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Protein

Dehydrogenase/reductase SDR family member 1

Gene

DHRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151SubstrateBy similarity1
Active sitei163Proton acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 19C member 1
Gene namesi
Name:DHRS1
Synonyms:SDR19C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:16445. DHRS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi115817.
OpenTargetsiENSG00000157379.
PharmGKBiPA134914102.

Polymorphism and mutation databases

BioMutaiDHRS1.
DMDMi37999854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000546402 – 313Dehydrogenase/reductase SDR family member 1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei21Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ96LJ7.
MaxQBiQ96LJ7.
PaxDbiQ96LJ7.
PeptideAtlasiQ96LJ7.
PRIDEiQ96LJ7.

PTM databases

iPTMnetiQ96LJ7.
PhosphoSitePlusiQ96LJ7.
SwissPalmiQ96LJ7.

Expressioni

Tissue specificityi

Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000157379.
CleanExiHS_DHRS1.
ExpressionAtlasiQ96LJ7. baseline and differential.
GenevisibleiQ96LJ7. HS.

Organism-specific databases

HPAiHPA000599.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-8P604105EBI-746300,EBI-10171774
KRTAP3-2Q9BYR73EBI-746300,EBI-751260
KRTAP5-9P263713EBI-746300,EBI-3958099
MDFIQ997503EBI-746300,EBI-724076
NOTCH2NLQ7Z3S95EBI-746300,EBI-945833

Protein-protein interaction databases

BioGridi125457. 8 interactors.
IntActiQ96LJ7. 14 interactors.
MINTiMINT-1453434.
STRINGi9606.ENSP00000288111.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 7Combined sources4
Beta strandi9 – 14Combined sources6
Helixi18 – 29Combined sources12
Beta strandi33 – 39Combined sources7
Helixi41 – 54Combined sources14
Beta strandi55 – 62Combined sources8
Helixi68 – 82Combined sources15
Beta strandi88 – 91Combined sources4
Helixi97 – 102Combined sources6
Turni103 – 105Combined sources3
Turni108 – 110Combined sources3
Helixi115 – 120Combined sources6
Turni121 – 124Combined sources4
Helixi125 – 138Combined sources14
Helixi139 – 141Combined sources3
Beta strandi145 – 149Combined sources5
Helixi152 – 154Combined sources3
Helixi161 – 181Combined sources21
Helixi182 – 184Combined sources3
Beta strandi187 – 192Combined sources6
Turni198 – 200Combined sources3
Helixi225 – 240Combined sources16
Helixi245 – 248Combined sources4
Beta strandi252 – 254Combined sources3
Helixi255 – 261Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQ5X-ray1.80A3-262[»]
ProteinModelPortaliQ96LJ7.
SMRiQ96LJ7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LJ7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ96LJ7.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG091G0CL5.
PhylomeDBiQ96LJ7.
TreeFamiTF314146.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE
60 70 80 90 100
AQSLGGQCVP VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI
110 120 130 140 150
LNTRNKAFWE TPASMWDDIN NVGLRGHYFC SVYGARLMVP AGQGLIVVIS
160 170 180 190 200
SPGSLQYMFN VPYGVGKAAC DKLAADCAHE LRRHGVSCVS LWPGIVQTEL
210 220 230 240 250
LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA TDPNILSLSG
260 270 280 290 300
KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR
310
VPKWIIALYT SKF
Length:313
Mass (Da):33,909
Last modified:December 1, 2001 - v1
Checksum:i832F83FA75D931A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → A in AAH15943 (PubMed:15489334).Curated1
Sequence conflicti162P → L in AAH14057 (PubMed:15489334).Curated1
Sequence conflicti303K → R in CAD38773 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052318241T → I.Corresponds to variant rs10134537dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418205 mRNA. Translation: AAN32660.1.
BX247980 mRNA. Translation: CAD62314.1.
AK058159 mRNA. Translation: BAB71694.1.
AL833917 mRNA. Translation: CAD38773.1.
CH471078 Genomic DNA. Translation: EAW66036.1.
CH471078 Genomic DNA. Translation: EAW66037.1.
CH471078 Genomic DNA. Translation: EAW66040.1.
BC014057 mRNA. Translation: AAH14057.1.
BC015943 mRNA. Translation: AAH15943.1.
CCDSiCCDS9623.1.
RefSeqiNP_001129522.1. NM_001136050.2.
NP_612461.1. NM_138452.2.
UniGeneiHs.348350.

Genome annotation databases

EnsembliENST00000288111; ENSP00000288111; ENSG00000157379.
ENST00000396813; ENSP00000380027; ENSG00000157379.
GeneIDi115817.
KEGGihsa:115817.
UCSCiuc001woj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418205 mRNA. Translation: AAN32660.1.
BX247980 mRNA. Translation: CAD62314.1.
AK058159 mRNA. Translation: BAB71694.1.
AL833917 mRNA. Translation: CAD38773.1.
CH471078 Genomic DNA. Translation: EAW66036.1.
CH471078 Genomic DNA. Translation: EAW66037.1.
CH471078 Genomic DNA. Translation: EAW66040.1.
BC014057 mRNA. Translation: AAH14057.1.
BC015943 mRNA. Translation: AAH15943.1.
CCDSiCCDS9623.1.
RefSeqiNP_001129522.1. NM_001136050.2.
NP_612461.1. NM_138452.2.
UniGeneiHs.348350.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQ5X-ray1.80A3-262[»]
ProteinModelPortaliQ96LJ7.
SMRiQ96LJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125457. 8 interactors.
IntActiQ96LJ7. 14 interactors.
MINTiMINT-1453434.
STRINGi9606.ENSP00000288111.

PTM databases

iPTMnetiQ96LJ7.
PhosphoSitePlusiQ96LJ7.
SwissPalmiQ96LJ7.

Polymorphism and mutation databases

BioMutaiDHRS1.
DMDMi37999854.

Proteomic databases

EPDiQ96LJ7.
MaxQBiQ96LJ7.
PaxDbiQ96LJ7.
PeptideAtlasiQ96LJ7.
PRIDEiQ96LJ7.

Protocols and materials databases

DNASUi115817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288111; ENSP00000288111; ENSG00000157379.
ENST00000396813; ENSP00000380027; ENSG00000157379.
GeneIDi115817.
KEGGihsa:115817.
UCSCiuc001woj.3. human.

Organism-specific databases

CTDi115817.
DisGeNETi115817.
GeneCardsiDHRS1.
HGNCiHGNC:16445. DHRS1.
HPAiHPA000599.
MIMi610410. gene.
neXtProtiNX_Q96LJ7.
OpenTargetsiENSG00000157379.
PharmGKBiPA134914102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ96LJ7.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG091G0CL5.
PhylomeDBiQ96LJ7.
TreeFamiTF314146.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157379-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ96LJ7.
GeneWikiiDHRS1.
GenomeRNAii115817.
PROiQ96LJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157379.
CleanExiHS_DHRS1.
ExpressionAtlasiQ96LJ7. baseline and differential.
GenevisibleiQ96LJ7. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS1_HUMAN
AccessioniPrimary (citable) accession number: Q96LJ7
Secondary accession number(s): D3DS71
, Q8NDG3, Q96B59, Q96CQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.