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Protein

Tripartite motif-containing protein 47

Gene

TRIM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 5850RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 21741B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 47
Alternative name(s):
Gene overexpressed in astrocytoma protein
RING finger protein 100
Gene namesi
Name:TRIM47
Synonyms:GOA, RNF100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19020. TRIM47.

Subcellular locationi

  1. Cytoplasm 1 Publication
  2. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883590.

Polymorphism and mutation databases

BioMutaiTRIM47.
DMDMi313104035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Tripartite motif-containing protein 47PRO_0000056270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei461 – 4611Phosphoserine1 Publication
Modified residuei588 – 5881Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96LD4.
PaxDbiQ96LD4.
PRIDEiQ96LD4.

PTM databases

PhosphoSiteiQ96LD4.

Expressioni

Tissue specificityi

Low expression in most tissues. Higher expression in kidney tubular cells. Overexpressed in astrocytoma tumor cells.1 Publication

Gene expression databases

BgeeiQ96LD4.
CleanExiHS_TRIM47.
ExpressionAtlasiQ96LD4. baseline and differential.
GenevestigatoriQ96LD4.

Organism-specific databases

HPAiHPA014933.

Interactioni

Protein-protein interaction databases

BioGridi124794. 17 interactions.
IntActiQ96LD4. 5 interactions.
STRINGi9606.ENSP00000254816.

Structurei

3D structure databases

ProteinModelPortaliQ96LD4.
SMRiQ96LD4. Positions 9-57, 421-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini410 – 631222B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili296 – 32429Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 12642Pro-richAdd
BLAST
Compositional biasi272 – 2776Poly-Ala

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 5850RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 21741B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG147429.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000231104.
HOVERGENiHBG074469.
InParanoidiQ96LD4.
KOiK12023.
OMAiGFQTQVL.
OrthoDBiEOG7TXKG7.
PhylomeDBiQ96LD4.
TreeFamiTF351086.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG
60 70 80 90 100
AARCPLCQEP FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS
110 120 130 140 150
APSALPSVPE PSAPCAPEPW PAGEEPVRCD ACPEGAALPA ALSCLSCLAS
160 170 180 190 200
FCPAHLGPHE RSPALRGHRL VPPLRRLEES LCPRHLRPLE RYCRAERVCL
210 220 230 240 250
CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD ELGAGIAQSR
260 270 280 290 300
RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS
310 320 330 340 350
QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG
360 370 380 390 400
PGPPRELSFT KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE
410 420 430 440 450
ADAEPQDLES TNLLESEAPR DYFLKFAYIV DLDSDTADKF LQLFGTKGVK
460 470 480 490 500
RVLCPINYPL SPTRFTHCEQ VLGEGALDRG TYYWEVEIIE GWVSMGVMAE
510 520 530 540 550
DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL PHPFSPTVGV
560 570 580 590 600
CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH
610 620 630
FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR
Length:638
Mass (Da):69,532
Last modified:November 30, 2010 - v2
Checksum:iF524910DFC5CDF28
GO
Isoform 2 (identifier: Q96LD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Note: No experimental confirmation available. Contains a N-acetylmethionine at position 1.1 Publication

Show »
Length:400
Mass (Da):44,410
Checksum:i09B0BAC8319A3589
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti500 – 5001E → A.
Corresponds to variant rs1047043 [ dbSNP | Ensembl ].
VAR_057223

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 238238Missing in isoform 2. 1 PublicationVSP_055440Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
BC017299 mRNA. Translation: AAH17299.1.
CCDSiCCDS32737.1. [Q96LD4-1]
PIRiJC7753.
RefSeqiNP_258411.2. NM_033452.2. [Q96LD4-1]
XP_005257844.1. XM_005257787.3. [Q96LD4-2]
XP_005257845.1. XM_005257788.3. [Q96LD4-2]
UniGeneiHs.293660.

Genome annotation databases

EnsembliENST00000254816; ENSP00000254816; ENSG00000132481. [Q96LD4-1]
ENST00000587339; ENSP00000465010; ENSG00000132481. [Q96LD4-2]
GeneIDi91107.
KEGGihsa:91107.
UCSCiuc002jpv.3. human. [Q96LD4-1]

Polymorphism and mutation databases

BioMutaiTRIM47.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
BC017299 mRNA. Translation: AAH17299.1.
CCDSiCCDS32737.1. [Q96LD4-1]
PIRiJC7753.
RefSeqiNP_258411.2. NM_033452.2. [Q96LD4-1]
XP_005257844.1. XM_005257787.3. [Q96LD4-2]
XP_005257845.1. XM_005257788.3. [Q96LD4-2]
UniGeneiHs.293660.

3D structure databases

ProteinModelPortaliQ96LD4.
SMRiQ96LD4. Positions 9-57, 421-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124794. 17 interactions.
IntActiQ96LD4. 5 interactions.
STRINGi9606.ENSP00000254816.

PTM databases

PhosphoSiteiQ96LD4.

Polymorphism and mutation databases

BioMutaiTRIM47.
DMDMi313104035.

Proteomic databases

MaxQBiQ96LD4.
PaxDbiQ96LD4.
PRIDEiQ96LD4.

Protocols and materials databases

DNASUi91107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254816; ENSP00000254816; ENSG00000132481. [Q96LD4-1]
ENST00000587339; ENSP00000465010; ENSG00000132481. [Q96LD4-2]
GeneIDi91107.
KEGGihsa:91107.
UCSCiuc002jpv.3. human. [Q96LD4-1]

Organism-specific databases

CTDi91107.
GeneCardsiGC17M073870.
H-InvDBHIX0027215.
HIX0202491.
HGNCiHGNC:19020. TRIM47.
HPAiHPA014933.
MIMi611041. gene.
neXtProtiNX_Q96LD4.
PharmGKBiPA134883590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147429.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000231104.
HOVERGENiHBG074469.
InParanoidiQ96LD4.
KOiK12023.
OMAiGFQTQVL.
OrthoDBiEOG7TXKG7.
PhylomeDBiQ96LD4.
TreeFamiTF351086.

Miscellaneous databases

GenomeRNAii91107.
NextBioi77100.
PROiQ96LD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LD4.
CleanExiHS_TRIM47.
ExpressionAtlasiQ96LD4. baseline and differential.
GenevestigatoriQ96LD4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GOA, a novel gene encoding a ring finger B-box coiled-coil protein, is overexpressed in astrocytoma."
    Vandeputte D.A.A., Meije C.B., van Dartel M., Leenstra S., Ijlst-Keizers H., Das P.K., Troost D., Bosch D.A., Baas F., Hulsebos T.J.M.
    Biochem. Biophys. Res. Commun. 286:574-579(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
    Tissue: Astrocytoma.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-638 (ISOFORM 1).
    Tissue: Lung and Pancreas.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTRI47_HUMAN
AccessioniPrimary (citable) accession number: Q96LD4
Secondary accession number(s): Q96AD0, Q96GU5, Q9BRN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: April 29, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.