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Q96L93

- KI16B_HUMAN

UniProt

Q96L93 - KI16B_HUMAN

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Protein
Kinesin-like protein KIF16B
Gene
KIF16B, C20orf23, KIAA1590, SNX23
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  3. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  4. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  5. phosphatidylinositol-3-phosphate binding Source: UniProtKB
  6. plus-end-directed microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. Golgi to endosome transport Source: UniProtKB
  2. early endosome to late endosome transport Source: UniProtKB
  3. endoderm development Source: UniProtKB
  4. epidermal growth factor receptor signaling pathway Source: UniProtKB
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. formation of primary germ layer Source: UniProtKB
  7. microtubule-based movement Source: InterPro
  8. receptor catabolic process Source: UniProtKB
  9. regulation of receptor recycling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.4. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF16B
Alternative name(s):
Sorting nexin-23
Gene namesi
Name:KIF16B
Synonyms:C20orf23, KIAA1590, SNX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15869. KIF16B.

Subcellular locationi

Cytoplasmcytoskeleton Inferred. Early endosome membrane
Note: It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns3P)-binding or via its interaction with RAB14.2 Publications

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. early endosome membrane Source: UniProtKB-SubCell
  3. endosome Source: UniProtKB
  4. kinesin complex Source: InterPro
  5. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091S → A: Impairs plus end-directed microtubule-dependent motor activity, leading to impair EGFR recycling. 1 Publication
Mutagenesisi1220 – 12201R → A: Abolishes PtdIns(3)P-binding. 1 Publication
Mutagenesisi1225 – 12251R → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1229 and A-1232. 1 Publication
Mutagenesisi1229 – 12291K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1232. 1 Publication
Mutagenesisi1232 – 12321K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1229. 1 Publication
Mutagenesisi1248 – 12481L → A: Induces a 7-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1249. 1 Publication
Mutagenesisi1248 – 12481L → V: Induces a 6-fold decrease in PtdIns(3)P-binding. 1 Publication
Mutagenesisi1249 – 12491F → A: Induces a 5-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1248. 1 Publication
Mutagenesisi1260 – 12601R → A: Induces a 30-fold decrease in PtdIns(3)P-binding. 1 Publication

Organism-specific databases

PharmGKBiPA162393227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13171317Kinesin-like protein KIF16B
PRO_0000125466Add
BLAST

Post-translational modificationi

Isoform 4 is ubiquitinated at Lys-685.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96L93.
PaxDbiQ96L93.
PRIDEiQ96L93.

PTM databases

PhosphoSiteiQ96L93.

Expressioni

Tissue specificityi

Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ96L93.
BgeeiQ96L93.
CleanExiHS_KIF16B.
GenevestigatoriQ96L93.

Organism-specific databases

HPAiHPA051198.

Interactioni

Subunit structurei

Interacts with RAB14 By similarity. Interacts with PTPN21.1 Publication

Protein-protein interaction databases

BioGridi120754. 4 interactions.
IntActiQ96L93. 2 interactions.
MINTiMINT-5225330.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1184 – 119613
Beta strandi1201 – 121010
Beta strandi1213 – 12197
Helixi1221 – 123414
Helixi1236 – 12405
Helixi1254 – 127724
Helixi1294 – 13007
Helixi1302 – 13043

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V14X-ray2.20A1179-1312[»]
ProteinModelPortaliQ96L93.
SMRiQ96L93. Positions 2-356, 406-563, 1179-1312.

Miscellaneous databases

EvolutionaryTraceiQ96L93.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 358356Kinesin motor
Add
BLAST
Domaini478 – 52952FHA
Add
BLAST
Domaini1182 – 1296115PX
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 42556 Reviewed prediction
Add
BLAST
Coiled coili595 – 882288 Reviewed prediction
Add
BLAST
Coiled coili936 – 1087152 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi597 – 1070474Glu-rich
Add
BLAST

Domaini

The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).2 Publications

Sequence similaritiesi

Contains 1 FHA domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOVERGENiHBG099335.
KOiK17916.
OMAiLHIDKVG.
OrthoDBiEOG77Q4VS.
PhylomeDBiQ96L93.
TreeFamiTF105221.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96L93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR     50
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA 100
YGQTGSGKSY TMMGNSGDSG LIPRICEGLF SRINETTRWD EASFRTEVSY 150
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYGDVEE 200
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM PCETVSKIHL 250
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANTL 300
AKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR 350
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT 400
ALSMEEKLQQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD 450
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GRDDASTEQD IVLHGLDLES 500
EHCIFENIGG TVTLIPLSGS QCSVNGVQIV EATHLNQGAV ILLGRTNMFR 550
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSRENLSAVM LYNPGLEFER 600
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RKETEIVQLQ 650
IRKQEESLKR RSFHIENKLK DLLAEKEKFE EERLREQQEI ELQKKRQEEE 700
TFLRVQEELQ RLKELNNNEK AEKFQIFQEL DQLQKEKDEQ YAKLELEKKR 750
LEEQEKEQVM LVAHLEEQLR EKQEMIQLLR RGEVQWVEEE KRDLEGIRES 800
LLRVKEARAG GDEDGEELEK AQLRFFEFKR RQLVKLVNLE KDLVQQKDIL 850
KKEVQEEQEI LECLKCEHDK ESRLLEKHDE SVTDVTEVPQ DFEKIKPVEY 900
RLQYKERQLQ YLLQNHLPTL LEEKQRAFEI LDRGPLSLDN TLYQVEKEME 950
EKEEQLAQYQ ANANQLQKLQ ATFEFTANIA RQEEKVRKKE KEILESREKQ 1000
QREALERALA RLERRHSALQ RHSTLGMEIE EQRQKLASLN SGSREQSGLQ 1050
ASLEAEQEAL EKDQERLEYE IQQLKQKIYE VDGVQKDHHG TLEGKVASSS 1100
LPVSAEKSHL VPLMDARINA YIEEEVQRRL QDLHRVISEG CSTSADTMKD 1150
NEKLHNGTIQ RKLKYERMVS RSLGANPDDL KDPIKISIPR YVLCGQGKDA 1200
HFEFEVKITV LDETWTVFRR YSRFREMHKT LKLKYAELAA LEFPPKKLFG 1250
NKDERVIAER RSHLEKYLRD FFSVMLQSAT SPLHINKVGL TLSKHTICEF 1300
SPFFKKGVFD YSSHGTG 1317
Length:1,317
Mass (Da):152,011
Last modified:July 19, 2004 - v2
Checksum:i278E9CB88D9C04DF
GO
Isoform 2 (identifier: Q96L93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1317: RMVSRSLGAN...VFDYSSHGTG → LCRDLLCVLM...LWLISHLTRL

Note: Ubiquitinated at position 685.

Show »
Length:1,392
Mass (Da):159,831
Checksum:i85A4365F83AADDB9
GO
Isoform 3 (identifier: Q96L93-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1208-1237: Missing.

Note: No experimental confirmation available.

Show »
Length:1,287
Mass (Da):148,211
Checksum:i9BA79E2857090F5F
GO
Isoform 4 (identifier: Q96L93-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-840: Missing.

Note: No experimental confirmation available.

Show »
Length:1,161
Mass (Da):132,866
Checksum:i078AB4C77FBAA4C3
GO
Isoform 5 (identifier: Q96L93-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1207: Missing.

Note: No experimental confirmation available.

Show »
Length:1,276
Mass (Da):147,398
Checksum:i430E508AEE6E2E12
GO

Sequence cautioni

The sequence BAA90971.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA90971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB13416.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB15530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI43062.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI43179.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti772 – 7721K → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036218
Natural varianti810 – 8101G → R.
Corresponds to variant rs2236145 [ dbSNP | Ensembl ].
VAR_049700
Natural varianti824 – 8241R → S.
Corresponds to variant rs2236144 [ dbSNP | Ensembl ].
VAR_019396
Natural varianti999 – 9991K → N.
Corresponds to variant rs8116503 [ dbSNP | Ensembl ].
VAR_065248
Natural varianti1027 – 10271M → T.3 Publications
Corresponds to variant rs6034464 [ dbSNP | Ensembl ].
VAR_019397
Natural varianti1119 – 11191N → S.
Corresponds to variant rs8123195 [ dbSNP | Ensembl ].
VAR_019398

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei685 – 840156Missing in isoform 4.
VSP_015858Add
BLAST
Alternative sequencei1167 – 1317151RMVSR…SHGTG → LCRDLLCVLMPEPDAAACAN HPLLQQDLVQLSLDWKTEIP DLVLPNGVQVSSKFQTTLVD MIYFLHGNMEVNVPSLAEVQ LLLYTTVKVMGDSGHDQCQS LVLLNTHIALVKEDCVFYPR IRSRNIPPPGAQFDVIKCHA LSEFRCVVVPEKKNVSTVEL VFLQKLKPSVGSRNSPPEHL QEAPNVQLFTTPLYLQGSQN VAPEVWKLTFNSQDEALWLI SHLTRL in isoform 2.
VSP_010851Add
BLAST
Alternative sequencei1167 – 120741Missing in isoform 5.
VSP_041318Add
BLAST
Alternative sequencei1208 – 123730Missing in isoform 3.
VSP_010852Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181K → E in AK095322. 1 Publication
Sequence conflicti274 – 2741N → D in CAI46105. 1 Publication
Sequence conflicti583 – 5831R → H in BAA90971. 1 Publication
Sequence conflicti649 – 6491L → H in CAI46266. 1 Publication
Sequence conflicti1056 – 10572EQ → SE in AAH34984. 1 Publication
Sequence conflicti1100 – 11001S → N in CAI46105. 1 Publication
Sequence conflicti1108 – 11081S → L in AAH34984. 1 Publication
Sequence conflicti1244 – 12441P → A in AAO17292. 1 Publication
Sequence conflicti1244 – 12441P → A in BAB15530. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046810 mRNA. Translation: BAB13416.2. Different initiation.
BX647572 mRNA. Translation: CAI46105.1.
BX648426 mRNA. Translation: CAI46266.1.
AY166853 mRNA. Translation: AAO17292.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAI22745.2.
AL117376, AL049794, AL118509 Genomic DNA. Translation: CAI43180.2.
AL117376 Genomic DNA. Translation: CAI43181.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAI43063.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAM28305.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAM28307.1.
AL118509, AL117376 Genomic DNA. Translation: CAI43062.1. Sequence problems.
AL117376, AL118509 Genomic DNA. Translation: CAI43179.1. Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1.
BC034984 mRNA. Translation: AAH34984.2.
BC110317 mRNA. Translation: AAI10318.1.
BC150261 mRNA. Translation: AAI50262.1.
AY044654 mRNA. Translation: AAK98768.1.
AK000142 mRNA. Translation: BAA90971.1. Sequence problems.
AK026698 mRNA. Translation: BAB15530.1. Different initiation.
AK095322 mRNA. No translation available.
CCDSiCCDS13122.1. [Q96L93-1]
CCDS56178.1. [Q96L93-2]
RefSeqiNP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2]
NP_078980.3. NM_024704.4. [Q96L93-1]
UniGeneiHs.101774.

Genome annotation databases

EnsembliENST00000354981; ENSP00000347076; ENSG00000089177. [Q96L93-1]
ENST00000355755; ENSP00000347995; ENSG00000089177. [Q96L93-4]
ENST00000408042; ENSP00000384164; ENSG00000089177. [Q96L93-2]
GeneIDi55614.
KEGGihsa:55614.
UCSCiuc002wpe.1. human. [Q96L93-4]
uc002wpf.1. human. [Q96L93-6]
uc002wpg.2. human. [Q96L93-1]
uc010gci.2. human. [Q96L93-2]

Polymorphism databases

DMDMi50403793.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046810 mRNA. Translation: BAB13416.2 . Different initiation.
BX647572 mRNA. Translation: CAI46105.1 .
BX648426 mRNA. Translation: CAI46266.1 .
AY166853 mRNA. Translation: AAO17292.1 .
AL049794 , AL117376 , AL118509 Genomic DNA. Translation: CAI22745.2 .
AL117376 , AL049794 , AL118509 Genomic DNA. Translation: CAI43180.2 .
AL117376 Genomic DNA. Translation: CAI43181.2 .
AL118509 , AL049794 , AL117376 Genomic DNA. Translation: CAI43063.2 .
AL118509 , AL049794 , AL117376 Genomic DNA. Translation: CAM28305.1 .
AL049794 , AL117376 , AL118509 Genomic DNA. Translation: CAM28307.1 .
AL118509 , AL117376 Genomic DNA. Translation: CAI43062.1 . Sequence problems.
AL117376 , AL118509 Genomic DNA. Translation: CAI43179.1 . Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1 .
BC034984 mRNA. Translation: AAH34984.2 .
BC110317 mRNA. Translation: AAI10318.1 .
BC150261 mRNA. Translation: AAI50262.1 .
AY044654 mRNA. Translation: AAK98768.1 .
AK000142 mRNA. Translation: BAA90971.1 . Sequence problems.
AK026698 mRNA. Translation: BAB15530.1 . Different initiation.
AK095322 mRNA. No translation available.
CCDSi CCDS13122.1. [Q96L93-1 ]
CCDS56178.1. [Q96L93-2 ]
RefSeqi NP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2 ]
NP_078980.3. NM_024704.4. [Q96L93-1 ]
UniGenei Hs.101774.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V14 X-ray 2.20 A 1179-1312 [» ]
ProteinModelPortali Q96L93.
SMRi Q96L93. Positions 2-356, 406-563, 1179-1312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120754. 4 interactions.
IntActi Q96L93. 2 interactions.
MINTi MINT-5225330.

PTM databases

PhosphoSitei Q96L93.

Polymorphism databases

DMDMi 50403793.

Proteomic databases

MaxQBi Q96L93.
PaxDbi Q96L93.
PRIDEi Q96L93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354981 ; ENSP00000347076 ; ENSG00000089177 . [Q96L93-1 ]
ENST00000355755 ; ENSP00000347995 ; ENSG00000089177 . [Q96L93-4 ]
ENST00000408042 ; ENSP00000384164 ; ENSG00000089177 . [Q96L93-2 ]
GeneIDi 55614.
KEGGi hsa:55614.
UCSCi uc002wpe.1. human. [Q96L93-4 ]
uc002wpf.1. human. [Q96L93-6 ]
uc002wpg.2. human. [Q96L93-1 ]
uc010gci.2. human. [Q96L93-2 ]

Organism-specific databases

CTDi 55614.
GeneCardsi GC20M016201.
HGNCi HGNC:15869. KIF16B.
HPAi HPA051198.
neXtProti NX_Q96L93.
PharmGKBi PA162393227.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOVERGENi HBG099335.
KOi K17916.
OMAi LHIDKVG.
OrthoDBi EOG77Q4VS.
PhylomeDBi Q96L93.
TreeFami TF105221.

Enzyme and pathway databases

BRENDAi 3.6.4.4. 2681.

Miscellaneous databases

ChiTaRSi KIF16B. human.
EvolutionaryTracei Q96L93.
GeneWikii KIF16B.
GenomeRNAii 55614.
NextBioi 60192.
PROi Q96L93.

Gene expression databases

ArrayExpressi Q96L93.
Bgeei Q96L93.
CleanExi HS_KIF16B.
Genevestigatori Q96L93.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-1027.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 557-1317 (ISOFORM 4), VARIANT THR-1027.
    Tissue: Adipose tissue and Salivary gland.
  3. Guo J.H.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 916-1317 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1056-1317 (ISOFORM 3), VARIANT THR-1027.
    Tissue: Hippocampus and Liver.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-948 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1085-1317 (ISOFORMS 1/4).
    Tissue: Colon, Lung and Tongue.
  8. "A new member (SNX23) of the sorting nexin family."
    Hong W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1114-1317 (ISOFORMS 1/4).
  9. "Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B."
    Hoepfner S., Severin F., Cabezas A., Habermann B., Runge A., Gillooly D., Stenmark H., Zerial M.
    Cell 121:437-450(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN PX, PHOSPHATIDYLINOSITOL-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-109.
  10. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-685 (ISOFORM 4).
    Tissue: Lung adenocarcinoma.
  11. Cited for: INTERACTION WITH PTPN21.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The structural basis of novel endosome anchoring activity of KIF16B kinesin."
    Blatner N.R., Wilson M.I., Lei C., Hong W., Murray D., Williams R.L., Cho W.
    EMBO J. 26:3709-3719(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1179-1312, SUBCELLULAR LOCATION, PHOSPHATIDYLINOSITOL-BINDING, DOMAIN PX, MUTAGENESIS OF ARG-1220; ARG-1225; LYS-1229; LYS-1232; LEU-1248; PHE-1249 AND ARG-1260.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-772.

Entry informationi

Entry nameiKI16B_HUMAN
AccessioniPrimary (citable) accession number: Q96L93
Secondary accession number(s): A6NKJ9
, A7E2A8, B1AKG3, B1AKT7, C9JDN5, C9JI52, C9JSM8, C9JWJ7, Q2TBF5, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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