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Q96LD4

- TRI47_HUMAN

UniProt

Q96LD4 - TRI47_HUMAN

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Protein

Tripartite motif-containing protein 47

Gene
TRIM47, GOA, RNF100
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 5850RING-typeAdd
BLAST
Zinc fingeri177 – 21741B box-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 47
Alternative name(s):
Gene overexpressed in astrocytoma protein
RING finger protein 100
Gene namesi
Name:TRIM47
Synonyms:GOA, RNF100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:19020. TRIM47.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Tripartite motif-containing protein 47PRO_0000056270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei461 – 4611Phosphoserine1 Publication
Modified residuei588 – 5881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96LD4.
PaxDbiQ96LD4.
PRIDEiQ96LD4.

PTM databases

PhosphoSiteiQ96LD4.

Expressioni

Tissue specificityi

Low expression in most tissues. Higher expression in kidney tubular cells. Overexpressed in astrocytoma tumor cells.1 Publication

Gene expression databases

ArrayExpressiQ96LD4.
BgeeiQ96LD4.
CleanExiHS_TRIM47.
GenevestigatoriQ96LD4.

Organism-specific databases

HPAiHPA014933.

Interactioni

Protein-protein interaction databases

BioGridi124794. 16 interactions.
IntActiQ96LD4. 5 interactions.
STRINGi9606.ENSP00000254816.

Structurei

3D structure databases

ProteinModelPortaliQ96LD4.
SMRiQ96LD4. Positions 9-57, 421-624.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini410 – 631222B30.2/SPRYAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili296 – 32429 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 12642Pro-richAdd
BLAST
Compositional biasi272 – 2776Poly-Ala

Sequence similaritiesi

Belongs to the TRIM/RBCC family.
Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG147429.
HOGENOMiHOG000231104.
HOVERGENiHBG074469.
InParanoidiQ96LD4.
KOiK12023.
OMAiGFQTQVL.
OrthoDBiEOG7TXKG7.
PhylomeDBiQ96LD4.
TreeFamiTF351086.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96LD4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG    50
AARCPLCQEP FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS 100
APSALPSVPE PSAPCAPEPW PAGEEPVRCD ACPEGAALPA ALSCLSCLAS 150
FCPAHLGPHE RSPALRGHRL VPPLRRLEES LCPRHLRPLE RYCRAERVCL 200
CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD ELGAGIAQSR 250
RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS 300
QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG 350
PGPPRELSFT KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE 400
ADAEPQDLES TNLLESEAPR DYFLKFAYIV DLDSDTADKF LQLFGTKGVK 450
RVLCPINYPL SPTRFTHCEQ VLGEGALDRG TYYWEVEIIE GWVSMGVMAE 500
DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL PHPFSPTVGV 550
CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH 600
FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR 638
Length:638
Mass (Da):69,532
Last modified:November 30, 2010 - v2
Checksum:iF524910DFC5CDF28
GO
Isoform 2 (identifier: Q96LD4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-238: Missing.

Note: No experimental confirmation available.

Show »
Length:400
Mass (Da):44,410
Checksum:i09B0BAC8319A3589
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti500 – 5001E → A.
Corresponds to variant rs1047043 [ dbSNP | Ensembl ].
VAR_057223

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 238238Missing in isoform 2. VSP_055440Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY026763 mRNA. Translation: AAK07687.1.
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1.
BC006153 mRNA. Translation: AAH06153.1.
BC009225 mRNA. Translation: AAH09225.2.
BC017299 mRNA. Translation: AAH17299.1.
CCDSiCCDS32737.1.
PIRiJC7753.
RefSeqiNP_258411.2. NM_033452.2.
UniGeneiHs.293660.

Genome annotation databases

EnsembliENST00000254816; ENSP00000254816; ENSG00000132481.
ENST00000587339; ENSP00000465010; ENSG00000132481.
GeneIDi91107.
KEGGihsa:91107.
UCSCiuc002jpv.3. human.

Polymorphism databases

DMDMi313104035.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY026763 mRNA. Translation: AAK07687.1 .
AC087289 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89332.1 .
BC006153 mRNA. Translation: AAH06153.1 .
BC009225 mRNA. Translation: AAH09225.2 .
BC017299 mRNA. Translation: AAH17299.1 .
CCDSi CCDS32737.1.
PIRi JC7753.
RefSeqi NP_258411.2. NM_033452.2.
UniGenei Hs.293660.

3D structure databases

ProteinModelPortali Q96LD4.
SMRi Q96LD4. Positions 9-57, 421-624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124794. 16 interactions.
IntActi Q96LD4. 5 interactions.
STRINGi 9606.ENSP00000254816.

PTM databases

PhosphoSitei Q96LD4.

Polymorphism databases

DMDMi 313104035.

Proteomic databases

MaxQBi Q96LD4.
PaxDbi Q96LD4.
PRIDEi Q96LD4.

Protocols and materials databases

DNASUi 91107.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254816 ; ENSP00000254816 ; ENSG00000132481 .
ENST00000587339 ; ENSP00000465010 ; ENSG00000132481 .
GeneIDi 91107.
KEGGi hsa:91107.
UCSCi uc002jpv.3. human.

Organism-specific databases

CTDi 91107.
GeneCardsi GC17M073870.
H-InvDB HIX0027215.
HIX0202491.
HGNCi HGNC:19020. TRIM47.
HPAi HPA014933.
MIMi 611041. gene.
neXtProti NX_Q96LD4.
PharmGKBi PA134883590.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147429.
HOGENOMi HOG000231104.
HOVERGENi HBG074469.
InParanoidi Q96LD4.
KOi K12023.
OMAi GFQTQVL.
OrthoDBi EOG7TXKG7.
PhylomeDBi Q96LD4.
TreeFami TF351086.

Miscellaneous databases

GenomeRNAii 91107.
NextBioi 77100.
PROi Q96LD4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96LD4.
Bgeei Q96LD4.
CleanExi HS_TRIM47.
Genevestigatori Q96LD4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GOA, a novel gene encoding a ring finger B-box coiled-coil protein, is overexpressed in astrocytoma."
    Vandeputte D.A.A., Meije C.B., van Dartel M., Leenstra S., Ijlst-Keizers H., Das P.K., Troost D., Bosch D.A., Baas F., Hulsebos T.J.M.
    Biochem. Biophys. Res. Commun. 286:574-579(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
    Tissue: Astrocytoma.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-638 (ISOFORM 1).
    Tissue: Lung and Pancreas.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRI47_HUMAN
AccessioniPrimary (citable) accession number: Q96LD4
Secondary accession number(s): Q96AD0, Q96GU5, Q9BRN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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