Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit G 3

Gene

ATP6V1G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Caution

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • proton-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS07734-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Name:ATP6V1G3
Synonyms:ATP6G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000151418.11
HGNCiHGNC:18265 ATP6V1G3
neXtProtiNX_Q96LB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi127124
OpenTargetsiENSG00000151418
PharmGKBiPA38515

Polymorphism and mutation databases

BioMutaiATP6V1G3
DMDMi20140697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929041 – 118V-type proton ATPase subunit G 3Add BLAST118

Proteomic databases

PaxDbiQ96LB4
PeptideAtlasiQ96LB4
PRIDEiQ96LB4

PTM databases

iPTMnetiQ96LB4
PhosphoSitePlusiQ96LB4

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiENSG00000151418
CleanExiHS_ATP6V1G3
GenevisibleiQ96LB4 HS

Organism-specific databases

HPAiHPA028701

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1260421 interactor.
IntActiQ96LB4 1 interactor.
STRINGi9606.ENSP00000281087

Structurei

3D structure databases

ProteinModelPortaliQ96LB4
SMRiQ96LB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 54Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiQ96LB4
KOiK02152
OMAiYNKYMES
OrthoDBiEOG091G0XIZ
PhylomeDBiQ96LB4
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ
60 70 80 90 100
RDKEFRLKQS KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL
110
SMVCDMKPEI HVNYRATN
Length:118
Mass (Da):13,917
Last modified:December 1, 2001 - v1
Checksum:i651F8F5497164754
GO
Isoform 2 (identifier: Q96LB4-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q96LB4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-118: RKGKRLKQAK...EIHVNYRATN → ILHLLFLKRRDWDCFWKRKAIEASQGGSNGRN

Show »
Length:59
Mass (Da):6,895
Checksum:i2EDA379DF6385E11
GO
Isoform 4 (identifier: Q96LB4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: R → KTGTASG

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):14,363
Checksum:iE80336A5FFDF483A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04834354E → Q. Corresponds to variant dbSNP:rs16843254Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03642328 – 118RKGKR…YRATN → ILHLLFLKRRDWDCFWKRKA IEASQGGSNGRN in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_03642628R → KTGTASG in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039760 mRNA Translation: AAK83465.1
AL157402 Genomic DNA Translation: CAI15638.1
BC101129 mRNA Translation: AAI01130.1
BC101130 mRNA Translation: AAI01131.1
BC101131 mRNA Translation: AAI01132.2
CCDSiCCDS1395.1 [Q96LB4-1]
CCDS1396.1 [Q96LB4-3]
CCDS81414.1 [Q96LB4-4]
RefSeqiNP_001307147.1, NM_001320218.1 [Q96LB4-4]
NP_573569.1, NM_133262.2 [Q96LB4-1]
NP_579872.1, NM_133326.1 [Q96LB4-3]
XP_006711226.1, XM_006711163.3 [Q96LB4-1]
XP_011507488.1, XM_011509186.2 [Q96LB4-4]
XP_011507489.1, XM_011509187.2 [Q96LB4-3]
UniGeneiHs.127743

Genome annotation databases

EnsembliENST00000281087; ENSP00000281087; ENSG00000151418 [Q96LB4-1]
ENST00000309309; ENSP00000309574; ENSG00000151418 [Q96LB4-3]
ENST00000367381; ENSP00000356351; ENSG00000263014 [Q96LB4-1]
ENST00000367382; ENSP00000356352; ENSG00000151418 [Q96LB4-1]
ENST00000489986; ENSP00000417171; ENSG00000151418 [Q96LB4-4]
ENST00000571439; ENSP00000461616; ENSG00000263014 [Q96LB4-3]
ENST00000573121; ENSP00000461329; ENSG00000263014 [Q96LB4-1]
ENST00000575971; ENSP00000461228; ENSG00000263014 [Q96LB4-4]
GeneIDi127124
KEGGihsa:127124
UCSCiuc001guo.3 human [Q96LB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVATG3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB4
Secondary accession number(s): Q495K2, Q495K4, Q5T9L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome