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Protein

Mas-related G-protein coupled receptor member X2

Gene

MRGPRX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.By similarity1 Publication6 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB
  • mast cell secretagogue receptor activity Source: UniProtKB
  • neuropeptide binding Source: UniProtKB

GO - Biological processi

  • mast cell activation Source: UniProtKB
  • mast cell degranulation Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • sensory perception of pain Source: UniProtKB
  • sleep Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31459-MONOMER.
SIGNORiQ96LB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X2
Gene namesi
Name:MRGPRX2
Synonyms:MRGX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17983. MRGPRX2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 63CytoplasmicSequence analysis9
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 96ExtracellularSequence analysisAdd BLAST12
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 144CytoplasmicSequence analysisAdd BLAST27
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 184ExtracellularSequence analysisAdd BLAST19
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 228CytoplasmicSequence analysisAdd BLAST23
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 264ExtracellularSequence analysisAdd BLAST15
Transmembranei265 – 285Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini286 – 330CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • mast cell granule Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi117194.
OpenTargetsiENSG00000183695.
PharmGKBiPA142671335.

Chemistry databases

ChEMBLiCHEMBL5849.
GuidetoPHARMACOLOGYi157.

Polymorphism and mutation databases

BioMutaiMRGPRX2.
DMDMi50401127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697751 – 330Mas-related G-protein coupled receptor member X2Add BLAST330

Proteomic databases

PaxDbiQ96LB1.
PeptideAtlasiQ96LB1.
PRIDEiQ96LB1.

Expressioni

Tissue specificityi

Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).2 Publications

Gene expression databases

BgeeiENSG00000183695.
GenevisibleiQ96LB1. HS.

Organism-specific databases

HPAiHPA055220.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333800.

Chemistry databases

BindingDBiQ96LB1.

Structurei

3D structure databases

ProteinModelPortaliQ96LB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ96LB1.
KOiK08396.
OMAiFCHIHPV.
OrthoDBiEOG091G0CSX.
PhylomeDBiQ96LB1.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTTPAWGT ESTTVNGNDQ ALLLLCGKET LIPVFLILFI ALVGLVGNGF
60 70 80 90 100
VLWLLGFRMR RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSISIN
110 120 130 140 150
FPSFFTTVMT CAYLAGLSML STVSTERCLS VLWPIWYRCR RPRHLSAVVC
160 170 180 190 200
VLLWALSLLL SILEGKFCGF LFSDGDSGWC QTFDFITAAW LIFLFMVLCG
210 220 230 240 250
SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG IQWFLILWIW
260 270 280 290 300
KDSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGSFRKQWR LQQPILKLAL
310 320 330
QRALQDIAEV DHSEGCFRQG TPEMSRSSLV
Length:330
Mass (Da):37,099
Last modified:December 1, 2001 - v1
Checksum:i0B328FD78B1DF6BE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02473916N → H.1 PublicationCorresponds to variant rs11024970dbSNPEnsembl.1
Natural variantiVAR_04941843V → I.Corresponds to variant rs11823569dbSNPEnsembl.1
Natural variantiVAR_01943362N → S.2 PublicationsCorresponds to variant rs10833049dbSNPEnsembl.1
Natural variantiVAR_02474078F → L.1 PublicationCorresponds to variant rs79763999dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042214 Genomic DNA. Translation: AAK91805.1.
HG426071 Genomic DNA. Translation: CDG86189.1.
AY651130 Genomic DNA. Translation: AAW70043.1.
AY651131 Genomic DNA. Translation: AAW70044.1.
AY651132 Genomic DNA. Translation: AAW70045.1.
AY651133 Genomic DNA. Translation: AAW70046.1.
AY651134 Genomic DNA. Translation: AAW70047.1.
AY651135 Genomic DNA. Translation: AAW70048.1.
AY651136 Genomic DNA. Translation: AAW70049.1.
AY651137 Genomic DNA. Translation: AAW70050.1.
AY651138 Genomic DNA. Translation: AAW70051.1.
AY651139 Genomic DNA. Translation: AAW70052.1.
AY651140 Genomic DNA. Translation: AAW70053.1.
AY651141 Genomic DNA. Translation: AAW70054.1.
AY651142 Genomic DNA. Translation: AAW70055.1.
AY651143 Genomic DNA. Translation: AAW70056.1.
AY651144 Genomic DNA. Translation: AAW70057.1.
AY651145 Genomic DNA. Translation: AAW70058.1.
AY651146 Genomic DNA. Translation: AAW70059.1.
AY651147 Genomic DNA. Translation: AAW70060.1.
AY651148 Genomic DNA. Translation: AAW70061.1.
AY651149 Genomic DNA. Translation: AAW70062.1.
AY651150 Genomic DNA. Translation: AAW70063.1.
AY651151 Genomic DNA. Translation: AAW70064.1.
AY651152 Genomic DNA. Translation: AAW70065.1.
AY651153 Genomic DNA. Translation: AAW70066.1.
AY651154 Genomic DNA. Translation: AAW70067.1.
AY651155 Genomic DNA. Translation: AAW70068.1.
AY651156 Genomic DNA. Translation: AAW70069.1.
AY651157 Genomic DNA. Translation: AAW70070.1.
AY651158 Genomic DNA. Translation: AAW70071.1.
AY651159 Genomic DNA. Translation: AAW70072.1.
AY651160 Genomic DNA. Translation: AAW70073.1.
AY651161 Genomic DNA. Translation: AAW70074.1.
AY845175 Genomic DNA. Translation: AAW70082.1.
AY845176 Genomic DNA. Translation: AAW70083.1.
EU883579 Genomic DNA. Translation: ACG60653.1.
AB083626 Genomic DNA. Translation: BAB89339.1.
AB065811 Genomic DNA. Translation: BAC06030.1.
CH471064 Genomic DNA. Translation: EAW68359.1.
BC063450 mRNA. Translation: AAH63450.1.
CCDSiCCDS7847.1.
RefSeqiNP_001290544.1. NM_001303615.1.
NP_473371.1. NM_054030.3.
UniGeneiHs.350566.

Genome annotation databases

EnsembliENST00000329773; ENSP00000333800; ENSG00000183695.
GeneIDi117194.
KEGGihsa:117194.
UCSCiuc001mph.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042214 Genomic DNA. Translation: AAK91805.1.
HG426071 Genomic DNA. Translation: CDG86189.1.
AY651130 Genomic DNA. Translation: AAW70043.1.
AY651131 Genomic DNA. Translation: AAW70044.1.
AY651132 Genomic DNA. Translation: AAW70045.1.
AY651133 Genomic DNA. Translation: AAW70046.1.
AY651134 Genomic DNA. Translation: AAW70047.1.
AY651135 Genomic DNA. Translation: AAW70048.1.
AY651136 Genomic DNA. Translation: AAW70049.1.
AY651137 Genomic DNA. Translation: AAW70050.1.
AY651138 Genomic DNA. Translation: AAW70051.1.
AY651139 Genomic DNA. Translation: AAW70052.1.
AY651140 Genomic DNA. Translation: AAW70053.1.
AY651141 Genomic DNA. Translation: AAW70054.1.
AY651142 Genomic DNA. Translation: AAW70055.1.
AY651143 Genomic DNA. Translation: AAW70056.1.
AY651144 Genomic DNA. Translation: AAW70057.1.
AY651145 Genomic DNA. Translation: AAW70058.1.
AY651146 Genomic DNA. Translation: AAW70059.1.
AY651147 Genomic DNA. Translation: AAW70060.1.
AY651148 Genomic DNA. Translation: AAW70061.1.
AY651149 Genomic DNA. Translation: AAW70062.1.
AY651150 Genomic DNA. Translation: AAW70063.1.
AY651151 Genomic DNA. Translation: AAW70064.1.
AY651152 Genomic DNA. Translation: AAW70065.1.
AY651153 Genomic DNA. Translation: AAW70066.1.
AY651154 Genomic DNA. Translation: AAW70067.1.
AY651155 Genomic DNA. Translation: AAW70068.1.
AY651156 Genomic DNA. Translation: AAW70069.1.
AY651157 Genomic DNA. Translation: AAW70070.1.
AY651158 Genomic DNA. Translation: AAW70071.1.
AY651159 Genomic DNA. Translation: AAW70072.1.
AY651160 Genomic DNA. Translation: AAW70073.1.
AY651161 Genomic DNA. Translation: AAW70074.1.
AY845175 Genomic DNA. Translation: AAW70082.1.
AY845176 Genomic DNA. Translation: AAW70083.1.
EU883579 Genomic DNA. Translation: ACG60653.1.
AB083626 Genomic DNA. Translation: BAB89339.1.
AB065811 Genomic DNA. Translation: BAC06030.1.
CH471064 Genomic DNA. Translation: EAW68359.1.
BC063450 mRNA. Translation: AAH63450.1.
CCDSiCCDS7847.1.
RefSeqiNP_001290544.1. NM_001303615.1.
NP_473371.1. NM_054030.3.
UniGeneiHs.350566.

3D structure databases

ProteinModelPortaliQ96LB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333800.

Chemistry databases

BindingDBiQ96LB1.
ChEMBLiCHEMBL5849.
GuidetoPHARMACOLOGYi157.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMRGPRX2.
DMDMi50401127.

Proteomic databases

PaxDbiQ96LB1.
PeptideAtlasiQ96LB1.
PRIDEiQ96LB1.

Protocols and materials databases

DNASUi117194.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329773; ENSP00000333800; ENSG00000183695.
GeneIDi117194.
KEGGihsa:117194.
UCSCiuc001mph.4. human.

Organism-specific databases

CTDi117194.
DisGeNETi117194.
GeneCardsiMRGPRX2.
HGNCiHGNC:17983. MRGPRX2.
HPAiHPA055220.
MIMi607228. gene.
neXtProtiNX_Q96LB1.
OpenTargetsiENSG00000183695.
PharmGKBiPA142671335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ96LB1.
KOiK08396.
OMAiFCHIHPV.
OrthoDBiEOG091G0CSX.
PhylomeDBiQ96LB1.
TreeFamiTF336336.

Enzyme and pathway databases

BioCyciZFISH:G66-31459-MONOMER.
SIGNORiQ96LB1.

Miscellaneous databases

GeneWikiiMRGPRX2.
GenomeRNAii117194.
PROiQ96LB1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183695.
GenevisibleiQ96LB1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGX2_HUMAN
AccessioniPrimary (citable) accession number: Q96LB1
Secondary accession number(s): B5B0C7
, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, W8W3L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.