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Protein

Alpha-protein kinase 3

Gene

ALPK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 3 (EC:2.7.11.-)
Alternative name(s):
Muscle alpha-protein kinase
Gene namesi
Name:ALPK3
Synonyms:KIAA1330, MAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17574. ALPK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57538.
OpenTargetsiENSG00000136383.
PharmGKBiPA134921552.

Polymorphism and mutation databases

BioMutaiALPK3.
DMDMi296434393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600311 – 1907Alpha-protein kinase 3Add BLAST1907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei430PhosphoserineBy similarity1
Modified residuei1424PhosphoserineBy similarity1
Disulfide bondi1498 ↔ 1548PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ96L96.
PaxDbiQ96L96.
PeptideAtlasiQ96L96.
PRIDEiQ96L96.

PTM databases

iPTMnetiQ96L96.
PhosphoSitePlusiQ96L96.

Expressioni

Gene expression databases

BgeeiENSG00000136383.
CleanExiHS_ALPK3.
HS_MAK.
GenevisibleiQ96L96. HS.

Organism-specific databases

HPAiHPA026558.

Interactioni

Protein-protein interaction databases

IntActiQ96L96. 1 interactor.
STRINGi9606.ENSP00000258888.

Structurei

3D structure databases

ProteinModelPortaliQ96L96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 370Ig-like 1Add BLAST92
Domaini1476 – 1564Ig-like 2Add BLAST89
Domaini1592 – 1827Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 175Poly-Ala6
Compositional biasi517 – 521Poly-Lys5
Compositional biasi766 – 771Poly-Ser6
Compositional biasi1166 – 1172Poly-Leu7

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ96L96.
KOiK08868.
OMAiSSHQCNT.
OrthoDBiEOG091G01T6.
PhylomeDBiQ96L96.
TreeFamiTF332629.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL
60 70 80 90 100
APLAPARPRG PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP
110 120 130 140 150
GPLQTRRYCR HQGRQGSGLG AGPGAGTWAP APPGVSKPRC PGRARPGEGQ
160 170 180 190 200
QQVTTARPPA INRGARQPRA GAAAAGRGPG AGAWRTGEAA ASAGPAVGEG
210 220 230 240 250
GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS YLLSVRPETS
260 270 280 290 300
LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC
310 320 330 340 350
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA
360 370 380 390 400
IYQASAQNSK GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ
410 420 430 440 450
SWKHEKAVPG EVDTLRKLSP DRFQRKRRLS GAQAPGPSVP TREPEGGTLA
460 470 480 490 500
AWQEGETETA QHSGLGLINS FASGEVTTNG EAAPENGEDG EHGLLTYICD
510 520 530 540 550
AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS RRSSENCIPS
560 570 580 590 600
SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK
610 620 630 640 650
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG
660 670 680 690 700
KAPLRARSEG VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP
710 720 730 740 750
ISSLSQAPEC GAQSLGKAPP QASVQVPTPP ARRRHGTRDS TLQGQAGHRT
760 770 780 790 800
PGEVLECQTT TAPTMSASSS SDVASIGVST SGSQGIIEPM DMETQEDGRT
810 820 830 840 850
SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK TQVDAGTQES
860 870 880 890 900
KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM
910 920 930 940 950
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR
960 970 980 990 1000
APLNIECFVQ TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL
1010 1020 1030 1040 1050
MLPAQPPHEG SVEQVGGERC RGPQSSGPVE AKQEDSPFQC PKEERPGGVP
1060 1070 1080 1090 1100
CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS PKAGPCSTPT SQHGSTATFL
1110 1120 1130 1140 1150
PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ VPDVEGRTPG
1160 1170 1180 1190 1200
PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT
1210 1220 1230 1240 1250
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV
1260 1270 1280 1290 1300
QAGRQALAAA RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE
1310 1320 1330 1340 1350
GPGLLGASQE SSMAGRLGEA GGQAAPGQGP SAESIAQEPS QEEKFPGEAL
1360 1370 1380 1390 1400
TGLPAATPEE LALGARRKRF LPKVRAAGDG EATTPEERES PTVSPRGPRK
1410 1420 1430 1440 1450
SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL GPSPKAGGLD
1460 1470 1480 1490 1500
TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF
1510 1520 1530 1540 1550
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI
1560 1570 1580 1590 1600
HNEHGSASTD FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW
1610 1620 1630 1640 1650
GDKLFGRLVS EELRGGGYGC GLRKASQAKV IYGLEPIFES GRTCIIKVSS
1660 1670 1680 1690 1700
LLVFGPSSET SLVGRNYDVT IQGCKIQNMS REYCKIFAAE ARAAPGFGEV
1710 1720 1730 1740 1750
PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA EAPTASGSSE
1760 1770 1780 1790 1800
AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES
1810 1820 1830 1840 1850
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK
1860 1870 1880 1890 1900
GSQLSPQPQK KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG

SKAQGMR
Length:1,907
Mass (Da):201,272
Last modified:May 18, 2010 - v2
Checksum:i3896A1EC187BF5C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210S → T in AAK95951 (PubMed:10021370).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041524336R → H.1 PublicationCorresponds to variant rs34407151dbSNPEnsembl.1
Natural variantiVAR_041525338T → I.1 PublicationCorresponds to variant rs56015306dbSNPEnsembl.1
Natural variantiVAR_028989414T → S.1 PublicationCorresponds to variant rs3803403dbSNPEnsembl.1
Natural variantiVAR_041526433Q → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_028990579G → E.1 PublicationCorresponds to variant rs3803405dbSNPEnsembl.1
Natural variantiVAR_041527602Q → R.1 PublicationCorresponds to variant rs55702300dbSNPEnsembl.1
Natural variantiVAR_041528663G → D.1 PublicationCorresponds to variant rs34409363dbSNPEnsembl.1
Natural variantiVAR_028991761T → M.1 PublicationCorresponds to variant rs16974569dbSNPEnsembl.1
Natural variantiVAR_041529836R → L.1 PublicationCorresponds to variant rs34906636dbSNPEnsembl.1
Natural variantiVAR_041530929E → D.1 PublicationCorresponds to variant rs56191073dbSNPEnsembl.1
Natural variantiVAR_0577431013E → K.Corresponds to variant rs35633849dbSNPEnsembl.1
Natural variantiVAR_0577441137A → G.Corresponds to variant rs34173528dbSNPEnsembl.1
Natural variantiVAR_0289921299P → L.3 PublicationsCorresponds to variant rs306197dbSNPEnsembl.1
Natural variantiVAR_0415311364G → E in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0415321412R → W.1 PublicationCorresponds to variant rs55752937dbSNPEnsembl.1
Natural variantiVAR_0415331557A → D.1 PublicationCorresponds to variant rs34775428dbSNPEnsembl.1
Natural variantiVAR_0289931622L → P.1 PublicationCorresponds to variant rs187316dbSNPEnsembl.1
Natural variantiVAR_0577451873A → V.Corresponds to variant rs36002219dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044449 mRNA. Translation: AAK95951.1.
AB037751 mRNA. Translation: BAA92568.1.
AC012291 Genomic DNA. No translation available.
CCDSiCCDS10333.1.
RefSeqiNP_065829.3. NM_020778.4.
UniGeneiHs.459183.

Genome annotation databases

EnsembliENST00000258888; ENSP00000258888; ENSG00000136383.
GeneIDi57538.
KEGGihsa:57538.
UCSCiuc002ble.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044449 mRNA. Translation: AAK95951.1.
AB037751 mRNA. Translation: BAA92568.1.
AC012291 Genomic DNA. No translation available.
CCDSiCCDS10333.1.
RefSeqiNP_065829.3. NM_020778.4.
UniGeneiHs.459183.

3D structure databases

ProteinModelPortaliQ96L96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96L96. 1 interactor.
STRINGi9606.ENSP00000258888.

PTM databases

iPTMnetiQ96L96.
PhosphoSitePlusiQ96L96.

Polymorphism and mutation databases

BioMutaiALPK3.
DMDMi296434393.

Proteomic databases

EPDiQ96L96.
PaxDbiQ96L96.
PeptideAtlasiQ96L96.
PRIDEiQ96L96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258888; ENSP00000258888; ENSG00000136383.
GeneIDi57538.
KEGGihsa:57538.
UCSCiuc002ble.3. human.

Organism-specific databases

CTDi57538.
DisGeNETi57538.
GeneCardsiALPK3.
H-InvDBHIX0012537.
HGNCiHGNC:17574. ALPK3.
HPAiHPA026558.
neXtProtiNX_Q96L96.
OpenTargetsiENSG00000136383.
PharmGKBiPA134921552.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000169775.
HOVERGENiHBG074162.
InParanoidiQ96L96.
KOiK08868.
OMAiSSHQCNT.
OrthoDBiEOG091G01T6.
PhylomeDBiQ96L96.
TreeFamiTF332629.

Miscellaneous databases

GenomeRNAii57538.
PROiQ96L96.

Gene expression databases

BgeeiENSG00000136383.
CleanExiHS_ALPK3.
HS_MAK.
GenevisibleiQ96L96. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALPK3_HUMAN
AccessioniPrimary (citable) accession number: Q96L96
Secondary accession number(s): Q9P2L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.