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Q96L96 (ALPK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-protein kinase 3

EC=2.7.11.-
Alternative name(s):
Muscle alpha-protein kinase
Gene names
Name:ALPK3
Synonyms:KIAA1330, MAK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1907 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.

Contains 1 alpha-type protein kinase domain.

Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
   Molecular functionDevelopmental protein
Kinase
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from sequence or structural similarity. Source: HGNC

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: HGNC

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19071907Alpha-protein kinase 3
PRO_0000260031

Regions

Domain279 – 37092Ig-like 1
Domain1476 – 156489Ig-like 2
Domain1592 – 1827236Alpha-type protein kinase
Compositional bias170 – 1756Poly-Ala
Compositional bias517 – 5215Poly-Lys
Compositional bias766 – 7716Poly-Ser
Compositional bias1166 – 11727Poly-Leu

Amino acid modifications

Disulfide bond1498 ↔ 1548 By similarity

Natural variations

Natural variant3361R → H. Ref.4
Corresponds to variant rs34407151 [ dbSNP | Ensembl ].
VAR_041524
Natural variant3381T → I. Ref.4
Corresponds to variant rs56015306 [ dbSNP | Ensembl ].
VAR_041525
Natural variant4141T → S. Ref.4
Corresponds to variant rs3803403 [ dbSNP | Ensembl ].
VAR_028989
Natural variant4331Q → E in a lung large cell carcinoma sample; somatic mutation. Ref.4
VAR_041526
Natural variant5791G → E. Ref.4
Corresponds to variant rs3803405 [ dbSNP | Ensembl ].
VAR_028990
Natural variant6021Q → R. Ref.4
Corresponds to variant rs55702300 [ dbSNP | Ensembl ].
VAR_041527
Natural variant6631G → D. Ref.4
Corresponds to variant rs34409363 [ dbSNP | Ensembl ].
VAR_041528
Natural variant7611T → M. Ref.4
Corresponds to variant rs16974569 [ dbSNP | Ensembl ].
VAR_028991
Natural variant8361R → L. Ref.4
VAR_041529
Natural variant9291E → D. Ref.4
VAR_041530
Natural variant10131E → K.
Corresponds to variant rs35633849 [ dbSNP | Ensembl ].
VAR_057743
Natural variant11371A → G.
Corresponds to variant rs34173528 [ dbSNP | Ensembl ].
VAR_057744
Natural variant12991P → L. Ref.1 Ref.2 Ref.4
Corresponds to variant rs306197 [ dbSNP | Ensembl ].
VAR_028992
Natural variant13641G → E in a metastatic melanoma sample; somatic mutation. Ref.4
VAR_041531
Natural variant14121R → W. Ref.4
Corresponds to variant rs55752937 [ dbSNP | Ensembl ].
VAR_041532
Natural variant15571A → D. Ref.4
Corresponds to variant rs34775428 [ dbSNP | Ensembl ].
VAR_041533
Natural variant16221L → P. Ref.4
Corresponds to variant rs187316 [ dbSNP | Ensembl ].
VAR_028993
Natural variant18731A → V.
Corresponds to variant rs36002219 [ dbSNP | Ensembl ].
VAR_057745

Experimental info

Sequence conflict2101S → T in AAK95951. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96L96 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 3896A1EC187BF5C7

FASTA1,907201,272
        10         20         30         40         50         60 
MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL APLAPARPRG 

        70         80         90        100        110        120 
PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP GPLQTRRYCR HQGRQGSGLG 

       130        140        150        160        170        180 
AGPGAGTWAP APPGVSKPRC PGRARPGEGQ QQVTTARPPA INRGARQPRA GAAAAGRGPG 

       190        200        210        220        230        240 
AGAWRTGEAA ASAGPAVGEG GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS 

       250        260        270        280        290        300 
YLLSVRPETS LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC 

       310        320        330        340        350        360 
IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA IYQASAQNSK 

       370        380        390        400        410        420 
GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ SWKHEKAVPG EVDTLRKLSP 

       430        440        450        460        470        480 
DRFQRKRRLS GAQAPGPSVP TREPEGGTLA AWQEGETETA QHSGLGLINS FASGEVTTNG 

       490        500        510        520        530        540 
EAAPENGEDG EHGLLTYICD AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS 

       550        560        570        580        590        600 
RRSSENCIPS SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK 

       610        620        630        640        650        660 
AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG KAPLRARSEG 

       670        680        690        700        710        720 
VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP ISSLSQAPEC GAQSLGKAPP 

       730        740        750        760        770        780 
QASVQVPTPP ARRRHGTRDS TLQGQAGHRT PGEVLECQTT TAPTMSASSS SDVASIGVST 

       790        800        810        820        830        840 
SGSQGIIEPM DMETQEDGRT SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK 

       850        860        870        880        890        900 
TQVDAGTQES KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM 

       910        920        930        940        950        960 
QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR APLNIECFVQ 

       970        980        990       1000       1010       1020 
TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL MLPAQPPHEG SVEQVGGERC 

      1030       1040       1050       1060       1070       1080 
RGPQSSGPVE AKQEDSPFQC PKEERPGGVP CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS 

      1090       1100       1110       1120       1130       1140 
PKAGPCSTPT SQHGSTATFL PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ 

      1150       1160       1170       1180       1190       1200 
VPDVEGRTPG PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT 

      1210       1220       1230       1240       1250       1260 
PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV QAGRQALAAA 

      1270       1280       1290       1300       1310       1320 
RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE GPGLLGASQE SSMAGRLGEA 

      1330       1340       1350       1360       1370       1380 
GGQAAPGQGP SAESIAQEPS QEEKFPGEAL TGLPAATPEE LALGARRKRF LPKVRAAGDG 

      1390       1400       1410       1420       1430       1440 
EATTPEERES PTVSPRGPRK SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL 

      1450       1460       1470       1480       1490       1500 
GPSPKAGGLD TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF 

      1510       1520       1530       1540       1550       1560 
FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI HNEHGSASTD 

      1570       1580       1590       1600       1610       1620 
FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW GDKLFGRLVS EELRGGGYGC 

      1630       1640       1650       1660       1670       1680 
GLRKASQAKV IYGLEPIFES GRTCIIKVSS LLVFGPSSET SLVGRNYDVT IQGCKIQNMS 

      1690       1700       1710       1720       1730       1740 
REYCKIFAAE ARAAPGFGEV PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA 

      1750       1760       1770       1780       1790       1800 
EAPTASGSSE AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES 

      1810       1820       1830       1840       1850       1860 
CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK GSQLSPQPQK 

      1870       1880       1890       1900 
KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG SKAQGMR 

« Hide

References

« Hide 'large scale' references
[1]"Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
Ryazanov A.G., Pavur K.S., Dorovkov M.V.
Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-1299.
[2]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1907, VARIANT LEU-1299.
Tissue: Brain.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-336; ILE-338; SER-414; GLU-433; GLU-579; ARG-602; ASP-663; MET-761; LEU-836; ASP-929; LEU-1299; GLU-1364; TRP-1412; ASP-1557 AND PRO-1622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY044449 mRNA. Translation: AAK95951.1.
AB037751 mRNA. Translation: BAA92568.1.
AC012291 Genomic DNA. No translation available.
CCDSCCDS10333.1.
RefSeqNP_065829.3. NM_020778.4.
UniGeneHs.459183.

3D structure databases

ProteinModelPortalQ96L96.
SMRQ96L96. Positions 279-371, 1489-1565.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96L96. 1 interaction.
STRING9606.ENSP00000258888.

PTM databases

PhosphoSiteQ96L96.

Polymorphism databases

DMDM296434393.

Proteomic databases

PaxDbQ96L96.
PRIDEQ96L96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258888; ENSP00000258888; ENSG00000136383.
GeneID57538.
KEGGhsa:57538.
UCSCuc002ble.3. human.

Organism-specific databases

CTD57538.
GeneCardsGC15P085359.
H-InvDBHIX0012537.
HGNCHGNC:17574. ALPK3.
HPAHPA026558.
neXtProtNX_Q96L96.
PharmGKBPA134921552.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148552.
HOGENOMHOG000169775.
HOVERGENHBG074162.
InParanoidQ96L96.
KOK08868.
OMALKPLKGP.
OrthoDBEOG7H1JJN.
PhylomeDBQ96L96.
TreeFamTF332629.

Gene expression databases

BgeeQ96L96.
CleanExHS_ALPK3.
HS_MAK.
GenevestigatorQ96L96.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTSM00811. Alpha_kinase. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57538.
NextBio63964.
PROQ96L96.

Entry information

Entry nameALPK3_HUMAN
AccessionPrimary (citable) accession number: Q96L96
Secondary accession number(s): Q9P2L6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM