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Protein

Fc receptor-like protein 2

Gene

FCRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an regulatory role in normal and neoplastic B cell development.1 Publication

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • positive regulation of signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 2
Short name:
FcR-like protein 2
Short name:
FcRL2
Alternative name(s):
Fc receptor homolog 2
Short name:
FcRH2
IFGP family protein 4
Immunoglobulin receptor translocation-associated protein 4
SH2 domain-containing phosphatase anchor protein 1
CD_antigen: CD307b
Gene namesi
Name:FCRL2
Synonyms:FCRH2, IFGP4, IRTA4, SPAP1
ORF Names:UNQ9236/PRO31998
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14875. FCRL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 401382ExtracellularSequence analysisAdd
BLAST
Transmembranei402 – 42221HelicalSequence analysisAdd
BLAST
Topological domaini423 – 50886CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37913.

Polymorphism and mutation databases

BioMutaiFCRL2.
DMDMi68052374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 508489Fc receptor-like protein 2PRO_0000014761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi128 ↔ 177PROSITE-ProRule annotation
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi226 ↔ 275PROSITE-ProRule annotation
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi321 ↔ 368PROSITE-ProRule annotation
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Isoform 2 is N- and O-glycosylated, and phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96LA5.
PRIDEiQ96LA5.
TopDownProteomicsiQ96LA5-1. [Q96LA5-1]

PTM databases

iPTMnetiQ96LA5.
PhosphoSiteiQ96LA5.

Expressioni

Tissue specificityi

Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).4 Publications

Gene expression databases

BgeeiQ96LA5.
CleanExiHS_FCRL2.
GenevisibleiQ96LA5. HS.

Organism-specific databases

HPAiCAB017619.
HPA041426.

Interactioni

Subunit structurei

The tyrosine-phosphorylated isoform 2 interacts with PTPN6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436393EBI-10185081,EBI-713635

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122656. 2 interactions.
IntActiQ96LA5. 1 interaction.
STRINGi9606.ENSP00000355157.

Structurei

3D structure databases

ProteinModelPortaliQ96LA5.
SMRiQ96LA5. Positions 20-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 9879Ig-like C2-type 1Add
BLAST
Domaini109 – 18779Ig-like C2-type 2Add
BLAST
Domaini201 – 29090Ig-like C2-type 3Add
BLAST
Domaini300 – 38788Ig-like C2-type 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi446 – 4516ITIM motif 1
Motifi460 – 4656ITIM motif 2
Motifi472 – 4776ITIM motif 3
Motifi500 – 5056ITIM motif 4

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5T. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOVERGENiHBG074073.
InParanoidiQ96LA5.
OMAiTHRIRKQ.
OrthoDBiEOG7BP81V.
PhylomeDBiQ96LA5.
TreeFamiTF351107.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96LA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLWSLLVIF DAVTEQADSL TLVAPSSVFE GDSIVLKCQG EQNWKIQKMA
60 70 80 90 100
YHKDNKELSV FKKFSDFLIQ SAVLSDSGNY FCSTKGQLFL WDKTSNIVKI
110 120 130 140 150
KVQELFQRPV LTASSFQPIE GGPVSLKCET RLSPQRLDVQ LQFCFFRENQ
160 170 180 190 200
VLGSGWSSSP ELQISAVWSE DTGSYWCKAE TVTHRIRKQS LQSQIHVQRI
210 220 230 240 250
PISNVSLEIR APGGQVTEGQ KLILLCSVAG GTGNVTFSWY REATGTSMGK
260 270 280 290 300
KTQRSLSAEL EIPAVKESDA GKYYCRADNG HVPIQSKVVN IPVRIPVSRP
310 320 330 340 350
VLTLRSPGAQ AAVGDLLELH CEALRGSPPI LYQFYHEDVT LGNSSAPSGG
360 370 380 390 400
GASFNLSLTA EHSGNYSCEA NNGLGAQCSE AVPVSISGPD GYRRDLMTAG
410 420 430 440 450
VLWGLFGVLG FTGVALLLYA LFHKISGESS ATNEPRGASR PNPQEFTYSS
460 470 480 490 500
PTPDMEELQP VYVNVGSVDV DVVYSQVWSM QQPESSANIR TLLENKDSQV

IYSSVKKS
Length:508
Mass (Da):55,542
Last modified:December 1, 2001 - v1
Checksum:i9AB30E0411B41EDC
GO
Isoform 2 (identifier: Q96LA5-2) [UniParc]FASTAAdd to basket

Also known as: SPAP1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV

Show »
Length:255
Mass (Da):27,546
Checksum:i826E6447FB6BAB14
GO
Isoform 3 (identifier: Q96LA5-3) [UniParc]FASTAAdd to basket

Also known as: SPAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV
     428-445: ESSATNEPRGASRPNPQE → CIYHLDSPYFAMTFPLLI
     446-508: Missing.

Show »
Length:192
Mass (Da):20,680
Checksum:iC9962BBB4B15B08D
GO
Isoform 4 (identifier: Q96LA5-4) [UniParc]FASTAAdd to basket

Also known as: SPAP1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.
     254-295: RSLSAELEIP...SKVVNIPVRI → MWEWKICNSH...FLIAPLCLSV
     389-397: PDGYRRDLM → GWVLPGYRV
     398-508: Missing.

Show »
Length:144
Mass (Da):15,373
Checksum:iD03F859338237CA5
GO
Isoform 5 (identifier: Q96LA5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-387: Missing.
     465-486: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,533
Checksum:i9D6C578B6E136E6E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021I → N.
Corresponds to variant rs16839100 [ dbSNP | Ensembl ].
VAR_049873

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 253253Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_014111Add
BLAST
Alternative sequencei104 – 387284Missing in isoform 5. 1 PublicationVSP_014113Add
BLAST
Alternative sequencei254 – 29542RSLSA…IPVRI → MWEWKICNSHGARPFAEPAG WEFVNLLRHHKSFLIAPLCL SV in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_014112Add
BLAST
Alternative sequencei389 – 3979PDGYRRDLM → GWVLPGYRV in isoform 4. 1 PublicationVSP_014114
Alternative sequencei398 – 508111Missing in isoform 4. 1 PublicationVSP_014115Add
BLAST
Alternative sequencei428 – 44518ESSAT…PNPQE → CIYHLDSPYFAMTFPLLI in isoform 3. 1 PublicationVSP_014116Add
BLAST
Alternative sequencei446 – 50863Missing in isoform 3. 1 PublicationVSP_014117Add
BLAST
Alternative sequencei465 – 48622Missing in isoform 5. 1 PublicationVSP_014118Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043465 mRNA. Translation: AAK91778.1.
AF319438 mRNA. Translation: AAK01402.1.
AF319439 mRNA. Translation: AAK01403.1.
AF319440 mRNA. Translation: AAK01404.1.
AF459633 mRNA. Translation: AAL60249.1.
AF390037 mRNA. Translation: AAM12152.1.
EF064733 Genomic DNA. Translation: ABK41916.1.
AY358130 mRNA. Translation: AAQ88497.1.
AL356276 Genomic DNA. Translation: CAH73060.1.
AL356276 Genomic DNA. Translation: CAH73061.1.
AL356276 Genomic DNA. Translation: CAH73062.1.
AL356276 Genomic DNA. Translation: CAH73063.1.
CH471121 Genomic DNA. Translation: EAW52864.1.
CH471121 Genomic DNA. Translation: EAW52867.1.
CH471121 Genomic DNA. Translation: EAW52869.1.
BC069185 mRNA. Translation: AAH69185.1.
BC129836 mRNA. Translation: AAI29837.1.
CCDSiCCDS1168.1. [Q96LA5-1]
PIRiJC7593.
RefSeqiNP_001152960.1. NM_001159488.1.
NP_110391.2. NM_030764.3. [Q96LA5-1]
XP_011508282.1. XM_011509980.1. [Q96LA5-2]
UniGeneiHs.437393.

Genome annotation databases

EnsembliENST00000361516; ENSP00000355157; ENSG00000132704. [Q96LA5-1]
ENST00000368181; ENSP00000357163; ENSG00000132704. [Q96LA5-5]
ENST00000469986; ENSP00000417393; ENSG00000132704. [Q96LA5-3]
GeneIDi79368.
KEGGihsa:79368.
UCSCiuc001fre.3. human. [Q96LA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043465 mRNA. Translation: AAK91778.1.
AF319438 mRNA. Translation: AAK01402.1.
AF319439 mRNA. Translation: AAK01403.1.
AF319440 mRNA. Translation: AAK01404.1.
AF459633 mRNA. Translation: AAL60249.1.
AF390037 mRNA. Translation: AAM12152.1.
EF064733 Genomic DNA. Translation: ABK41916.1.
AY358130 mRNA. Translation: AAQ88497.1.
AL356276 Genomic DNA. Translation: CAH73060.1.
AL356276 Genomic DNA. Translation: CAH73061.1.
AL356276 Genomic DNA. Translation: CAH73062.1.
AL356276 Genomic DNA. Translation: CAH73063.1.
CH471121 Genomic DNA. Translation: EAW52864.1.
CH471121 Genomic DNA. Translation: EAW52867.1.
CH471121 Genomic DNA. Translation: EAW52869.1.
BC069185 mRNA. Translation: AAH69185.1.
BC129836 mRNA. Translation: AAI29837.1.
CCDSiCCDS1168.1. [Q96LA5-1]
PIRiJC7593.
RefSeqiNP_001152960.1. NM_001159488.1.
NP_110391.2. NM_030764.3. [Q96LA5-1]
XP_011508282.1. XM_011509980.1. [Q96LA5-2]
UniGeneiHs.437393.

3D structure databases

ProteinModelPortaliQ96LA5.
SMRiQ96LA5. Positions 20-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122656. 2 interactions.
IntActiQ96LA5. 1 interaction.
STRINGi9606.ENSP00000355157.

PTM databases

iPTMnetiQ96LA5.
PhosphoSiteiQ96LA5.

Polymorphism and mutation databases

BioMutaiFCRL2.
DMDMi68052374.

Proteomic databases

PaxDbiQ96LA5.
PRIDEiQ96LA5.
TopDownProteomicsiQ96LA5-1. [Q96LA5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361516; ENSP00000355157; ENSG00000132704. [Q96LA5-1]
ENST00000368181; ENSP00000357163; ENSG00000132704. [Q96LA5-5]
ENST00000469986; ENSP00000417393; ENSG00000132704. [Q96LA5-3]
GeneIDi79368.
KEGGihsa:79368.
UCSCiuc001fre.3. human. [Q96LA5-1]

Organism-specific databases

CTDi79368.
GeneCardsiFCRL2.
HGNCiHGNC:14875. FCRL2.
HPAiCAB017619.
HPA041426.
MIMi606509. gene.
neXtProtiNX_Q96LA5.
PharmGKBiPA37913.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5T. Eukaryota.
ENOG410YF57. LUCA.
GeneTreeiENSGT00760000119130.
HOVERGENiHBG074073.
InParanoidiQ96LA5.
OMAiTHRIRKQ.
OrthoDBiEOG7BP81V.
PhylomeDBiQ96LA5.
TreeFamiTF351107.

Miscellaneous databases

GeneWikiiFCRL2.
GenomeRNAii79368.
PROiQ96LA5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96LA5.
CleanExiHS_FCRL2.
GenevisibleiQ96LA5. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of Fc receptor homologs with preferential B cell expression."
    Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lymph node.
  2. "Molecular cloning and characterization of SPAP1, an inhibitory receptor."
    Xu M.-J., Zhao R., Zhao Z.J.
    Biochem. Biophys. Res. Commun. 280:768-775(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), INTERACTION WITH PTPN6, TISSUE SPECIFICITY, PHOSPHORYLATION, GLYCOSYLATION.
  3. "IRTAs: a new family of immunoglobulin-like receptors differentially expressed in B cells."
    Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C., Dalla-Favera R.
    Blood 99:2662-2669(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  4. "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1."
    Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M., Volkova O.Y., Alabyev B.Y., Taranin A.V.
    Immunogenetics 54:87-95(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Tonsil.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  11. "Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia."
    Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C., Hongo J.-A., Koeppen H., Ebens A.
    Int. Immunol. 18:1363-1373(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFCRL2_HUMAN
AccessioniPrimary (citable) accession number: Q96LA5
Secondary accession number(s): A0N0M5
, A1L307, A6NMS0, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.