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Q96L96

- ALPK3_HUMAN

UniProt

Q96L96 - ALPK3_HUMAN

Protein

Alpha-protein kinase 3

Gene

ALPK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. heart development Source: HGNC

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-protein kinase 3 (EC:2.7.11.-)
    Alternative name(s):
    Muscle alpha-protein kinase
    Gene namesi
    Name:ALPK3
    Synonyms:KIAA1330, MAK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17574. ALPK3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134921552.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19071907Alpha-protein kinase 3PRO_0000260031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1498 ↔ 1548PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ96L96.
    PRIDEiQ96L96.

    PTM databases

    PhosphoSiteiQ96L96.

    Expressioni

    Gene expression databases

    BgeeiQ96L96.
    CleanExiHS_ALPK3.
    HS_MAK.
    GenevestigatoriQ96L96.

    Organism-specific databases

    HPAiHPA026558.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96L96. 1 interaction.
    STRINGi9606.ENSP00000258888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96L96.
    SMRiQ96L96. Positions 279-371, 1489-1565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini279 – 37092Ig-like 1Add
    BLAST
    Domaini1476 – 156489Ig-like 2Add
    BLAST
    Domaini1592 – 1827236Alpha-type protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi170 – 1756Poly-Ala
    Compositional biasi517 – 5215Poly-Lys
    Compositional biasi766 – 7716Poly-Ser
    Compositional biasi1166 – 11727Poly-Leu

    Sequence similaritiesi

    Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG148552.
    HOGENOMiHOG000169775.
    HOVERGENiHBG074162.
    InParanoidiQ96L96.
    KOiK08868.
    OMAiLKPLKGP.
    OrthoDBiEOG7H1JJN.
    PhylomeDBiQ96L96.
    TreeFamiTF332629.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view]
    PfamiPF02816. Alpha_kinase. 1 hit.
    PF07679. I-set. 1 hit.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96L96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVAWLVYVL GQQPLARQGE GQSRLVPGRG LVLWLPGLPR SSPSWPAVDL     50
    APLAPARPRG PLICHTGHEQ AGREPGPGSS TKGPVLHDQD TRCAFLPRPP 100
    GPLQTRRYCR HQGRQGSGLG AGPGAGTWAP APPGVSKPRC PGRARPGEGQ 150
    QQVTTARPPA INRGARQPRA GAAAAGRGPG AGAWRTGEAA ASAGPAVGEG 200
    GAMGSRRAPS RGWGAGGRSG AGGDGEDDGP VWIPSPASRS YLLSVRPETS 250
    LSSNRLSHPS SGRSTFCSII AQLTEETQPL FETTLKSRSV SEDSDVRFTC 300
    IVTGYPEPEV TWYKDDTELD RYCGLPKYEI THQGNRHTLQ LYRCREEDAA 350
    IYQASAQNSK GIVSCSGVLE VGTMTEYKIH QRWFAKLKRK AAAKLREIEQ 400
    SWKHEKAVPG EVDTLRKLSP DRFQRKRRLS GAQAPGPSVP TREPEGGTLA 450
    AWQEGETETA QHSGLGLINS FASGEVTTNG EAAPENGEDG EHGLLTYICD 500
    AMELGPQRAL KEESGAKKKK KDEESKQGLR KPELEKAAQS RRSSENCIPS 550
    SDEPDSCGTQ GPVGVEQVQT QPRGRAARGP GSSGTDSTRK PASAVGTPDK 600
    AQKAPGPGPG QEVYFSLKDM YLENTQAVRP LGEEGPQTLS VRAPGESPKG 650
    KAPLRARSEG VPGAPGQPTH SLTPQPTRPF NRKRFAPPKP KGEATTDSKP 700
    ISSLSQAPEC GAQSLGKAPP QASVQVPTPP ARRRHGTRDS TLQGQAGHRT 750
    PGEVLECQTT TAPTMSASSS SDVASIGVST SGSQGIIEPM DMETQEDGRT 800
    SANQRTGSKK NVQADGKIQV DGRTRGDGTQ TAQRTRADRK TQVDAGTQES 850
    KRPQSDRSAQ KGMMTQGRAE TQLETTQAGE KIQEDRKAQA DKGTQEDRRM 900
    QGEKGMQGEK GTQSEGSAPT AMEGQSEQEV ATSLGPPSRT PKLPPTAGPR 950
    APLNIECFVQ TPEGSCFPKK PGCLPRSEEA VVTASRNHEQ TVLGPLSGNL 1000
    MLPAQPPHEG SVEQVGGERC RGPQSSGPVE AKQEDSPFQC PKEERPGGVP 1050
    CMDQGGCPLA GLSQEVPTMP SLPGTGLTAS PKAGPCSTPT SQHGSTATFL 1100
    PSEDQVLMSS APTLHLGLGT PTQSHPPETM ATSSEGACAQ VPDVEGRTPG 1150
    PRSCDPGLID SLKNYLLLLL KLSSTETSGA GGESQVGAAT GGLVPSATLT 1200
    PTVEVAGLSP RTSRRILERV ENNHLVQSAQ TLLLSPCTSR RLTGLLDREV 1250
    QAGRQALAAA RGSWGPGPSS LTVPAIVVDE EDPGLASEGA SEGEGEVSPE 1300
    GPGLLGASQE SSMAGRLGEA GGQAAPGQGP SAESIAQEPS QEEKFPGEAL 1350
    TGLPAATPEE LALGARRKRF LPKVRAAGDG EATTPEERES PTVSPRGPRK 1400
    SLVPGSPGTP GRERRSPTQG RKASMLEVPR AEEELAAGDL GPSPKAGGLD 1450
    TEVALDEGKQ ETLAKPRKAK DLLKAPQVIR KIRVEQFPDA SGSLKLWCQF 1500
    FNILSDSVLT WAKDQRPVGE VGRSAGDEGP AALAIVQASP VDCGVYRCTI 1550
    HNEHGSASTD FCLSPEVLSG FISREEGEVG EEIEMTPMVF AKGLADSGCW 1600
    GDKLFGRLVS EELRGGGYGC GLRKASQAKV IYGLEPIFES GRTCIIKVSS 1650
    LLVFGPSSET SLVGRNYDVT IQGCKIQNMS REYCKIFAAE ARAAPGFGEV 1700
    PEIIPLYLIY RPANNIPYAT LEEDLGKPLE SYCSREWGCA EAPTASGSSE 1750
    AMQKCQTFQH WLYQWTNGSF LVTDLAGVDW KMTDVQIATK LRGYQGLKES 1800
    CFPALLDRFA SSHQCNAYCE LLGLTPLKGP EAAHPQAKAK GSKSPSAGRK 1850
    GSQLSPQPQK KGLPSPQGTR KSAPSSKATP QASEPVTTQL LGQPPTQEEG 1900
    SKAQGMR 1907
    Length:1,907
    Mass (Da):201,272
    Last modified:May 18, 2010 - v2
    Checksum:i3896A1EC187BF5C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101S → T in AAK95951. (PubMed:10021370)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti336 – 3361R → H.1 Publication
    Corresponds to variant rs34407151 [ dbSNP | Ensembl ].
    VAR_041524
    Natural varianti338 – 3381T → I.1 Publication
    Corresponds to variant rs56015306 [ dbSNP | Ensembl ].
    VAR_041525
    Natural varianti414 – 4141T → S.1 Publication
    Corresponds to variant rs3803403 [ dbSNP | Ensembl ].
    VAR_028989
    Natural varianti433 – 4331Q → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041526
    Natural varianti579 – 5791G → E.1 Publication
    Corresponds to variant rs3803405 [ dbSNP | Ensembl ].
    VAR_028990
    Natural varianti602 – 6021Q → R.1 Publication
    Corresponds to variant rs55702300 [ dbSNP | Ensembl ].
    VAR_041527
    Natural varianti663 – 6631G → D.1 Publication
    Corresponds to variant rs34409363 [ dbSNP | Ensembl ].
    VAR_041528
    Natural varianti761 – 7611T → M.1 Publication
    Corresponds to variant rs16974569 [ dbSNP | Ensembl ].
    VAR_028991
    Natural varianti836 – 8361R → L.1 Publication
    VAR_041529
    Natural varianti929 – 9291E → D.1 Publication
    VAR_041530
    Natural varianti1013 – 10131E → K.
    Corresponds to variant rs35633849 [ dbSNP | Ensembl ].
    VAR_057743
    Natural varianti1137 – 11371A → G.
    Corresponds to variant rs34173528 [ dbSNP | Ensembl ].
    VAR_057744
    Natural varianti1299 – 12991P → L.3 Publications
    Corresponds to variant rs306197 [ dbSNP | Ensembl ].
    VAR_028992
    Natural varianti1364 – 13641G → E in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041531
    Natural varianti1412 – 14121R → W.1 Publication
    Corresponds to variant rs55752937 [ dbSNP | Ensembl ].
    VAR_041532
    Natural varianti1557 – 15571A → D.1 Publication
    Corresponds to variant rs34775428 [ dbSNP | Ensembl ].
    VAR_041533
    Natural varianti1622 – 16221L → P.1 Publication
    Corresponds to variant rs187316 [ dbSNP | Ensembl ].
    VAR_028993
    Natural varianti1873 – 18731A → V.
    Corresponds to variant rs36002219 [ dbSNP | Ensembl ].
    VAR_057745

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044449 mRNA. Translation: AAK95951.1.
    AB037751 mRNA. Translation: BAA92568.1.
    AC012291 Genomic DNA. No translation available.
    CCDSiCCDS10333.1.
    RefSeqiNP_065829.3. NM_020778.4.
    UniGeneiHs.459183.

    Genome annotation databases

    EnsembliENST00000258888; ENSP00000258888; ENSG00000136383.
    GeneIDi57538.
    KEGGihsa:57538.
    UCSCiuc002ble.3. human.

    Polymorphism databases

    DMDMi296434393.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044449 mRNA. Translation: AAK95951.1 .
    AB037751 mRNA. Translation: BAA92568.1 .
    AC012291 Genomic DNA. No translation available.
    CCDSi CCDS10333.1.
    RefSeqi NP_065829.3. NM_020778.4.
    UniGenei Hs.459183.

    3D structure databases

    ProteinModelPortali Q96L96.
    SMRi Q96L96. Positions 279-371, 1489-1565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96L96. 1 interaction.
    STRINGi 9606.ENSP00000258888.

    PTM databases

    PhosphoSitei Q96L96.

    Polymorphism databases

    DMDMi 296434393.

    Proteomic databases

    PaxDbi Q96L96.
    PRIDEi Q96L96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258888 ; ENSP00000258888 ; ENSG00000136383 .
    GeneIDi 57538.
    KEGGi hsa:57538.
    UCSCi uc002ble.3. human.

    Organism-specific databases

    CTDi 57538.
    GeneCardsi GC15P085359.
    H-InvDB HIX0012537.
    HGNCi HGNC:17574. ALPK3.
    HPAi HPA026558.
    neXtProti NX_Q96L96.
    PharmGKBi PA134921552.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148552.
    HOGENOMi HOG000169775.
    HOVERGENi HBG074162.
    InParanoidi Q96L96.
    KOi K08868.
    OMAi LKPLKGP.
    OrthoDBi EOG7H1JJN.
    PhylomeDBi Q96L96.
    TreeFami TF332629.

    Miscellaneous databases

    GenomeRNAii 57538.
    NextBioi 63964.
    PROi Q96L96.

    Gene expression databases

    Bgeei Q96L96.
    CleanExi HS_ALPK3.
    HS_MAK.
    Genevestigatori Q96L96.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view ]
    Pfami PF02816. Alpha_kinase. 1 hit.
    PF07679. I-set. 1 hit.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
      Ryazanov A.G., Pavur K.S., Dorovkov M.V.
      Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-1299.
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 963-1907, VARIANT LEU-1299.
      Tissue: Brain.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-336; ILE-338; SER-414; GLU-433; GLU-579; ARG-602; ASP-663; MET-761; LEU-836; ASP-929; LEU-1299; GLU-1364; TRP-1412; ASP-1557 AND PRO-1622.

    Entry informationi

    Entry nameiALPK3_HUMAN
    AccessioniPrimary (citable) accession number: Q96L96
    Secondary accession number(s): Q9P2L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3