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Q96LM5 (CD045_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C4orf45
Gene names
Name:C4orf45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAB71665.1 differs from that shown. Reason: Frameshift at position 178.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Uncharacterized protein C4orf45
PRO_0000325755

Natural variations

Natural variant461A → V.
Corresponds to variant rs17037864 [ dbSNP | Ensembl ].
VAR_039901
Natural variant751S → G. Ref.1
Corresponds to variant rs662473 [ dbSNP | Ensembl ].
VAR_039902
Natural variant841Y → C.
Corresponds to variant rs17037858 [ dbSNP | Ensembl ].
VAR_039903
Natural variant931G → E. Ref.1
Corresponds to variant rs619128 [ dbSNP | Ensembl ].
VAR_039904
Natural variant1341R → H.
Corresponds to variant rs10517695 [ dbSNP | Ensembl ].
VAR_039905

Experimental info

Sequence conflict721E → K in BAB71665. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96LM5 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 5DF02D604613DF2B

FASTA18621,723
        10         20         30         40         50         60 
MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT GDLRYLWRPA 

        70         80         90        100        110        120 
SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY EELSQASLDS ITHRYQNPWQ 

       130        140        150        160        170        180 
PKPHVLDMQG KQSRASFAWH MSAFEDTDQR NSKWAILVRQ CKSSLPRASK PPKLPKLPKK 


EKKRKH 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-75 AND GLU-93.
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK058100 mRNA. Translation: BAB71665.1. Frameshift.
AC093700 Genomic DNA. No translation available.
AC109823 Genomic DNA. No translation available.
RefSeqNP_689756.2. NM_152543.2.
UniGeneHs.415576.

3D structure databases

ProteinModelPortalQ96LM5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000412215.

PTM databases

PhosphoSiteQ96LM5.

Polymorphism databases

DMDM296439413.

Proteomic databases

PaxDbQ96LM5.
PRIDEQ96LM5.

Protocols and materials databases

DNASU152940.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000434826; ENSP00000412215; ENSG00000164123.
GeneID152940.
KEGGhsa:152940.
UCSCuc003iqf.1. human.

Organism-specific databases

CTD152940.
GeneCardsGC04M159814.
HGNCHGNC:26342. C4orf45.
neXtProtNX_Q96LM5.
PharmGKBPA162379953.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75666.
HOGENOMHOG000074185.
HOVERGENHBG107627.
OMAKTGDLRY.
OrthoDBEOG7NPFVG.
PhylomeDBQ96LM5.
TreeFamTF329701.

Gene expression databases

BgeeQ96LM5.
CleanExHS_C4orf45.
GenevestigatorQ96LM5.

Family and domain databases

InterProIPR027814. DUF4562.
[Graphical view]
PfamPF15123. DUF4562. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi152940.
NextBio87059.

Entry information

Entry nameCD045_HUMAN
AccessionPrimary (citable) accession number: Q96LM5
Secondary accession number(s): A8MPU3, C9J0T8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM