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Q96L93

- KI16B_HUMAN

UniProt

Q96L93 - KI16B_HUMAN

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Protein

Kinesin-like protein KIF16B

Gene

KIF16B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  4. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  5. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  6. phosphatidylinositol-3-phosphate binding Source: UniProtKB
  7. plus-end-directed microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. early endosome to late endosome transport Source: UniProtKB
  3. endoderm development Source: UniProtKB
  4. epidermal growth factor receptor signaling pathway Source: UniProtKB
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. formation of primary germ layer Source: UniProtKB
  7. Golgi to endosome transport Source: UniProtKB
  8. microtubule-based movement Source: RefGenome
  9. receptor catabolic process Source: UniProtKB
  10. regulation of receptor recycling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.4. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF16B
Alternative name(s):
Sorting nexin-23
Gene namesi
Name:KIF16B
Synonyms:C20orf23, KIAA1590, SNX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15869. KIF16B.

Subcellular locationi

Cytoplasmcytoskeleton Curated. Early endosome membrane
Note: It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns3P)-binding or via its interaction with RAB14.

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. endosome Source: UniProtKB
  3. kinesin complex Source: RefGenome
  4. membrane Source: UniProtKB-KW
  5. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091S → A: Impairs plus end-directed microtubule-dependent motor activity, leading to impair EGFR recycling. 1 Publication
Mutagenesisi1220 – 12201R → A: Abolishes PtdIns(3)P-binding. 1 Publication
Mutagenesisi1225 – 12251R → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1229 and A-1232. 1 Publication
Mutagenesisi1229 – 12291K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1232. 1 Publication
Mutagenesisi1232 – 12321K → A: Induces a 3-fold decrease in PtdIns(3)P-binding; when associated with A-1225 and A-1229. 1 Publication
Mutagenesisi1248 – 12481L → A: Induces a 7-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1249. 1 Publication
Mutagenesisi1248 – 12481L → V: Induces a 6-fold decrease in PtdIns(3)P-binding. 1 Publication
Mutagenesisi1249 – 12491F → A: Induces a 5-fold decrease in PtdIns(3)P-binding and abolishes endosome localization. Induces a 25-fold decrease in PtdIns(3)P-binding; when associated with A-1248. 1 Publication
Mutagenesisi1260 – 12601R → A: Induces a 30-fold decrease in PtdIns(3)P-binding. 1 Publication

Organism-specific databases

PharmGKBiPA162393227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13171317Kinesin-like protein KIF16BPRO_0000125466Add
BLAST

Post-translational modificationi

Isoform 4 is ubiquitinated at Lys-685.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96L93.
PaxDbiQ96L93.
PRIDEiQ96L93.

PTM databases

PhosphoSiteiQ96L93.

Expressioni

Tissue specificityi

Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ96L93.
CleanExiHS_KIF16B.
GenevestigatoriQ96L93.

Organism-specific databases

HPAiHPA051198.

Interactioni

Subunit structurei

Interacts with RAB14 (By similarity). Interacts with PTPN21.By similarity1 Publication

Protein-protein interaction databases

BioGridi120754. 4 interactions.
IntActiQ96L93. 2 interactions.
MINTiMINT-5225330.

Structurei

Secondary structure

1
1317
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1184 – 119613Combined sources
Beta strandi1201 – 121010Combined sources
Beta strandi1213 – 12197Combined sources
Helixi1221 – 123414Combined sources
Helixi1236 – 12405Combined sources
Helixi1254 – 127724Combined sources
Helixi1294 – 13007Combined sources
Helixi1302 – 13043Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V14X-ray2.20A1179-1312[»]
ProteinModelPortaliQ96L93.
SMRiQ96L93. Positions 2-389, 428-563, 1179-1312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96L93.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 358356Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Domaini478 – 52952FHAAdd
BLAST
Domaini1182 – 1296115PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 42556Sequence AnalysisAdd
BLAST
Coiled coili595 – 882288Sequence AnalysisAdd
BLAST
Coiled coili936 – 1087152Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi597 – 1070474Glu-richAdd
BLAST

Domaini

The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).2 Publications

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120451.
HOVERGENiHBG099335.
InParanoidiQ96L93.
KOiK17916.
OMAiLHIDKVG.
OrthoDBiEOG77Q4VS.
PhylomeDBiQ96L93.
TreeFamiTF105221.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96L93-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR
60 70 80 90 100
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA
110 120 130 140 150
YGQTGSGKSY TMMGNSGDSG LIPRICEGLF SRINETTRWD EASFRTEVSY
160 170 180 190 200
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYGDVEE
210 220 230 240 250
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM PCETVSKIHL
260 270 280 290 300
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANTL
310 320 330 340 350
AKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR
360 370 380 390 400
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT
410 420 430 440 450
ALSMEEKLQQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD
460 470 480 490 500
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GRDDASTEQD IVLHGLDLES
510 520 530 540 550
EHCIFENIGG TVTLIPLSGS QCSVNGVQIV EATHLNQGAV ILLGRTNMFR
560 570 580 590 600
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSRENLSAVM LYNPGLEFER
610 620 630 640 650
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RKETEIVQLQ
660 670 680 690 700
IRKQEESLKR RSFHIENKLK DLLAEKEKFE EERLREQQEI ELQKKRQEEE
710 720 730 740 750
TFLRVQEELQ RLKELNNNEK AEKFQIFQEL DQLQKEKDEQ YAKLELEKKR
760 770 780 790 800
LEEQEKEQVM LVAHLEEQLR EKQEMIQLLR RGEVQWVEEE KRDLEGIRES
810 820 830 840 850
LLRVKEARAG GDEDGEELEK AQLRFFEFKR RQLVKLVNLE KDLVQQKDIL
860 870 880 890 900
KKEVQEEQEI LECLKCEHDK ESRLLEKHDE SVTDVTEVPQ DFEKIKPVEY
910 920 930 940 950
RLQYKERQLQ YLLQNHLPTL LEEKQRAFEI LDRGPLSLDN TLYQVEKEME
960 970 980 990 1000
EKEEQLAQYQ ANANQLQKLQ ATFEFTANIA RQEEKVRKKE KEILESREKQ
1010 1020 1030 1040 1050
QREALERALA RLERRHSALQ RHSTLGMEIE EQRQKLASLN SGSREQSGLQ
1060 1070 1080 1090 1100
ASLEAEQEAL EKDQERLEYE IQQLKQKIYE VDGVQKDHHG TLEGKVASSS
1110 1120 1130 1140 1150
LPVSAEKSHL VPLMDARINA YIEEEVQRRL QDLHRVISEG CSTSADTMKD
1160 1170 1180 1190 1200
NEKLHNGTIQ RKLKYERMVS RSLGANPDDL KDPIKISIPR YVLCGQGKDA
1210 1220 1230 1240 1250
HFEFEVKITV LDETWTVFRR YSRFREMHKT LKLKYAELAA LEFPPKKLFG
1260 1270 1280 1290 1300
NKDERVIAER RSHLEKYLRD FFSVMLQSAT SPLHINKVGL TLSKHTICEF
1310
SPFFKKGVFD YSSHGTG
Length:1,317
Mass (Da):152,011
Last modified:July 19, 2004 - v2
Checksum:i278E9CB88D9C04DF
GO
Isoform 2 (identifier: Q96L93-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1317: RMVSRSLGAN...VFDYSSHGTG → LCRDLLCVLM...LWLISHLTRL

Note: Ubiquitinated at position 685.

Show »
Length:1,392
Mass (Da):159,831
Checksum:i85A4365F83AADDB9
GO
Isoform 3 (identifier: Q96L93-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1208-1237: Missing.

Note: No experimental confirmation available.

Show »
Length:1,287
Mass (Da):148,211
Checksum:i9BA79E2857090F5F
GO
Isoform 4 (identifier: Q96L93-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-840: Missing.

Note: No experimental confirmation available.

Show »
Length:1,161
Mass (Da):132,866
Checksum:i078AB4C77FBAA4C3
GO
Isoform 5 (identifier: Q96L93-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1207: Missing.

Note: No experimental confirmation available.

Show »
Length:1,276
Mass (Da):147,398
Checksum:i430E508AEE6E2E12
GO

Sequence cautioni

The sequence BAA90971.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA90971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB13416.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI43062.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI43179.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181K → E in AK095322. (PubMed:14702039)Curated
Sequence conflicti274 – 2741N → D in CAI46105. (PubMed:17974005)Curated
Sequence conflicti583 – 5831R → H in BAA90971. (PubMed:14702039)Curated
Sequence conflicti649 – 6491L → H in CAI46266. (PubMed:17974005)Curated
Sequence conflicti1056 – 10572EQ → SE in AAH34984. (PubMed:15489334)Curated
Sequence conflicti1100 – 11001S → N in CAI46105. (PubMed:17974005)Curated
Sequence conflicti1108 – 11081S → L in AAH34984. (PubMed:15489334)Curated
Sequence conflicti1244 – 12441P → A in AAO17292. 1 PublicationCurated
Sequence conflicti1244 – 12441P → A in BAB15530. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti772 – 7721K → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036218
Natural varianti810 – 8101G → R.
Corresponds to variant rs2236145 [ dbSNP | Ensembl ].
VAR_049700
Natural varianti824 – 8241R → S.
Corresponds to variant rs2236144 [ dbSNP | Ensembl ].
VAR_019396
Natural varianti999 – 9991K → N.
Corresponds to variant rs8116503 [ dbSNP | Ensembl ].
VAR_065248
Natural varianti1027 – 10271M → T.3 Publications
Corresponds to variant rs6034464 [ dbSNP | Ensembl ].
VAR_019397
Natural varianti1119 – 11191N → S.
Corresponds to variant rs8123195 [ dbSNP | Ensembl ].
VAR_019398

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei685 – 840156Missing in isoform 4. 1 PublicationVSP_015858Add
BLAST
Alternative sequencei1167 – 1317151RMVSR…SHGTG → LCRDLLCVLMPEPDAAACAN HPLLQQDLVQLSLDWKTEIP DLVLPNGVQVSSKFQTTLVD MIYFLHGNMEVNVPSLAEVQ LLLYTTVKVMGDSGHDQCQS LVLLNTHIALVKEDCVFYPR IRSRNIPPPGAQFDVIKCHA LSEFRCVVVPEKKNVSTVEL VFLQKLKPSVGSRNSPPEHL QEAPNVQLFTTPLYLQGSQN VAPEVWKLTFNSQDEALWLI SHLTRL in isoform 2. 2 PublicationsVSP_010851Add
BLAST
Alternative sequencei1167 – 120741Missing in isoform 5. 1 PublicationVSP_041318Add
BLAST
Alternative sequencei1208 – 123730Missing in isoform 3. 1 PublicationVSP_010852Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046810 mRNA. Translation: BAB13416.2. Different initiation.
BX647572 mRNA. Translation: CAI46105.1.
BX648426 mRNA. Translation: CAI46266.1.
AY166853 mRNA. Translation: AAO17292.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAI22745.2.
AL117376, AL049794, AL118509 Genomic DNA. Translation: CAI43180.2.
AL117376 Genomic DNA. Translation: CAI43181.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAI43063.2.
AL118509, AL049794, AL117376 Genomic DNA. Translation: CAM28305.1.
AL049794, AL117376, AL118509 Genomic DNA. Translation: CAM28307.1.
AL118509, AL117376 Genomic DNA. Translation: CAI43062.1. Sequence problems.
AL117376, AL118509 Genomic DNA. Translation: CAI43179.1. Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1.
BC034984 mRNA. Translation: AAH34984.2.
BC110317 mRNA. Translation: AAI10318.1.
BC150261 mRNA. Translation: AAI50262.1.
AY044654 mRNA. Translation: AAK98768.1.
AK000142 mRNA. Translation: BAA90971.1. Sequence problems.
AK026698 mRNA. Translation: BAB15530.1. Different initiation.
AK095322 mRNA. No translation available.
CCDSiCCDS13122.1. [Q96L93-1]
CCDS56178.1. [Q96L93-2]
RefSeqiNP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2]
NP_078980.3. NM_024704.4. [Q96L93-1]
UniGeneiHs.101774.

Genome annotation databases

EnsembliENST00000354981; ENSP00000347076; ENSG00000089177. [Q96L93-1]
ENST00000408042; ENSP00000384164; ENSG00000089177. [Q96L93-2]
GeneIDi55614.
KEGGihsa:55614.
UCSCiuc002wpe.1. human. [Q96L93-4]
uc002wpf.1. human. [Q96L93-6]
uc002wpg.2. human. [Q96L93-1]
uc010gci.2. human. [Q96L93-2]

Polymorphism databases

DMDMi50403793.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046810 mRNA. Translation: BAB13416.2 . Different initiation.
BX647572 mRNA. Translation: CAI46105.1 .
BX648426 mRNA. Translation: CAI46266.1 .
AY166853 mRNA. Translation: AAO17292.1 .
AL049794 , AL117376 , AL118509 Genomic DNA. Translation: CAI22745.2 .
AL117376 , AL049794 , AL118509 Genomic DNA. Translation: CAI43180.2 .
AL117376 Genomic DNA. Translation: CAI43181.2 .
AL118509 , AL049794 , AL117376 Genomic DNA. Translation: CAI43063.2 .
AL118509 , AL049794 , AL117376 Genomic DNA. Translation: CAM28305.1 .
AL049794 , AL117376 , AL118509 Genomic DNA. Translation: CAM28307.1 .
AL118509 , AL117376 Genomic DNA. Translation: CAI43062.1 . Sequence problems.
AL117376 , AL118509 Genomic DNA. Translation: CAI43179.1 . Sequence problems.
CH471133 Genomic DNA. Translation: EAX10290.1 .
BC034984 mRNA. Translation: AAH34984.2 .
BC110317 mRNA. Translation: AAI10318.1 .
BC150261 mRNA. Translation: AAI50262.1 .
AY044654 mRNA. Translation: AAK98768.1 .
AK000142 mRNA. Translation: BAA90971.1 . Sequence problems.
AK026698 mRNA. Translation: BAB15530.1 . Different initiation.
AK095322 mRNA. No translation available.
CCDSi CCDS13122.1. [Q96L93-1 ]
CCDS56178.1. [Q96L93-2 ]
RefSeqi NP_001186794.1. NM_001199865.1.
NP_001186795.1. NM_001199866.1. [Q96L93-2 ]
NP_078980.3. NM_024704.4. [Q96L93-1 ]
UniGenei Hs.101774.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V14 X-ray 2.20 A 1179-1312 [» ]
ProteinModelPortali Q96L93.
SMRi Q96L93. Positions 2-389, 428-563, 1179-1312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120754. 4 interactions.
IntActi Q96L93. 2 interactions.
MINTi MINT-5225330.

PTM databases

PhosphoSitei Q96L93.

Polymorphism databases

DMDMi 50403793.

Proteomic databases

MaxQBi Q96L93.
PaxDbi Q96L93.
PRIDEi Q96L93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354981 ; ENSP00000347076 ; ENSG00000089177 . [Q96L93-1 ]
ENST00000408042 ; ENSP00000384164 ; ENSG00000089177 . [Q96L93-2 ]
GeneIDi 55614.
KEGGi hsa:55614.
UCSCi uc002wpe.1. human. [Q96L93-4 ]
uc002wpf.1. human. [Q96L93-6 ]
uc002wpg.2. human. [Q96L93-1 ]
uc010gci.2. human. [Q96L93-2 ]

Organism-specific databases

CTDi 55614.
GeneCardsi GC20M016252.
HGNCi HGNC:15869. KIF16B.
HPAi HPA051198.
neXtProti NX_Q96L93.
PharmGKBi PA162393227.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120451.
HOVERGENi HBG099335.
InParanoidi Q96L93.
KOi K17916.
OMAi LHIDKVG.
OrthoDBi EOG77Q4VS.
PhylomeDBi Q96L93.
TreeFami TF105221.

Enzyme and pathway databases

BRENDAi 3.6.4.4. 2681.

Miscellaneous databases

ChiTaRSi KIF16B. human.
EvolutionaryTracei Q96L93.
GeneWikii KIF16B.
GenomeRNAii 55614.
NextBioi 60192.
PROi Q96L93.

Gene expression databases

Bgeei Q96L93.
CleanExi HS_KIF16B.
Genevestigatori Q96L93.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
3.30.1520.10. 1 hit.
3.40.850.10. 1 hit.
InterProi IPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR001683. Phox.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
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Publicationsi

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  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-1027.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 557-1317 (ISOFORM 4), VARIANT THR-1027.
    Tissue: Adipose tissue and Salivary gland.
  3. Guo J.H.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 916-1317 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1056-1317 (ISOFORM 3), VARIANT THR-1027.
    Tissue: Hippocampus and Liver.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-948 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1085-1317 (ISOFORMS 1/4).
    Tissue: Colon, Lung and Tongue.
  8. "A new member (SNX23) of the sorting nexin family."
    Hong W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1114-1317 (ISOFORMS 1/4).
  9. "Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B."
    Hoepfner S., Severin F., Cabezas A., Habermann B., Runge A., Gillooly D., Stenmark H., Zerial M.
    Cell 121:437-450(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN PX, PHOSPHATIDYLINOSITOL-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-109.
  10. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-685 (ISOFORM 4).
    Tissue: Lung adenocarcinoma.
  11. Cited for: INTERACTION WITH PTPN21.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The structural basis of novel endosome anchoring activity of KIF16B kinesin."
    Blatner N.R., Wilson M.I., Lei C., Hong W., Murray D., Williams R.L., Cho W.
    EMBO J. 26:3709-3719(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1179-1312, SUBCELLULAR LOCATION, PHOSPHATIDYLINOSITOL-BINDING, DOMAIN PX, MUTAGENESIS OF ARG-1220; ARG-1225; LYS-1229; LYS-1232; LEU-1248; PHE-1249 AND ARG-1260.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-772.

Entry informationi

Entry nameiKI16B_HUMAN
AccessioniPrimary (citable) accession number: Q96L93
Secondary accession number(s): A6NKJ9
, A7E2A8, B1AKG3, B1AKT7, C9JDN5, C9JI52, C9JSM8, C9JWJ7, Q2TBF5, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3