Q96LA6 (FCRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fc receptor-like protein 1
Short name=FcR-like protein 1
Short name=FcRL1

Alternative name(s):
Fc receptor homolog 1
Short name=FcRH1
IFGP family protein 1
Short name=hIFGP1
Immune receptor translocation-associated protein 5
CD_antigen=CD307a

Gene names

Name:	FCRL1
Synonyms:	FCRH1, IFGP1, IRTA5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. Ref.10
Subcellular location	Cell membrane; Single-pass type I membrane protein Ref.10 Ref.11.
Tissue specificity	Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level). Ref.1 Ref.9 Ref.10 Ref.11
Induction	Down-regulated in activated B-cells. Ref.10
Post-translational modification	Phosphorylated on tyrosines upon activation. Ref.10
Sequence similarities	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96LA6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96LA6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     395-395: Missing.

Isoform 3 (identifier: Q96LA6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     296-334: Missing.
     372-429: VNVVSGDEVY...ITDVDYEDAM → EPREQSVAVHGRQQHSSEQKAQKPWGHIWRTRFP

Isoform 4 (identifier: Q96LA6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     203-238: IPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPI → SKFHYPSFSQPVTNWAPHFPGAHKVSLGHAEEVQWG
     239-429: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 429	413	Fc receptor-like protein 1		PRO_0000331638
Regions
	Topological domain	17 – 307	291	Extracellular Potential
	Transmembrane	308 – 328	21	Helical; Potential
	Topological domain	329 – 429	101	Cytoplasmic Potential
	Domain	17 – 104	88	Ig-like C2-type 1
	Domain	109 – 200	92	Ig-like C2-type 2
	Domain	208 – 291	84	Ig-like C2-type 3
	Motif	354 – 359	6	ITIM motif 1
	Motif	367 – 372	6	ITIM motif 2
	Motif	379 – 384	6	ITIM motif 3
	Motif	410 – 415	6	ITIM motif 4
	Motif	423 – 428	6	ITIM motif 5
Amino acid modifications
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Disulfide bond	38 ↔ 86		By similarity
	Disulfide bond	134 ↔ 183		By similarity
	Disulfide bond	229 ↔ 276		By similarity
Natural variations
	Alternative sequence	1 – 39	39	Missing in isoform 4.		VSP_033290
	Alternative sequence	203 – 238	36	IPVSR…GSPPI → SKFHYPSFSQPVTNWAPHFP GAHKVSLGHAEEVQWG in isoform 4.		VSP_033291
	Alternative sequence	239 – 429	191	Missing in isoform 4.		VSP_033292
	Alternative sequence	296 – 334	39	Missing in isoform 3.		VSP_033293
	Alternative sequence	372 – 429	58	VNVVS…YEDAM → EPREQSVAVHGRQQHSSEQK AQKPWGHIWRTRFP in isoform 3.		VSP_033294
	Alternative sequence	395	1	Missing in isoform 2.		VSP_033295
	Natural variant	124	1	V → M. Corresponds to variant rs12078586 [ dbSNP | Ensembl ].		VAR_042923

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F6BB19942C9C7C06	FASTA	429	46,936
	10 20 30 40 50 60 MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA 70 80 90 100 110 120 LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP 130 140 150 160 170 180 GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ 190 200 210 220 230 240 YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY 250 260 270 280 290 300 WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA 310 320 330 340 350 360 RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP 370 380 390 400 410 420 TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAAETLG THMEDKVSLD IYSRLRKANI TDVDYEDAM
	Isoform 2 [UniParc]. Checksum: F20BA3110BBC7828	FASTA	428	46,865
	10 20 30 40 50 60 MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA 70 80 90 100 110 120 LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP 130 140 150 160 170 180 GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ 190 200 210 220 230 240 YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY 250 260 270 280 290 300 WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA 310 320 330 340 350 360 RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP 370 380 390 400 410 420 TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAETLGT HMEDKVSLDI YSRLRKANIT DVDYEDAM
	Isoform 3 [UniParc]. Checksum: 6F79D0F9EBDE2AE0	FASTA	366	40,435
	10 20 30 40 50 60 MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA 70 80 90 100 110 120 LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP 130 140 150 160 170 180 GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ 190 200 210 220 230 240 YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY 250 260 270 280 290 300 WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTGRRSA 310 320 330 340 350 360 RDPLRSLPSP LPQEFTYLNS PTPGQLQPIY ENEPREQSVA VHGRQQHSSE QKAQKPWGHI WRTRFP
	Isoform 4 [UniParc]. Checksum: B64B24B45F3C19B2	FASTA	199	22,068
	10 20 30 40 50 60 MPFLQSSDAQ FQFCFFRDTR ALGPGWSSSP KLQIAAMWKE DTGSYWCEAQ TMASKVLRSR 70 80 90 100 110 120 RSQINVHRVP VADVSLETQP PGGQVMEGDR LVLICSVAMG TGDITFLWYK GAVGLNLQSK 130 140 150 160 170 180 TQRSLTAEYE IPSVRESDAE QYYCVAENGY GPSPSGLVSI TVRSKFHYPS FSQPVTNWAP 190 HFPGAHKVSL GHAEEVQWG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a family of Fc receptor homologs with preferential B cell expression." Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D. Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Lymph node.
[2]	"A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1." Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M., Volkova O.Y., Alabyev B.Y., Taranin A.V. Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Tonsil.
[3]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Peripheral blood.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph node.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood.
[9]	"IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells." Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R. Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
[10]	"FcRH1: an activation coreceptor on human B cells." Leu C.-M., Davis R.S., Gartland L.A., Fine W.D., Cooper M.D. Blood 105:1121-1126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INDUCTION, TISSUE SPECIFICITY.
[11]	"Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia." Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A. Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY043464 mRNA. Translation: AAK91777.1. AF329488 mRNA. Translation: AAL23898.1. EF064734 Genomic DNA. Translation: ABK41917.1. AK096690 mRNA. Translation: BAC04842.1. AK315748 mRNA. Translation: BAG38102.1. AL833970 mRNA. Translation: CAD38815.1. AL139409, AL356276 Genomic DNA. Translation: CAH70232.1. AL139409, AL356276 Genomic DNA. Translation: CAH70233.1. AL139409, AL356276 Genomic DNA. Translation: CAH70234.1. AL356276, AL139409 Genomic DNA. Translation: CAH73052.1. AL356276, AL139409 Genomic DNA. Translation: CAH73053.1. AL356276, AL139409 Genomic DNA. Translation: CAH73054.1. CH471121 Genomic DNA. Translation: EAW52861.1. CH471121 Genomic DNA. Translation: EAW52862.1. BC033690 mRNA. Translation: AAH33690.1.
IPI	IPI00064951. IPI00167103. IPI00386065. IPI00644153.
RefSeq	NP_001152869.1. NM_001159397.1. NP_001152870.1. NM_001159398.1. NP_443170.1. NM_052938.4.
UniGene	Hs.656112.
3D structure databases
ProteinModelPortal	Q96LA6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357158.
Polymorphism databases
DMDM	74760931.
Proteomic databases
PaxDb	Q96LA6.
PRIDE	Q96LA6.
Protocols and materials databases
DNASU	115350.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358292; ENSP00000351039; ENSG00000163534. ENST00000368176; ENSP00000357158; ENSG00000163534. ENST00000491942; ENSP00000418130; ENSG00000163534.
GeneID	115350.
KEGG	hsa:115350.
UCSC	uc001frg.3. human. uc001frh.3. human. uc001fri.3. human.
Organism-specific databases
CTD	115350.
GeneCards	GC01M157764.
HGNC	HGNC:18509. FCRL1.
HPA	HPA013323.
MIM	606508. gene.
neXtProt	NX_Q96LA6.
PharmGKB	PA142671766.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44406.
HOGENOM	HOG000036945.
HOVERGEN	HBG074073.
InParanoid	Q96LA6.
OMA	QFQFCFF.
Gene expression databases
Bgee	Q96LA6.
CleanEx	HS_FCRL1.
Genevestigator	Q96LA6.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FCRL1. human.
GenomeRNAi	115350.
NextBio	79570.
SOURCE	Search...

Entry information

Entry name

FCRL1_HUMAN

Accession

Primary (citable) accession number: Q96LA6
Secondary accession number(s): B2RE05 , Q8N759, Q8NDI0, Q96PJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.