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Protein

Spermatogenesis-associated protein 32

Gene

SPATA32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 32
Alternative name(s):
Testis-expressed protein 34
Gene namesi
Name:SPATA32
Synonyms:C17orf46, TEX34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000184361.12.
HGNCiHGNC:26349. SPATA32.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184361.
PharmGKBiPA142672229.

Polymorphism and mutation databases

BioMutaiSPATA32.
DMDMi296439385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829061 – 384Spermatogenesis-associated protein 32Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96LK8.
PeptideAtlasiQ96LK8.
PRIDEiQ96LK8.

PTM databases

iPTMnetiQ96LK8.
PhosphoSitePlusiQ96LK8.

Expressioni

Tissue specificityi

Detected in testis, and on the acrosomal cap of spermatids.

Gene expression databases

BgeeiENSG00000184361.
CleanExiHS_C17orf46.
ExpressionAtlasiQ96LK8. baseline and differential.
GenevisibleiQ96LK8. HS.

Organism-specific databases

HPAiHPA024549.

Interactioni

Subunit structurei

Interacts with syntaxin-1 and ACTB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96LK8. 2 interactors.
STRINGi9606.ENSP00000331532.

Structurei

3D structure databases

ProteinModelPortaliQ96LK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JBQ4. Eukaryota.
ENOG41119M8. LUCA.
GeneTreeiENSGT00390000006879.
HOGENOMiHOG000140856.
HOVERGENiHBG060335.
InParanoidiQ96LK8.
OMAiTSKHLFW.
OrthoDBiEOG091G0NZF.
PhylomeDBiQ96LK8.
TreeFamiTF338309.

Family and domain databases

InterProiView protein in InterPro
IPR029297. SPATA32.
PfamiView protein in Pfam
PF15310. VAD1-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTGAHGFP CCGKGSVEVA EMRDDLSQHQ IQEEQELEAD MLEQKPQLQV
60 70 80 90 100
DLDLDPDPDP DPELEIGQVP ALLESELYPA LKLEAELDTE ANSNEESDFE
110 120 130 140 150
EPMQLVCKIE SVHSNMGLPT PQTFRPWSLN SNCRSFTEEN HVSACHHSIS
160 170 180 190 200
AQTSKHLFWA NKLIQASEHS LQRAINMQLN NGSAGQPIRS PLREAIPTNA
210 220 230 240 250
LCSEEQLQIP DAHSAPPTTS SQAPSPLLSS DLPPPIDLTE LITFASSLAM
260 270 280 290 300
ASSSRMDLPS LEHMMKAPPQ EALEPSTEPL LTTVEEREPE NHAETLPEKP
310 320 330 340 350
REARAPLKSW SQEDKNFAQS YFDFSKPGIK RATIKGQIQL LQPPATSPLL
360 370 380
QGSKEDSVPP GKEKENPLLV KIHFKLSAPT IPEK
Length:384
Mass (Da):42,325
Last modified:May 18, 2010 - v3
Checksum:i129700AB96ABFFD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112V → A in BAB71683 (PubMed:14702039).Curated1
Sequence conflicti198 – 199TN → SK in AAP97314 (Ref. 2) Curated2
Sequence conflicti218 – 219TT → SK in AAP97314 (Ref. 2) Curated2
Sequence conflicti223A → E in AAP97314 (Ref. 2) Curated1
Sequence conflicti234P → A in AAP97314 (Ref. 2) Curated1
Sequence conflicti237D → E in AAP97314 (Ref. 2) Curated1
Sequence conflicti243T → H in AAP97314 (Ref. 2) Curated1
Sequence conflicti251A → D in AAP97314 (Ref. 2) Curated1
Sequence conflicti343P → S in BAB71683 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060279142V → M2 PublicationsCorresponds to variant dbSNP:rs11651968Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058143 mRNA. Translation: BAB71683.1.
AF433663 mRNA. Translation: AAP97314.1.
AC008105 Genomic DNA. No translation available.
BC028124 mRNA. Translation: AAH28124.1.
CCDSiCCDS32669.1.
RefSeqiNP_689556.2. NM_152343.2.
UniGeneiHs.412719.

Genome annotation databases

EnsembliENST00000331780; ENSP00000331532; ENSG00000184361.
GeneIDi124783.
KEGGihsa:124783.
UCSCiuc002iis.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPT32_HUMAN
AccessioniPrimary (citable) accession number: Q96LK8
Secondary accession number(s): Q7Z4U1, Q8N6V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations