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Protein

Dehydrogenase/reductase SDR family member 1

Gene

DHRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei151 – 1511SubstrateBy similarity
Active sitei163 – 1631Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 1 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 19C member 1
Gene namesi
Name:DHRS1
Synonyms:SDR19C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:16445. DHRS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914102.

Polymorphism and mutation databases

BioMutaiDHRS1.
DMDMi37999854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 313312Dehydrogenase/reductase SDR family member 1PRO_0000054640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96LJ7.
MaxQBiQ96LJ7.
PaxDbiQ96LJ7.
PeptideAtlasiQ96LJ7.
PRIDEiQ96LJ7.

PTM databases

iPTMnetiQ96LJ7.
PhosphoSiteiQ96LJ7.
SwissPalmiQ96LJ7.

Expressioni

Tissue specificityi

Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ96LJ7.
CleanExiHS_DHRS1.
ExpressionAtlasiQ96LJ7. baseline and differential.
GenevisibleiQ96LJ7. HS.

Organism-specific databases

HPAiHPA000599.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-8P604103EBI-746300,EBI-10171774
KRTAP3-2Q9BYR73EBI-746300,EBI-751260
KRTAP5-9P263713EBI-746300,EBI-3958099
NOTCH2NLQ7Z3S93EBI-746300,EBI-945833

Protein-protein interaction databases

BioGridi125457. 8 interactions.
IntActiQ96LJ7. 6 interactions.
MINTiMINT-1453434.
STRINGi9606.ENSP00000288111.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 74Combined sources
Beta strandi9 – 146Combined sources
Helixi18 – 2912Combined sources
Beta strandi33 – 397Combined sources
Helixi41 – 5414Combined sources
Beta strandi55 – 628Combined sources
Helixi68 – 8215Combined sources
Beta strandi88 – 914Combined sources
Helixi97 – 1026Combined sources
Turni103 – 1053Combined sources
Turni108 – 1103Combined sources
Helixi115 – 1206Combined sources
Turni121 – 1244Combined sources
Helixi125 – 13814Combined sources
Helixi139 – 1413Combined sources
Beta strandi145 – 1495Combined sources
Helixi152 – 1543Combined sources
Helixi161 – 18121Combined sources
Helixi182 – 1843Combined sources
Beta strandi187 – 1926Combined sources
Turni198 – 2003Combined sources
Helixi225 – 24016Combined sources
Helixi245 – 2484Combined sources
Beta strandi252 – 2543Combined sources
Helixi255 – 2617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QQ5X-ray1.80A3-262[»]
ProteinModelPortaliQ96LJ7.
SMRiQ96LJ7. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LJ7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ96LJ7.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG72ZCFC.
PhylomeDBiQ96LJ7.
TreeFamiTF314146.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMNGQVC VVTGASRGIG RGIALQLCKA GATVYITGRH LDTLRVVAQE
60 70 80 90 100
AQSLGGQCVP VVCDSSQESE VRSLFEQVDR EQQGRLDVLV NNAYAGVQTI
110 120 130 140 150
LNTRNKAFWE TPASMWDDIN NVGLRGHYFC SVYGARLMVP AGQGLIVVIS
160 170 180 190 200
SPGSLQYMFN VPYGVGKAAC DKLAADCAHE LRRHGVSCVS LWPGIVQTEL
210 220 230 240 250
LKEHMAKEEV LQDPVLKQFK SAFSSAETTE LSGKCVVALA TDPNILSLSG
260 270 280 290 300
KVLPSCDLAR RYGLRDVDGR PVQDYLSLSS VLSHVSGLGW LASYLPSFLR
310
VPKWIIALYT SKF
Length:313
Mass (Da):33,909
Last modified:December 1, 2001 - v1
Checksum:i832F83FA75D931A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → A in AAH15943 (PubMed:15489334).Curated
Sequence conflicti162 – 1621P → L in AAH14057 (PubMed:15489334).Curated
Sequence conflicti303 – 3031K → R in CAD38773 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411T → I.
Corresponds to variant rs10134537 [ dbSNP | Ensembl ].
VAR_052318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418205 mRNA. Translation: AAN32660.1.
BX247980 mRNA. Translation: CAD62314.1.
AK058159 mRNA. Translation: BAB71694.1.
AL833917 mRNA. Translation: CAD38773.1.
CH471078 Genomic DNA. Translation: EAW66036.1.
CH471078 Genomic DNA. Translation: EAW66037.1.
CH471078 Genomic DNA. Translation: EAW66040.1.
BC014057 mRNA. Translation: AAH14057.1.
BC015943 mRNA. Translation: AAH15943.1.
CCDSiCCDS9623.1.
RefSeqiNP_001129522.1. NM_001136050.2.
NP_612461.1. NM_138452.2.
UniGeneiHs.348350.

Genome annotation databases

EnsembliENST00000288111; ENSP00000288111; ENSG00000157379.
ENST00000396813; ENSP00000380027; ENSG00000157379.
GeneIDi115817.
KEGGihsa:115817.
UCSCiuc001woj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418205 mRNA. Translation: AAN32660.1.
BX247980 mRNA. Translation: CAD62314.1.
AK058159 mRNA. Translation: BAB71694.1.
AL833917 mRNA. Translation: CAD38773.1.
CH471078 Genomic DNA. Translation: EAW66036.1.
CH471078 Genomic DNA. Translation: EAW66037.1.
CH471078 Genomic DNA. Translation: EAW66040.1.
BC014057 mRNA. Translation: AAH14057.1.
BC015943 mRNA. Translation: AAH15943.1.
CCDSiCCDS9623.1.
RefSeqiNP_001129522.1. NM_001136050.2.
NP_612461.1. NM_138452.2.
UniGeneiHs.348350.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QQ5X-ray1.80A3-262[»]
ProteinModelPortaliQ96LJ7.
SMRiQ96LJ7. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125457. 8 interactions.
IntActiQ96LJ7. 6 interactions.
MINTiMINT-1453434.
STRINGi9606.ENSP00000288111.

PTM databases

iPTMnetiQ96LJ7.
PhosphoSiteiQ96LJ7.
SwissPalmiQ96LJ7.

Polymorphism and mutation databases

BioMutaiDHRS1.
DMDMi37999854.

Proteomic databases

EPDiQ96LJ7.
MaxQBiQ96LJ7.
PaxDbiQ96LJ7.
PeptideAtlasiQ96LJ7.
PRIDEiQ96LJ7.

Protocols and materials databases

DNASUi115817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288111; ENSP00000288111; ENSG00000157379.
ENST00000396813; ENSP00000380027; ENSG00000157379.
GeneIDi115817.
KEGGihsa:115817.
UCSCiuc001woj.3. human.

Organism-specific databases

CTDi115817.
GeneCardsiDHRS1.
HGNCiHGNC:16445. DHRS1.
HPAiHPA000599.
MIMi610410. gene.
neXtProtiNX_Q96LJ7.
PharmGKBiPA134914102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00720000108845.
HOVERGENiHBG051351.
InParanoidiQ96LJ7.
KOiK11163.
OMAiRYNWETP.
OrthoDBiEOG72ZCFC.
PhylomeDBiQ96LJ7.
TreeFamiTF314146.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1155-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ96LJ7.
GeneWikiiDHRS1.
GenomeRNAii115817.
NextBioi79690.
PROiQ96LJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LJ7.
CleanExiHS_DHRS1.
ExpressionAtlasiQ96LJ7. baseline and differential.
GenevisibleiQ96LJ7. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel dehydrogenase/reductase (SDR family) member 1 gene from human fetal brain."
    Wu Q., Xu M., Cheng C., Zhou Z., Huang Y., Zhao W., Zeng L., Xu J., Fu X., Ying K., Xie Y., Mao Y.
    Mol. Biol. Rep. 28:193-198(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Skin.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Crystal structure of human SDR family member 1."
    Structural genomics consortium (SGC)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 3-262.

Entry informationi

Entry nameiDHRS1_HUMAN
AccessioniPrimary (citable) accession number: Q96LJ7
Secondary accession number(s): D3DS71
, Q8NDG3, Q96B59, Q96CQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 13, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.