Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zeta-sarcoglycan

Gene

SGCZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity).By similarity

GO - Biological processi

  • cardiac muscle tissue development Source: GO_Central
  • heart contraction Source: GO_Central
  • membrane organization Source: BHF-UCL
  • muscle cell cellular homeostasis Source: BHF-UCL
  • muscle cell development Source: BHF-UCL
  • muscle organ development Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zeta-sarcoglycan
Short name:
Zeta-SG
Alternative name(s):
ZSG1
Gene namesi
Name:SGCZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14075. SGCZ.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini59 – 299241ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • sarcoglycan complex Source: BHF-UCL
  • sarcolemma Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38378.

Polymorphism and mutation databases

BioMutaiSGCZ.
DMDMi41018110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Zeta-sarcoglycanPRO_0000175251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi273 ↔ 289Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LD1.
PRIDEiQ96LD1.

PTM databases

PhosphoSiteiQ96LD1.

Expressioni

Gene expression databases

BgeeiQ96LD1.
CleanExiHS_SGCZ.
ExpressionAtlasiQ96LD1. baseline.
GenevisibleiQ96LD1. HS.

Organism-specific databases

HPAiHPA017585.

Interactioni

Protein-protein interaction databases

BioGridi126488. 10 interactions.
STRINGi9606.ENSP00000371512.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi252 – 26312Poly-SerAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318936.
GeneTreeiENSGT00390000017950.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiQ96LD1.
OMAiNSRQTVY.
OrthoDBiEOG7SN8DC.
PhylomeDBiQ96LD1.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN
60 70 80 90 100
LAMTIWILKV MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD
110 120 130 140 150
SPLVLQSDRN VTVNARNHMG QLTGQLTIGA DAVEAQCKRF EVRASEDGRV
160 170 180 190 200
LFSADEDEIT IGAEKLKVTG TEGAVFGHSV ETPHIRAEPS QDLRLESPTR
210 220 230 240 250
SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA ETIKLGNLPT
260 270 280 290
GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS
Length:299
Mass (Da):32,949
Last modified:December 1, 2001 - v1
Checksum:iBB2C14302AD477C0
GO
Isoform 2 (identifier: Q96LD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDRSTNLDIEELKM

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):34,494
Checksum:i4EFE83C1D7B4E8F1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MDRSTNLDIEELKM in isoform 2. 1 PublicationVSP_037410

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028700 mRNA. Translation: AAK21962.1.
AY502063 mRNA. Translation: AAR89453.1.
BC069459 mRNA. Translation: AAH69459.1.
CCDSiCCDS5992.2. [Q96LD1-2]
RefSeqiNP_631906.2. NM_139167.2. [Q96LD1-2]
UniGeneiHs.676196.

Genome annotation databases

EnsembliENST00000382080; ENSP00000371512; ENSG00000185053. [Q96LD1-2]
GeneIDi137868.
KEGGihsa:137868.
UCSCiuc003wwq.3. human. [Q96LD1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028700 mRNA. Translation: AAK21962.1.
AY502063 mRNA. Translation: AAR89453.1.
BC069459 mRNA. Translation: AAH69459.1.
CCDSiCCDS5992.2. [Q96LD1-2]
RefSeqiNP_631906.2. NM_139167.2. [Q96LD1-2]
UniGeneiHs.676196.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126488. 10 interactions.
STRINGi9606.ENSP00000371512.

PTM databases

PhosphoSiteiQ96LD1.

Polymorphism and mutation databases

BioMutaiSGCZ.
DMDMi41018110.

Proteomic databases

PaxDbiQ96LD1.
PRIDEiQ96LD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382080; ENSP00000371512; ENSG00000185053. [Q96LD1-2]
GeneIDi137868.
KEGGihsa:137868.
UCSCiuc003wwq.3. human. [Q96LD1-2]

Organism-specific databases

CTDi137868.
GeneCardsiGC08M013991.
HGNCiHGNC:14075. SGCZ.
HPAiHPA017585.
MIMi608113. gene.
neXtProtiNX_Q96LD1.
PharmGKBiPA38378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318936.
GeneTreeiENSGT00390000017950.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiQ96LD1.
OMAiNSRQTVY.
OrthoDBiEOG7SN8DC.
PhylomeDBiQ96LD1.
TreeFamiTF313538.

Miscellaneous databases

ChiTaRSiSGCZ. human.
GeneWikiiSGCZ.
GenomeRNAii137868.
NextBioi83685.
PROiQ96LD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LD1.
CleanExiHS_SGCZ.
ExpressionAtlasiQ96LD1. baseline.
GenevisibleiQ96LD1. HS.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human sarcoglycan."
    Kutzick C., Herrmann R., Voit T.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human zeta-sarcoglycan, a novel member of the sarcoglycan family."
    Kutzick C., Herrmann R., Voit T.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiSGCZ_HUMAN
AccessioniPrimary (citable) accession number: Q96LD1
Secondary accession number(s): Q6REU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.