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Protein

Uncharacterized protein C4orf45

Gene

C4orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf45
Gene namesi
Name:C4orf45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26342. C4orf45.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Uncharacterized protein C4orf45PRO_0000325755Add
BLAST

Proteomic databases

PaxDbiQ96LM5.
PRIDEiQ96LM5.

PTM databases

PhosphoSiteiQ96LM5.

Expressioni

Gene expression databases

BgeeiQ96LM5.
CleanExiHS_C4orf45.
GenevestigatoriQ96LM5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412215.

Structurei

3D structure databases

ProteinModelPortaliQ96LM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG75666.
GeneTreeiENSGT00390000012736.
HOGENOMiHOG000074185.
HOVERGENiHBG107627.
InParanoidiQ96LM5.
OMAiLRYLWRP.
OrthoDBiEOG7NPFVG.
PhylomeDBiQ96LM5.
TreeFamiTF329701.

Family and domain databases

InterProiIPR027814. DUF4562.
[Graphical view]
PfamiPF15123. DUF4562. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT
60 70 80 90 100
GDLRYLWRPA SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY
110 120 130 140 150
EELSQASLDS ITHRYQNPWQ PKPHVLDMQG KQSRASFAWH MSAFEDTDQR
160 170 180
NSKWAILVRQ CKSSLPRASK PPKLPKLPKK EKKRKH
Length:186
Mass (Da):21,723
Last modified:May 17, 2010 - v3
Checksum:i5DF02D604613DF2B
GO

Sequence cautioni

The sequence BAB71665.1 differs from that shown. Reason: Frameshift at position 178. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721E → K in BAB71665 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461A → V.
Corresponds to variant rs17037864 [ dbSNP | Ensembl ].
VAR_039901
Natural varianti75 – 751S → G.1 Publication
Corresponds to variant rs662473 [ dbSNP | Ensembl ].
VAR_039902
Natural varianti84 – 841Y → C.
Corresponds to variant rs17037858 [ dbSNP | Ensembl ].
VAR_039903
Natural varianti93 – 931G → E.1 Publication
Corresponds to variant rs619128 [ dbSNP | Ensembl ].
VAR_039904
Natural varianti134 – 1341R → H.
Corresponds to variant rs10517695 [ dbSNP | Ensembl ].
VAR_039905

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058100 mRNA. Translation: BAB71665.1. Frameshift.
AC093700 Genomic DNA. No translation available.
AC109823 Genomic DNA. No translation available.
CCDSiCCDS47156.1.
RefSeqiNP_689756.2. NM_152543.2.
UniGeneiHs.415576.

Genome annotation databases

EnsembliENST00000434826; ENSP00000412215; ENSG00000164123.
GeneIDi152940.
KEGGihsa:152940.
UCSCiuc003iqf.1. human.

Polymorphism databases

DMDMi296439413.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058100 mRNA. Translation: BAB71665.1. Frameshift.
AC093700 Genomic DNA. No translation available.
AC109823 Genomic DNA. No translation available.
CCDSiCCDS47156.1.
RefSeqiNP_689756.2. NM_152543.2.
UniGeneiHs.415576.

3D structure databases

ProteinModelPortaliQ96LM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000412215.

PTM databases

PhosphoSiteiQ96LM5.

Polymorphism databases

DMDMi296439413.

Proteomic databases

PaxDbiQ96LM5.
PRIDEiQ96LM5.

Protocols and materials databases

DNASUi152940.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434826; ENSP00000412215; ENSG00000164123.
GeneIDi152940.
KEGGihsa:152940.
UCSCiuc003iqf.1. human.

Organism-specific databases

CTDi152940.
GeneCardsiGC04M159814.
HGNCiHGNC:26342. C4orf45.
neXtProtiNX_Q96LM5.
PharmGKBiPA162379953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG75666.
GeneTreeiENSGT00390000012736.
HOGENOMiHOG000074185.
HOVERGENiHBG107627.
InParanoidiQ96LM5.
OMAiLRYLWRP.
OrthoDBiEOG7NPFVG.
PhylomeDBiQ96LM5.
TreeFamiTF329701.

Miscellaneous databases

ChiTaRSiC4orf45. human.
GenomeRNAii152940.
NextBioi87059.

Gene expression databases

BgeeiQ96LM5.
CleanExiHS_C4orf45.
GenevestigatoriQ96LM5.

Family and domain databases

InterProiIPR027814. DUF4562.
[Graphical view]
PfamiPF15123. DUF4562. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-75 AND GLU-93.
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCD045_HUMAN
AccessioniPrimary (citable) accession number: Q96LM5
Secondary accession number(s): A8MPU3, C9J0T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 17, 2008
Last sequence update: May 17, 2010
Last modified: January 6, 2015
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.