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Q96LB4 (VATG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit G 3

Short name=V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene names
Name:ATP6V1G3
Synonyms:ATP6G3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) By similarity.

Tissue specificity

Kidney. Ref.1

Sequence similarities

Belongs to the V-ATPase G subunit family.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96LB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96LB4-2)

The sequence of this isoform is not available.
Isoform 3 (identifier: Q96LB4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     28-118: RKGKRLKQAK...EIHVNYRATN → ILHLLFLKRRDWDCFWKRKAIEASQGGSNGRN
Isoform 4 (identifier: Q96LB4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: R → KTGTASG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118V-type proton ATPase subunit G 3
PRO_0000192904

Regions

Coiled coil5 – 5450 Potential

Natural variations

Alternative sequence28 – 11891RKGKR…YRATN → ILHLLFLKRRDWDCFWKRKA IEASQGGSNGRN in isoform 3.
VSP_036423
Alternative sequence281R → KTGTASG in isoform 4.
VSP_036426
Natural variant541E → Q.
Corresponds to variant rs16843254 [ dbSNP | Ensembl ].
VAR_048343

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 651F8F5497164754

FASTA11813,917
        10         20         30         40         50         60 
MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ RDKEFRLKQS 

        70         80         90        100        110 
KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL SMVCDMKPEI HVNYRATN 

« Hide

Isoform 2 (Sequence not available).
Isoform 3 [UniParc].

Checksum: 2EDA379DF6385E11
Show »

FASTA596,895
Isoform 4 [UniParc].

Checksum: E80336A5FFDF483A
Show »

FASTA12414,363

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
Smith A.N., Borthwick K.J., Karet F.E.
Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY039760 mRNA. Translation: AAK83465.1.
AL157402 Genomic DNA. Translation: CAI15638.1.
BC101129 mRNA. Translation: AAI01130.1.
BC101130 mRNA. Translation: AAI01131.1.
BC101131 mRNA. Translation: AAI01132.2.
CCDSCCDS1395.1. [Q96LB4-1]
CCDS1396.1. [Q96LB4-3]
RefSeqNP_573569.1. NM_133262.2. [Q96LB4-1]
NP_579872.1. NM_133326.1. [Q96LB4-3]
XP_006711226.1. XM_006711163.1. [Q96LB4-1]
XP_006725021.1. XM_006724958.1. [Q96LB4-1]
UniGeneHs.127743.

3D structure databases

ProteinModelPortalQ96LB4.
SMRQ96LB4. Positions 3-81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000281087.

Protein family/group databases

TCDB3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteQ96LB4.

Polymorphism databases

DMDM20140697.

Proteomic databases

PaxDbQ96LB4.
PRIDEQ96LB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281087; ENSP00000281087; ENSG00000151418. [Q96LB4-1]
ENST00000309309; ENSP00000309574; ENSG00000151418. [Q96LB4-3]
ENST00000367381; ENSP00000356351; ENSG00000151418. [Q96LB4-4]
ENST00000367382; ENSP00000356352; ENSG00000151418. [Q96LB4-1]
ENST00000489986; ENSP00000417171; ENSG00000151418. [Q96LB4-4]
ENST00000571439; ENSP00000461616; ENSG00000263014. [Q96LB4-3]
ENST00000573121; ENSP00000461329; ENSG00000263014. [Q96LB4-1]
ENST00000575971; ENSP00000461228; ENSG00000263014. [Q96LB4-4]
GeneID127124.
KEGGhsa:127124.
UCSCuc001guo.3. human. [Q96LB4-3]
uc001gup.3. human. [Q96LB4-1]
uc009wzd.3. human. [Q96LB4-4]

Organism-specific databases

CTD127124.
GeneCardsGC01M198492.
HGNCHGNC:18265. ATP6V1G3.
HPAHPA028701.
neXtProtNX_Q96LB4.
PharmGKBPA38515.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235870.
HOGENOMHOG000186416.
HOVERGENHBG057827.
KOK02152.
OMAHDEEFAT.
OrthoDBEOG7MWH0X.
PhylomeDBQ96LB4.
TreeFamTF313777.

Enzyme and pathway databases

BioCycMetaCyc:HS07734-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ96LB4.
CleanExHS_ATP6V1G3.
GenevestigatorQ96LB4.

Family and domain databases

InterProIPR005124. V-ATPase_G.
[Graphical view]
PANTHERPTHR12713. PTHR12713. 1 hit.
TIGRFAMsTIGR01147. V_ATP_synt_G. 1 hit.
ProtoNetSearch...

Other

GeneWikiATP6V1G3.
GenomeRNAi127124.
NextBio82029.
PROQ96LB4.

Entry information

Entry nameVATG3_HUMAN
AccessionPrimary (citable) accession number: Q96LB4
Secondary accession number(s): Q495K2, Q495K4, Q5T9L6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM