Q96LM5 (CD045_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C4orf45

Gene names

Name:

C4orf45

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAB71665.1 differs from that shown. Reason: Frameshift at position 178.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Uncharacterized protein C4orf45		PRO_0000325755
Natural variations
	Natural variant	46	1	A → V. Corresponds to variant rs17037864 [ dbSNP | Ensembl ].		VAR_039901
	Natural variant	75	1	S → G. Ref.1 Corresponds to variant rs662473 [ dbSNP | Ensembl ].		VAR_039902
	Natural variant	84	1	Y → C. Corresponds to variant rs17037858 [ dbSNP | Ensembl ].		VAR_039903
	Natural variant	93	1	G → E. Ref.1 Corresponds to variant rs619128 [ dbSNP | Ensembl ].		VAR_039904
	Natural variant	134	1	R → H. Corresponds to variant rs10517695 [ dbSNP | Ensembl ].		VAR_039905
Experimental info
	Sequence conflict	72	1	E → K in BAB71665. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96LM5 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 5DF02D604613DF2B	FASTA	186	21,723
	10 20 30 40 50 60 MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT GDLRYLWRPA 70 80 90 100 110 120 SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY EELSQASLDS ITHRYQNPWQ 130 140 150 160 170 180 PKPHVLDMQG KQSRASFAWH MSAFEDTDQR NSKWAILVRQ CKSSLPRASK PPKLPKLPKK EKKRKH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-75 AND GLU-93. Tissue: Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK058100 mRNA. Translation: BAB71665.1. Frameshift. AC093700 Genomic DNA. No translation available. AC109823 Genomic DNA. No translation available.
IPI	IPI00873240.
RefSeq	NP_689756.2. NM_152543.2.
UniGene	Hs.415576.
3D structure databases
ProteinModelPortal	Q96LM5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000412215.
PTM databases
PhosphoSite	Q96LM5.
Polymorphism databases
DMDM	296439413.
Proteomic databases
PaxDb	Q96LM5.
PRIDE	Q96LM5.
Protocols and materials databases
DNASU	152940.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000434826; ENSP00000412215; ENSG00000164123.
GeneID	152940.
KEGG	hsa:152940.
UCSC	uc003iqf.1. human.
Organism-specific databases
CTD	152940.
GeneCards	GC04M159814.
HGNC	HGNC:26342. C4orf45.
neXtProt	NX_Q96LM5.
PharmGKB	PA162379953.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG75666.
HOGENOM	HOG000074185.
HOVERGEN	HBG107627.
OMA	YKHEYVG.
OrthoDB	EOG46HGBX.
PhylomeDB	Q96LM5.
Gene expression databases
Bgee	Q96LM5.
CleanEx	HS_C4orf45.
Genevestigator	Q96LM5.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	152940.
NextBio	87059.

Entry information

Entry name

CD045_HUMAN

Accession

Primary (citable) accession number: Q96LM5
Secondary accession number(s): A8MPU3, C9J0T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.