.1.
CCDSiCCDS2003.1.
RefSeqiNP_689883.1. NM_152670.2.
XP_005264245.2. XM_005264188.2.
UniGeneiHs.132104.

3D structure databases

ProteinModelPortaliQ96LM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128332. 6 interactions.
IntActiQ96LM6. 5 interactions.
MINTiMINT-1456070.
STRINGi9606.ENSP00000307142.

PTM databases

PhosphoSiteiQ96LM6.

Polymorphism and mutation databases

BioMutaiTEX37.

Proteomic databases

PaxDbiQ96LM6.
PRIDEiQ96LM6.

Protocols and materials databases

DNASUi200523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303254; ENSP00000307142; ENSG00000172073.
GeneIDi200523.
KEGGihsa:200523.
UCSCiuc002stb.2. human.

Organism-specific databases

CTDi200523.
GeneCardsiGC02P088825.
HGNCiHGNC:26341. TEX37.
HPAiHPA043987.
neXtProtiNX_Q96LM6.
PharmGKBiPA162379191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41061.
GeneTreeiENSGT00390000012177.
HOGENOMiHOG000154692.
HOVERGENiHBG108602.
InParanoidiQ96LM6.
OMAiRWGPLMP.
OrthoDBiEOG7RZ5RG.
PhylomeDBiQ96LM6.
TreeFamiTF337872.

Miscellaneous databases

GenomeRNAii200523.
NextBioi89932.
PROiQ96LM6.

Gene expression databases

BgeeiQ96LM6.
CleanExiHS_C2orf51.
GenevestigatoriQ96LM6.

Family and domain databases

InterProiIPR029361. TEX37.
[Graphical view]
PfamiPF15217. TSC21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Identification and characteristics of a novel testis-specific gene, Tsc21, in mice and human."
    Yu Z., Tang A., Gui Y., Guo X., Zhu H., Long Y., Li Z., Cai Z.
    Mol. Biol. Rep. 34:127-134(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTEX37_HUMAN
AccessioniPrimary (citable) accession number: Q96LM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.