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Protein

Mas-related G-protein coupled receptor member X4

Gene

MRGPRX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X4
Alternative name(s):
Sensory neuron-specific G-protein coupled receptor 5/6
Gene namesi
Name:MRGPRX4
Synonyms:MRGX4, SNSR5, SNSR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17617. MRGPRX4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence analysis
Transmembranei61 – 8121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini82 – 9615ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13720CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 17719ExtracellularSequence analysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini199 – 21820CytoplasmicSequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini240 – 25415ExtracellularSequence analysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini276 – 32247CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671337.

Polymorphism and mutation databases

BioMutaiMRGPRX4.
DMDMi322510048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Mas-related G-protein coupled receptor member X4PRO_0000069783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96LA9.
PRIDEiQ96LA9.

Expressioni

Tissue specificityi

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.1 Publication

Gene expression databases

BgeeiENSG00000179817.
CleanExiHS_MRGPRX4.
ExpressionAtlasiQ96LA9. baseline and differential.
GenevisibleiQ96LA9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314042.

Structurei

3D structure databases

ProteinModelPortaliQ96LA9.
SMRiQ96LA9. Positions 21-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ96LA9.
KOiK08396.
OMAiVYLVCMS.
PhylomeDBiQ96LA9.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR027344. MRGPCRX4.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF23. PTHR11334:SF23. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96LA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTVPVFGT KLTPINGREE TPCYNQTLSF TVLTCIISLV GLTGNAVVLW
60 70 80 90 100
LLGYRMRRNA VSIYILNLAA ADFLFLSFQI IRLPLRLINI SHLIRKILVS
110 120 130 140 150
VMTFPYFTGL SMLSAISTER CLSVLWPIWY RCRRPTHLSA VVCVLLWGLS
160 170 180 190 200
LLFSMLEWRF CDFLFSGADS SWCETSDFIP VAWLIFLCVV LCVSSLVLLV
210 220 230 240 250
RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGILGALIY RMHLNLEVLY
260 270 280 290 300
CHVYLVCMSL SSLNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDKPE
310 320
VDKGEGQLPE ESLELSGSRL GP
Length:322
Mass (Da):36,461
Last modified:February 8, 2011 - v2
Checksum:iA0D7B1ECD08FD15A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181S → R in AAL86882 (PubMed:11850634).Curated
Sequence conflicti319 – 3191R → K in AAL86883 (PubMed:11850634).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81F → L.1 Publication
Corresponds to variant rs2468774 [ dbSNP | Ensembl ].
VAR_019435
Natural varianti25 – 251N → K.1 Publication
Corresponds to variant rs2445180 [ dbSNP | Ensembl ].
VAR_019436
Natural varianti54 – 541Y → C.1 Publication
Corresponds to variant rs1869788 [ dbSNP | Ensembl ].
VAR_019437
Natural varianti83 – 831L → S.3 Publications
Corresponds to variant rs2445179 [ dbSNP | Ensembl ].
VAR_019438
Natural varianti182 – 1821A → V.2 Publications
Corresponds to variant rs11024532 [ dbSNP | Ensembl ].
VAR_025506
Natural varianti245 – 2451N → S.
Corresponds to variant rs7102322 [ dbSNP | Ensembl ].
VAR_049419

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042216 Genomic DNA. Translation: AAK91807.1.
AF474991 Genomic DNA. Translation: AAL86882.1.
AF474992 Genomic DNA. Translation: AAL86883.1.
AC090099 Genomic DNA. No translation available.
BC095509 mRNA. Translation: AAH95509.1.
BC107099 mRNA. Translation: AAI07100.1.
BC107100 mRNA. Translation: AAI07101.1.
CCDSiCCDS7831.1.
RefSeqiNP_473373.2. NM_054032.3.
UniGeneiHs.632138.

Genome annotation databases

EnsembliENST00000314254; ENSP00000314042; ENSG00000179817.
GeneIDi117196.
KEGGihsa:117196.
UCSCiuc001mnv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY042216 Genomic DNA. Translation: AAK91807.1.
AF474991 Genomic DNA. Translation: AAL86882.1.
AF474992 Genomic DNA. Translation: AAL86883.1.
AC090099 Genomic DNA. No translation available.
BC095509 mRNA. Translation: AAH95509.1.
BC107099 mRNA. Translation: AAI07100.1.
BC107100 mRNA. Translation: AAI07101.1.
CCDSiCCDS7831.1.
RefSeqiNP_473373.2. NM_054032.3.
UniGeneiHs.632138.

3D structure databases

ProteinModelPortaliQ96LA9.
SMRiQ96LA9. Positions 21-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314042.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMRGPRX4.
DMDMi322510048.

Proteomic databases

PaxDbiQ96LA9.
PRIDEiQ96LA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314254; ENSP00000314042; ENSG00000179817.
GeneIDi117196.
KEGGihsa:117196.
UCSCiuc001mnv.1. human.

Organism-specific databases

CTDi117196.
GeneCardsiMRGPRX4.
H-InvDBHIX0036111.
HGNCiHGNC:17617. MRGPRX4.
MIMi607230. gene.
neXtProtiNX_Q96LA9.
PharmGKBiPA142671337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9NM. Eukaryota.
ENOG4111AUB. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG003592.
InParanoidiQ96LA9.
KOiK08396.
OMAiVYLVCMS.
PhylomeDBiQ96LA9.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMRGPRX4.
GenomeRNAii117196.
PROiQ96LA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179817.
CleanExiHS_MRGPRX4.
ExpressionAtlasiQ96LA9. baseline and differential.
GenevisibleiQ96LA9. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR027344. MRGPCRX4.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF23. PTHR11334:SF23. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGX4_HUMAN
AccessioniPrimary (citable) accession number: Q96LA9
Secondary accession number(s): Q3KNU3
, Q3KNU4, Q502W0, Q8TDD6, Q8TDD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.