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Q96LI5

- CNO6L_HUMAN

UniProt

Q96LI5 - CNO6L_HUMAN

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Protein

CCR4-NOT transcription complex subunit 6-like

Gene

CNOT6L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.2 Publications

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei240 – 24011 Publication
Metal bindingi240 – 2401Magnesium 1
Metal bindingi410 – 4101Magnesium 2
Metal bindingi412 – 4121Magnesium 2
Active sitei489 – 48911 Publication
Active sitei529 – 52911 Publication
Metal bindingi529 – 5291Magnesium 2

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. poly(A)-specific ribonuclease activity Source: Reactome

GO - Biological processi

  1. gene expression Source: Reactome
  2. gene silencing by RNA Source: UniProtKB-KW
  3. mRNA destabilization Source: Ensembl
  4. mRNA metabolic process Source: Reactome
  5. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
  6. nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
  7. positive regulation of cell proliferation Source: UniProtKB
  8. positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
  9. regulation of transcription, DNA-templated Source: UniProtKB-KW
  10. regulation of translation Source: UniProtKB-KW
  11. RNA metabolic process Source: Reactome
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_20514. Deadenylation of mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 6-like (EC:3.1.13.4)
Alternative name(s):
Carbon catabolite repressor protein 4 homolog B
Gene namesi
Name:CNOT6L
Synonyms:CCR4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18042. CNOT6L.

Subcellular locationi

GO - Cellular componenti

  1. CCR4-NOT complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Reactome
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi240 – 2401E → A: No enzymatic activity. 1 Publication
Mutagenesisi410 – 4101D → A: Loss of deadenylase activity. 1 Publication
Mutagenesisi489 – 4891D → A: Loss of deadenylase activity. 2 Publications
Mutagenesisi489 – 4891D → A: No enzymatic activity. 2 Publications
Mutagenesisi529 – 5291H → A: Loss of deadenylase activity. 2 Publications
Mutagenesisi529 – 5291H → A: No enzymatic activity. 2 Publications

Organism-specific databases

PharmGKBiPA38480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555CCR4-NOT transcription complex subunit 6-likePRO_0000314587Add
BLAST

Proteomic databases

MaxQBiQ96LI5.
PaxDbiQ96LI5.
PRIDEiQ96LI5.

PTM databases

PhosphoSiteiQ96LI5.

Expressioni

Tissue specificityi

Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.1 Publication

Gene expression databases

BgeeiQ96LI5.
CleanExiHS_CNOT6L.
ExpressionAtlasiQ96LI5. baseline and differential.
GenevestigatoriQ96LI5.

Organism-specific databases

HPAiHPA042688.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with NANOS2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT1A5YKK62EBI-1046635,EBI-1222758
CNOT3O751752EBI-1046635,EBI-743073
TOB1P506163EBI-1046635,EBI-723281

Protein-protein interaction databases

BioGridi128873. 15 interactions.
DIPiDIP-46837N.
IntActiQ96LI5. 19 interactions.
STRINGi9606.ENSP00000264903.

Structurei

Secondary structure

1
555
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi174 – 1763Combined sources
Beta strandi187 – 1959Combined sources
Helixi199 – 2013Combined sources
Turni204 – 2063Combined sources
Helixi212 – 2154Combined sources
Helixi217 – 23115Combined sources
Beta strandi234 – 2429Combined sources
Helixi243 – 2486Combined sources
Helixi250 – 2567Combined sources
Beta strandi259 – 2668Combined sources
Beta strandi268 – 2703Combined sources
Helixi274 – 2785Combined sources
Beta strandi281 – 2888Combined sources
Turni289 – 2913Combined sources
Beta strandi292 – 30110Combined sources
Helixi302 – 3087Combined sources
Helixi314 – 3185Combined sources
Turni319 – 3224Combined sources
Beta strandi326 – 3349Combined sources
Helixi336 – 3383Combined sources
Beta strandi353 – 3608Combined sources
Helixi365 – 3673Combined sources
Helixi368 – 38619Combined sources
Beta strandi405 – 4106Combined sources
Helixi418 – 4258Combined sources
Beta strandi427 – 4293Combined sources
Helixi433 – 4353Combined sources
Helixi443 – 4475Combined sources
Beta strandi459 – 4613Combined sources
Beta strandi466 – 4683Combined sources
Turni469 – 4735Combined sources
Beta strandi474 – 4763Combined sources
Beta strandi478 – 4803Combined sources
Beta strandi489 – 4946Combined sources
Turni495 – 4973Combined sources
Beta strandi498 – 5047Combined sources
Helixi509 – 5146Combined sources
Beta strandi519 – 5224Combined sources
Beta strandi527 – 5293Combined sources
Beta strandi532 – 5387Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGNX-ray2.40A158-555[»]
3NGOX-ray2.20A158-555[»]
3NGQX-ray1.80A158-555[»]
ProteinModelPortaliQ96LI5.
SMRiQ96LI5. Positions 36-540.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LI5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 7822LRR 1Add
BLAST
Repeati80 – 10122LRR 2Add
BLAST
Repeati103 – 12523LRR 3Add
BLAST
Repeati126 – 14823LRR 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 152152Required for interaction with CNOT1, CNOT3 and CNOT7Add
BLAST
Regioni158 – 555398Nuclease domainAdd
BLAST

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000294222.
HOVERGENiHBG052641.
InParanoidiQ96LI5.
KOiK12603.
OrthoDBiEOG7JX35D.
PhylomeDBiQ96LI5.
TreeFamiTF323175.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96LI5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLIGMPKEK YDPPDPRRIY TIMSAEEVAN GKKSHWAELE ISGRVRSLST
60 70 80 90 100
SLWSLTHLTA LHLNDNYLSR IPPDIAKLHN LVYLDLSSNK LRSLPAELGN
110 120 130 140 150
MVSLRELLLN NNLLRVLPYE LGRLFQLQTL GLKGNPLSQD ILNLYQDPDG
160 170 180 190 200
TRKLLNFMLD NLAVHPEQLP PRPWITLKER DQILPSASFT VMCYNVLCDK
210 220 230 240 250
YATRQLYGYC PSWALNWEYR KKGIMEEIVN CDADIISLQE VETEQYFTLF
260 270 280 290 300
LPALKERGYD GFFSPKSRAK IMSEQERKHV DGCAIFFKTE KFTLVQKHTV
310 320 330 340 350
EFNQVAMANS DGSEAMLNRV MTKDNIGVAV VLEVHKELFG AGMKPIHAAD
360 370 380 390 400
KQLLIVANAH MHWDPEYSDV KLIQTMMFVS EVKNILEKAS SRPGSPTADP
410 420 430 440 450
NSIPLVLCAD LNSLPDSGVV EYLSNGGVAD NHKDFKELRY NECLMNFSCN
460 470 480 490 500
GKNGSSEGRI THGFQLKSAY ENNLMPYTNY TFDFKGVIDY IFYSKTHMNV
510 520 530 540 550
LGVLGPLDPQ WLVENNITGC PHPHIPSDHF SLLTQLELHP PLLPLVNGVH

LPNRR
Length:555
Mass (Da):63,001
Last modified:January 15, 2008 - v2
Checksum:iC6E94F1BAE222241
GO
Isoform 2 (identifier: Q96LI5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-153: Missing.
     486-502: GVIDYIFYSKTHMNVLG → VSGSLWAGVEIISDTSM
     503-555: Missing.

Show »
Length:475
Mass (Da):53,891
Checksum:i6E2E2BB67749C501
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti439 – 4391R → G in BAB71707. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 15327Missing in isoform 2. 1 PublicationVSP_030321Add
BLAST
Alternative sequencei486 – 50217GVIDY…MNVLG → VSGSLWAGVEIISDTSM in isoform 2. 1 PublicationVSP_030322Add
BLAST
Alternative sequencei503 – 55553Missing in isoform 2. 1 PublicationVSP_030323Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058188 mRNA. Translation: BAB71707.1.
AC104701 Genomic DNA. No translation available.
AL133112 mRNA. Translation: CAB61415.1.
CCDSiCCDS68731.1. [Q96LI5-1]
PIRiT42705.
RefSeqiNP_001273719.1. NM_001286790.1. [Q96LI5-1]
NP_653172.2. NM_144571.2. [Q96LI5-1]
UniGeneiHs.592519.

Genome annotation databases

EnsembliENST00000504123; ENSP00000424896; ENSG00000138767. [Q96LI5-1]
GeneIDi246175.
KEGGihsa:246175.
UCSCiuc003hks.3. human. [Q96LI5-1]
uc003hkt.1. human. [Q96LI5-2]

Polymorphism databases

DMDMi166216089.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058188 mRNA. Translation: BAB71707.1 .
AC104701 Genomic DNA. No translation available.
AL133112 mRNA. Translation: CAB61415.1 .
CCDSi CCDS68731.1. [Q96LI5-1 ]
PIRi T42705.
RefSeqi NP_001273719.1. NM_001286790.1. [Q96LI5-1 ]
NP_653172.2. NM_144571.2. [Q96LI5-1 ]
UniGenei Hs.592519.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NGN X-ray 2.40 A 158-555 [» ]
3NGO X-ray 2.20 A 158-555 [» ]
3NGQ X-ray 1.80 A 158-555 [» ]
ProteinModelPortali Q96LI5.
SMRi Q96LI5. Positions 36-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128873. 15 interactions.
DIPi DIP-46837N.
IntActi Q96LI5. 19 interactions.
STRINGi 9606.ENSP00000264903.

PTM databases

PhosphoSitei Q96LI5.

Polymorphism databases

DMDMi 166216089.

Proteomic databases

MaxQBi Q96LI5.
PaxDbi Q96LI5.
PRIDEi Q96LI5.

Protocols and materials databases

DNASUi 246175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000504123 ; ENSP00000424896 ; ENSG00000138767 . [Q96LI5-1 ]
GeneIDi 246175.
KEGGi hsa:246175.
UCSCi uc003hks.3. human. [Q96LI5-1 ]
uc003hkt.1. human. [Q96LI5-2 ]

Organism-specific databases

CTDi 246175.
GeneCardsi GC04M078634.
HGNCi HGNC:18042. CNOT6L.
HPAi HPA042688.
neXtProti NX_Q96LI5.
PharmGKBi PA38480.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00550000074364.
HOGENOMi HOG000294222.
HOVERGENi HBG052641.
InParanoidi Q96LI5.
KOi K12603.
OrthoDBi EOG7JX35D.
PhylomeDBi Q96LI5.
TreeFami TF323175.

Enzyme and pathway databases

Reactomei REACT_20514. Deadenylation of mRNA.

Miscellaneous databases

ChiTaRSi CNOT6L. human.
EvolutionaryTracei Q96LI5.
GenomeRNAii 246175.
NextBioi 91870.
PROi Q96LI5.

Gene expression databases

Bgeei Q96LI5.
CleanExi HS_CNOT6L.
ExpressionAtlasi Q96LI5. baseline and differential.
Genevestigatori Q96LI5.

Family and domain databases

Gene3Di 3.60.10.10. 1 hit.
InterProi IPR005135. Endo/exonuclease/phosphatase.
IPR001611. Leu-rich_rpt.
[Graphical view ]
Pfami PF03372. Exo_endo_phos. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 1 hit.
PROSITEi PS51450. LRR. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-555 (ISOFORM 1).
    Tissue: Testis.
  4. "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth."
    Morita M., Suzuki T., Nakamura T., Yokoyama K., Miyasaka T., Yamamoto T.
    Mol. Cell. Biol. 27:4980-4990(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CNOT1; CNOT3; CNOT7; CNOT8 AND CNOT9, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-410; ASP-489 AND HIS-529.
  5. "Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex."
    Miyasaka T., Morita M., Ito K., Suzuki T., Fukuda H., Takeda S., Inoue J., Semba K., Yamamoto T.
    Cancer Sci. 99:755-761(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, INTERACTION WITH TOB1.
  6. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence."
    Mittal S., Aslam A., Doidge R., Medica R., Winkler G.S.
    Mol. Biol. Cell 22:748-758(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity."
    Wang H., Morita M., Yang X., Suzuki T., Yang W., Wang J., Ito K., Wang Q., Zhao C., Bartlam M., Yamamoto T., Rao Z.
    EMBO J. 29:2566-2576(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 158-555 ALONE AND IN COMPLEX WITH AMP ANALOG AND POLY-A DNA, MUTAGENESIS OF GLU-240; ASP-489 AND HIS-529, COFACTOR, ACTIVE SITE, MAGNESIUM-BINDING SITES.

Entry informationi

Entry nameiCNO6L_HUMAN
AccessioniPrimary (citable) accession number: Q96LI5
Secondary accession number(s): Q9UF92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of CNOT6L causes cell growth defect.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3