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Protein

Peptidoglycan recognition protein 3

Gene

PGLYRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231Murein1
Binding sitei235Murein1
Binding sitei242Murein1

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
  • peptidoglycan binding Source: UniProtKB
  • peptidoglycan receptor activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159527-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan recognition protein 3
Alternative name(s):
Peptidoglycan recognition protein I-alpha
Short name:
PGLYRPIalpha
Short name:
PGRP-I-alpha
Peptidoglycan recognition protein intermediate alpha
Gene namesi
Name:PGLYRP3
Synonyms:PGRPIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30014. PGLYRP3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • intracellular Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi114771.
OpenTargetsiENSG00000159527.
PharmGKBiPA134861692.

Polymorphism and mutation databases

BioMutaiPGLYRP3.
DMDMi38604974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002392318 – 341Peptidoglycan recognition protein 3Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi178 ↔ 300
Disulfide bondi194 ↔ 238
Disulfide bondi214 ↔ 220

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LB9.
PeptideAtlasiQ96LB9.
PRIDEiQ96LB9.

PTM databases

iPTMnetiQ96LB9.
PhosphoSitePlusiQ96LB9.

Expressioni

Tissue specificityi

Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.2 Publications

Inductioni

Up-regulated by exposure to Gram-positive and Gram-negative bacteria.1 Publication

Gene expression databases

BgeeiENSG00000159527.
CleanExiHS_PGLYRP3.
GenevisibleiQ96LB9. HS.

Organism-specific databases

HPAiHPA030369.

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.4 Publications

Protein-protein interaction databases

BioGridi125341. 2 interactors.
IntActiQ96LB9. 2 interactors.
STRINGi9606.ENSP00000290722.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi184 – 187Combined sources4
Beta strandi199 – 208Combined sources10
Helixi217 – 233Combined sources17
Beta strandi243 – 246Combined sources4
Beta strandi252 – 256Combined sources5
Beta strandi258 – 260Combined sources3
Beta strandi263 – 265Combined sources3
Turni269 – 271Combined sources3
Beta strandi272 – 279Combined sources8
Beta strandi282 – 284Combined sources3
Helixi288 – 303Combined sources16
Beta strandi306 – 315Combined sources10
Helixi316 – 318Combined sources3
Beta strandi320 – 322Combined sources3
Helixi328 – 333Combined sources6
Turni337 – 340Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SK3X-ray2.80A177-341[»]
1SK4X-ray1.65A179-341[»]
1TWQX-ray2.30A177-341[»]
2APHX-ray2.10A/B177-341[»]
ProteinModelPortaliQ96LB9.
SMRiQ96LB9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96LB9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 269Interaction with murein6

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG053579.
InParanoidiQ96LB9.
KOiK01446.
OMAiHTYGFND.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ96LB9.
TreeFamiTF323898.

Family and domain databases

CDDicd06583. PGRP. 2 hits.
Gene3Di3.40.80.10. 2 hits.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96LB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLPWLLAF FILGLQAWDT PTIVSRKEWG ARPLACRALL TLPVAYIITD
60 70 80 90 100
QLPGMQCQQQ SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG
110 120 130 140 150
WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL
160 170 180 190 200
SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP
210 220 230 240 250
AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHFLVGQDG
260 270 280 290 300
GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC
310 320 330 340
AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H
Length:341
Mass (Da):37,611
Last modified:December 1, 2001 - v1
Checksum:i8ADD5AA97B632076
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06151535A → T.Corresponds to variant rs55991125dbSNPEnsembl.1
Natural variantiVAR_024561126G → S.1 PublicationCorresponds to variant rs843971dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035376 mRNA. Translation: AAK72484.1.
AL591704, AL161636 Genomic DNA. Translation: CAI19491.1.
AL161636, AL591704 Genomic DNA. Translation: CAI19556.1.
BC069741 mRNA. Translation: AAH69741.1.
BC069798 mRNA. Translation: AAH69798.1.
BC069801 mRNA. Translation: AAH69801.1.
BC128114 mRNA. Translation: AAI28115.1.
BC128115 mRNA. Translation: AAI28116.1.
CCDSiCCDS1035.1.
RefSeqiNP_443123.1. NM_052891.2.
XP_011507421.1. XM_011509119.1.
UniGeneiHs.348266.

Genome annotation databases

EnsembliENST00000290722; ENSP00000290722; ENSG00000159527.
GeneIDi114771.
KEGGihsa:114771.
UCSCiuc001fbn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035376 mRNA. Translation: AAK72484.1.
AL591704, AL161636 Genomic DNA. Translation: CAI19491.1.
AL161636, AL591704 Genomic DNA. Translation: CAI19556.1.
BC069741 mRNA. Translation: AAH69741.1.
BC069798 mRNA. Translation: AAH69798.1.
BC069801 mRNA. Translation: AAH69801.1.
BC128114 mRNA. Translation: AAI28115.1.
BC128115 mRNA. Translation: AAI28116.1.
CCDSiCCDS1035.1.
RefSeqiNP_443123.1. NM_052891.2.
XP_011507421.1. XM_011509119.1.
UniGeneiHs.348266.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SK3X-ray2.80A177-341[»]
1SK4X-ray1.65A179-341[»]
1TWQX-ray2.30A177-341[»]
2APHX-ray2.10A/B177-341[»]
ProteinModelPortaliQ96LB9.
SMRiQ96LB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125341. 2 interactors.
IntActiQ96LB9. 2 interactors.
STRINGi9606.ENSP00000290722.

PTM databases

iPTMnetiQ96LB9.
PhosphoSitePlusiQ96LB9.

Polymorphism and mutation databases

BioMutaiPGLYRP3.
DMDMi38604974.

Proteomic databases

PaxDbiQ96LB9.
PeptideAtlasiQ96LB9.
PRIDEiQ96LB9.

Protocols and materials databases

DNASUi114771.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290722; ENSP00000290722; ENSG00000159527.
GeneIDi114771.
KEGGihsa:114771.
UCSCiuc001fbn.1. human.

Organism-specific databases

CTDi114771.
DisGeNETi114771.
GeneCardsiPGLYRP3.
HGNCiHGNC:30014. PGLYRP3.
HPAiHPA030369.
MIMi608197. gene.
neXtProtiNX_Q96LB9.
OpenTargetsiENSG00000159527.
PharmGKBiPA134861692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYTD. Eukaryota.
ENOG4111PQD. LUCA.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000267017.
HOVERGENiHBG053579.
InParanoidiQ96LB9.
KOiK01446.
OMAiHTYGFND.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ96LB9.
TreeFamiTF323898.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159527-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Miscellaneous databases

EvolutionaryTraceiQ96LB9.
GenomeRNAii114771.
PROiQ96LB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159527.
CleanExiHS_PGLYRP3.
GenevisibleiQ96LB9. HS.

Family and domain databases

CDDicd06583. PGRP. 2 hits.
Gene3Di3.40.80.10. 2 hits.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 2 hits.
[Graphical view]
SMARTiSM00644. Ami_2. 2 hits.
SM00701. PGRP. 2 hits.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB9
Secondary accession number(s): A1A4U8, Q5SY65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.