ID   SMIP2_HUMAN             Reviewed;         186 AA.
AC   Q96LM5; A8MPU3; C9J0T8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=Protein SPMIP2 {ECO:0000305};
DE   AltName: Full=Sperm-associated microtubule inner protein 2 {ECO:0000312|HGNC:HGNC:26342};
GN   Name=SPMIP2 {ECO:0000312|HGNC:HGNC:26342}; Synonyms=C4orf45;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-75 AND GLU-93.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- INTERACTION:
CC       Q96LM5; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12020542, EBI-11524452;
CC       Q96LM5; P41182: BCL6; NbExp=3; IntAct=EBI-12020542, EBI-765407;
CC       Q96LM5; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-12020542, EBI-11983447;
CC       Q96LM5; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12020542, EBI-3866279;
CC       Q96LM5; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-12020542, EBI-11977221;
CC       Q96LM5; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-12020542, EBI-10961624;
CC       Q96LM5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12020542, EBI-3867333;
CC       Q96LM5; O60662: KLHL41; NbExp=3; IntAct=EBI-12020542, EBI-5353084;
CC       Q96LM5; Q6A162: KRT40; NbExp=3; IntAct=EBI-12020542, EBI-10171697;
CC       Q96LM5; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-12020542, EBI-726739;
CC       Q96LM5; Q99750: MDFI; NbExp=3; IntAct=EBI-12020542, EBI-724076;
CC       Q96LM5; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-12020542, EBI-742459;
CC       Q96LM5; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-12020542, EBI-10271199;
CC       Q96LM5; Q99471: PFDN5; NbExp=3; IntAct=EBI-12020542, EBI-357275;
CC       Q96LM5; O15160: POLR1C; NbExp=3; IntAct=EBI-12020542, EBI-1055079;
CC       Q96LM5; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-12020542, EBI-5280197;
CC       Q96LM5; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-12020542, EBI-10268630;
CC       Q96LM5; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-12020542, EBI-741515;
CC       Q96LM5; Q13077: TRAF1; NbExp=3; IntAct=EBI-12020542, EBI-359224;
CC       Q96LM5; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-12020542, EBI-11525489;
CC       Q96LM5; O43167: ZBTB24; NbExp=3; IntAct=EBI-12020542, EBI-744471;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71665.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK058100; BAB71665.1; ALT_FRAME; mRNA.
DR   EMBL; AC093700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47156.1; -.
DR   RefSeq; NP_689756.2; NM_152543.2.
DR   RefSeq; XP_016863297.1; XM_017007808.1.
DR   RefSeq; XP_016863298.1; XM_017007809.1.
DR   RefSeq; XP_016863299.1; XM_017007810.1.
DR   AlphaFoldDB; Q96LM5; -.
DR   SMR; Q96LM5; -.
DR   BioGRID; 127473; 22.
DR   IntAct; Q96LM5; 22.
DR   MINT; Q96LM5; -.
DR   STRING; 9606.ENSP00000412215; -.
DR   iPTMnet; Q96LM5; -.
DR   PhosphoSitePlus; Q96LM5; -.
DR   BioMuta; C4orf45; -.
DR   DMDM; 296439413; -.
DR   MassIVE; Q96LM5; -.
DR   PaxDb; 9606-ENSP00000412215; -.
DR   PeptideAtlas; Q96LM5; -.
DR   ProteomicsDB; 77225; -.
DR   Antibodypedia; 56684; 37 antibodies from 7 providers.
DR   DNASU; 152940; -.
DR   Ensembl; ENST00000434826.3; ENSP00000412215.2; ENSG00000164123.7.
DR   GeneID; 152940; -.
DR   KEGG; hsa:152940; -.
DR   MANE-Select; ENST00000434826.3; ENSP00000412215.2; NM_152543.3; NP_689756.2.
DR   UCSC; uc003iqf.2; human.
DR   AGR; HGNC:26342; -.
DR   CTD; 152940; -.
DR   DisGeNET; 152940; -.
DR   GeneCards; SPMIP2; -.
DR   HGNC; HGNC:26342; SPMIP2.
DR   HPA; ENSG00000164123; Tissue enriched (testis).
DR   neXtProt; NX_Q96LM5; -.
DR   OpenTargets; ENSG00000164123; -.
DR   PharmGKB; PA162379953; -.
DR   VEuPathDB; HostDB:ENSG00000164123; -.
DR   eggNOG; ENOG502S3MZ; Eukaryota.
DR   GeneTree; ENSGT00390000012736; -.
DR   HOGENOM; CLU_105465_0_0_1; -.
DR   InParanoid; Q96LM5; -.
DR   OMA; DRRNSKW; -.
DR   OrthoDB; 2965761at2759; -.
DR   PhylomeDB; Q96LM5; -.
DR   TreeFam; TF329701; -.
DR   PathwayCommons; Q96LM5; -.
DR   SignaLink; Q96LM5; -.
DR   BioGRID-ORCS; 152940; 19 hits in 1115 CRISPR screens.
DR   ChiTaRS; C4orf45; human.
DR   GenomeRNAi; 152940; -.
DR   Pharos; Q96LM5; Tdark.
DR   PRO; PR:Q96LM5; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q96LM5; Protein.
DR   Bgee; ENSG00000164123; Expressed in sperm and 90 other cell types or tissues.
DR   InterPro; IPR027814; DUF4562.
DR   PANTHER; PTHR34833; GENE, 17359-RELATED; 1.
DR   PANTHER; PTHR34833:SF1; GENE, 17359-RELATED; 1.
DR   Pfam; PF15123; DUF4562; 1.
DR   Genevisible; Q96LM5; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..186
FT                   /note="Protein SPMIP2"
FT                   /id="PRO_0000325755"
FT   REGION          163..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         46
FT                   /note="A -> V (in dbSNP:rs17037864)"
FT                   /id="VAR_039901"
FT   VARIANT         75
FT                   /note="S -> G (in dbSNP:rs662473)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_039902"
FT   VARIANT         84
FT                   /note="Y -> C (in dbSNP:rs17037858)"
FT                   /id="VAR_039903"
FT   VARIANT         93
FT                   /note="G -> E (in dbSNP:rs619128)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_039904"
FT   VARIANT         134
FT                   /note="R -> H (in dbSNP:rs10517695)"
FT                   /id="VAR_039905"
FT   CONFLICT        72
FT                   /note="E -> K (in Ref. 1; BAB71665)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  21723 MW;  5DF02D604613DF2B CRC64;
     MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT GDLRYLWRPA
     SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY EELSQASLDS ITHRYQNPWQ
     PKPHVLDMQG KQSRASFAWH MSAFEDTDQR NSKWAILVRQ CKSSLPRASK PPKLPKLPKK
     EKKRKH
//