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Q96LB9

- PGRP3_HUMAN

UniProt

Q96LB9 - PGRP3_HUMAN

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Protein

Peptidoglycan recognition protein 3

Gene

PGLYRP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311Murein
Binding sitei235 – 2351Murein
Binding sitei242 – 2421Murein

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
  2. peptidoglycan binding Source: UniProtKB
  3. peptidoglycan receptor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: UniProtKB
  2. detection of bacterium Source: UniProtKB
  3. growth of symbiont in host Source: Ensembl
  4. innate immune response Source: UniProtKB
  5. negative regulation of interferon-gamma production Source: Ensembl
  6. negative regulation of natural killer cell differentiation involved in immune response Source: Ensembl
  7. pattern recognition receptor signaling pathway Source: GOC
  8. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 3
Alternative name(s):
Peptidoglycan recognition protein I-alpha
Short name:
PGLYRPIalpha
Short name:
PGRP-I-alpha
Peptidoglycan recognition protein intermediate alpha
Gene namesi
Name:PGLYRP3
Synonyms:PGRPIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30014. PGLYRP3.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. intracellular Source: UniProtKB
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 341324Peptidoglycan recognition protein 3PRO_0000023923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi178 ↔ 300
Disulfide bondi194 ↔ 238
Disulfide bondi214 ↔ 220

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LB9.
PRIDEiQ96LB9.

PTM databases

PhosphoSiteiQ96LB9.

Expressioni

Tissue specificityi

Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.2 Publications

Inductioni

Up-regulated by exposure to Gram-positive and Gram-negative bacteria.1 Publication

Gene expression databases

BgeeiQ96LB9.
CleanExiHS_PGLYRP3.
GenevestigatoriQ96LB9.

Organism-specific databases

HPAiHPA030369.

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.4 Publications

Protein-protein interaction databases

BioGridi125341. 2 interactions.
STRINGi9606.ENSP00000290722.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi184 – 1874
Beta strandi199 – 20810
Helixi217 – 23317
Beta strandi243 – 2464
Beta strandi252 – 2565
Beta strandi258 – 2603
Beta strandi263 – 2653
Turni269 – 2713
Beta strandi272 – 2798
Beta strandi282 – 2843
Helixi288 – 30316
Beta strandi306 – 31510
Helixi316 – 3183
Beta strandi320 – 3223
Helixi328 – 3336
Turni337 – 3404

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SK3X-ray2.80A177-341[»]
1SK4X-ray1.65A179-341[»]
1TWQX-ray2.30A177-341[»]
2APHX-ray2.10A/B177-341[»]
ProteinModelPortaliQ96LB9.
SMRiQ96LB9. Positions 21-341.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LB9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni264 – 2696Interaction with murein

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5479.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG053579.
InParanoidiQ96LB9.
KOiK01446.
OMAiVEKPPNA.
OrthoDBiEOG757CZ5.
PhylomeDBiQ96LB9.
TreeFamiTF323898.

Family and domain databases

Gene3Di3.40.80.10. 2 hits.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTLPWLLAF FILGLQAWDT PTIVSRKEWG ARPLACRALL TLPVAYIITD
60 70 80 90 100
QLPGMQCQQQ SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG
110 120 130 140 150
WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL
160 170 180 190 200
SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP
210 220 230 240 250
AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHFLVGQDG
260 270 280 290 300
GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC
310 320 330 340
AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H
Length:341
Mass (Da):37,611
Last modified:December 1, 2001 - v1
Checksum:i8ADD5AA97B632076
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351A → T.
Corresponds to variant rs55991125 [ dbSNP | Ensembl ].
VAR_061515
Natural varianti126 – 1261G → S.1 Publication
Corresponds to variant rs843971 [ dbSNP | Ensembl ].
VAR_024561

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035376 mRNA. Translation: AAK72484.1.
AL591704, AL161636 Genomic DNA. Translation: CAI19491.1.
AL161636, AL591704 Genomic DNA. Translation: CAI19556.1.
BC069741 mRNA. Translation: AAH69741.1.
BC069798 mRNA. Translation: AAH69798.1.
BC069801 mRNA. Translation: AAH69801.1.
BC128114 mRNA. Translation: AAI28115.1.
BC128115 mRNA. Translation: AAI28116.1.
CCDSiCCDS1035.1.
RefSeqiNP_443123.1. NM_052891.1.
UniGeneiHs.348266.

Genome annotation databases

EnsembliENST00000290722; ENSP00000290722; ENSG00000159527.
GeneIDi114771.
KEGGihsa:114771.
UCSCiuc001fbn.1. human.

Polymorphism databases

DMDMi38604974.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035376 mRNA. Translation: AAK72484.1 .
AL591704 , AL161636 Genomic DNA. Translation: CAI19491.1 .
AL161636 , AL591704 Genomic DNA. Translation: CAI19556.1 .
BC069741 mRNA. Translation: AAH69741.1 .
BC069798 mRNA. Translation: AAH69798.1 .
BC069801 mRNA. Translation: AAH69801.1 .
BC128114 mRNA. Translation: AAI28115.1 .
BC128115 mRNA. Translation: AAI28116.1 .
CCDSi CCDS1035.1.
RefSeqi NP_443123.1. NM_052891.1.
UniGenei Hs.348266.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SK3 X-ray 2.80 A 177-341 [» ]
1SK4 X-ray 1.65 A 179-341 [» ]
1TWQ X-ray 2.30 A 177-341 [» ]
2APH X-ray 2.10 A/B 177-341 [» ]
ProteinModelPortali Q96LB9.
SMRi Q96LB9. Positions 21-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125341. 2 interactions.
STRINGi 9606.ENSP00000290722.

PTM databases

PhosphoSitei Q96LB9.

Polymorphism databases

DMDMi 38604974.

Proteomic databases

PaxDbi Q96LB9.
PRIDEi Q96LB9.

Protocols and materials databases

DNASUi 114771.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290722 ; ENSP00000290722 ; ENSG00000159527 .
GeneIDi 114771.
KEGGi hsa:114771.
UCSCi uc001fbn.1. human.

Organism-specific databases

CTDi 114771.
GeneCardsi GC01M153270.
HGNCi HGNC:30014. PGLYRP3.
HPAi HPA030369.
MIMi 608197. gene.
neXtProti NX_Q96LB9.
PharmGKBi PA134861692.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5479.
GeneTreei ENSGT00390000016833.
HOGENOMi HOG000267017.
HOVERGENi HBG053579.
InParanoidi Q96LB9.
KOi K01446.
OMAi VEKPPNA.
OrthoDBi EOG757CZ5.
PhylomeDBi Q96LB9.
TreeFami TF323898.

Miscellaneous databases

EvolutionaryTracei Q96LB9.
GenomeRNAii 114771.
NextBioi 79145.
PROi Q96LB9.
SOURCEi Search...

Gene expression databases

Bgeei Q96LB9.
CleanExi HS_PGLYRP3.
Genevestigatori Q96LB9.

Family and domain databases

Gene3Di 3.40.80.10. 2 hits.
InterProi IPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 2 hits.
[Graphical view ]
SMARTi SM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules."
    Liu C., Xu Z., Gupta D., Dziarski R.
    J. Biol. Chem. 276:34686-34694(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-126.
  4. "Peptidoglycan recognition proteins are a new class of human bactericidal proteins."
    Lu X., Wang M., Qi J., Wang H., Li X., Gupta D., Dziarski R.
    J. Biol. Chem. 281:5895-5907(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, GLYCOSYLATION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  5. "Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha."
    Guan R., Malchiodi E.L., Wang Q., Schuck P., Mariuzza R.A.
    J. Biol. Chem. 279:31873-31882(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 177-341, SUBUNIT.
  6. "Structural basis for peptidoglycan binding by peptidoglycan recognition proteins."
    Guan R., Roychowdhury A., Ember B., Kumar S., Boons G.-J., Mariuzza R.A.
    Proc. Natl. Acad. Sci. U.S.A. 101:17168-17173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 177-341 IN COMPLEX WITH MUREIN FRAGMENT.
  7. "Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria."
    Guan R., Brown P.H., Swaminathan C.P., Roychowdhury A., Boons G.-J., Mariuzza R.A.
    Protein Sci. 15:1199-1206(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 177-341 IN COMPLEX WITH MUREIN FRAGMENT.

Entry informationi

Entry nameiPGRP3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB9
Secondary accession number(s): A1A4U8, Q5SY65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3