Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96LD4 (TRI47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 47
Alternative name(s):
Gene overexpressed in astrocytoma protein
RING finger protein 100
Gene names
Name:TRIM47
Synonyms:GOA, RNF100
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Low expression in most tissues. Higher expression in kidney tubular cells. Overexpressed in astrocytoma tumor cells. Ref.1

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638Tripartite motif-containing protein 47
PRO_0000056270

Regions

Domain410 – 631222B30.2/SPRY
Zinc finger9 – 5850RING-type
Zinc finger177 – 21741B box-type
Coiled coil296 – 32429 Potential
Compositional bias85 – 12642Pro-rich
Compositional bias272 – 2776Poly-Ala

Amino acid modifications

Modified residue4611Phosphoserine Ref.5
Modified residue5881Phosphoserine Ref.4

Natural variations

Natural variant5001E → A.
Corresponds to variant rs1047043 [ dbSNP | Ensembl ].
VAR_057223

Sequences

Sequence LengthMass (Da)Tools
Q96LD4 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: F524910DFC5CDF28

FASTA63869,532
        10         20         30         40         50         60 
MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG AARCPLCQEP 

        70         80         90        100        110        120 
FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS APSALPSVPE PSAPCAPEPW 

       130        140        150        160        170        180 
PAGEEPVRCD ACPEGAALPA ALSCLSCLAS FCPAHLGPHE RSPALRGHRL VPPLRRLEES 

       190        200        210        220        230        240 
LCPRHLRPLE RYCRAERVCL CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD 

       250        260        270        280        290        300 
ELGAGIAQSR RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS 

       310        320        330        340        350        360 
QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG PGPPRELSFT 

       370        380        390        400        410        420 
KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE ADAEPQDLES TNLLESEAPR 

       430        440        450        460        470        480 
DYFLKFAYIV DLDSDTADKF LQLFGTKGVK RVLCPINYPL SPTRFTHCEQ VLGEGALDRG 

       490        500        510        520        530        540 
TYYWEVEIIE GWVSMGVMAE DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL 

       550        560        570        580        590        600 
PHPFSPTVGV CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH 

       610        620        630 
FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR 

« Hide

References

« Hide 'large scale' references
[1]"GOA, a novel gene encoding a ring finger B-box coiled-coil protein, is overexpressed in astrocytoma."
Vandeputte D.A.A., Meije C.B., van Dartel M., Leenstra S., Ijlst-Keizers H., Das P.K., Troost D., Bosch D.A., Baas F., Hulsebos T.J.M.
Biochem. Biophys. Res. Commun. 286:574-579(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
Tissue: Astrocytoma.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-638.
Tissue: Lung and Pancreas.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
PIRJC7753.
RefSeqNP_258411.2. NM_033452.2.
UniGeneHs.293660.

3D structure databases

ProteinModelPortalQ96LD4.
SMRQ96LD4. Positions 9-57, 120-221, 421-624.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124794. 16 interactions.
IntActQ96LD4. 5 interactions.
STRING9606.ENSP00000254816.

PTM databases

PhosphoSiteQ96LD4.

Polymorphism databases

DMDM313104035.

Proteomic databases

PaxDbQ96LD4.
PRIDEQ96LD4.

Protocols and materials databases

DNASU91107.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254816; ENSP00000254816; ENSG00000132481.
GeneID91107.
KEGGhsa:91107.
UCSCuc002jpv.3. human.

Organism-specific databases

CTD91107.
GeneCardsGC17M073870.
H-InvDBHIX0027215.
HIX0202491.
HGNCHGNC:19020. TRIM47.
HPAHPA014933.
MIM611041. gene.
neXtProtNX_Q96LD4.
PharmGKBPA134883590.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147429.
HOGENOMHOG000231104.
HOVERGENHBG074469.
InParanoidQ96LD4.
KOK12023.
OMAEGFSPQE.
OrthoDBEOG7TXKG7.
PhylomeDBQ96LD4.
TreeFamTF351086.

Gene expression databases

ArrayExpressQ96LD4.
BgeeQ96LD4.
CleanExHS_TRIM47.
GenevestigatorQ96LD4.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91107.
NextBio77100.
PROQ96LD4.
SOURCESearch...

Entry information

Entry nameTRI47_HUMAN
AccessionPrimary (citable) accession number: Q96LD4
Secondary accession number(s): Q96GU5, Q9BRN7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM