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Protein

UBX domain-containing protein 10

Gene

UBXN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662).1 Publication

GO - Biological processi

  • cilium assembly Source: UniProtKB

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 10Curated
Alternative name(s):
UBX domain-containing protein 3
Gene namesi
Name:UBXN10Imported
Synonyms:UBXD3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162543.5.
HGNCiHGNC:26354. UBXN10.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi244M → A: Reduced interaction with VCP. 1 Publication1
Mutagenesisi245E → A: Reduced interaction with VCP. 1 Publication1
Mutagenesisi246V → A: Reduced interaction with VCP. 1 Publication1
Mutagenesisi247P → A: Reduced interaction with VCP. 1 Publication1
Mutagenesisi248R → A: Reduced interaction with VCP. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000162543.
PharmGKBiPA162408337.

Polymorphism and mutation databases

BioMutaiUBXN10.
DMDMi55976757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110291 – 280UBX domain-containing protein 10Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96LJ8.
PaxDbiQ96LJ8.
PeptideAtlasiQ96LJ8.
PRIDEiQ96LJ8.

PTM databases

iPTMnetiQ96LJ8.
PhosphoSitePlusiQ96LJ8.

Expressioni

Gene expression databases

BgeeiENSG00000162543.
CleanExiHS_UBXN10.
GenevisibleiQ96LJ8. HS.

Organism-specific databases

HPAiHPA028555.
HPA028564.

Interactioni

Subunit structurei

Interacts with CLUAP1; the interaction is direct and mediates interaction with the intraflagellar transport complex B (IFT-B) (PubMed:26389662). Interacts with VCP; the interaction is direct (PubMed:26389662).1 Publication

Protein-protein interaction databases

BioGridi126082. 39 interactors.
IntActiQ96LJ8. 5 interactors.
MINTiMINT-8417727.
STRINGi9606.ENSP00000364240.

Structurei

3D structure databases

ProteinModelPortaliQ96LJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 271UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the UBXN10 family.Curated

Phylogenomic databases

eggNOGiENOG410IGEF. Eukaryota.
ENOG410XTZS. LUCA.
GeneTreeiENSGT00390000012939.
HOGENOMiHOG000231750.
HOVERGENiHBG056934.
InParanoidiQ96LJ8.
OMAiIETMEVP.
OrthoDBiEOG091G0GZJ.
PhylomeDBiQ96LJ8.
TreeFamiTF335927.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-like_domsf.
IPR001012. UBX_dom.
PfamiView protein in Pfam
PF00789. UBX. 1 hit.
SMARTiView protein in SMART
SM00166. UBX. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50033. UBX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96LJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEAPVNIA PPECSTVVST AVDSLIWQPN SLNMHMIRPK SAKGRTRPSL
60 70 80 90 100
QKSQGVEVCA HHIPSPPPAI PYELPSSQKP GACAPKSPNQ GASDEIPELQ
110 120 130 140 150
QQVPTGASSS LNKYPVLPSI NRKNLEEEAV ETVAKKASSL QLSSIRALYQ
160 170 180 190 200
DETGTMKTSE EDSRARACAV ERKFIVRTKK QGSSRAGNLE EPSDQEPRLL
210 220 230 240 250
LAVRSPTGQR FVRHFRPTDD LQTIVAVAEQ KNKTSYRHCS IETMEVPRRR
260 270 280
FSDLTKSLQE CRIPHKSVLG ISLEDGEGWP
Length:280
Mass (Da):30,811
Last modified:December 1, 2001 - v1
Checksum:iA0B5D24C7F01F947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058158 mRNA. Translation: BAB71693.1.
Z98257 Genomic DNA. No translation available.
CH471134 Genomic DNA. Translation: EAW94920.1.
BC047428 mRNA. Translation: AAH47428.1.
CCDSiCCDS205.1.
RefSeqiNP_689589.1. NM_152376.4.
XP_005245799.1. XM_005245742.3.
XP_011539001.1. XM_011540699.2.
UniGeneiHs.432503.

Genome annotation databases

EnsembliENST00000375099; ENSP00000364240; ENSG00000162543.
GeneIDi127733.
KEGGihsa:127733.
UCSCiuc001bdb.4. human.

Similar proteinsi

Entry informationi

Entry nameiUBX10_HUMAN
AccessioniPrimary (citable) accession number: Q96LJ8
Secondary accession number(s): Q5R386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families