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Protein

Tripartite motif-containing protein 47

Gene

TRIM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 58RING-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri177 – 217B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 47
Alternative name(s):
Gene overexpressed in astrocytoma protein
RING finger protein 100
Gene namesi
Name:TRIM47
Synonyms:GOA, RNF100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19020. TRIM47.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132481.
PharmGKBiPA134883590.

Polymorphism and mutation databases

BioMutaiTRIM47.
DMDMi313104035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562701 – 638Tripartite motif-containing protein 47Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphothreonineBy similarity1
Modified residuei461PhosphoserineCombined sources1
Modified residuei582Omega-N-methylarginineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Isoform 2 (identifier: Q96LD4-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96LD4.
MaxQBiQ96LD4.
PaxDbiQ96LD4.
PeptideAtlasiQ96LD4.
PRIDEiQ96LD4.

PTM databases

iPTMnetiQ96LD4.
PhosphoSitePlusiQ96LD4.

Expressioni

Tissue specificityi

Low expression in most tissues. Higher expression in kidney tubular cells. Overexpressed in astrocytoma tumor cells.1 Publication

Gene expression databases

BgeeiENSG00000132481.
CleanExiHS_TRIM47.
ExpressionAtlasiQ96LD4. baseline and differential.
GenevisibleiQ96LD4. HS.

Organism-specific databases

HPAiHPA014933.

Interactioni

Protein-protein interaction databases

BioGridi124794. 19 interactors.
IntActiQ96LD4. 9 interactors.
STRINGi9606.ENSP00000254816.

Structurei

3D structure databases

ProteinModelPortaliQ96LD4.
SMRiQ96LD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini410 – 631B30.2/SPRYPROSITE-ProRule annotationAdd BLAST222

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 324Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 126Pro-richAdd BLAST42
Compositional biasi272 – 277Poly-Ala6

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 58RING-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri177 – 217B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ9G. Eukaryota.
ENOG41116W7. LUCA.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000231104.
HOVERGENiHBG074469.
InParanoidiQ96LD4.
KOiK12023.
OMAiGFQTQVL.
OrthoDBiEOG091G055Y.
PhylomeDBiQ96LD4.
TreeFamiTF351086.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG
60 70 80 90 100
AARCPLCQEP FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS
110 120 130 140 150
APSALPSVPE PSAPCAPEPW PAGEEPVRCD ACPEGAALPA ALSCLSCLAS
160 170 180 190 200
FCPAHLGPHE RSPALRGHRL VPPLRRLEES LCPRHLRPLE RYCRAERVCL
210 220 230 240 250
CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD ELGAGIAQSR
260 270 280 290 300
RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS
310 320 330 340 350
QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG
360 370 380 390 400
PGPPRELSFT KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE
410 420 430 440 450
ADAEPQDLES TNLLESEAPR DYFLKFAYIV DLDSDTADKF LQLFGTKGVK
460 470 480 490 500
RVLCPINYPL SPTRFTHCEQ VLGEGALDRG TYYWEVEIIE GWVSMGVMAE
510 520 530 540 550
DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL PHPFSPTVGV
560 570 580 590 600
CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH
610 620 630
FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR
Length:638
Mass (Da):69,532
Last modified:November 30, 2010 - v2
Checksum:iF524910DFC5CDF28
GO
Isoform 2 (identifier: Q96LD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:400
Mass (Da):44,410
Checksum:i09B0BAC8319A3589
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057223500E → A.Corresponds to variant rs1047043dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554401 – 238Missing in isoform 2. 1 PublicationAdd BLAST238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
BC017299 mRNA. Translation: AAH17299.1.
CCDSiCCDS32737.1. [Q96LD4-1]
PIRiJC7753.
RefSeqiNP_258411.2. NM_033452.2. [Q96LD4-1]
XP_005257844.1. XM_005257787.4. [Q96LD4-2]
XP_005257845.1. XM_005257788.4. [Q96LD4-2]
UniGeneiHs.293660.

Genome annotation databases

EnsembliENST00000254816; ENSP00000254816; ENSG00000132481. [Q96LD4-1]
GeneIDi91107.
KEGGihsa:91107.
UCSCiuc002jpv.4. human. [Q96LD4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
BC017299 mRNA. Translation: AAH17299.1.
CCDSiCCDS32737.1. [Q96LD4-1]
PIRiJC7753.
RefSeqiNP_258411.2. NM_033452.2. [Q96LD4-1]
XP_005257844.1. XM_005257787.4. [Q96LD4-2]
XP_005257845.1. XM_005257788.4. [Q96LD4-2]
UniGeneiHs.293660.

3D structure databases

ProteinModelPortaliQ96LD4.
SMRiQ96LD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124794. 19 interactors.
IntActiQ96LD4. 9 interactors.
STRINGi9606.ENSP00000254816.

PTM databases

iPTMnetiQ96LD4.
PhosphoSitePlusiQ96LD4.

Polymorphism and mutation databases

BioMutaiTRIM47.
DMDMi313104035.

Proteomic databases

EPDiQ96LD4.
MaxQBiQ96LD4.
PaxDbiQ96LD4.
PeptideAtlasiQ96LD4.
PRIDEiQ96LD4.

Protocols and materials databases

DNASUi91107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254816; ENSP00000254816; ENSG00000132481. [Q96LD4-1]
GeneIDi91107.
KEGGihsa:91107.
UCSCiuc002jpv.4. human. [Q96LD4-1]

Organism-specific databases

CTDi91107.
GeneCardsiTRIM47.
H-InvDBHIX0027215.
HIX0202491.
HGNCiHGNC:19020. TRIM47.
HPAiHPA014933.
MIMi611041. gene.
neXtProtiNX_Q96LD4.
OpenTargetsiENSG00000132481.
PharmGKBiPA134883590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9G. Eukaryota.
ENOG41116W7. LUCA.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000231104.
HOVERGENiHBG074469.
InParanoidiQ96LD4.
KOiK12023.
OMAiGFQTQVL.
OrthoDBiEOG091G055Y.
PhylomeDBiQ96LD4.
TreeFamiTF351086.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132481-MONOMER.

Miscellaneous databases

GenomeRNAii91107.
PROiQ96LD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132481.
CleanExiHS_TRIM47.
ExpressionAtlasiQ96LD4. baseline and differential.
GenevisibleiQ96LD4. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI47_HUMAN
AccessioniPrimary (citable) accession number: Q96LD4
Secondary accession number(s): Q96AD0, Q96GU5, Q9BRN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.