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Protein

V-type proton ATPase subunit G 3

Gene

ATP6V1G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. ATPase binding Source: UniProtKB
  2. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

  1. cellular iron ion homeostasis Source: Reactome
  2. insulin receptor signaling pathway Source: Reactome
  3. interaction with host Source: Reactome
  4. phagosome maturation Source: Reactome
  5. transferrin transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS07734-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Name:ATP6V1G3
Synonyms:ATP6G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 1, Unplaced

Organism-specific databases

HGNCiHGNC:18265. ATP6V1G3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. vacuolar proton-transporting V-type ATPase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 3PRO_0000192904Add
BLAST

Proteomic databases

PaxDbiQ96LB4.
PRIDEiQ96LB4.

PTM databases

PhosphoSiteiQ96LB4.

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiQ96LB4.
CleanExiHS_ATP6V1G3.
GenevestigatoriQ96LB4.

Organism-specific databases

HPAiHPA028701.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Protein-protein interaction databases

BioGridi126042. 1 interaction.
STRINGi9606.ENSP00000281087.

Structurei

3D structure databases

ProteinModelPortaliQ96LB4.
SMRiQ96LB4. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5450Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG235870.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ96LB4.
KOiK02152.
OMAiHVNYRAT.
OrthoDBiEOG7MWH0X.
PhylomeDBiQ96LB4.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ
60 70 80 90 100
RDKEFRLKQS KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL
110
SMVCDMKPEI HVNYRATN
Length:118
Mass (Da):13,917
Last modified:December 1, 2001 - v1
Checksum:i651F8F5497164754
GO
Isoform 2 (identifier: Q96LB4-2)

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q96LB4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-118: RKGKRLKQAK...EIHVNYRATN → ILHLLFLKRRDWDCFWKRKAIEASQGGSNGRN

Show »
Length:59
Mass (Da):6,895
Checksum:i2EDA379DF6385E11
GO
Isoform 4 (identifier: Q96LB4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: R → KTGTASG

Note: No experimental confirmation available.

Show »
Length:124
Mass (Da):14,363
Checksum:iE80336A5FFDF483A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541E → Q.
Corresponds to variant rs16843254 [ dbSNP | Ensembl ].
VAR_048343

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 11891RKGKR…YRATN → ILHLLFLKRRDWDCFWKRKA IEASQGGSNGRN in isoform 3. 1 PublicationVSP_036423Add
BLAST
Alternative sequencei28 – 281R → KTGTASG in isoform 4. 1 PublicationVSP_036426

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039760 mRNA. Translation: AAK83465.1.
AL157402 Genomic DNA. Translation: CAI15638.1.
BC101129 mRNA. Translation: AAI01130.1.
BC101130 mRNA. Translation: AAI01131.1.
BC101131 mRNA. Translation: AAI01132.2.
CCDSiCCDS1395.1. [Q96LB4-1]
CCDS1396.1. [Q96LB4-3]
RefSeqiNP_573569.1. NM_133262.2. [Q96LB4-1]
NP_579872.1. NM_133326.1. [Q96LB4-3]
XP_006711226.1. XM_006711163.1. [Q96LB4-1]
XP_006725021.1. XM_006724958.1. [Q96LB4-1]
UniGeneiHs.127743.

Genome annotation databases

EnsembliENST00000281087; ENSP00000281087; ENSG00000151418. [Q96LB4-1]
ENST00000309309; ENSP00000309574; ENSG00000151418. [Q96LB4-3]
ENST00000367381; ENSP00000356351; ENSG00000263014. [Q96LB4-1]
ENST00000367382; ENSP00000356352; ENSG00000151418. [Q96LB4-1]
ENST00000489986; ENSP00000417171; ENSG00000151418. [Q96LB4-4]
ENST00000571439; ENSP00000461616; ENSG00000263014. [Q96LB4-3]
ENST00000573121; ENSP00000461329; ENSG00000263014. [Q96LB4-1]
ENST00000575971; ENSP00000461228; ENSG00000263014. [Q96LB4-4]
GeneIDi127124.
KEGGihsa:127124.
UCSCiuc001guo.3. human. [Q96LB4-3]
uc001gup.3. human. [Q96LB4-1]
uc009wzd.3. human. [Q96LB4-4]

Polymorphism databases

DMDMi20140697.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039760 mRNA. Translation: AAK83465.1.
AL157402 Genomic DNA. Translation: CAI15638.1.
BC101129 mRNA. Translation: AAI01130.1.
BC101130 mRNA. Translation: AAI01131.1.
BC101131 mRNA. Translation: AAI01132.2.
CCDSiCCDS1395.1. [Q96LB4-1]
CCDS1396.1. [Q96LB4-3]
RefSeqiNP_573569.1. NM_133262.2. [Q96LB4-1]
NP_579872.1. NM_133326.1. [Q96LB4-3]
XP_006711226.1. XM_006711163.1. [Q96LB4-1]
XP_006725021.1. XM_006724958.1. [Q96LB4-1]
UniGeneiHs.127743.

3D structure databases

ProteinModelPortaliQ96LB4.
SMRiQ96LB4. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126042. 1 interaction.
STRINGi9606.ENSP00000281087.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteiQ96LB4.

Polymorphism databases

DMDMi20140697.

Proteomic databases

PaxDbiQ96LB4.
PRIDEiQ96LB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281087; ENSP00000281087; ENSG00000151418. [Q96LB4-1]
ENST00000309309; ENSP00000309574; ENSG00000151418. [Q96LB4-3]
ENST00000367381; ENSP00000356351; ENSG00000263014. [Q96LB4-1]
ENST00000367382; ENSP00000356352; ENSG00000151418. [Q96LB4-1]
ENST00000489986; ENSP00000417171; ENSG00000151418. [Q96LB4-4]
ENST00000571439; ENSP00000461616; ENSG00000263014. [Q96LB4-3]
ENST00000573121; ENSP00000461329; ENSG00000263014. [Q96LB4-1]
ENST00000575971; ENSP00000461228; ENSG00000263014. [Q96LB4-4]
GeneIDi127124.
KEGGihsa:127124.
UCSCiuc001guo.3. human. [Q96LB4-3]
uc001gup.3. human. [Q96LB4-1]
uc009wzd.3. human. [Q96LB4-4]

Organism-specific databases

CTDi127124.
GeneCardsiGC01M198492.
HGNCiHGNC:18265. ATP6V1G3.
HPAiHPA028701.
neXtProtiNX_Q96LB4.
PharmGKBiPA38515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG235870.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ96LB4.
KOiK02152.
OMAiHVNYRAT.
OrthoDBiEOG7MWH0X.
PhylomeDBiQ96LB4.
TreeFamiTF313777.

Enzyme and pathway databases

BioCyciMetaCyc:HS07734-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikiiATP6V1G3.
GenomeRNAii127124.
NextBioi82029.
PROiQ96LB4.

Gene expression databases

BgeeiQ96LB4.
CleanExiHS_ATP6V1G3.
GenevestigatoriQ96LB4.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
    Smith A.N., Borthwick K.J., Karet F.E.
    Gene 297:169-177(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).

Entry informationi

Entry nameiVATG3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB4
Secondary accession number(s): Q495K2, Q495K4, Q5T9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.