Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96LI5

- CNO6L_HUMAN

UniProt

Q96LI5 - CNO6L_HUMAN

Protein

CCR4-NOT transcription complex subunit 6-like

Gene

CNOT6L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.2 Publications

    Catalytic activityi

    Exonucleolytic cleavage of poly(A) to 5'-AMP.1 Publication

    Cofactori

    Magnesium.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei240 – 24011 Publication
    Metal bindingi240 – 2401Magnesium 1
    Metal bindingi410 – 4101Magnesium 2
    Metal bindingi412 – 4121Magnesium 2
    Active sitei489 – 48911 Publication
    Active sitei529 – 52911 Publication
    Metal bindingi529 – 5291Magnesium 2

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A)-specific ribonuclease activity Source: Reactome
    3. protein binding Source: IntAct

    GO - Biological processi

    1. gene expression Source: Reactome
    2. gene silencing by RNA Source: UniProtKB-KW
    3. mRNA destabilization Source: Ensembl
    4. mRNA metabolic process Source: Reactome
    5. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
    6. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
    7. positive regulation of cell proliferation Source: UniProtKB
    8. positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
    9. regulation of transcription, DNA-templated Source: UniProtKB-KW
    10. regulation of translation Source: UniProtKB-KW
    11. RNA metabolic process Source: Reactome
    12. RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_20514. Deadenylation of mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCR4-NOT transcription complex subunit 6-like (EC:3.1.13.4)
    Alternative name(s):
    Carbon catabolite repressor protein 4 homolog B
    Gene namesi
    Name:CNOT6L
    Synonyms:CCR4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:18042. CNOT6L.

    Subcellular locationi

    GO - Cellular componenti

    1. CCR4-NOT complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Reactome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi240 – 2401E → A: No enzymatic activity. 1 Publication
    Mutagenesisi410 – 4101D → A: Loss of deadenylase activity. 1 Publication
    Mutagenesisi489 – 4891D → A: Loss of deadenylase activity. 2 Publications
    Mutagenesisi489 – 4891D → A: No enzymatic activity. 2 Publications
    Mutagenesisi529 – 5291H → A: Loss of deadenylase activity. 2 Publications
    Mutagenesisi529 – 5291H → A: No enzymatic activity. 2 Publications

    Organism-specific databases

    PharmGKBiPA38480.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555CCR4-NOT transcription complex subunit 6-likePRO_0000314587Add
    BLAST

    Proteomic databases

    MaxQBiQ96LI5.
    PaxDbiQ96LI5.
    PRIDEiQ96LI5.

    PTM databases

    PhosphoSiteiQ96LI5.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.1 Publication

    Gene expression databases

    ArrayExpressiQ96LI5.
    BgeeiQ96LI5.
    CleanExiHS_CNOT6L.
    GenevestigatoriQ96LI5.

    Organism-specific databases

    HPAiHPA042688.

    Interactioni

    Subunit structurei

    Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with NANOS2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CNOT1A5YKK62EBI-1046635,EBI-1222758
    CNOT3O751752EBI-1046635,EBI-743073
    TOB1P506163EBI-1046635,EBI-723281

    Protein-protein interaction databases

    BioGridi128873. 12 interactions.
    DIPiDIP-46837N.
    IntActiQ96LI5. 19 interactions.
    STRINGi9606.ENSP00000264903.

    Structurei

    Secondary structure

    1
    555
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi174 – 1763
    Beta strandi187 – 1959
    Helixi199 – 2013
    Turni204 – 2063
    Helixi212 – 2154
    Helixi217 – 23115
    Beta strandi234 – 2429
    Helixi243 – 2486
    Helixi250 – 2567
    Beta strandi259 – 2668
    Beta strandi268 – 2703
    Helixi274 – 2785
    Beta strandi281 – 2888
    Turni289 – 2913
    Beta strandi292 – 30110
    Helixi302 – 3087
    Helixi314 – 3185
    Turni319 – 3224
    Beta strandi326 – 3349
    Helixi336 – 3383
    Beta strandi353 – 3608
    Helixi365 – 3673
    Helixi368 – 38619
    Beta strandi405 – 4106
    Helixi418 – 4258
    Beta strandi427 – 4293
    Helixi433 – 4353
    Helixi443 – 4475
    Beta strandi459 – 4613
    Beta strandi466 – 4683
    Turni469 – 4735
    Beta strandi474 – 4763
    Beta strandi478 – 4803
    Beta strandi489 – 4946
    Turni495 – 4973
    Beta strandi498 – 5047
    Helixi509 – 5146
    Beta strandi519 – 5224
    Beta strandi527 – 5293
    Beta strandi532 – 5387

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NGNX-ray2.40A158-555[»]
    3NGOX-ray2.20A158-555[»]
    3NGQX-ray1.80A158-555[»]
    ProteinModelPortaliQ96LI5.
    SMRiQ96LI5. Positions 36-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96LI5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 7822LRR 1Add
    BLAST
    Repeati80 – 10122LRR 2Add
    BLAST
    Repeati103 – 12523LRR 3Add
    BLAST
    Repeati126 – 14823LRR 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 152152Required for interaction with CNOT1, CNOT3 and CNOT7Add
    BLAST
    Regioni158 – 555398Nuclease domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCR4/nocturin family.Curated
    Contains 4 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000294222.
    HOVERGENiHBG052641.
    InParanoidiQ96LI5.
    KOiK12603.
    OrthoDBiEOG7JX35D.
    PhylomeDBiQ96LI5.
    TreeFamiTF323175.

    Family and domain databases

    Gene3Di3.60.10.10. 1 hit.
    InterProiIPR005135. Endo/exonuclease/phosphatase.
    IPR001611. Leu-rich_rpt.
    [Graphical view]
    PfamiPF03372. Exo_endo_phos. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 1 hit.
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96LI5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLIGMPKEK YDPPDPRRIY TIMSAEEVAN GKKSHWAELE ISGRVRSLST    50
    SLWSLTHLTA LHLNDNYLSR IPPDIAKLHN LVYLDLSSNK LRSLPAELGN 100
    MVSLRELLLN NNLLRVLPYE LGRLFQLQTL GLKGNPLSQD ILNLYQDPDG 150
    TRKLLNFMLD NLAVHPEQLP PRPWITLKER DQILPSASFT VMCYNVLCDK 200
    YATRQLYGYC PSWALNWEYR KKGIMEEIVN CDADIISLQE VETEQYFTLF 250
    LPALKERGYD GFFSPKSRAK IMSEQERKHV DGCAIFFKTE KFTLVQKHTV 300
    EFNQVAMANS DGSEAMLNRV MTKDNIGVAV VLEVHKELFG AGMKPIHAAD 350
    KQLLIVANAH MHWDPEYSDV KLIQTMMFVS EVKNILEKAS SRPGSPTADP 400
    NSIPLVLCAD LNSLPDSGVV EYLSNGGVAD NHKDFKELRY NECLMNFSCN 450
    GKNGSSEGRI THGFQLKSAY ENNLMPYTNY TFDFKGVIDY IFYSKTHMNV 500
    LGVLGPLDPQ WLVENNITGC PHPHIPSDHF SLLTQLELHP PLLPLVNGVH 550
    LPNRR 555
    Length:555
    Mass (Da):63,001
    Last modified:January 15, 2008 - v2
    Checksum:iC6E94F1BAE222241
    GO
    Isoform 2 (identifier: Q96LI5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         127-153: Missing.
         486-502: GVIDYIFYSKTHMNVLG → VSGSLWAGVEIISDTSM
         503-555: Missing.

    Show »
    Length:475
    Mass (Da):53,891
    Checksum:i6E2E2BB67749C501
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti439 – 4391R → G in BAB71707. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei127 – 15327Missing in isoform 2. 1 PublicationVSP_030321Add
    BLAST
    Alternative sequencei486 – 50217GVIDY…MNVLG → VSGSLWAGVEIISDTSM in isoform 2. 1 PublicationVSP_030322Add
    BLAST
    Alternative sequencei503 – 55553Missing in isoform 2. 1 PublicationVSP_030323Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058188 mRNA. Translation: BAB71707.1.
    AC104701 Genomic DNA. No translation available.
    AL133112 mRNA. Translation: CAB61415.1.
    CCDSiCCDS47082.1. [Q96LI5-1]
    CCDS68731.1. [Q96LI5-1]
    PIRiT42705.
    RefSeqiNP_001273719.1. NM_001286790.1. [Q96LI5-1]
    NP_653172.2. NM_144571.2. [Q96LI5-1]
    UniGeneiHs.592519.

    Genome annotation databases

    EnsembliENST00000504123; ENSP00000424896; ENSG00000138767. [Q96LI5-1]
    GeneIDi246175.
    KEGGihsa:246175.
    UCSCiuc003hks.3. human. [Q96LI5-1]
    uc003hkt.1. human. [Q96LI5-2]

    Polymorphism databases

    DMDMi166216089.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058188 mRNA. Translation: BAB71707.1 .
    AC104701 Genomic DNA. No translation available.
    AL133112 mRNA. Translation: CAB61415.1 .
    CCDSi CCDS47082.1. [Q96LI5-1 ]
    CCDS68731.1. [Q96LI5-1 ]
    PIRi T42705.
    RefSeqi NP_001273719.1. NM_001286790.1. [Q96LI5-1 ]
    NP_653172.2. NM_144571.2. [Q96LI5-1 ]
    UniGenei Hs.592519.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NGN X-ray 2.40 A 158-555 [» ]
    3NGO X-ray 2.20 A 158-555 [» ]
    3NGQ X-ray 1.80 A 158-555 [» ]
    ProteinModelPortali Q96LI5.
    SMRi Q96LI5. Positions 36-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128873. 12 interactions.
    DIPi DIP-46837N.
    IntActi Q96LI5. 19 interactions.
    STRINGi 9606.ENSP00000264903.

    PTM databases

    PhosphoSitei Q96LI5.

    Polymorphism databases

    DMDMi 166216089.

    Proteomic databases

    MaxQBi Q96LI5.
    PaxDbi Q96LI5.
    PRIDEi Q96LI5.

    Protocols and materials databases

    DNASUi 246175.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000504123 ; ENSP00000424896 ; ENSG00000138767 . [Q96LI5-1 ]
    GeneIDi 246175.
    KEGGi hsa:246175.
    UCSCi uc003hks.3. human. [Q96LI5-1 ]
    uc003hkt.1. human. [Q96LI5-2 ]

    Organism-specific databases

    CTDi 246175.
    GeneCardsi GC04M078634.
    HGNCi HGNC:18042. CNOT6L.
    HPAi HPA042688.
    neXtProti NX_Q96LI5.
    PharmGKBi PA38480.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000294222.
    HOVERGENi HBG052641.
    InParanoidi Q96LI5.
    KOi K12603.
    OrthoDBi EOG7JX35D.
    PhylomeDBi Q96LI5.
    TreeFami TF323175.

    Enzyme and pathway databases

    Reactomei REACT_20514. Deadenylation of mRNA.

    Miscellaneous databases

    EvolutionaryTracei Q96LI5.
    GenomeRNAii 246175.
    NextBioi 91870.
    PROi Q96LI5.

    Gene expression databases

    ArrayExpressi Q96LI5.
    Bgeei Q96LI5.
    CleanExi HS_CNOT6L.
    Genevestigatori Q96LI5.

    Family and domain databases

    Gene3Di 3.60.10.10. 1 hit.
    InterProi IPR005135. Endo/exonuclease/phosphatase.
    IPR001611. Leu-rich_rpt.
    [Graphical view ]
    Pfami PF03372. Exo_endo_phos. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 1 hit.
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-555 (ISOFORM 1).
      Tissue: Testis.
    4. "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth."
      Morita M., Suzuki T., Nakamura T., Yokoyama K., Miyasaka T., Yamamoto T.
      Mol. Cell. Biol. 27:4980-4990(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CNOT1; CNOT3; CNOT7; CNOT8 AND CNOT9, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-410; ASP-489 AND HIS-529.
    5. "Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex."
      Miyasaka T., Morita M., Ito K., Suzuki T., Fukuda H., Takeda S., Inoue J., Semba K., Yamamoto T.
      Cancer Sci. 99:755-761(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, INTERACTION WITH TOB1.
    6. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence."
      Mittal S., Aslam A., Doidge R., Medica R., Winkler G.S.
      Mol. Biol. Cell 22:748-758(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity."
      Wang H., Morita M., Yang X., Suzuki T., Yang W., Wang J., Ito K., Wang Q., Zhao C., Bartlam M., Yamamoto T., Rao Z.
      EMBO J. 29:2566-2576(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 158-555 ALONE AND IN COMPLEX WITH AMP ANALOG AND POLY-A DNA, MUTAGENESIS OF GLU-240; ASP-489 AND HIS-529, COFACTOR, ACTIVE SITE, MAGNESIUM-BINDING SITES.

    Entry informationi

    Entry nameiCNO6L_HUMAN
    AccessioniPrimary (citable) accession number: Q96LI5
    Secondary accession number(s): Q9UF92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Depletion of CNOT6L causes cell growth defect.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3