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Q96LB8

- PGRP4_HUMAN

UniProt

Q96LB8 - PGRP4_HUMAN

Protein

Peptidoglycan recognition protein 4

Gene

PGLYRP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei263 – 2631Murein
    Binding sitei274 – 2741Murein

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: InterPro
    2. peptidoglycan binding Source: UniProtKB
    3. peptidoglycan receptor activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. defense response to Gram-positive bacterium Source: UniProtKB
    2. detection of bacterium Source: UniProtKB
    3. growth of symbiont in host Source: Ensembl
    4. innate immune response Source: UniProtKB
    5. negative regulation of interferon-gamma production Source: Ensembl
    6. negative regulation of natural killer cell differentiation involved in immune response Source: Ensembl
    7. pattern recognition receptor signaling pathway Source: GOC
    8. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan recognition protein 4
    Alternative name(s):
    Peptidoglycan recognition protein I-beta
    Short name:
    PGLYRPIbeta
    Short name:
    PGRP-I-beta
    Peptidoglycan recognition protein intermediate beta
    Gene namesi
    Name:PGLYRP4
    Synonyms:PGRPIB
    ORF Names:SBBI67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30015. PGLYRP4.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. intracellular Source: UniProtKB
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134902492.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 373356Peptidoglycan recognition protein 4PRO_0000023924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi210 ↔ 3321 Publication
    Disulfide bondi226 ↔ 2701 Publication
    Disulfide bondi246 ↔ 2521 Publication
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96LB8.
    PRIDEiQ96LB8.

    PTM databases

    PhosphoSiteiQ96LB8.

    Expressioni

    Tissue specificityi

    Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus.2 Publications

    Inductioni

    Up-regulated by exposure to Gram-positive and Gram-negative bacteria.1 Publication

    Gene expression databases

    BgeeiQ96LB8.
    CleanExiHS_PGLYRP4.
    GenevestigatoriQ96LB8.

    Organism-specific databases

    HPAiCAB025879.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Heterodimer with PGLYRP3; disulfide-linked.2 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352672.

    Structurei

    Secondary structure

    1
    373
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi216 – 2194
    Beta strandi231 – 24010
    Helixi249 – 26517
    Beta strandi275 – 2784
    Beta strandi284 – 2885
    Beta strandi290 – 2923
    Turni298 – 3003
    Helixi301 – 3033
    Beta strandi304 – 3118
    Beta strandi314 – 3163
    Helixi320 – 33516
    Beta strandi338 – 34710
    Helixi348 – 3514
    Beta strandi352 – 3543
    Helixi359 – 3657

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EAVX-ray2.20A/B214-373[»]
    2EAXX-ray2.10A/B/C214-373[»]
    ProteinModelPortaliQ96LB8.
    SMRiQ96LB8. Positions 56-187, 210-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96LB8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni293 – 30210Interaction with murein
    Regioni353 – 3542Interaction with murein

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG241935.
    HOVERGENiHBG053579.
    InParanoidiQ96LB8.
    KOiK01446.
    OMAiHTAGRTC.
    OrthoDBiEOG757CZ5.
    PhylomeDBiQ96LB8.
    TreeFamiTF323898.

    Family and domain databases

    Gene3Di3.40.80.10. 2 hits.
    InterProiIPR002502. Amidase_domain.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view]
    PANTHERiPTHR11022. PTHR11022. 1 hit.
    PfamiPF01510. Amidase_2. 2 hits.
    [Graphical view]
    SMARTiSM00644. Ami_2. 2 hits.
    SM00701. PGRP. 2 hits.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96LB8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPWLLVFSA LGIQAWGDSS WNKTQAKQVS EGLQYLFENI SQLTEKGLPT    50
    DVSTTVSRKA WGAEAVGCSI QLTTPVNVLV IHHVPGLECH DQTVCSQRLR 100
    ELQAHHVHNN SGCDVAYNFL VGDDGRVYEG VGWNIQGVHT QGYNNISLGF 150
    AFFGTKKGHS PSPAALSAME NLITYAVQKG HLSSSYVQPL LGKGENCLAP 200
    RQKTSLKKAC PGVVPRSVWG ARETHCPRMT LPAKYGIIIH TAGRTCNISD 250
    ECRLLVRDIQ SFYIDRLKSC DIGYNFLVGQ DGAIYEGVGW NVQGSSTPGY 300
    DDIALGITFM GTFTGIPPNA AALEAAQDLI QCAMVKGYLT PNYLLVGHSD 350
    VARTLSPGQA LYNIISTWPH FKH 373
    Length:373
    Mass (Da):40,620
    Last modified:April 3, 2007 - v2
    Checksum:i8E882E1FF608F6F3
    GO
    Isoform 2 (identifier: Q96LB8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-50: Missing.

    Show »
    Length:369
    Mass (Da):40,252
    Checksum:i1D03920B70BDE735
    GO

    Sequence cautioni

    The sequence AAF99599.1 differs from that shown. Reason: Frameshift at positions 209, 224 and 227.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31P → L.2 Publications
    Corresponds to variant rs12096209 [ dbSNP | Ensembl ].
    VAR_050503
    Natural varianti13 – 131I → L.3 Publications
    Corresponds to variant rs3006458 [ dbSNP | Ensembl ].
    VAR_033283
    Natural varianti92 – 921Q → R.
    Corresponds to variant rs3006453 [ dbSNP | Ensembl ].
    VAR_031586
    Natural varianti192 – 1921G → V.3 Publications
    Corresponds to variant rs3006448 [ dbSNP | Ensembl ].
    VAR_031587
    Natural varianti213 – 2131V → I.2 Publications
    Corresponds to variant rs12063091 [ dbSNP | Ensembl ].
    VAR_031588
    Natural varianti301 – 3011D → N.
    Corresponds to variant rs35347202 [ dbSNP | Ensembl ].
    VAR_031589

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 504Missing in isoform 2. 1 PublicationVSP_024388

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035377 mRNA. Translation: AAK72485.1.
    AF242518 mRNA. Translation: AAF99599.1. Frameshift.
    AK292203 mRNA. Translation: BAF84892.1.
    AL591704 Genomic DNA. Translation: CAI19492.1.
    AL591704 Genomic DNA. Translation: CAI19493.1.
    BC142636 mRNA. Translation: AAI42637.1.
    BC107157 mRNA. Translation: AAI07158.1.
    BC107158 mRNA. Translation: AAI07159.1.
    CCDSiCCDS30871.1. [Q96LB8-1]
    RefSeqiNP_065126.2. NM_020393.2. [Q96LB8-1]
    UniGeneiHs.58356.

    Genome annotation databases

    EnsembliENST00000359650; ENSP00000352672; ENSG00000163218. [Q96LB8-1]
    ENST00000368739; ENSP00000357728; ENSG00000163218. [Q96LB8-2]
    GeneIDi57115.
    KEGGihsa:57115.
    UCSCiuc001fbo.3. human. [Q96LB8-1]
    uc001fbp.3. human. [Q96LB8-2]

    Polymorphism databases

    DMDMi143811439.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035377 mRNA. Translation: AAK72485.1 .
    AF242518 mRNA. Translation: AAF99599.1 . Frameshift.
    AK292203 mRNA. Translation: BAF84892.1 .
    AL591704 Genomic DNA. Translation: CAI19492.1 .
    AL591704 Genomic DNA. Translation: CAI19493.1 .
    BC142636 mRNA. Translation: AAI42637.1 .
    BC107157 mRNA. Translation: AAI07158.1 .
    BC107158 mRNA. Translation: AAI07159.1 .
    CCDSi CCDS30871.1. [Q96LB8-1 ]
    RefSeqi NP_065126.2. NM_020393.2. [Q96LB8-1 ]
    UniGenei Hs.58356.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EAV X-ray 2.20 A/B 214-373 [» ]
    2EAX X-ray 2.10 A/B/C 214-373 [» ]
    ProteinModelPortali Q96LB8.
    SMRi Q96LB8. Positions 56-187, 210-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352672.

    PTM databases

    PhosphoSitei Q96LB8.

    Polymorphism databases

    DMDMi 143811439.

    Proteomic databases

    PaxDbi Q96LB8.
    PRIDEi Q96LB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359650 ; ENSP00000352672 ; ENSG00000163218 . [Q96LB8-1 ]
    ENST00000368739 ; ENSP00000357728 ; ENSG00000163218 . [Q96LB8-2 ]
    GeneIDi 57115.
    KEGGi hsa:57115.
    UCSCi uc001fbo.3. human. [Q96LB8-1 ]
    uc001fbp.3. human. [Q96LB8-2 ]

    Organism-specific databases

    CTDi 57115.
    GeneCardsi GC01M153302.
    H-InvDB HIX0028539.
    HGNCi HGNC:30015. PGLYRP4.
    HPAi CAB025879.
    MIMi 608198. gene.
    neXtProti NX_Q96LB8.
    PharmGKBi PA134902492.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241935.
    HOVERGENi HBG053579.
    InParanoidi Q96LB8.
    KOi K01446.
    OMAi HTAGRTC.
    OrthoDBi EOG757CZ5.
    PhylomeDBi Q96LB8.
    TreeFami TF323898.

    Miscellaneous databases

    EvolutionaryTracei Q96LB8.
    GenomeRNAii 57115.
    NextBioi 62975.
    PROi Q96LB8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96LB8.
    CleanExi HS_PGLYRP4.
    Genevestigatori Q96LB8.

    Family and domain databases

    Gene3Di 3.40.80.10. 2 hits.
    InterProi IPR002502. Amidase_domain.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view ]
    PANTHERi PTHR11022. PTHR11022. 1 hit.
    Pfami PF01510. Amidase_2. 2 hits.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 2 hits.
    SM00701. PGRP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules."
      Liu C., Xu Z., Gupta D., Dziarski R.
      J. Biol. Chem. 276:34686-34694(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS LEU-13 AND VAL-192.
    2. Zhang W., Wan T., Cao X.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS LEU-3 AND ILE-213.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-13 AND VAL-192.
      Tissue: Esophagus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-3; LEU-13; VAL-192 AND ILE-213.
    6. "Peptidoglycan recognition proteins are a new class of human bactericidal proteins."
      Lu X., Wang M., Qi J., Wang H., Li X., Gupta D., Dziarski R.
      J. Biol. Chem. 281:5895-5907(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, GLYCOSYLATION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins."
      Cho S., Wang Q., Swaminathan C.P., Hesek D., Lee M., Boons G.-J., Mobashery S., Mariuzza R.A.
      Proc. Natl. Acad. Sci. U.S.A. 104:8761-8766(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 210-373 IN COMPLEX WITH PEPTIDOGLYCAN-PEPTIDE, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPGRP4_HUMAN
    AccessioniPrimary (citable) accession number: Q96LB8
    Secondary accession number(s): A8K838
    , Q3B822, Q3B823, Q5SY63, Q5SY64, Q9HD75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3