Q96LI6 (HSFY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock transcription factor, Y-linked

Alternative name(s):
Heat shock transcription factor 2-like protein
Short name=HSF2-like

Gene names

Name:	HSFY1
Synonyms:	HSF2L, HSFY
AND
Name:	HSFY2
Synonyms:	HSF2L, HSFY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus. Cytoplasm Ref.5.
Tissue specificity	Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level). Ref.2 Ref.5
Sequence similarities	Belongs to the HSF family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96LI6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96LI6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     172-203: LKFYYNPNFKRGYPQLLVRVKRRIGVKNASPI → IRFTKMKLSRSSTYENRYLCCNLHLKDESNYS
     204-401: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96LI6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     173-214: KFYYNPNFKR...TLFNEDFNKK → HVFVFHHSLF...STWSGDSWLL
     215-401: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Heat shock transcription factor, Y-linked		PRO_0000124573
Regions
	DNA binding	76 – 194	119	By similarity
Natural variations
	Alternative sequence	172 – 203	32	LKFYY…NASPI → IRFTKMKLSRSSTYENRYLC CNLHLKDESNYS in isoform 2.		VSP_009179
	Alternative sequence	173 – 214	42	KFYYN…DFNKK → HVFVFHHSLFGATFGEHHFQ PCPLPSGNKAPISTWSGDSW LL in isoform 3.		VSP_009180
	Alternative sequence	204 – 401	198	Missing in isoform 2.		VSP_009181
	Alternative sequence	215 – 401	187	Missing in isoform 3.		VSP_009182
Experimental info
	Sequence conflict	94 – 99	6	KSISWD → SLFSWE in AAK13479. Ref.2
	Sequence conflict	164	1	K → I in AAK13479. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1990C4D91E0BB277	FASTA	401	45,107
	10 20 30 40 50 60 MAHVSSETQD VSPKDELTAS EASTRSPLCE HTFPGDSDLR SMIEEHAFQV LSQGSLLESP 70 80 90 100 110 120 SYTVCVSEPD KDDDFLSLNF PRKLWKIVES DQFKSISWDE NGTCIVINEE LFKKEILETK 130 140 150 160 170 180 APYRIFQTDA IKSFVRQLNL YGFSKIQQNF QRSAFLATFL SEEKESSVLS KLKFYYNPNF 190 200 210 220 230 240 KRGYPQLLVR VKRRIGVKNA SPISTLFNED FNKKHFRAGA NMENHNSALA AEASEESLFS 250 260 270 280 290 300 ASKNLNMPLT RESSVRQIIA NSSVPIRSGF PPPSPSTSVG PSEQIATDQH AILNQLTTIH 310 320 330 340 350 360 MHSHSTYMQA RGHIVNFITT TTSQYHIISP LQNGYFGLTV EPSAVPTRYP LVSVNEAPYR 370 380 390 400 NMLPAGNPWL QMPTIADRSA APHSRLALQP SPLDKYHPNY N
	Isoform 2 [UniParc]. Checksum: 2E011799F83827D4	FASTA	203	23,370
	10 20 30 40 50 60 MAHVSSETQD VSPKDELTAS EASTRSPLCE HTFPGDSDLR SMIEEHAFQV LSQGSLLESP 70 80 90 100 110 120 SYTVCVSEPD KDDDFLSLNF PRKLWKIVES DQFKSISWDE NGTCIVINEE LFKKEILETK 130 140 150 160 170 180 APYRIFQTDA IKSFVRQLNL YGFSKIQQNF QRSAFLATFL SEEKESSVLS KIRFTKMKLS 190 200 RSSTYENRYL CCNLHLKDES NYS
	Isoform 3 [UniParc]. Checksum: 9DAE266BD44A25CF	FASTA	214	24,272
	10 20 30 40 50 60 MAHVSSETQD VSPKDELTAS EASTRSPLCE HTFPGDSDLR SMIEEHAFQV LSQGSLLESP 70 80 90 100 110 120 SYTVCVSEPD KDDDFLSLNF PRKLWKIVES DQFKSISWDE NGTCIVINEE LFKKEILETK 130 140 150 160 170 180 APYRIFQTDA IKSFVRQLNL YGFSKIQQNF QRSAFLATFL SEEKESSVLS KLHVFVFHHS 190 200 210 LFGATFGEHH FQPCPLPSGN KAPISTWSGD SWLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis." Salata E., Tessari A., Ferlin A., Bartoloni L., Slongo M., Foresta C. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Testis.
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Testis.
[5]	"Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility." Shinka T., Sato Y., Chen G., Naroda T., Kinoshita K., Unemi Y., Tsuji K., Toida K., Iwamoto T., Nakahori Y. Biol. Reprod. 71:297-306(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ566404 mRNA. Translation: CAD98806.1. AF332226 mRNA. Translation: AAK13478.1. AF332227 mRNA. Translation: AAK13479.1. AK058182 mRNA. Translation: BAB71706.1. BC036567 mRNA. Translation: AAH36567.1. BC055414 mRNA. Translation: AAH55414.1. BC117380 mRNA. Translation: AAI17381.1. BC117382 mRNA. Translation: AAI17383.1.
IPI	IPI00027534. IPI00307273. IPI00385119.
RefSeq	NP_001001877.1. NM_001001877.1. NP_149099.2. NM_033108.2. NP_689797.1. NM_152584.1. NP_714927.1. NM_153716.1.
UniGene	Hs.592255. Hs.662281.
3D structure databases
ProteinModelPortal	Q96LI6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96LI6. 1 interaction.
STRING	9606.ENSP00000303599.
PTM databases
PhosphoSite	Q96LI6.
Proteomic databases
PaxDb	Q96LI6.
PRIDE	Q96LI6.
Protocols and materials databases
DNASU	159119. 86614.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304790; ENSP00000306549; ENSG00000169953. ENST00000307393; ENSP00000303599; ENSG00000172468. ENST00000309834; ENSP00000311166; ENSG00000172468. ENST00000338876; ENSP00000342302; ENSG00000172468. ENST00000344884; ENSP00000340971; ENSG00000169953. ENST00000382852; ENSP00000372303; ENSG00000169953. ENST00000382856; ENSP00000372307; ENSG00000172468.
GeneID	159119. 86614.
KEGG	hsa:159119. hsa:86614.
UCSC	uc004ftp.3. human. uc004ftr.3. human.
Organism-specific databases
CTD	159119. 86614.
GeneCards	GC0YM020893. GC0YP020708.
HGNC	HGNC:18568. HSFY1. HGNC:23950. HSFY2.
MIM	400029. gene.
neXtProt	NX_Q96LI6.
PharmGKB	PA38580.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321106.
HOGENOM	HOG000112960.
HOVERGEN	HBG003735.
InParanoid	Q96LI6.
OMA	HIISPLQ.
OrthoDB	EOG4M0F33.
PhylomeDB	Q96LI6.
Gene expression databases
Bgee	Q96LI6.
CleanEx	HS_HSFY1. HS_HSFY2.
Genevestigator	Q96LI6.
GermOnline	ENSG00000169953. Homo sapiens. ENSG00000172468. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000232. HSF_DNA-bd. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00447. HSF_DNA-bind. 1 hit. [Graphical view]
SMART	SM00415. HSF. 1 hit. [Graphical view]
PROSITE	PS00434. HSF_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	76198.
SOURCE	Search...

Entry information

Entry name

HSFY1_HUMAN

Accession

Primary (citable) accession number: Q96LI6
Secondary accession number(s): Q17RC0 , Q7Z4L8, Q9BZA2, Q9BZA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.