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Protein

Mas-related G-protein coupled receptor member X3

Gene

MRGPRX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179826-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X3
Alternative name(s):
Sensory neuron-specific G-protein coupled receptor 1/2
Gene namesi
Name:MRGPRX3
Synonyms:MRGX3, SNSR1, SNSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17980. MRGPRX3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 96ExtracellularSequence analysisAdd BLAST15
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 140CytoplasmicSequence analysisAdd BLAST23
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 177ExtracellularSequence analysisAdd BLAST16
Transmembranei178 – 198Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini199 – 213CytoplasmicSequence analysisAdd BLAST15
Transmembranei214 – 234Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini235 – 254ExtracellularSequence analysisAdd BLAST20
Transmembranei255 – 275Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini276 – 322CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi117195.
OpenTargetsiENSG00000179826.
PharmGKBiPA142671336.

Polymorphism and mutation databases

BioMutaiMRGPRX3.
DMDMi311033400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697821 – 322Mas-related G-protein coupled receptor member X3Add BLAST322

Proteomic databases

PaxDbiQ96LB0.
PRIDEiQ96LB0.

Expressioni

Tissue specificityi

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.1 Publication

Gene expression databases

BgeeiENSG00000179826.
CleanExiHS_MRGPRX3.
ExpressionAtlasiQ96LB0. baseline and differential.
GenevisibleiQ96LB0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000379571.

Structurei

3D structure databases

ProteinModelPortaliQ96LB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ96LB0.
KOiK08396.
OMAiRIHLDWK.
OrthoDBiEOG091G0CSX.
PhylomeDBiQ96LB0.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTIPVLGT ELTPINGREE TPCYKQTLSF TGLTCIVSLV ALTGNAVVLW
60 70 80 90 100
LLGCRMRRNA VSIYILNLVA ADFLFLSGHI ICSPLRLINI RHPISKILSP
110 120 130 140 150
VMTFPYFIGL SMLSAISTER CLSILWPIWY HCRRPRYLSS VMCVLLWALS
160 170 180 190 200
LLRSILEWMF CDFLFSGANS VWCETSDFIT IAWLVFLCVV LCGSSLVLLV
210 220 230 240 250
RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGIQWALFS RIHLDWKVLF
260 270 280 290 300
CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDTPE
310 320
VDEGGGWLPQ ETLELSGSRL EQ
Length:322
Mass (Da):36,483
Last modified:November 2, 2010 - v2
Checksum:iCBDF55AF4C1EEB7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P in AAL86878 (PubMed:11850634).Curated1
Sequence conflicti3S → P in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti5I → V in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti91R → S in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti114S → N in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti149L → P in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti172W → R in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti188C → R in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti275V → M in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti281R → L in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti285 – 286QN → KT in AAL86879 (PubMed:11850634).Curated2
Sequence conflicti294A → D in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti306G → W in AAL86879 (PubMed:11850634).Curated1
Sequence conflicti307W → Q in AAH67292 (Ref. 5) Curated1
Sequence conflicti319R → K in AAL86878 (PubMed:11850634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02550782C → R.1 PublicationCorresponds to variant rs12291017dbSNPEnsembl.1
Natural variantiVAR_019434169N → D.5 PublicationsCorresponds to variant rs4274188dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042215 Genomic DNA. Translation: AAK91806.1.
AF474987 Genomic DNA. Translation: AAL86878.2.
AF474988 Genomic DNA. Translation: AAL86879.2.
EU432126 mRNA. Translation: ABY87925.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68417.1.
BC067292 mRNA. Translation: AAH67292.1.
CCDSiCCDS7830.1.
RefSeqiNP_473372.3. NM_054031.3.
XP_011518184.1. XM_011519882.2.
UniGeneiHs.380177.

Genome annotation databases

EnsembliENST00000396275; ENSP00000379571; ENSG00000179826.
ENST00000621697; ENSP00000481943; ENSG00000179826.
GeneIDi117195.
KEGGihsa:117195.
UCSCiuc001mnu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042215 Genomic DNA. Translation: AAK91806.1.
AF474987 Genomic DNA. Translation: AAL86878.2.
AF474988 Genomic DNA. Translation: AAL86879.2.
EU432126 mRNA. Translation: ABY87925.1.
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68417.1.
BC067292 mRNA. Translation: AAH67292.1.
CCDSiCCDS7830.1.
RefSeqiNP_473372.3. NM_054031.3.
XP_011518184.1. XM_011519882.2.
UniGeneiHs.380177.

3D structure databases

ProteinModelPortaliQ96LB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000379571.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMRGPRX3.
DMDMi311033400.

Proteomic databases

PaxDbiQ96LB0.
PRIDEiQ96LB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396275; ENSP00000379571; ENSG00000179826.
ENST00000621697; ENSP00000481943; ENSG00000179826.
GeneIDi117195.
KEGGihsa:117195.
UCSCiuc001mnu.3. human.

Organism-specific databases

CTDi117195.
DisGeNETi117195.
GeneCardsiMRGPRX3.
H-InvDBHIX0035991.
HGNCiHGNC:17980. MRGPRX3.
MIMi607229. gene.
neXtProtiNX_Q96LB0.
OpenTargetsiENSG00000179826.
PharmGKBiPA142671336.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ96LB0.
KOiK08396.
OMAiRIHLDWK.
OrthoDBiEOG091G0CSX.
PhylomeDBiQ96LB0.
TreeFamiTF336336.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179826-MONOMER.

Miscellaneous databases

GeneWikiiMRGPRX3.
GenomeRNAii117195.
PROiQ96LB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179826.
CleanExiHS_MRGPRX3.
ExpressionAtlasiQ96LB0. baseline and differential.
GenevisibleiQ96LB0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGX3_HUMAN
AccessioniPrimary (citable) accession number: Q96LB0
Secondary accession number(s): B0M0L1, Q8TDE0, Q8TDE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.