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Protein

Sialic acid-binding Ig-like lectin 10

Gene

SIGLEC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191Sialic acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 10
Short name:
Siglec-10
Alternative name(s):
Siglec-like protein 2
Gene namesi
Name:SIGLEC10
Synonyms:SLG2
ORF Names:UNQ477/PRO940
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15620. SIGLEC10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 550534ExtracellularSequence analysisAdd
BLAST
Transmembranei551 – 57121HelicalSequence analysisAdd
BLAST
Topological domaini572 – 697126CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi667 – 6671Y → F: Abolishes binding to PTPN6. 1 Publication

Organism-specific databases

PharmGKBiPA38004.

Polymorphism and mutation databases

BioMutaiSIGLEC10.
DMDMi118572721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 697681Sialic acid-binding Ig-like lectin 10PRO_0000014950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 173PROSITE-ProRule annotation
Disulfide bondi41 ↔ 101PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 215PROSITE-ProRule annotation
Disulfide bondi276 ↔ 323PROSITE-ProRule annotation
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi380 ↔ 425PROSITE-ProRule annotation
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence analysis
Modified residuei667 – 6671Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylation of Tyr-667 is involved in binding to PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96LC7.
MaxQBiQ96LC7.
PaxDbiQ96LC7.
PRIDEiQ96LC7.

PTM databases

iPTMnetiQ96LC7.
PhosphoSiteiQ96LC7.

Expressioni

Tissue specificityi

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Gene expression databases

BgeeiQ96LC7.
CleanExiHS_SIGLEC10.
ExpressionAtlasiQ96LC7. baseline and differential.
GenevisibleiQ96LC7. HS.

Organism-specific databases

HPAiCAB025807.
HPA027093.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 upon phosphorylation.1 Publication

Protein-protein interaction databases

BioGridi124602. 7 interactions.
IntActiQ96LC7. 1 interaction.
MINTiMINT-8020518.
STRINGi9606.ENSP00000345243.

Structurei

3D structure databases

ProteinModelPortaliQ96LC7.
SMRiQ96LC7. Positions 16-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 121104Ig-like V-typeAdd
BLAST
Domaini146 – 23186Ig-like C2-type 1Add
BLAST
Domaini251 – 33989Ig-like C2-type 2Add
BLAST
Domaini344 – 44198Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi595 – 6006ITIM motif 1
Motifi665 – 6706ITIM motif 2

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96LC7.
KOiK06749.
OMAiMKILPKR.
OrthoDBiEOG73JKV5.
PhylomeDBiQ96LC7.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LC7-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW
60 70 80 90 100
TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN
110 120 130 140 150
CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI
160 170 180 190 200
PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL
210 220 230 240 250
SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT
260 270 280 290 300
PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP
310 320 330 340 350
WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM
360 370 380 390 400
VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS
410 420 430 440 450
PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG
460 470 480 490 500
PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG
510 520 530 540 550
PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN
560 570 580 590 600
GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV
610 620 630 640 650
VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK
660 670 680 690
SSTQAPESQE SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ
Length:697
Mass (Da):76,592
Last modified:November 28, 2006 - v3
Checksum:iE1B787F34CF7201A
GO
Isoform 2 (identifier: Q96LC7-2) [UniParc]FASTAAdd to basket

Also known as: Short, Sv1

The sequence of this isoform differs from the canonical sequence as follows:
     445-539: Missing.

Show »
Length:602
Mass (Da):66,618
Checksum:i217A05584B94C5AA
GO
Isoform 3 (identifier: Q96LC7-3) [UniParc]FASTAAdd to basket

Also known as: Sv3

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.

Show »
Length:639
Mass (Da):70,313
Checksum:iCDD93752BDACDD45
GO
Isoform 4 (identifier: Q96LC7-4) [UniParc]FASTAAdd to basket

Also known as: Sv4

The sequence of this isoform differs from the canonical sequence as follows:
     125-214: Missing.

Show »
Length:607
Mass (Da):66,493
Checksum:i225AD8FB560EC751
GO
Isoform 5 (identifier: Q96LC7-5) [UniParc]FASTAAdd to basket

Also known as: Sv2

The sequence of this isoform differs from the canonical sequence as follows:
     140-185: TALTQKPDVY...PSFSWTGAAL → TGMRWGGNPC...NLPPRSLSQP
     186-697: Missing.

Show »
Length:185
Mass (Da):20,612
Checksum:i353945F95129A5C9
GO
Isoform 6 (identifier: Q96LC7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     445-539: Missing.

Show »
Length:544
Mass (Da):60,339
Checksum:iB56274BD619B164C
GO
Isoform 7 (identifier: Q96LC7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-188: Missing.
     445-539: Missing.

Note: No experimental confirmation available.
Show »
Length:554
Mass (Da):61,383
Checksum:iAAB64A61743F4535
GO
Isoform 8 (identifier: Q96LC7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     252-252: A → D
     253-342: Missing.
     445-539: Missing.

Note: No experimental confirmation available.
Show »
Length:454
Mass (Da):50,517
Checksum:i8E27B12146B5DC30
GO
Isoform 9 (identifier: Q96LC7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-228: Missing.
     445-539: Missing.

Show »
Length:519
Mass (Da):57,486
Checksum:i95F307C2BDDCF32D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281S → P in AAK51124 (PubMed:12163025).Curated
Sequence conflicti127 – 1271R → T in AAQ88703 (PubMed:12975309).Curated
Sequence conflicti134 – 1341G → R in AAK51124 (PubMed:12163025).Curated
Sequence conflicti268 – 2681K → R in AK303514 (PubMed:14702039).Curated
Sequence conflicti344 – 3441P → S in AAK92542 (PubMed:11358961).Curated
Sequence conflicti440 – 4401L → P in AAK51124 (PubMed:12163025).Curated
Sequence conflicti564 – 5641L → P in AK303514 (PubMed:14702039).Curated
Sequence conflicti587 – 5871R → K in AAK92542 (PubMed:11358961).Curated
Sequence conflicti624 – 6241L → P in AAQ88703 (PubMed:12975309).Curated
Sequence conflicti625 – 6251P → S in AAK92542 (PubMed:11358961).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261A → V.5 Publications
Corresponds to variant rs9304711 [ dbSNP | Ensembl ].
VAR_019955
Natural varianti520 – 5201R → S.
Corresponds to variant rs1833785 [ dbSNP | Ensembl ].
VAR_019956

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 21490Missing in isoform 4. CuratedVSP_002561Add
BLAST
Alternative sequencei140 – 18546TALTQ…TGAAL → TGMRWGGNPCLSHWGGTLGT AYGLSREGSQGPLQHKNLPP RSLSQP in isoform 5. CuratedVSP_002562Add
BLAST
Alternative sequencei141 – 19858Missing in isoform 3, isoform 6 and isoform 8. 3 PublicationsVSP_002564Add
BLAST
Alternative sequencei141 – 18848Missing in isoform 7. 1 PublicationVSP_045365Add
BLAST
Alternative sequencei146 – 22883Missing in isoform 9. CuratedVSP_045888Add
BLAST
Alternative sequencei186 – 697512Missing in isoform 5. CuratedVSP_002563Add
BLAST
Alternative sequencei252 – 2521A → D in isoform 8. CuratedVSP_045853
Alternative sequencei253 – 34290Missing in isoform 8. CuratedVSP_045854Add
BLAST
Alternative sequencei445 – 53995Missing in isoform 2, isoform 6, isoform 7, isoform 8 and isoform 9. 3 PublicationsVSP_002565Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029277 Genomic DNA. Translation: AAK40255.1.
AY029277 Genomic DNA. Translation: AAK40256.1.
AF310233 mRNA. Translation: AAK55139.1.
AF311905 mRNA. Translation: AAK92542.1.
AY032685 mRNA. Translation: AAK51124.1.
AY358337 mRNA. Translation: AAQ88703.1.
AK289900 mRNA. Translation: BAF82589.1.
AK290542 mRNA. Translation: BAF83231.1.
AK303514 mRNA. No translation available.
AC008750 Genomic DNA. No translation available.
BC009955 mRNA. Translation: AAH09955.2.
BC101725 mRNA. Translation: AAI01726.1.
CCDSiCCDS12832.1. [Q96LC7-1]
CCDS54301.1. [Q96LC7-8]
CCDS54302.1. [Q96LC7-6]
CCDS54303.1. [Q96LC7-3]
CCDS54304.1. [Q96LC7-7]
CCDS54305.1. [Q96LC7-2]
RefSeqiNP_001164627.1. NM_001171156.1. [Q96LC7-3]
NP_001164628.1. NM_001171157.1. [Q96LC7-2]
NP_001164629.1. NM_001171158.1. [Q96LC7-7]
NP_001164630.1. NM_001171159.1. [Q96LC7-6]
NP_001164632.1. NM_001171161.1. [Q96LC7-8]
NP_149121.2. NM_033130.4. [Q96LC7-1]
UniGeneiHs.284813.

Genome annotation databases

EnsembliENST00000339313; ENSP00000345243; ENSG00000142512. [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512. [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512. [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512. [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512. [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512. [Q96LC7-8]
GeneIDi89790.
KEGGihsa:89790.
UCSCiuc002pwo.4. human. [Q96LC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-10 [5 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-10 long

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029277 Genomic DNA. Translation: AAK40255.1.
AY029277 Genomic DNA. Translation: AAK40256.1.
AF310233 mRNA. Translation: AAK55139.1.
AF311905 mRNA. Translation: AAK92542.1.
AY032685 mRNA. Translation: AAK51124.1.
AY358337 mRNA. Translation: AAQ88703.1.
AK289900 mRNA. Translation: BAF82589.1.
AK290542 mRNA. Translation: BAF83231.1.
AK303514 mRNA. No translation available.
AC008750 Genomic DNA. No translation available.
BC009955 mRNA. Translation: AAH09955.2.
BC101725 mRNA. Translation: AAI01726.1.
CCDSiCCDS12832.1. [Q96LC7-1]
CCDS54301.1. [Q96LC7-8]
CCDS54302.1. [Q96LC7-6]
CCDS54303.1. [Q96LC7-3]
CCDS54304.1. [Q96LC7-7]
CCDS54305.1. [Q96LC7-2]
RefSeqiNP_001164627.1. NM_001171156.1. [Q96LC7-3]
NP_001164628.1. NM_001171157.1. [Q96LC7-2]
NP_001164629.1. NM_001171158.1. [Q96LC7-7]
NP_001164630.1. NM_001171159.1. [Q96LC7-6]
NP_001164632.1. NM_001171161.1. [Q96LC7-8]
NP_149121.2. NM_033130.4. [Q96LC7-1]
UniGeneiHs.284813.

3D structure databases

ProteinModelPortaliQ96LC7.
SMRiQ96LC7. Positions 16-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124602. 7 interactions.
IntActiQ96LC7. 1 interaction.
MINTiMINT-8020518.
STRINGi9606.ENSP00000345243.

PTM databases

iPTMnetiQ96LC7.
PhosphoSiteiQ96LC7.

Polymorphism and mutation databases

BioMutaiSIGLEC10.
DMDMi118572721.

Proteomic databases

EPDiQ96LC7.
MaxQBiQ96LC7.
PaxDbiQ96LC7.
PRIDEiQ96LC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339313; ENSP00000345243; ENSG00000142512. [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512. [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512. [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512. [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512. [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512. [Q96LC7-8]
GeneIDi89790.
KEGGihsa:89790.
UCSCiuc002pwo.4. human. [Q96LC7-1]

Organism-specific databases

CTDi89790.
GeneCardsiSIGLEC10.
H-InvDBHIX0027461.
HGNCiHGNC:15620. SIGLEC10.
HPAiCAB025807.
HPA027093.
MIMi606091. gene.
neXtProtiNX_Q96LC7.
PharmGKBiPA38004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96LC7.
KOiK06749.
OMAiMKILPKR.
OrthoDBiEOG73JKV5.
PhylomeDBiQ96LC7.
TreeFamiTF332441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiSIGLEC10. human.
GeneWikiiSIGLEC10.
GenomeRNAii89790.
NextBioi76277.
PROiQ96LC7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LC7.
CleanExiHS_SIGLEC10.
ExpressionAtlasiQ96LC7. baseline and differential.
GenevisibleiQ96LC7. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants."
    Yousef G.M., Ordon M.H., Foussias G., Diamandis E.P.
    Biochem. Biophys. Res. Commun. 284:900-910(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
  2. "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor."
    Munday J., Kerr S., Ni J., Cornish A.L., Zhang J.Q., Nicoll G., Floyd H., Mattei M.-G., Moore P., Liu D., Crocker P.R.
    Biochem. J. 355:489-497(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-226.
    Tissue: Spleen.
  3. "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells."
    Li N., Zhang W., Wan T., Zhang J., Chen T., Yu Y., Wang J., Cao X.
    J. Biol. Chem. 276:28106-28112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-226.
    Tissue: Dendritic cell.
  4. "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1."
    Kitzig F., Martinez-Barriocanal A., Lopez-Botet M., Sayos J.
    Biochem. Biophys. Res. Commun. 296:355-362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 4 AND 5), VARIANT VAL-226, PHOSPHORYLATION AT TYR-667, MUTAGENESIS OF TYR-667, INTERACTION WITH PTPN6.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANT VAL-226.
    Tissue: Brain and Thymus.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-226.
    Tissue: B-cell and Liver.

Entry informationi

Entry nameiSIG10_HUMAN
AccessioniPrimary (citable) accession number: Q96LC7
Secondary accession number(s): A8K1I5
, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 28, 2006
Last modified: May 11, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.