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Q96LD1

- SGCZ_HUMAN

UniProt

Q96LD1 - SGCZ_HUMAN

Protein

Zeta-sarcoglycan

Gene

SGCZ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability By similarity.By similarity

    GO - Biological processi

    1. membrane organization Source: BHF-UCL
    2. muscle cell cellular homeostasis Source: BHF-UCL
    3. muscle cell development Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zeta-sarcoglycan
    Short name:
    Zeta-SG
    Alternative name(s):
    ZSG1
    Gene namesi
    Name:SGCZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14075. SGCZ.

    Subcellular locationi

    Cell membranesarcolemma By similarity; Single-pass type II membrane protein By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. sarcoglycan complex Source: BHF-UCL
    5. sarcolemma Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38378.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Zeta-sarcoglycanPRO_0000175251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 289Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96LD1.
    PRIDEiQ96LD1.

    PTM databases

    PhosphoSiteiQ96LD1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96LD1.
    BgeeiQ96LD1.
    CleanExiHS_SGCZ.
    GenevestigatoriQ96LD1.

    Organism-specific databases

    HPAiHPA017585.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371512.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 299241ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi252 – 26312Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318936.
    HOGENOMiHOG000007853.
    HOVERGENiHBG008669.
    InParanoidiQ96LD1.
    OMAiCLYFFIL.
    OrthoDBiEOG7SN8DC.
    PhylomeDBiQ96LD1.
    TreeFamiTF313538.

    Family and domain databases

    InterProiIPR006875. Sarcoglycan.
    IPR027662. Sgcz.
    [Graphical view]
    PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
    PfamiPF04790. Sarcoglycan_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96LD1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN    50
    LAMTIWILKV MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD 100
    SPLVLQSDRN VTVNARNHMG QLTGQLTIGA DAVEAQCKRF EVRASEDGRV 150
    LFSADEDEIT IGAEKLKVTG TEGAVFGHSV ETPHIRAEPS QDLRLESPTR 200
    SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA ETIKLGNLPT 250
    GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS 299
    Length:299
    Mass (Da):32,949
    Last modified:December 1, 2001 - v1
    Checksum:iBB2C14302AD477C0
    GO
    Isoform 2 (identifier: Q96LD1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MDRSTNLDIEELKM

    Note: No experimental confirmation available.

    Show »
    Length:312
    Mass (Da):34,494
    Checksum:i4EFE83C1D7B4E8F1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MDRSTNLDIEELKM in isoform 2. 1 PublicationVSP_037410

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028700 mRNA. Translation: AAK21962.1.
    AY502063 mRNA. Translation: AAR89453.1.
    BC069459 mRNA. Translation: AAH69459.1.
    CCDSiCCDS5992.2. [Q96LD1-2]
    RefSeqiNP_631906.2. NM_139167.2. [Q96LD1-2]
    UniGeneiHs.676196.

    Genome annotation databases

    EnsembliENST00000382080; ENSP00000371512; ENSG00000185053. [Q96LD1-2]
    GeneIDi137868.
    KEGGihsa:137868.
    UCSCiuc003wwq.3. human. [Q96LD1-2]

    Polymorphism databases

    DMDMi41018110.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028700 mRNA. Translation: AAK21962.1 .
    AY502063 mRNA. Translation: AAR89453.1 .
    BC069459 mRNA. Translation: AAH69459.1 .
    CCDSi CCDS5992.2. [Q96LD1-2 ]
    RefSeqi NP_631906.2. NM_139167.2. [Q96LD1-2 ]
    UniGenei Hs.676196.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371512.

    PTM databases

    PhosphoSitei Q96LD1.

    Polymorphism databases

    DMDMi 41018110.

    Proteomic databases

    PaxDbi Q96LD1.
    PRIDEi Q96LD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382080 ; ENSP00000371512 ; ENSG00000185053 . [Q96LD1-2 ]
    GeneIDi 137868.
    KEGGi hsa:137868.
    UCSCi uc003wwq.3. human. [Q96LD1-2 ]

    Organism-specific databases

    CTDi 137868.
    GeneCardsi GC08M013991.
    HGNCi HGNC:14075. SGCZ.
    HPAi HPA017585.
    MIMi 608113. gene.
    neXtProti NX_Q96LD1.
    PharmGKBi PA38378.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318936.
    HOGENOMi HOG000007853.
    HOVERGENi HBG008669.
    InParanoidi Q96LD1.
    OMAi CLYFFIL.
    OrthoDBi EOG7SN8DC.
    PhylomeDBi Q96LD1.
    TreeFami TF313538.

    Miscellaneous databases

    ChiTaRSi SGCZ. human.
    GeneWikii SGCZ.
    GenomeRNAii 137868.
    NextBioi 83685.
    PROi Q96LD1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96LD1.
    Bgeei Q96LD1.
    CleanExi HS_SGCZ.
    Genevestigatori Q96LD1.

    Family and domain databases

    InterProi IPR006875. Sarcoglycan.
    IPR027662. Sgcz.
    [Graphical view ]
    PANTHERi PTHR12939:SF5. PTHR12939:SF5. 1 hit.
    Pfami PF04790. Sarcoglycan_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human sarcoglycan."
      Kutzick C., Herrmann R., Voit T.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human zeta-sarcoglycan, a novel member of the sarcoglycan family."
      Kutzick C., Herrmann R., Voit T.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Skeletal muscle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiSGCZ_HUMAN
    AccessioniPrimary (citable) accession number: Q96LD1
    Secondary accession number(s): Q6REU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3