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Protein

Sialic acid-binding Ig-like lectin 10

Gene

SIGLEC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119Sialic acidBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142512-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SIGNORiQ96LC7.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 10
Short name:
Siglec-10
Alternative name(s):
Siglec-like protein 2
Gene namesi
Name:SIGLEC10
Synonyms:SLG2
ORF Names:UNQ477/PRO940
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15620. SIGLEC10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 550ExtracellularSequence analysisAdd BLAST534
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 697CytoplasmicSequence analysisAdd BLAST126

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi667Y → F: Abolishes binding to PTPN6. 1 Publication1

Organism-specific databases

DisGeNETi89790.
OpenTargetsiENSG00000142512.
PharmGKBiPA38004.

Polymorphism and mutation databases

BioMutaiSIGLEC10.
DMDMi118572721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001495017 – 697Sialic acid-binding Ig-like lectin 10Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 173PROSITE-ProRule annotation
Disulfide bondi41 ↔ 101PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 215PROSITE-ProRule annotation
Disulfide bondi276 ↔ 323PROSITE-ProRule annotation
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi380 ↔ 425PROSITE-ProRule annotation
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1
Modified residuei667Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylation of Tyr-667 is involved in binding to PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96LC7.
MaxQBiQ96LC7.
PaxDbiQ96LC7.
PeptideAtlasiQ96LC7.
PRIDEiQ96LC7.

PTM databases

iPTMnetiQ96LC7.
PhosphoSitePlusiQ96LC7.

Expressioni

Tissue specificityi

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Gene expression databases

BgeeiENSG00000142512.
CleanExiHS_SIGLEC10.
ExpressionAtlasiQ96LC7. baseline and differential.
GenevisibleiQ96LC7. HS.

Organism-specific databases

HPAiCAB025807.
HPA027093.

Interactioni

Subunit structurei

Interacts with PTPN6/SHP-1 upon phosphorylation.1 Publication

Protein-protein interaction databases

BioGridi124602. 7 interactors.
IntActiQ96LC7. 1 interactor.
MINTiMINT-8020518.
STRINGi9606.ENSP00000345243.

Structurei

3D structure databases

ProteinModelPortaliQ96LC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 121Ig-like V-typeAdd BLAST104
Domaini146 – 231Ig-like C2-type 1Add BLAST86
Domaini251 – 339Ig-like C2-type 2Add BLAST89
Domaini344 – 441Ig-like C2-type 3Add BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi595 – 600ITIM motif 16
Motifi665 – 670ITIM motif 26

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96LC7.
KOiK06749.
OMAiWIRVQES.
OrthoDBiEOG091G0BMG.
PhylomeDBiQ96LC7.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LC7-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW
60 70 80 90 100
TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN
110 120 130 140 150
CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI
160 170 180 190 200
PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL
210 220 230 240 250
SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT
260 270 280 290 300
PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP
310 320 330 340 350
WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM
360 370 380 390 400
VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS
410 420 430 440 450
PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG
460 470 480 490 500
PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG
510 520 530 540 550
PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN
560 570 580 590 600
GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV
610 620 630 640 650
VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK
660 670 680 690
SSTQAPESQE SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ
Length:697
Mass (Da):76,592
Last modified:November 28, 2006 - v3
Checksum:iE1B787F34CF7201A
GO
Isoform 2 (identifier: Q96LC7-2) [UniParc]FASTAAdd to basket
Also known as: Short, Sv1

The sequence of this isoform differs from the canonical sequence as follows:
     445-539: Missing.

Show »
Length:602
Mass (Da):66,618
Checksum:i217A05584B94C5AA
GO
Isoform 3 (identifier: Q96LC7-3) [UniParc]FASTAAdd to basket
Also known as: Sv3

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.

Show »
Length:639
Mass (Da):70,313
Checksum:iCDD93752BDACDD45
GO
Isoform 4 (identifier: Q96LC7-4) [UniParc]FASTAAdd to basket
Also known as: Sv4

The sequence of this isoform differs from the canonical sequence as follows:
     125-214: Missing.

Show »
Length:607
Mass (Da):66,493
Checksum:i225AD8FB560EC751
GO
Isoform 5 (identifier: Q96LC7-5) [UniParc]FASTAAdd to basket
Also known as: Sv2

The sequence of this isoform differs from the canonical sequence as follows:
     140-185: TALTQKPDVY...PSFSWTGAAL → TGMRWGGNPC...NLPPRSLSQP
     186-697: Missing.

Show »
Length:185
Mass (Da):20,612
Checksum:i353945F95129A5C9
GO
Isoform 6 (identifier: Q96LC7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     445-539: Missing.

Show »
Length:544
Mass (Da):60,339
Checksum:iB56274BD619B164C
GO
Isoform 7 (identifier: Q96LC7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-188: Missing.
     445-539: Missing.

Note: No experimental confirmation available.
Show »
Length:554
Mass (Da):61,383
Checksum:iAAB64A61743F4535
GO
Isoform 8 (identifier: Q96LC7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-198: Missing.
     252-252: A → D
     253-342: Missing.
     445-539: Missing.

Note: No experimental confirmation available.
Show »
Length:454
Mass (Da):50,517
Checksum:i8E27B12146B5DC30
GO
Isoform 9 (identifier: Q96LC7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-228: Missing.
     445-539: Missing.

Show »
Length:519
Mass (Da):57,486
Checksum:i95F307C2BDDCF32D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28S → P in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti127R → T in AAQ88703 (PubMed:12975309).Curated1
Sequence conflicti134G → R in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti268K → R in AK303514 (PubMed:14702039).Curated1
Sequence conflicti344P → S in AAK92542 (PubMed:11358961).Curated1
Sequence conflicti440L → P in AAK51124 (PubMed:12163025).Curated1
Sequence conflicti564L → P in AK303514 (PubMed:14702039).Curated1
Sequence conflicti587R → K in AAK92542 (PubMed:11358961).Curated1
Sequence conflicti624L → P in AAQ88703 (PubMed:12975309).Curated1
Sequence conflicti625P → S in AAK92542 (PubMed:11358961).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019955226A → V.5 PublicationsCorresponds to variant rs9304711dbSNPEnsembl.1
Natural variantiVAR_019956520R → S.Corresponds to variant rs1833785dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002561125 – 214Missing in isoform 4. CuratedAdd BLAST90
Alternative sequenceiVSP_002562140 – 185TALTQ…TGAAL → TGMRWGGNPCLSHWGGTLGT AYGLSREGSQGPLQHKNLPP RSLSQP in isoform 5. CuratedAdd BLAST46
Alternative sequenceiVSP_002564141 – 198Missing in isoform 3, isoform 6 and isoform 8. 3 PublicationsAdd BLAST58
Alternative sequenceiVSP_045365141 – 188Missing in isoform 7. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_045888146 – 228Missing in isoform 9. CuratedAdd BLAST83
Alternative sequenceiVSP_002563186 – 697Missing in isoform 5. CuratedAdd BLAST512
Alternative sequenceiVSP_045853252A → D in isoform 8. Curated1
Alternative sequenceiVSP_045854253 – 342Missing in isoform 8. CuratedAdd BLAST90
Alternative sequenceiVSP_002565445 – 539Missing in isoform 2, isoform 6, isoform 7, isoform 8 and isoform 9. 3 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029277 Genomic DNA. Translation: AAK40255.1.
AY029277 Genomic DNA. Translation: AAK40256.1.
AF310233 mRNA. Translation: AAK55139.1.
AF311905 mRNA. Translation: AAK92542.1.
AY032685 mRNA. Translation: AAK51124.1.
AY358337 mRNA. Translation: AAQ88703.1.
AK289900 mRNA. Translation: BAF82589.1.
AK290542 mRNA. Translation: BAF83231.1.
AK303514 mRNA. No translation available.
AC008750 Genomic DNA. No translation available.
BC009955 mRNA. Translation: AAH09955.2.
BC101725 mRNA. Translation: AAI01726.1.
CCDSiCCDS12832.1. [Q96LC7-1]
CCDS54301.1. [Q96LC7-8]
CCDS54302.1. [Q96LC7-6]
CCDS54303.1. [Q96LC7-3]
CCDS54304.1. [Q96LC7-7]
CCDS54305.1. [Q96LC7-2]
RefSeqiNP_001164627.1. NM_001171156.1. [Q96LC7-3]
NP_001164628.1. NM_001171157.1. [Q96LC7-2]
NP_001164629.1. NM_001171158.1. [Q96LC7-7]
NP_001164630.1. NM_001171159.1. [Q96LC7-6]
NP_001164632.1. NM_001171161.1. [Q96LC7-8]
NP_001309034.1. NM_001322105.1.
NP_149121.2. NM_033130.4. [Q96LC7-1]
UniGeneiHs.284813.

Genome annotation databases

EnsembliENST00000339313; ENSP00000345243; ENSG00000142512. [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512. [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512. [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512. [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512. [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512. [Q96LC7-8]
GeneIDi89790.
KEGGihsa:89790.
UCSCiuc002pwo.4. human. [Q96LC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-10 [5 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-10 long

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029277 Genomic DNA. Translation: AAK40255.1.
AY029277 Genomic DNA. Translation: AAK40256.1.
AF310233 mRNA. Translation: AAK55139.1.
AF311905 mRNA. Translation: AAK92542.1.
AY032685 mRNA. Translation: AAK51124.1.
AY358337 mRNA. Translation: AAQ88703.1.
AK289900 mRNA. Translation: BAF82589.1.
AK290542 mRNA. Translation: BAF83231.1.
AK303514 mRNA. No translation available.
AC008750 Genomic DNA. No translation available.
BC009955 mRNA. Translation: AAH09955.2.
BC101725 mRNA. Translation: AAI01726.1.
CCDSiCCDS12832.1. [Q96LC7-1]
CCDS54301.1. [Q96LC7-8]
CCDS54302.1. [Q96LC7-6]
CCDS54303.1. [Q96LC7-3]
CCDS54304.1. [Q96LC7-7]
CCDS54305.1. [Q96LC7-2]
RefSeqiNP_001164627.1. NM_001171156.1. [Q96LC7-3]
NP_001164628.1. NM_001171157.1. [Q96LC7-2]
NP_001164629.1. NM_001171158.1. [Q96LC7-7]
NP_001164630.1. NM_001171159.1. [Q96LC7-6]
NP_001164632.1. NM_001171161.1. [Q96LC7-8]
NP_001309034.1. NM_001322105.1.
NP_149121.2. NM_033130.4. [Q96LC7-1]
UniGeneiHs.284813.

3D structure databases

ProteinModelPortaliQ96LC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124602. 7 interactors.
IntActiQ96LC7. 1 interactor.
MINTiMINT-8020518.
STRINGi9606.ENSP00000345243.

PTM databases

iPTMnetiQ96LC7.
PhosphoSitePlusiQ96LC7.

Polymorphism and mutation databases

BioMutaiSIGLEC10.
DMDMi118572721.

Proteomic databases

EPDiQ96LC7.
MaxQBiQ96LC7.
PaxDbiQ96LC7.
PeptideAtlasiQ96LC7.
PRIDEiQ96LC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339313; ENSP00000345243; ENSG00000142512. [Q96LC7-1]
ENST00000353836; ENSP00000342389; ENSG00000142512. [Q96LC7-2]
ENST00000436984; ENSP00000414324; ENSG00000142512. [Q96LC7-7]
ENST00000439889; ENSP00000389132; ENSG00000142512. [Q96LC7-3]
ENST00000441969; ENSP00000408387; ENSG00000142512. [Q96LC7-6]
ENST00000442846; ENSP00000395475; ENSG00000142512. [Q96LC7-8]
GeneIDi89790.
KEGGihsa:89790.
UCSCiuc002pwo.4. human. [Q96LC7-1]

Organism-specific databases

CTDi89790.
DisGeNETi89790.
GeneCardsiSIGLEC10.
H-InvDBHIX0027461.
HGNCiHGNC:15620. SIGLEC10.
HPAiCAB025807.
HPA027093.
MIMi606091. gene.
neXtProtiNX_Q96LC7.
OpenTargetsiENSG00000142512.
PharmGKBiPA38004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ96LC7.
KOiK06749.
OMAiWIRVQES.
OrthoDBiEOG091G0BMG.
PhylomeDBiQ96LC7.
TreeFamiTF332441.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142512-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SIGNORiQ96LC7.

Miscellaneous databases

ChiTaRSiSIGLEC10. human.
GeneWikiiSIGLEC10.
GenomeRNAii89790.
PROiQ96LC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142512.
CleanExiHS_SIGLEC10.
ExpressionAtlasiQ96LC7. baseline and differential.
GenevisibleiQ96LC7. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIG10_HUMAN
AccessioniPrimary (citable) accession number: Q96LC7
Secondary accession number(s): A8K1I5
, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.