Tripartite motif-containing protein 47

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Q96LD4 (TRI47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 47

Alternative name(s):
Gene overexpressed in astrocytoma protein
RING finger protein 100

Gene names

Name:	TRIM47
Synonyms:	GOA, RNF100

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Low expression in most tissues. Higher expression in kidney tubular cells. Overexpressed in astrocytoma tumor cells. Ref.1

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 638

638

Tripartite motif-containing protein 47

PRO_0000056270

Regions

Domain

410 – 631

222

B30.2/SPRY

Zinc finger

9 – 58

RING-type

Zinc finger

177 – 217

B box-type

Coiled coil

296 – 324

Potential

Compositional bias

85 – 126

Pro-rich

Compositional bias

272 – 277

Poly-Ala

Amino acid modifications

Modified residue

461

Phosphoserine Ref.5

Modified residue

588

Phosphoserine Ref.4

Natural variations

Natural variant

500

E → A.
Corresponds to variant rs1047043 [ dbSNP | Ensembl ].

VAR_057223

Sequences

Sequence

Length

Mass (Da)

Tools

Q96LD4 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: F524910DFC5CDF28
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FASTA

638

69,532

        10         20         30         40         50         60 
MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG AARCPLCQEP 

        70         80         90        100        110        120 
FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS APSALPSVPE PSAPCAPEPW 

       130        140        150        160        170        180 
PAGEEPVRCD ACPEGAALPA ALSCLSCLAS FCPAHLGPHE RSPALRGHRL VPPLRRLEES 

       190        200        210        220        230        240 
LCPRHLRPLE RYCRAERVCL CEACAAQEHR GHELVPLEQE RALQEAEQSK VLSAVEDRMD 

       250        260        270        280        290        300 
ELGAGIAQSR RTVALIKSAA VAERERVSRL FADAAAALQG FQTQVLGFIE EGEAAMLGRS 

       310        320        330        340        350        360 
QGDLRRQEEQ RSRLSRARQN LSQVPEADSV SFLQELLALR LALEDGCGPG PGPPRELSFT 

       370        380        390        400        410        420 
KSSQAVRAVR DMLAVACVNQ WEQLRGPGGN EDGPQKLDSE ADAEPQDLES TNLLESEAPR 

       430        440        450        460        470        480 
DYFLKFAYIV DLDSDTADKF LQLFGTKGVK RVLCPINYPL SPTRFTHCEQ VLGEGALDRG 

       490        500        510        520        530        540 
TYYWEVEIIE GWVSMGVMAE DFSPQEPYDR GRLGRNAHSC CLQWNGRSFS VWFHGLEAPL 

       550        560        570        580        590        600 
PHPFSPTVGV CLEYADRALA FYAVRDGKMS LLRRLKASRP RRGGIPASPI DPFQSRLDSH 

       610        620        630 
FAGLFTHRLK PAFFLESVDA HLQIGPLKKS CISVLKRR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GOA, a novel gene encoding a ring finger B-box coiled-coil protein, is overexpressed in astrocytoma." Vandeputte D.A.A., Meije C.B., van Dartel M., Leenstra S., Ijlst-Keizers H., Das P.K., Troost D., Bosch D.A., Baas F., Hulsebos T.J.M. Biochem. Biophys. Res. Commun. 286:574-579(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION. Tissue: Astrocytoma.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 236-638. Tissue: Lung and Pancreas.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026763 mRNA. Translation: AAK07687.1. AC087289 Genomic DNA. No translation available. BC006153 mRNA. Translation: AAH06153.1. BC009225 mRNA. Translation: AAH09225.2.
IPI	IPI00307165.
PIR	JC7753.
RefSeq	NP_258411.2. NM_033452.2.
UniGene	Hs.293660.
3D structure databases
ProteinModelPortal	Q96LD4.
SMR	Q96LD4. Positions 9-57, 120-221.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96LD4. 5 interactions.
STRING	9606.ENSP00000254816.
PTM databases
PhosphoSite	Q96LD4.
Polymorphism databases
DMDM	55976756.
Proteomic databases
PaxDb	Q96LD4.
PRIDE	Q96LD4.
Protocols and materials databases
DNASU	91107.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254816; ENSP00000254816; ENSG00000132481.
GeneID	91107.
KEGG	hsa:91107.
UCSC	uc002jpv.3. human.
Organism-specific databases
CTD	91107.
GeneCards	GC17M073870.
H-InvDB	HIX0027215. HIX0202491.
HGNC	HGNC:19020. TRIM47.
HPA	HPA014933.
MIM	611041. gene.
neXtProt	NX_Q96LD4.
PharmGKB	PA134883590.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147429.
HOGENOM	HOG000231104.
HOVERGEN	HBG074469.
InParanoid	Q96LD4.
KO	K12023.
OMA	EGFSPQE.
OrthoDB	EOG434W5R.
PhylomeDB	Q96LD4.
Gene expression databases
ArrayExpress	Q96LD4.
Bgee	Q96LD4.
CleanEx	HS_TRIM47.
Genevestigator	Q96LD4.
GermOnline	ENSG00000132481. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit. 4.10.45.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	91107.
NextBio	77100.
SOURCE	Search...

Entry information

Entry name

TRI47_HUMAN

Accession

Primary (citable) accession number: Q96LD4
Secondary accession number(s): Q96GU5, Q9BRN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 30, 2010
Last modified:	May 29, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents