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Protein

Alpha-protein kinase 3

Gene

ALPK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 3 (EC:2.7.11.-)
Alternative name(s):
Muscle alpha-protein kinase
Gene namesi
Name:ALPK3
Synonyms:KIAA1330, MAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17574. ALPK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921552.

Polymorphism and mutation databases

BioMutaiALPK3.
DMDMi296434393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19071907Alpha-protein kinase 3PRO_0000260031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1498 ↔ 1548PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96L96.
PRIDEiQ96L96.

PTM databases

PhosphoSiteiQ96L96.

Expressioni

Gene expression databases

BgeeiQ96L96.
CleanExiHS_ALPK3.
HS_MAK.
GenevestigatoriQ96L96.

Organism-specific databases

HPAiHPA026558.

Interactioni

Protein-protein interaction databases

IntActiQ96L96. 1 interaction.
STRINGi9606.ENSP00000258888.

Structurei

3D structure databases

ProteinModelPortaliQ96L96.
SMRiQ96L96. Positions 279-371, 1475-1565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini279 – 37092Ig-like 1Add
BLAST
Domaini1476 – 156489Ig-like 2Add
BLAST
Domaini1592 – 1827236Alpha-type protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 1756Poly-Ala
Compositional biasi517 – 5215Poly-Lys
Compositional biasi766 – 7716Poly-Ser
Compositional biasi1166 – 11727Poly-Leu

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG148552.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ96L96.
KOiK08868.
OMAiSEGACAQ.
OrthoDBiEOG7H1JJN.
PhylomeDBiQ96L96.
TreeFamiTF332629.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL
60 70 80 90 100
APLAPARPRG PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP
110 120 130 140 150
GPLQTRRYCR HQGRQGSGLG AGPGAGTWAP APPGVSKPRC PGRARPGEGQ
160 170 180 190 200
QQVTTARPPA INRGARQPRA GAAAAGRGPG AGAWRTGEAA ASAGPAVGEG
210 220 230 240 250
GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS YLLSVRPETS
260 270 280 290 300
LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC
310 320 330 340 350
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA
360 370 380 390 400
IYQASAQNSK GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ
410 420 430 440 450
SWKHEKAVPG EVDTLRKLSP DRFQRKRRLS GAQAPGPSVP TREPEGGTLA
460 470 480 490 500
AWQEGETETA QHSGLGLINS FASGEVTTNG EAAPENGEDG EHGLLTYICD
510 520 530 540 550
AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS RRSSENCIPS
560 570 580 590 600
SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK
610 620 630 640 650
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG
660 670 680 690 700
KAPLRARSEG VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP
710 720 730 740 750
ISSLSQAPEC GAQSLGKAPP QASVQVPTPP ARRRHGTRDS TLQGQAGHRT
760 770 780 790 800
PGEVLECQTT TAPTMSASSS SDVASIGVST SGSQGIIEPM DMETQEDGRT
810 820 830 840 850
SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK TQVDAGTQES
860 870 880 890 900
KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM
910 920 930 940 950
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR
960 970 980 990 1000
APLNIECFVQ TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL
1010 1020 1030 1040 1050
MLPAQPPHEG SVEQVGGERC RGPQSSGPVE AKQEDSPFQC PKEERPGGVP
1060 1070 1080 1090 1100
CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS PKAGPCSTPT SQHGSTATFL
1110 1120 1130 1140 1150
PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ VPDVEGRTPG
1160 1170 1180 1190 1200
PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT
1210 1220 1230 1240 1250
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV
1260 1270 1280 1290 1300
QAGRQALAAA RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE
1310 1320 1330 1340 1350
GPGLLGASQE SSMAGRLGEA GGQAAPGQGP SAESIAQEPS QEEKFPGEAL
1360 1370 1380 1390 1400
TGLPAATPEE LALGARRKRF LPKVRAAGDG EATTPEERES PTVSPRGPRK
1410 1420 1430 1440 1450
SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL GPSPKAGGLD
1460 1470 1480 1490 1500
TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF
1510 1520 1530 1540 1550
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI
1560 1570 1580 1590 1600
HNEHGSASTD FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW
1610 1620 1630 1640 1650
GDKLFGRLVS EELRGGGYGC GLRKASQAKV IYGLEPIFES GRTCIIKVSS
1660 1670 1680 1690 1700
LLVFGPSSET SLVGRNYDVT IQGCKIQNMS REYCKIFAAE ARAAPGFGEV
1710 1720 1730 1740 1750
PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA EAPTASGSSE
1760 1770 1780 1790 1800
AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES
1810 1820 1830 1840 1850
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK
1860 1870 1880 1890 1900
GSQLSPQPQK KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG

SKAQGMR
Length:1,907
Mass (Da):201,272
Last modified:May 18, 2010 - v2
Checksum:i3896A1EC187BF5C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101S → T in AAK95951 (PubMed:10021370).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti336 – 3361R → H.1 Publication
Corresponds to variant rs34407151 [ dbSNP | Ensembl ].
VAR_041524
Natural varianti338 – 3381T → I.1 Publication
Corresponds to variant rs56015306 [ dbSNP | Ensembl ].
VAR_041525
Natural varianti414 – 4141T → S.1 Publication
Corresponds to variant rs3803403 [ dbSNP | Ensembl ].
VAR_028989
Natural varianti433 – 4331Q → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_041526
Natural varianti579 – 5791G → E.1 Publication
Corresponds to variant rs3803405 [ dbSNP | Ensembl ].
VAR_028990
Natural varianti602 – 6021Q → R.1 Publication
Corresponds to variant rs55702300 [ dbSNP | Ensembl ].
VAR_041527
Natural varianti663 – 6631G → D.1 Publication
Corresponds to variant rs34409363 [ dbSNP | Ensembl ].
VAR_041528
Natural varianti761 – 7611T → M.1 Publication
Corresponds to variant rs16974569 [ dbSNP | Ensembl ].
VAR_028991
Natural varianti836 – 8361R → L.1 Publication
VAR_041529
Natural varianti929 – 9291E → D.1 Publication
VAR_041530
Natural varianti1013 – 10131E → K.
Corresponds to variant rs35633849 [ dbSNP | Ensembl ].
VAR_057743
Natural varianti1137 – 11371A → G.
Corresponds to variant rs34173528 [ dbSNP | Ensembl ].
VAR_057744
Natural varianti1299 – 12991P → L.3 Publications
Corresponds to variant rs306197 [ dbSNP | Ensembl ].
VAR_028992
Natural varianti1364 – 13641G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041531
Natural varianti1412 – 14121R → W.1 Publication
Corresponds to variant rs55752937 [ dbSNP | Ensembl ].
VAR_041532
Natural varianti1557 – 15571A → D.1 Publication
Corresponds to variant rs34775428 [ dbSNP | Ensembl ].
VAR_041533
Natural varianti1622 – 16221L → P.1 Publication
Corresponds to variant rs187316 [ dbSNP | Ensembl ].
VAR_028993
Natural varianti1873 – 18731A → V.
Corresponds to variant rs36002219 [ dbSNP | Ensembl ].
VAR_057745

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044449 mRNA. Translation: AAK95951.1.
AB037751 mRNA. Translation: BAA92568.1.
AC012291 Genomic DNA. No translation available.
CCDSiCCDS10333.1.
RefSeqiNP_065829.3. NM_020778.4.
UniGeneiHs.459183.

Genome annotation databases

EnsembliENST00000258888; ENSP00000258888; ENSG00000136383.
GeneIDi57538.
KEGGihsa:57538.
UCSCiuc002ble.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044449 mRNA. Translation: AAK95951.1.
AB037751 mRNA. Translation: BAA92568.1.
AC012291 Genomic DNA. No translation available.
CCDSiCCDS10333.1.
RefSeqiNP_065829.3. NM_020778.4.
UniGeneiHs.459183.

3D structure databases

ProteinModelPortaliQ96L96.
SMRiQ96L96. Positions 279-371, 1475-1565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96L96. 1 interaction.
STRINGi9606.ENSP00000258888.

PTM databases

PhosphoSiteiQ96L96.

Polymorphism and mutation databases

BioMutaiALPK3.
DMDMi296434393.

Proteomic databases

PaxDbiQ96L96.
PRIDEiQ96L96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258888; ENSP00000258888; ENSG00000136383.
GeneIDi57538.
KEGGihsa:57538.
UCSCiuc002ble.3. human.

Organism-specific databases

CTDi57538.
GeneCardsiGC15P085359.
H-InvDBHIX0012537.
HGNCiHGNC:17574. ALPK3.
HPAiHPA026558.
neXtProtiNX_Q96L96.
PharmGKBiPA134921552.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148552.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ96L96.
KOiK08868.
OMAiSEGACAQ.
OrthoDBiEOG7H1JJN.
PhylomeDBiQ96L96.
TreeFamiTF332629.

Miscellaneous databases

GenomeRNAii57538.
NextBioi63964.
PROiQ96L96.

Gene expression databases

BgeeiQ96L96.
CleanExiHS_ALPK3.
HS_MAK.
GenevestigatoriQ96L96.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
    Ryazanov A.G., Pavur K.S., Dorovkov M.V.
    Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-1299.
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1907, VARIANT LEU-1299.
    Tissue: Brain.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-336; ILE-338; SER-414; GLU-433; GLU-579; ARG-602; ASP-663; MET-761; LEU-836; ASP-929; LEU-1299; GLU-1364; TRP-1412; ASP-1557 AND PRO-1622.

Entry informationi

Entry nameiALPK3_HUMAN
AccessioniPrimary (citable) accession number: Q96L96
Secondary accession number(s): Q9P2L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.