Q96LD1 (SGCZ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zeta-sarcoglycan
Short name=Zeta-SG

Alternative name(s):
ZSG1

Gene names

Name:

SGCZ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability By similarity.
Subcellular location	Cell membrane › sarcolemma; Single-pass type II membrane protein By similarity. Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement PubMed 17438352. Source: BHF-UCL cytoskeleton organization Inferred from electronic annotation. Source: InterPro muscle cell development Traceable author statement PubMed 17438352. Source: BHF-UCL muscle cell homeostasis Traceable author statement PubMed 17438352. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW sarcoglycan complex Traceable author statement PubMed 17438352. Source: BHF-UCL sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96LD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96LD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDRSTNLDIEELKM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Zeta-sarcoglycan		PRO_0000175251
Regions
	Topological domain	1 – 37	37	Cytoplasmic Potential
	Transmembrane	38 – 58	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	59 – 299	241	Extracellular Potential
	Compositional bias	252 – 263	12	Poly-Ser
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Disulfide bond	273 ↔ 289		Potential
Natural variations
	Alternative sequence	1	1	M → MDRSTNLDIEELKM in isoform 2.		VSP_037410

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BB2C14302AD477C0	FASTA	299	32,949
	10 20 30 40 50 60 MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN LAMTIWILKV 70 80 90 100 110 120 MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD SPLVLQSDRN VTVNARNHMG 130 140 150 160 170 180 QLTGQLTIGA DAVEAQCKRF EVRASEDGRV LFSADEDEIT IGAEKLKVTG TEGAVFGHSV 190 200 210 220 230 240 ETPHIRAEPS QDLRLESPTR SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA 250 260 270 280 290 ETIKLGNLPT GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS
	Isoform 2 [UniParc]. Checksum: 4EFE83C1D7B4E8F1	FASTA	312	34,494
	10 20 30 40 50 60 MDRSTNLDIE ELKMTREQYI LATQQNNLPR TENAQLYPVG IYGWRKRCLY FFVLLLLVTM 70 80 90 100 110 120 IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL LPLYVKEIHS RKDSPLVLQS 130 140 150 160 170 180 DRNVTVNARN HMGQLTGQLT IGADAVEAQC KRFEVRASED GRVLFSADED EITIGAEKLK 190 200 210 220 230 240 VTGTEGAVFG HSVETPHIRA EPSQDLRLES PTRSLIMEAP RGVQVSAAAG DFKATCRKEL 250 260 270 280 290 300 HLQSTEGEIF LNAETIKLGN LPTGSFSSSS PSSSSSRQTV YELCVCPNGK LYLSPAGVGS 310 TCQSSSNICL WS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human sarcoglycan." Kutzick C., Herrmann R., Voit T. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Human zeta-sarcoglycan, a novel member of the sarcoglycan family." Kutzick C., Herrmann R., Voit T. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY028700 mRNA. Translation: AAK21962.1. AY502063 mRNA. Translation: AAR89453.1. BC069459 mRNA. Translation: AAH69459.1.
IPI	IPI00064994. IPI00793580.
RefSeq	NP_631906.2. NM_139167.2.
UniGene	Hs.676196.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371512.
PTM databases
PhosphoSite	Q96LD1.
Polymorphism databases
DMDM	41018110.
Proteomic databases
PaxDb	Q96LD1.
PRIDE	Q96LD1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382080; ENSP00000371512; ENSG00000185053.
GeneID	137868.
KEGG	hsa:137868.
UCSC	uc003wwq.3. human.
Organism-specific databases
CTD	137868.
GeneCards	GC08M013991.
HGNC	HGNC:14075. SGCZ.
HPA	HPA017585.
MIM	608113. gene.
neXtProt	NX_Q96LD1.
PharmGKB	PA38378.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318936.
HOGENOM	HOG000007853.
HOVERGEN	HBG008669.
InParanoid	Q96LD1.
OMA	NSRQTVY.
OrthoDB	EOG4P5K9J.
PhylomeDB	Q96LD1.
Gene expression databases
ArrayExpress	Q96LD1.
Bgee	Q96LD1.
CleanEx	HS_SGCZ.
Genevestigator	Q96LD1.
GermOnline	ENSG00000185053. Homo sapiens.
Family and domain databases
InterPro	IPR006875. Sarcoglycan. [Graphical view]
Pfam	PF04790. Sarcoglycan_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SGCZ. human.
GenomeRNAi	137868.
NextBio	83685.
SOURCE	Search...

Entry information

Entry name

SGCZ_HUMAN

Accession

Primary (citable) accession number: Q96LD1
Secondary accession number(s): Q6REU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.