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Protein

Uncharacterized protein C4orf45

Gene

C4orf45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf45
Gene namesi
Name:C4orf45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26342. C4orf45.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164123.
PharmGKBiPA162379953.

Polymorphism and mutation databases

BioMutaiC4orf45.
DMDMi296439413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257551 – 186Uncharacterized protein C4orf45Add BLAST186

Proteomic databases

PaxDbiQ96LM5.
PRIDEiQ96LM5.

PTM databases

iPTMnetiQ96LM5.
PhosphoSitePlusiQ96LM5.

Expressioni

Gene expression databases

BgeeiENSG00000164123.
CleanExiHS_C4orf45.
GenevisibleiQ96LM5. HS.

Interactioni

Protein-protein interaction databases

IntActiQ96LM5. 7 interactors.
STRINGi9606.ENSP00000412215.

Structurei

3D structure databases

ProteinModelPortaliQ96LM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXB9. Eukaryota.
ENOG411257E. LUCA.
GeneTreeiENSGT00390000012736.
HOGENOMiHOG000074185.
HOVERGENiHBG107627.
InParanoidiQ96LM5.
OMAiYKHEYVG.
OrthoDBiEOG091G1442.
PhylomeDBiQ96LM5.
TreeFamiTF329701.

Family and domain databases

InterProiIPR027814. DUF4562.
[Graphical view]
PfamiPF15123. DUF4562. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT
60 70 80 90 100
GDLRYLWRPA SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY
110 120 130 140 150
EELSQASLDS ITHRYQNPWQ PKPHVLDMQG KQSRASFAWH MSAFEDTDQR
160 170 180
NSKWAILVRQ CKSSLPRASK PPKLPKLPKK EKKRKH
Length:186
Mass (Da):21,723
Last modified:May 18, 2010 - v3
Checksum:i5DF02D604613DF2B
GO

Sequence cautioni

The sequence BAB71665 differs from that shown. Reason: Frameshift at position 178.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72E → K in BAB71665 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03990146A → V.Corresponds to variant rs17037864dbSNPEnsembl.1
Natural variantiVAR_03990275S → G.1 PublicationCorresponds to variant rs662473dbSNPEnsembl.1
Natural variantiVAR_03990384Y → C.Corresponds to variant rs17037858dbSNPEnsembl.1
Natural variantiVAR_03990493G → E.1 PublicationCorresponds to variant rs619128dbSNPEnsembl.1
Natural variantiVAR_039905134R → H.Corresponds to variant rs10517695dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058100 mRNA. Translation: BAB71665.1. Frameshift.
AC093700 Genomic DNA. No translation available.
AC109823 Genomic DNA. No translation available.
CCDSiCCDS47156.1.
RefSeqiNP_689756.2. NM_152543.2.
XP_016863297.1. XM_017007808.1.
XP_016863298.1. XM_017007809.1.
XP_016863299.1. XM_017007810.1.
UniGeneiHs.415576.

Genome annotation databases

EnsembliENST00000434826; ENSP00000412215; ENSG00000164123.
GeneIDi152940.
KEGGihsa:152940.
UCSCiuc003iqf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058100 mRNA. Translation: BAB71665.1. Frameshift.
AC093700 Genomic DNA. No translation available.
AC109823 Genomic DNA. No translation available.
CCDSiCCDS47156.1.
RefSeqiNP_689756.2. NM_152543.2.
XP_016863297.1. XM_017007808.1.
XP_016863298.1. XM_017007809.1.
XP_016863299.1. XM_017007810.1.
UniGeneiHs.415576.

3D structure databases

ProteinModelPortaliQ96LM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96LM5. 7 interactors.
STRINGi9606.ENSP00000412215.

PTM databases

iPTMnetiQ96LM5.
PhosphoSitePlusiQ96LM5.

Polymorphism and mutation databases

BioMutaiC4orf45.
DMDMi296439413.

Proteomic databases

PaxDbiQ96LM5.
PRIDEiQ96LM5.

Protocols and materials databases

DNASUi152940.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434826; ENSP00000412215; ENSG00000164123.
GeneIDi152940.
KEGGihsa:152940.
UCSCiuc003iqf.2. human.

Organism-specific databases

CTDi152940.
GeneCardsiC4orf45.
HGNCiHGNC:26342. C4orf45.
neXtProtiNX_Q96LM5.
OpenTargetsiENSG00000164123.
PharmGKBiPA162379953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXB9. Eukaryota.
ENOG411257E. LUCA.
GeneTreeiENSGT00390000012736.
HOGENOMiHOG000074185.
HOVERGENiHBG107627.
InParanoidiQ96LM5.
OMAiYKHEYVG.
OrthoDBiEOG091G1442.
PhylomeDBiQ96LM5.
TreeFamiTF329701.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164123-MONOMER.

Miscellaneous databases

ChiTaRSiC4orf45. human.
GenomeRNAii152940.
PROiQ96LM5.

Gene expression databases

BgeeiENSG00000164123.
CleanExiHS_C4orf45.
GenevisibleiQ96LM5. HS.

Family and domain databases

InterProiIPR027814. DUF4562.
[Graphical view]
PfamiPF15123. DUF4562. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD045_HUMAN
AccessioniPrimary (citable) accession number: Q96LM5
Secondary accession number(s): A8MPU3, C9J0T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.