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Q96LB4

- VATG3_HUMAN

UniProt

Q96LB4 - VATG3_HUMAN

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Protein

V-type proton ATPase subunit G 3

Gene
ATP6V1G3, ATP6G3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. ATPase binding Source: UniProtKB
  2. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

  1. cellular iron ion homeostasis Source: Reactome
  2. insulin receptor signaling pathway Source: Reactome
  3. interaction with host Source: Reactome
  4. phagosome maturation Source: Reactome
  5. transferrin transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS07734-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 3
Short name:
V-ATPase subunit G 3
Alternative name(s):
V-ATPase 13 kDa subunit 3
Vacuolar proton pump subunit G 3
Gene namesi
Synonyms:ATP6G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18265. ATP6V1G3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. vacuolar proton-transporting V-type ATPase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 3PRO_0000192904Add
BLAST

Proteomic databases

PaxDbiQ96LB4.
PRIDEiQ96LB4.

PTM databases

PhosphoSiteiQ96LB4.

Expressioni

Tissue specificityi

Kidney.1 Publication

Gene expression databases

BgeeiQ96LB4.
CleanExiHS_ATP6V1G3.
GenevestigatoriQ96LB4.

Organism-specific databases

HPAiHPA028701.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000281087.

Structurei

3D structure databases

ProteinModelPortaliQ96LB4.
SMRiQ96LB4. Positions 3-81.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5450 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG235870.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
KOiK02152.
OMAiHDEEFAT.
OrthoDBiEOG7MWH0X.
PhylomeDBiQ96LB4.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96LB4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ    50
RDKEFRLKQS KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL 100
SMVCDMKPEI HVNYRATN 118
Length:118
Mass (Da):13,917
Last modified:December 1, 2001 - v1
Checksum:i651F8F5497164754
GO
Isoform 2 (identifier: Q96LB4-2)

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q96LB4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-118: RKGKRLKQAK...EIHVNYRATN → ILHLLFLKRRDWDCFWKRKAIEASQGGSNGRN

Show »
Length:59
Mass (Da):6,895
Checksum:i2EDA379DF6385E11
GO
Isoform 4 (identifier: Q96LB4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: R → KTGTASG

Note: No experimental confirmation available.

Show »
Length:124
Mass (Da):14,363
Checksum:iE80336A5FFDF483A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541E → Q.
Corresponds to variant rs16843254 [ dbSNP | Ensembl ].
VAR_048343

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 11891RKGKR…YRATN → ILHLLFLKRRDWDCFWKRKA IEASQGGSNGRN in isoform 3. VSP_036423Add
BLAST
Alternative sequencei28 – 281R → KTGTASG in isoform 4. VSP_036426

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039760 mRNA. Translation: AAK83465.1.
AL157402 Genomic DNA. Translation: CAI15638.1.
BC101129 mRNA. Translation: AAI01130.1.
BC101130 mRNA. Translation: AAI01131.1.
BC101131 mRNA. Translation: AAI01132.2.
CCDSiCCDS1395.1. [Q96LB4-1]
CCDS1396.1. [Q96LB4-3]
RefSeqiNP_573569.1. NM_133262.2. [Q96LB4-1]
NP_579872.1. NM_133326.1. [Q96LB4-3]
XP_006711226.1. XM_006711163.1. [Q96LB4-1]
XP_006725021.1. XM_006724958.1. [Q96LB4-1]
UniGeneiHs.127743.

Genome annotation databases

EnsembliENST00000281087; ENSP00000281087; ENSG00000151418. [Q96LB4-1]
ENST00000309309; ENSP00000309574; ENSG00000151418. [Q96LB4-3]
ENST00000367381; ENSP00000356351; ENSG00000151418. [Q96LB4-4]
ENST00000367382; ENSP00000356352; ENSG00000151418. [Q96LB4-1]
ENST00000489986; ENSP00000417171; ENSG00000151418. [Q96LB4-4]
ENST00000571439; ENSP00000461616; ENSG00000263014. [Q96LB4-3]
ENST00000573121; ENSP00000461329; ENSG00000263014. [Q96LB4-1]
ENST00000575971; ENSP00000461228; ENSG00000263014. [Q96LB4-4]
GeneIDi127124.
KEGGihsa:127124.
UCSCiuc001guo.3. human. [Q96LB4-3]
uc001gup.3. human. [Q96LB4-1]
uc009wzd.3. human. [Q96LB4-4]

Polymorphism databases

DMDMi20140697.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY039760 mRNA. Translation: AAK83465.1 .
AL157402 Genomic DNA. Translation: CAI15638.1 .
BC101129 mRNA. Translation: AAI01130.1 .
BC101130 mRNA. Translation: AAI01131.1 .
BC101131 mRNA. Translation: AAI01132.2 .
CCDSi CCDS1395.1. [Q96LB4-1 ]
CCDS1396.1. [Q96LB4-3 ]
RefSeqi NP_573569.1. NM_133262.2. [Q96LB4-1 ]
NP_579872.1. NM_133326.1. [Q96LB4-3 ]
XP_006711226.1. XM_006711163.1. [Q96LB4-1 ]
XP_006725021.1. XM_006724958.1. [Q96LB4-1 ]
UniGenei Hs.127743.

3D structure databases

ProteinModelPortali Q96LB4.
SMRi Q96LB4. Positions 3-81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000281087.

Protein family/group databases

TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei Q96LB4.

Polymorphism databases

DMDMi 20140697.

Proteomic databases

PaxDbi Q96LB4.
PRIDEi Q96LB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281087 ; ENSP00000281087 ; ENSG00000151418 . [Q96LB4-1 ]
ENST00000309309 ; ENSP00000309574 ; ENSG00000151418 . [Q96LB4-3 ]
ENST00000367381 ; ENSP00000356351 ; ENSG00000151418 . [Q96LB4-4 ]
ENST00000367382 ; ENSP00000356352 ; ENSG00000151418 . [Q96LB4-1 ]
ENST00000489986 ; ENSP00000417171 ; ENSG00000151418 . [Q96LB4-4 ]
ENST00000571439 ; ENSP00000461616 ; ENSG00000263014 . [Q96LB4-3 ]
ENST00000573121 ; ENSP00000461329 ; ENSG00000263014 . [Q96LB4-1 ]
ENST00000575971 ; ENSP00000461228 ; ENSG00000263014 . [Q96LB4-4 ]
GeneIDi 127124.
KEGGi hsa:127124.
UCSCi uc001guo.3. human. [Q96LB4-3 ]
uc001gup.3. human. [Q96LB4-1 ]
uc009wzd.3. human. [Q96LB4-4 ]

Organism-specific databases

CTDi 127124.
GeneCardsi GC01M198492.
HGNCi HGNC:18265. ATP6V1G3.
HPAi HPA028701.
neXtProti NX_Q96LB4.
PharmGKBi PA38515.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235870.
HOGENOMi HOG000186416.
HOVERGENi HBG057827.
KOi K02152.
OMAi HDEEFAT.
OrthoDBi EOG7MWH0X.
PhylomeDBi Q96LB4.
TreeFami TF313777.

Enzyme and pathway databases

BioCyci MetaCyc:HS07734-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

GeneWikii ATP6V1G3.
GenomeRNAii 127124.
NextBioi 82029.
PROi Q96LB4.

Gene expression databases

Bgeei Q96LB4.
CleanExi HS_ATP6V1G3.
Genevestigatori Q96LB4.

Family and domain databases

InterProi IPR005124. V-ATPase_G.
[Graphical view ]
PANTHERi PTHR12713. PTHR12713. 1 hit.
TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
    Smith A.N., Borthwick K.J., Karet F.E.
    Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).

Entry informationi

Entry nameiVATG3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB4
Secondary accession number(s): Q495K2, Q495K4, Q5T9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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