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Q96LD1 (SGCZ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zeta-sarcoglycan

Short name=Zeta-SG
Alternative name(s):
ZSG1
Gene names
Name:SGCZ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability By similarity.

Subcellular location

Cell membranesarcolemma; Single-pass type II membrane protein By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96LD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96LD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDRSTNLDIEELKM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Zeta-sarcoglycan
PRO_0000175251

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain59 – 299241Extracellular Potential
Compositional bias252 – 26312Poly-Ser

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Disulfide bond273 ↔ 289 Potential

Natural variations

Alternative sequence11M → MDRSTNLDIEELKM in isoform 2.
VSP_037410

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BB2C14302AD477C0

FASTA29932,949
        10         20         30         40         50         60 
MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN LAMTIWILKV 

        70         80         90        100        110        120 
MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD SPLVLQSDRN VTVNARNHMG 

       130        140        150        160        170        180 
QLTGQLTIGA DAVEAQCKRF EVRASEDGRV LFSADEDEIT IGAEKLKVTG TEGAVFGHSV 

       190        200        210        220        230        240 
ETPHIRAEPS QDLRLESPTR SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA 

       250        260        270        280        290 
ETIKLGNLPT GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS 

« Hide

Isoform 2 [UniParc].

Checksum: 4EFE83C1D7B4E8F1
Show »

FASTA31234,494

References

« Hide 'large scale' references
[1]"Identification of a novel human sarcoglycan."
Kutzick C., Herrmann R., Voit T.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Human zeta-sarcoglycan, a novel member of the sarcoglycan family."
Kutzick C., Herrmann R., Voit T.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Skeletal muscle.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY028700 mRNA. Translation: AAK21962.1.
AY502063 mRNA. Translation: AAR89453.1.
BC069459 mRNA. Translation: AAH69459.1.
CCDSCCDS5992.2. [Q96LD1-2]
RefSeqNP_631906.2. NM_139167.2. [Q96LD1-2]
UniGeneHs.676196.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371512.

PTM databases

PhosphoSiteQ96LD1.

Polymorphism databases

DMDM41018110.

Proteomic databases

PaxDbQ96LD1.
PRIDEQ96LD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382080; ENSP00000371512; ENSG00000185053. [Q96LD1-2]
GeneID137868.
KEGGhsa:137868.
UCSCuc003wwq.3. human. [Q96LD1-2]

Organism-specific databases

CTD137868.
GeneCardsGC08M013991.
HGNCHGNC:14075. SGCZ.
HPAHPA017585.
MIM608113. gene.
neXtProtNX_Q96LD1.
PharmGKBPA38378.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318936.
HOGENOMHOG000007853.
HOVERGENHBG008669.
InParanoidQ96LD1.
OMACLYFFIL.
OrthoDBEOG7SN8DC.
PhylomeDBQ96LD1.
TreeFamTF313538.

Gene expression databases

ArrayExpressQ96LD1.
BgeeQ96LD1.
CleanExHS_SGCZ.
GenevestigatorQ96LD1.

Family and domain databases

InterProIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSGCZ. human.
GeneWikiSGCZ.
GenomeRNAi137868.
NextBio83685.
PROQ96LD1.
SOURCESearch...

Entry information

Entry nameSGCZ_HUMAN
AccessionPrimary (citable) accession number: Q96LD1
Secondary accession number(s): Q6REU0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM