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Protein

Sorting nexin-22

Gene

SNX22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Phosphatidylinositol 3-phosphate1
Binding sitei45Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen1
Binding sitei66Phosphatidylinositol 3-phosphate1
Binding sitei79Phosphatidylinositol 3-phosphate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-22
Gene namesi
Name:SNX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:16315. SNX22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157734.
PharmGKBiPA134897329.

Polymorphism and mutation databases

BioMutaiSNX22.
DMDMi20140142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138711 – 193Sorting nexin-22Add BLAST193

Proteomic databases

MaxQBiQ96L94.
PaxDbiQ96L94.
PeptideAtlasiQ96L94.
PRIDEiQ96L94.

PTM databases

iPTMnetiQ96L94.
PhosphoSitePlusiQ96L94.

Expressioni

Gene expression databases

BgeeiENSG00000157734.
CleanExiHS_SNX22.
ExpressionAtlasiQ96L94. baseline and differential.
GenevisibleiQ96L94. HS.

Organism-specific databases

HPAiHPA038470.

Interactioni

Protein-protein interaction databases

BioGridi122945. 9 interactors.
IntActiQ96L94. 5 interactors.
STRINGi9606.ENSP00000323435.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Beta strandi26 – 33Combined sources8
Beta strandi36 – 43Combined sources8
Helixi44 – 55Combined sources12
Beta strandi71 – 74Combined sources4
Helixi76 – 93Combined sources18
Beta strandi94 – 97Combined sources4
Helixi99 – 105Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ETTNMR-A2-120[»]
ProteinModelPortaliQ96L94.
SMRiQ96L94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96L94.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 118PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IMHS. Eukaryota.
ENOG4111RIF. LUCA.
GeneTreeiENSGT00390000001280.
HOGENOMiHOG000253944.
HOVERGENiHBG064936.
InParanoidiQ96L94.
KOiK17941.
OMAiWGTLGEF.
OrthoDBiEOG091G0U2N.
PhylomeDBiQ96L94.
TreeFamiTF332414.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96L94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL
60 70 80 90 100
HKRIKKLYKV PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE
110 120 130 140 150
LLEFLRLRHF PTDPKASNWG TLREFLPGDS SSQQHQRPVL SFHVDPYVCN
160 170 180 190
PSPESLPNVV VNGVLQGLYS FSISPDKAQP KAACHPAPLP PMP
Length:193
Mass (Da):22,068
Last modified:December 1, 2001 - v1
Checksum:iB57D8F8B737F429E
GO
Isoform 2 (identifier: Q96L94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-193: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):14,194
Checksum:iB97221C3546F468B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191P → L in BAB14776 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056595121 – 193Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044653 mRNA. Translation: AAK98767.1.
AK024014 mRNA. Translation: BAB14776.1.
AC100840 Genomic DNA. No translation available.
BC019655 mRNA. Translation: AAH19655.1.
CCDSiCCDS10190.1. [Q96L94-1]
RefSeqiNP_079074.2. NM_024798.2. [Q96L94-1]
UniGeneiHs.744250.

Genome annotation databases

EnsembliENST00000325881; ENSP00000323435; ENSG00000157734. [Q96L94-1]
ENST00000558466; ENSP00000452692; ENSG00000157734. [Q96L94-2]
GeneIDi79856.
KEGGihsa:79856.
UCSCiuc002anc.1. human. [Q96L94-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044653 mRNA. Translation: AAK98767.1.
AK024014 mRNA. Translation: BAB14776.1.
AC100840 Genomic DNA. No translation available.
BC019655 mRNA. Translation: AAH19655.1.
CCDSiCCDS10190.1. [Q96L94-1]
RefSeqiNP_079074.2. NM_024798.2. [Q96L94-1]
UniGeneiHs.744250.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ETTNMR-A2-120[»]
ProteinModelPortaliQ96L94.
SMRiQ96L94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122945. 9 interactors.
IntActiQ96L94. 5 interactors.
STRINGi9606.ENSP00000323435.

PTM databases

iPTMnetiQ96L94.
PhosphoSitePlusiQ96L94.

Polymorphism and mutation databases

BioMutaiSNX22.
DMDMi20140142.

Proteomic databases

MaxQBiQ96L94.
PaxDbiQ96L94.
PeptideAtlasiQ96L94.
PRIDEiQ96L94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325881; ENSP00000323435; ENSG00000157734. [Q96L94-1]
ENST00000558466; ENSP00000452692; ENSG00000157734. [Q96L94-2]
GeneIDi79856.
KEGGihsa:79856.
UCSCiuc002anc.1. human. [Q96L94-1]

Organism-specific databases

CTDi79856.
GeneCardsiSNX22.
HGNCiHGNC:16315. SNX22.
HPAiHPA038470.
neXtProtiNX_Q96L94.
OpenTargetsiENSG00000157734.
PharmGKBiPA134897329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHS. Eukaryota.
ENOG4111RIF. LUCA.
GeneTreeiENSGT00390000001280.
HOGENOMiHOG000253944.
HOVERGENiHBG064936.
InParanoidiQ96L94.
KOiK17941.
OMAiWGTLGEF.
OrthoDBiEOG091G0U2N.
PhylomeDBiQ96L94.
TreeFamiTF332414.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157734-MONOMER.

Miscellaneous databases

ChiTaRSiSNX22. human.
EvolutionaryTraceiQ96L94.
GenomeRNAii79856.
PROiQ96L94.

Gene expression databases

BgeeiENSG00000157734.
CleanExiHS_SNX22.
ExpressionAtlasiQ96L94. baseline and differential.
GenevisibleiQ96L94. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX22_HUMAN
AccessioniPrimary (citable) accession number: Q96L94
Secondary accession number(s): Q8WUS9, Q9H844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.