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Protein

Kinesin-like protein KIF16B

Gene

KIF16B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: UniProtKB
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • early endosome to late endosome transport Source: UniProtKB
  • endoderm development Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • formation of primary germ layer Source: UniProtKB
  • Golgi to endosome transport Source: UniProtKB
  • microtubule-based movement Source: GO_Central
  • receptor catabolic process Source: UniProtKB
  • regulation of receptor recycling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089177-MONOMER.
BRENDAi3.6.4.4. 2681.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF16B
Alternative name(s):
Sorting nexin-23
Gene namesi
Name:KIF16B
Synonyms:C20orf23, KIAA1590, SNX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15869. KIF16B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • endosome Source: UniProtKB
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109S → A: Impairs plus end-directed microtubule-dependent motor activity, leading to impair EGFR recycling. 1 Publication1
Mutagenesisi1220R → A: Abolishes PtdIns(3)P-binding. 1 Publication1
Mutagenesisi1225R → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1229 and A-1232. 1 Publication1
Mutagenesisi1229K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1232. 1 Publication1
Mutagenesisi1232K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1229. 1 Publication1
Mutagenesisi1248L → A: Induces a 7-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1249. 1 Publication1
Mutagenesisi1248L → V: Induces a 6-fold decrease in PtdIns(3)P-binding. 1 Publication1
Mutagenesisi1249F → A: Induces a 5-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1248. 1 Publication1
Mutagenesisi1260R → A: Induces a 30-fold decrease in PtdIns(3)P-binding. 1 Publication1

Organism-specific databases

DisGeNETi55614.
OpenTargetsiENSG00000089177.
PharmGKBiPA162393227.

Polymorphism and mutation databases

BioMutaiKIF16B.
DMDMi50403793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254661 – 1317Kinesin-like protein KIF16BAdd BLAST1317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei398PhosphoserineCombined sources1
Modified residuei577PhosphothreonineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei1052PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96L93.
PaxDbiQ96L93.
PeptideAtlasiQ96L93.
PRIDEiQ96L93.

PTM databases

iPTMnetiQ96L93.
PhosphoSitePlusiQ96L93.

Expressioni

Tissue specificityi

Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000089177.
CleanExiHS_KIF16B.
ExpressionAtlasiQ96L93. baseline and differential.
GenevisibleiQ96L93. HS.

Organism-specific databases

HPAiHPA051198.

Interactioni

Subunit structurei

Interacts with RAB14 (By similarity). Interacts with PTPN21.By similarity1 Publication

Protein-protein interaction databases

BioGridi120754. 13 interactors.
IntActiQ96L93. 9 interactors.
MINTiMINT-5225330.
STRINGi9606.ENSP00000384164.

Structurei

Secondary structure

11317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1184 – 1196Combined sources13
Beta strandi1201 – 1210Combined sources10
Beta strandi1213 – 1219Combined sources7
Helixi1221 – 1234Combined sources14
Helixi1236 – 1240Combined sources5
Helixi1254 – 1277Combined sources24
Helixi1294 – 1300Combined sources7
Helixi1302 – 1304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V14X-ray2.20A1179-1312[»]
ProteinModelPortaliQ96L93.
SMRiQ96L93.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96L93.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 358Kinesin motorPROSITE-ProRule annotationAdd BLAST356
Domaini478 – 529FHAAdd BLAST52
Domaini1182 – 1296PXPROSITE-ProRule annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili370 – 425Sequence analysisAdd BLAST56
Coiled coili595 – 882Sequence analysisAdd BLAST288
Coiled coili936 – 1087Sequence analysisAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi597 – 1070Glu-richAdd BLAST474

Domaini

The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).2 Publications

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG099335.
InParanoidiQ96L93.
KOiK17916.
OMAiLHIDKVG.
OrthoDBiEOG091G00V7.
PhylomeDBiQ96L93.
TreeFamiTF105221.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96L93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR
60 70 80 90 100
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA
110 120 130 140 150
YGQTGSGKSY TMMGNSGDSG LIPRICEGLF SRINETTRWD EASFRTEVSY
160 170 180 190 200
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYGDVEE
210 220 230 240 250
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM PCETVSKIHL
260 270 280 290 300
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANTL
310 320 330 340 350
AKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR
360 370 380 390 400
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT
410 420 430 440 450
ALSMEEKLQQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD
460 470 480 490 500
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GRDDASTEQD IVLHGLDLES
510 520 530 540 550
EHCIFENIGG TVTLIPLSGS QCSVNGVQIV EATHLNQGAV ILLGRTNMFR
560 570 580 590 600
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSRENLSAVM LYNPGLEFER
610 620 630 640 650
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RKETEIVQLQ
660 670 680 690 700
IRKQEESLKR RSFHIENKLK DLLAEKEKFE EERLREQQEI ELQKKRQEEE
710 720 730 740 750
TFLRVQEELQ RLKELNNNEK AEKFQIFQEL DQLQKEKDEQ YAKLELEKKR
760 770 780 790 800
LEEQEKEQVM LVAHLEEQLR EKQEMIQLLR RGEVQWVEEE KRDLEGIRES
810 820 830 840 850
LLRVKEARAG GDEDGEELEK AQLRFFEFKR RQLVKLVNLE KDLVQQKDIL
860 870 880 890 900
KKEVQEEQEI LECLKCEHDK ESRLLEKHDE SVTDVTEVPQ DFEKIKPVEY
910 920 930 940 950
RLQYKERQLQ YLLQNHLPTL LEEKQRAFEI LDRGPLSLDN TLYQVEKEME
960 970 980 990 1000
EKEEQLAQYQ ANANQLQKLQ ATFEFTANIA RQEEKVRKKE KEILESREKQ
1010 1020 1030 1040 1050
QREALERALA RLERRHSALQ RHSTLGMEIE EQRQKLASLN SGSREQSGLQ
1060 1070 1080 1090 1100
ASLEAEQEAL EKDQERLEYE IQQLKQKIYE VDGVQKDHHG TLEGKVASSS
1110 1120 1130 1140 1150
LPVSAEKSHL VPLMDARINA YIEEEVQRRL QDLHRVISEG CSTSADTMKD
1160 1170 1180 1190 1200
NEKLHNGTIQ RKLKYERMVS RSLGANPDDL KDPIKISIPR YVLCGQGKDA
1210 1220 1230 1240 1250
HFEFEVKITV LDETWTVFRR YSRFREMHKT LKLKYAELAA LEFPPKKLFG
1260 1270 1280 1290 1300
NKDERVIAER RSHLEKYLRD FFSVMLQSAT SPLHINKVGL TLSKHTICEF
1310
SPFFKKGVFD YSSHGTG
Length:1,317
Mass (Da):152,011
Last modified:July 19, 2004 - v2
Checksum:i278E9CB88D9C04DF
GO
Isoform 2 (identifier: Q96L93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1317: RMVSRSLGAN...VFDYSSHGTG → LCRDLLCVLM...LWLISHLTRL

Show »
Length:1,392
Mass (Da):159,831
Checksum:i85A4365F83AADDB9
GO
Isoform 3 (identifier: Q96L93-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1208-1237: Missing.

Note: No experimental confirmation available.
Show »
Length:1,287
Mass (Da):148,211
Checksum:i9BA79E2857090F5F
GO
Isoform 4 (identifier: Q96L93-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-840: Missing.

Note: No experimental confirmation available.
Show »
Length:1,161
Mass (Da):132,866
Checksum:i078AB4C77FBAA4C3
GO
Isoform 5 (identifier: Q96L93-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1207: Missing.

Note: No experimental confirmation available.
Show »
Length:1,276
Mass (Da):147,398
Checksum:i430E508AEE6E2E12
GO

Sequence cautioni

The sequence BAA90971 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA90971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB13416 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI43062 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI43179 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18K → E in AK095322 (PubMed:14702039).Curated1
Sequence conflicti274N → D in CAI46105 (PubMed:17974005).Curated1
Sequence conflicti583R → H in BAA90971 (PubMed:14702039).Curated1
Sequence conflicti649L → H in CAI46266 (PubMed:17974005).Curated1
Sequence conflicti1056 – 1057EQ → SE in AAH34984 (PubMed:15489334).Curated2
Sequence conflicti1100S → N in CAI46105 (PubMed:17974005).Curated1
Sequence conflicti1108S → L in AAH34984 (PubMed:15489334).Curated1
Sequence conflicti1244P → A in AAO17292 (Ref. 3) Curated1
Sequence conflicti1244P → A in BAB15530 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036218772K → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049700810G → R.Corresponds to variant rs2236145dbSNPEnsembl.1
Natural variantiVAR_019396824R → S.Corresponds to variant rs2236144dbSNPEnsembl.1
Natural variantiVAR_065248999K → N.Corresponds to variant rs8116503dbSNPEnsembl.1
Natural variantiVAR_0193971027M → T.3 PublicationsCorresponds to variant rs6034464dbSNPEnsembl.1
Natural variantiVAR_0193981119N → S.Corresponds to variant rs8123195dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015858685 – 840Missing in isoform 4. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_0108511167 – 1317RMVSR…SHGTG → LCRDLLCVLMPEPDAAACAN HPLLQQDLVQLSLDWKTEIP DLVLPNGVQVSSKFQTTLVD MIYFLHGNMEVNVPSLAEVQ LLLYTTVKVMGDSGHDQCQS LVLLNTHIALVKEDCVFYPR IRSRNIPPPGAQFDVIKCHA LSEFRCVVVPEKKNVSTVEL VFLQKLKPSVGSRNSPPEHL QEAPNVQLFTTPLYLQGSQN VAPEVWKLTFNSQDEALWLI SHLTRL in isoform 2. 2 PublicationsAdd BLAST151
Alternative sequenceiVSP_0413181167 – 1207Missing in isoform 5. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0108521208 – 1237Missing in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046810 mRNA. Translation: BAB13416.2. Different initiation.
BX647572 mRNA. Translation: CAI46105.1.
BX648426 mRNA. Translation: CAI46266.1.
AY166853 mRNA. Translation: AAO17292.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAI22745.2.
AL117376, AL049794, AL118509 Genomic DNA. Translation: CAI43180.2.
AL117376 Genomic DNA. Translation: CAI43181.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAI43063.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAM28305.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAM28307.1.
AL118509, AL117376 Genomic DNA. Translation: CAI43062.1. Sequence problems.
AL117376, AL118509 Genomic DNA. Translation: CAI43179.1. Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1.
BC034984 mRNA. Translation: AAH34984.2.
BC110317 mRNA. Translation: AAI10318.1.
BC150261 mRNA. Translation: AAI50262.1.
AY044654 mRNA. Translation: AAK98768.1.
AK000142 mRNA. Translation: BAA90971.1. Sequence problems.
AK026698 mRNA. Translation: BAB15530.1. Different initiation.
AK095322 mRNA. No translation available.
CCDSiCCDS13122.1. [Q96L93-1]
CCDS56178.1. [Q96L93-2]
RefSeqiNP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2]
NP_078980.3. NM_024704.4. [Q96L93-1]
XP_016883415.1. XM_017027926.1. [Q96L93-6]
UniGeneiHs.101774.

Genome annotation databases

EnsembliENST00000354981; ENSP00000347076; ENSG00000089177. [Q96L93-1]
ENST00000408042; ENSP00000384164; ENSG00000089177. [Q96L93-2]
GeneIDi55614.
KEGGihsa:55614.
UCSCiuc002wpg.3. human. [Q96L93-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046810 mRNA. Translation: BAB13416.2. Different initiation.
BX647572 mRNA. Translation: CAI46105.1.
BX648426 mRNA. Translation: CAI46266.1.
AY166853 mRNA. Translation: AAO17292.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAI22745.2.
AL117376, AL049794, AL118509 Genomic DNA. Translation: CAI43180.2.
AL117376 Genomic DNA. Translation: CAI43181.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAI43063.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAM28305.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAM28307.1.
AL118509, AL117376 Genomic DNA. Translation: CAI43062.1. Sequence problems.
AL117376, AL118509 Genomic DNA. Translation: CAI43179.1. Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1.
BC034984 mRNA. Translation: AAH34984.2.
BC110317 mRNA. Translation: AAI10318.1.
BC150261 mRNA. Translation: AAI50262.1.
AY044654 mRNA. Translation: AAK98768.1.
AK000142 mRNA. Translation: BAA90971.1. Sequence problems.
AK026698 mRNA. Translation: BAB15530.1. Different initiation.
AK095322 mRNA. No translation available.
CCDSiCCDS13122.1. [Q96L93-1]
CCDS56178.1. [Q96L93-2]
RefSeqiNP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2]
NP_078980.3. NM_024704.4. [Q96L93-1]
XP_016883415.1. XM_017027926.1. [Q96L93-6]
UniGeneiHs.101774.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V14X-ray2.20A1179-1312[»]
ProteinModelPortaliQ96L93.
SMRiQ96L93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120754. 13 interactors.
IntActiQ96L93. 9 interactors.
MINTiMINT-5225330.
STRINGi9606.ENSP00000384164.

PTM databases

iPTMnetiQ96L93.
PhosphoSitePlusiQ96L93.

Polymorphism and mutation databases

BioMutaiKIF16B.
DMDMi50403793.

Proteomic databases

MaxQBiQ96L93.
PaxDbiQ96L93.
PeptideAtlasiQ96L93.
PRIDEiQ96L93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354981; ENSP00000347076; ENSG00000089177. [Q96L93-1]
ENST00000408042; ENSP00000384164; ENSG00000089177. [Q96L93-2]
GeneIDi55614.
KEGGihsa:55614.
UCSCiuc002wpg.3. human. [Q96L93-1]

Organism-specific databases

CTDi55614.
DisGeNETi55614.
GeneCardsiKIF16B.
HGNCiHGNC:15869. KIF16B.
HPAiHPA051198.
neXtProtiNX_Q96L93.
OpenTargetsiENSG00000089177.
PharmGKBiPA162393227.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOVERGENiHBG099335.
InParanoidiQ96L93.
KOiK17916.
OMAiLHIDKVG.
OrthoDBiEOG091G00V7.
PhylomeDBiQ96L93.
TreeFamiTF105221.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089177-MONOMER.
BRENDAi3.6.4.4. 2681.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF16B. human.
EvolutionaryTraceiQ96L93.
GeneWikiiKIF16B.
GenomeRNAii55614.
PROiQ96L93.

Gene expression databases

BgeeiENSG00000089177.
CleanExiHS_KIF16B.
ExpressionAtlasiQ96L93. baseline and differential.
GenevisibleiQ96L93. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
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Entry informationi

Entry nameiKI16B_HUMAN
AccessioniPrimary (citable) accession number: Q96L93
Secondary accession number(s): A6NKJ9
, A7E2A8, B1AKG3, B1AKT7, C9JDN5, C9JI52, C9JSM8, C9JWJ7, Q2TBF5, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.