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Protein

Dehydrogenase/reductase SDR family member 1

Gene

DHRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151SubstrateBy similarity1
Active sitei163Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 19C member 1
Gene namesi
Name:DHRS1
Synonyms:SDR19C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000157379.13
HGNCiHGNC:16445 DHRS1
MIMi610410 gene
neXtProtiNX_Q96LJ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi115817
OpenTargetsiENSG00000157379
PharmGKBiPA134914102

Polymorphism and mutation databases

BioMutaiDHRS1
DMDMi37999854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000546402 – 313Dehydrogenase/reductase SDR family member 1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei21Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ96LJ7
MaxQBiQ96LJ7
PaxDbiQ96LJ7
PeptideAtlasiQ96LJ7
PRIDEiQ96LJ7

PTM databases

iPTMnetiQ96LJ7
PhosphoSitePlusiQ96LJ7
SwissPalmiQ96LJ7

Expressioni

Tissue specificityi

Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000157379
CleanExiHS_DHRS1
ExpressionAtlasiQ96LJ7 baseline and differential
GenevisibleiQ96LJ7 HS

Organism-specific databases

HPAiHPA000599

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125457, 8 interactors
IntActiQ96LJ7, 23 interactors
STRINGi9606.ENSP00000288111

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 7Combined sources4
Beta strandi9 – 14Combined sources6
Helixi18 – 29Combined sources12
Beta strandi33 – 39Combined sources7
Helixi41 – 54Combined sources14
Beta strandi55 – 62Combined sources8
Helixi68 – 82Combined sources15
Beta strandi88 – 91Combined sources4
Helixi97 – 102Combined sources6
Turni103 – 105Combined sources3
Turni108 – 110Combined sources3
Helixi115 – 120Combined sources6
Turni121 – 124Combined sources4
Helixi125 – 138Combined sources14
Helixi139 – 141Combined sources3
Beta strandi145 – 149Combined sources5
Helixi152 – 154Combined sources3
Helixi161 – 181Combined sources21
Helixi182 – 184Combined sources3
Beta strandi187 – 192Combined sources6
Turni198 – 200Combined sources3
Helixi225 – 240Combined sources16
Helixi245 – 248Combined sources4
Beta strandi252 – 254Combined sources3
Helixi255 – 261Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQ5X-ray1.80A3-262[»]
ProteinModelPortaliQ96LJ7
SMRiQ96LJ7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LJ7

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00900000140982
HOVERGENiHBG051351
InParanoidiQ96LJ7
KOiK11163
OMAiPADVTGY
OrthoDBiEOG091G0CL5
PhylomeDBiQ96LJ7
TreeFamiTF314146

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE
60 70 80 90 100
AQSLGGQCVP VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI
110 120 130 140 150
LNTRNKAFWE TPASMWDDIN NVGLRGHYFC SVYGARLMVP AGQGLIVVIS
160 170 180 190 200
SPGSLQYMFN VPYGVGKAAC DKLAADCAHE LRRHGVSCVS LWPGIVQTEL
210 220 230 240 250
LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA TDPNILSLSG
260 270 280 290 300
KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR
310
VPKWIIALYT SKF
Length:313
Mass (Da):33,909
Last modified:December 1, 2001 - v1
Checksum:i832F83FA75D931A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → A in AAH15943 (PubMed:15489334).Curated1
Sequence conflicti162P → L in AAH14057 (PubMed:15489334).Curated1
Sequence conflicti303K → R in CAD38773 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052318241T → I. Corresponds to variant dbSNP:rs10134537Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418205 mRNA Translation: AAN32660.1
BX247980 mRNA Translation: CAD62314.1
AK058159 mRNA Translation: BAB71694.1
AL833917 mRNA Translation: CAD38773.1
CH471078 Genomic DNA Translation: EAW66036.1
CH471078 Genomic DNA Translation: EAW66037.1
CH471078 Genomic DNA Translation: EAW66040.1
BC014057 mRNA Translation: AAH14057.1
BC015943 mRNA Translation: AAH15943.1
CCDSiCCDS9623.1
RefSeqiNP_001129522.1, NM_001136050.2
NP_612461.1, NM_138452.2
UniGeneiHs.348350

Genome annotation databases

EnsembliENST00000288111; ENSP00000288111; ENSG00000157379
ENST00000396813; ENSP00000380027; ENSG00000157379
GeneIDi115817
KEGGihsa:115817
UCSCiuc001woj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDHRS1_HUMAN
AccessioniPrimary (citable) accession number: Q96LJ7
Secondary accession number(s): D3DS71
, Q8NDG3, Q96B59, Q96CQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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