Reviewed, UniProtKB/Swiss-Prot Q96L91 (EP400_HUMAN)

Names and origin

Protein names

Recommended name:
    E1A-binding protein p400
    EC=3.6.1.-
Alternative name(s):
    p400 kDa SWI2/SNF2-related protein
    Domino homolog
      Short name=hDomino
    CAG repeat protein 32
    Trinucleotide repeat-containing gene 12 protein

Gene names

Name:	EP400
Synonyms:	CAGH32, KIAA1498, KIAA1818, TNRC12

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
Subunit structure	Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and EAF6. May also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with TRRAP, RUVBL1 and RUVBL2. Interacts with ZNF42 By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. Contains 1 Myb-like domain.
Sequence caution	The sequence AAB91441.1 differs from that shown. Reason: Frameshift at positions 2959 and 3020. The sequence AAH37208.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. The sequence AAH64554.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Chromatin regulator Helicase Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	NuA4 histone acetyltransferase complex Ref.10 Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96L91-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96L91-2)

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.

Isoform 3 (identifier: Q96L91-3)

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.
     482-482: Missing.
     515-550: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96L91-4)

The sequence of this isoform differs from the canonical sequence as follows:
     446-481: Missing.
     1519-1600: AAAAPFQTSQ...PSQAQARLPS → G

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3160	3160	E1A-binding protein p400		PRO_0000074312
Regions
	Domain	799 – 871	73	HSA
	Domain	1103 – 1268	166	Helicase ATP-binding
	Domain	1899 – 2056	158	Helicase C-terminal
	Domain	2360 – 2429	70	Myb-like
	Nucleotide binding	1116 – 1123	8	ATP Potential
	Region	951 – 1365	415	Interactions with RUVBL1 and RUVBL2
	Region	2524 – 2789	266	Interaction with ZNF42 By similarity
	Motif	1219 – 1222	4	DEAH box-like
	Compositional bias	278 – 281	4	Poly-Gln
	Compositional bias	316 – 319	4	Poly-Pro
	Compositional bias	426 – 437	12	Poly-Glu
	Compositional bias	1517 – 1522	6	Poly-Ala
	Compositional bias	2543 – 2554	12	Poly-Pro
	Compositional bias	2557 – 2564	8	Poly-Pro
	Compositional bias	2756 – 2785	30	Poly-Gln
	Compositional bias	2829 – 2835	7	Poly-Pro
Amino acid modifications
	Modified residue	314	1	Phosphothreonine Ref.13
	Modified residue	315	1	Phosphoserine Ref.13
	Modified residue	320	1	Phosphothreonine Ref.13
	Modified residue	736	1	Phosphoserine Ref.11
	Modified residue	755	1	Phosphoserine By similarity
	Modified residue	941	1	Phosphoserine Ref.13
	Modified residue	943	1	Phosphoserine Ref.13
	Modified residue	945	1	Phosphothreonine Ref.13
	Modified residue	1547	1	Phosphoserine Ref.12
	Modified residue	1728	1	Phosphoserine Ref.13
	Modified residue	1732	1	Phosphoserine Ref.13
	Modified residue	2814	1	Phosphothreonine Ref.13
Natural variations
	Alternative sequence	446 – 481	36	Missing in isoform 2, isoform 3 and isoform 4.		VSP_011992
	Alternative sequence	482	1	Missing in isoform 3.		VSP_011993
	Alternative sequence	515 – 550	36	Missing in isoform 3.		VSP_011994
	Alternative sequence	1519 – 1600	82	AAAAP…ARLPS → G in isoform 4.		VSP_011995
	Natural variant	1308	1	T → I: dbSNP rs13377636.		VAR_046957
Experimental info
	Sequence conflict	537	1	D → G in AAH37208. Ref.5
	Sequence conflict	810	1	S → P in AAH37208. Ref.5
	Sequence conflict	1563	1	S → F in AAK97789. Ref.1
	Sequence conflict	1642	1	L → F AA sequence Ref.1
	Sequence conflict	1645	1	L → F AA sequence Ref.1
	Sequence conflict	2756	1	Missing in AC137590. Ref.2
	Sequence conflict	2756	1	Missing in AC137632. Ref.2
	Sequence conflict	2845	1	T → A in AAK97789. Ref.1
	Sequence conflict	2845	1	T → A in AAB91441. Ref.7
	Sequence conflict	2898	1	A → S in AAK97789. Ref.1
	Sequence conflict	2898	1	A → S in AAB91441. Ref.7
	Sequence conflict	2913 – 2915	3	ALA → PLP in AAK97789. Ref.1
	Sequence conflict	2913 – 2915	3	ALA → PLP in AAB91441. Ref.7
	Sequence conflict	2991	1	A → T in AAK97789. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: 541EC3DC0B25FB80	FASTA	3,160	343,617
	10 20 30 40 50 60 MHHGTGPQNV QHQLQRSRAC PGSEGEEQPA HPNPPPSPAA PFAPSASPSA PQSPSYQIQQ 70 80 90 100 110 120 LMNRSPATGQ NVNITLQSVG PVVGGNQQIT LAPLPLPSPT SPGFQFSAQP RRFEHGSPSY 130 140 150 160 170 180 IQVTSPLSQQ VQTQSPTQPS PGPGQALQNV RAGAPGPGLG LCSSSPTGGF VDASVLVRQI 190 200 210 220 230 240 SLSPSSGGHF VFQDGSGLTQ IAQGAQVQLQ HPGTPITVRE RRPSQPHTQS GGTIHHLGPQ 250 260 270 280 290 300 SPAAAGGAGL QPLASPSHIT TANLPPQISS IIQGQLVQQQ QVLQGPPLPR PLGFERTPGV 310 320 330 340 350 360 LLPGAGGAAG FGMTSPPPPT SPSRTAVPPG LSSLPLTSVG NTGMKKVPKK LEEIPPASPE 370 380 390 400 410 420 MAQMRKQCLD YHYQEMQALK EVFKEYLIEL FFLQHFQGNM MDFLAFKKKH YAPLQAYLRQ 430 440 450 460 470 480 NDLDIEEEEE EEEEEEEKSE VINDEVKVVT GKDGQTGTPV AIATQLPPKV SAAFSSQQQP 490 500 510 520 530 540 FQQALAGSLV AGAGSTVETD LFKRQQAMPS TGMAEQSKRP RLEVGHQGVV FQHPGADAGV 550 560 570 580 590 600 PLQQLMPTAQ GGMPPTPQAA QLAGQRQSQQ QYDPSTGPPV QNAASLHTPL PQLPGRLPPA 610 620 630 640 650 660 GVPTAALSSA LQFAQQPQVV EAQTQLQIPV KTQQPNVPIP APPSSQLPIP PSQPAQLALH 670 680 690 700 710 720 VPTPGKVQVQ ASQLSSLPQM VASTRLPVDP APPCPRPLPT SSTSSLAPVS GSGPGPSPAR 730 740 750 760 770 780 SSPVNRPSSA TNKALSPVTS RTPGVVASAP TKPQSPAQNA TSSQDSSQDT LTEQITLENQ 790 800 810 820 830 840 VHQRIAELRK AGLWSQRRLP KLQEAPRPKS HWDYLLEEMQ WMATDFAQER RWKVAAAKKL 850 860 870 880 890 900 VRTVVRHHEE KQLREERGKK EEQSRLRRIA ASTAREIECF WSNIEQVVEI KLRVELEEKR 910 920 930 940 950 960 KKALNLQKVS RRGKELRPKG FDALQESSLD SGMSGRKRKA SISLTDDEVD DEEETIEEEE 970 980 990 1000 1010 1020 ANEGVVDHQT ELSNLAKEAE LPLLDLMKLY EGAFLPSSQW PRPKPDGEDT SGEEDADDCP 1030 1040 1050 1060 1070 1080 GDRESRKDLV LIDSLFIMDQ FKAAERMNIG KPNAKDIADV TAVAEAILPK GSARVTTSVK 1090 1100 1110 1120 1130 1140 FNAPSLLYGA LRDYQKIGLD WLAKLYRKNL NGILADEAGL GKTVQIIAFF AHLACNEGNW 1150 1160 1170 1180 1190 1200 GPHLVVVRSC NILKWELELK RWCPGLKILS YIGSHRELKA KRQEWAEPNS FHVCITSYTQ 1210 1220 1230 1240 1250 1260 FFRGLTAFTR VRWKCLVIDE MQRVKGMTER HWEAVFTLQS QQRLLLIDSP LHNTFLELWT 1270 1280 1290 1300 1310 1320 MVHFLVPGIS RPYLSSPLRA PSEESQDYYH KVVIRLHRVT QPFILRRTKR DVEKQLTKKY 1330 1340 1350 1360 1370 1380 EHVLKCRLSN RQKALYEDVI LQPGTQEALK SGHFVNVLSI LVRLQRICNH PGLVEPRHPG 1390 1400 1410 1420 1430 1440 SSYVAGPLEY PSASLILKAL ERDFWKEADL SMFDLIGLEN KITRHEAELL SKKKIPRKLM 1450 1460 1470 1480 1490 1500 EEISTSAAPA ARPAAAKLKA SRLFQPVQYG QKPEGRTVAF PSTHPPRTAA PTTASAAPQG 1510 1520 1530 1540 1550 1560 PLRGRPPIAT FSANPEAKAA AAPFQTSQAS ASAPRHQPAS ASSTAASPAH PAKLRAQTTA 1570 1580 1590 1600 1610 1620 QASTPGQPPP QPQAPSHAAG QSALPQRLVL PSQAQARLPS GEVVKIAQLA SITGPQSRVA 1630 1640 1650 1660 1670 1680 QPETPVTLQF QGSKFTLSHS QLRQLTAGQP LQLQGSVLQI VSAPGQPYLR APGPVVMQTV 1690 1700 1710 1720 1730 1740 SQAGAVHGAL GSKPPAGGPS PAPLTPQVGV PGRVAVNALA VGEPGTASKP ASPIGGPTQE 1750 1760 1770 1780 1790 1800 EKTRLLKERL DQIYLVNERR CSQAPVYGRD LLRICALPSH GRVQWRGSLD GRRGKEAGPA 1810 1820 1830 1840 1850 1860 HSYTSSSESP SELMLTLCRC GESLQDVIDR VAFVIPPVVA APPSLRVPRP PPLYSHRMRI 1870 1880 1890 1900 1910 1920 LRQGLREHAA PYFQQLRQTT APRLLQFPEL RLVQFDSGKL EALAILLQKL KSEGRRVLIL 1930 1940 1950 1960 1970 1980 SQMILMLDIL EMFLNFHYLT YVRIDENASS EQRQELMRSF NRDRRIFCAI LSTHSRTTGI 1990 2000 2010 2020 2030 2040 NLVEADTVVF YDNDLNPVMD AKAQEWCDRI GRCKDIHIYR LVSGNSIEEK LLKNGTKDLI 2050 2060 2070 2080 2090 2100 REVAAQGNDY SMAFLTQRTI QELFEVYSPM DDAGFPVKAE EFVVLSQEPS VTETIAPKIA 2110 2120 2130 2140 2150 2160 RPFIEALKSI EYLEEDAQKS AQEGVLGPHT DALSSDSENM PCDEEPSQLE ELADFMEQLT 2170 2180 2190 2200 2210 2220 PIEKYALNYL ELFHTSIEQE KERNSEDAVM TAVRAWEFWN LKTLQEREAR LRLEQEEAEL 2230 2240 2250 2260 2270 2280 LTYTREDAYS MEYVYEDVDG QTEVMPLWTP PTPPQDDSDI YLDSVMCLMY EATPIPEAKL 2290 2300 2310 2320 2330 2340 PPVYVRKERK RHKTDPSAAG RKKKQRHGEA VVPPRSLFDR ATPGLLKIRR EGKEQKKNIL 2350 2360 2370 2380 2390 2400 LKQQVPFAKP LPTFAKPTAE PGQDNPEWLI SEDWALLQAV KQLLELPLNL TIVSPAHTPN 2410 2420 2430 2440 2450 2460 WDLVSDVVNS CSRIYRSSKQ CRNRYENVII PREEGKSKNN RPLRTSQIYA QDENATHTQL 2470 2480 2490 2500 2510 2520 YTSHFDLMKM TAGKRSPPIK PLLGMNPFQK NPKHASVLAE SGINYDKPLP PIQVASLRAE 2530 2540 2550 2560 2570 2580 RIAKEKKALA DQQKAQQPAV AQPPPPQPQP PPPPQQPPPP LPQPQAAGSQ PPAGPPAVQP 2590 2600 2610 2620 2630 2640 QPQPQPQTQP QPVQAPAKAQ PAITTGGSAA VLAGTIKTSV TGTSMPTGAV SGNVIVNTIA 2650 2660 2670 2680 2690 2700 GVPAATFQSI NKRLASPVAP GALTTPGGSA PAQVVHTQPP PRAVGSPATA TPDLVSMATT 2710 2720 2730 2740 2750 2760 QGVRAVTSVT ASAVVTTNLT PVQTPARSLV PQVSQATGVQ LPGKTITPAH FQLLRQQQQQ 2770 2780 2790 2800 2810 2820 QQQQQQQQQQ QQQQQQQQQQ QQQQQTTTTS QVQVPQIQGQ AQSPAQIKAV GKLTPEHLIK 2830 2840 2850 2860 2870 2880 MQKQKLQMPP QPPPPQAQSA PPQPTAQVQV QTSQPPQQQS PQLTTVTAPR PGALLTGTTV 2890 2900 2910 2920 2930 2940 ANLQVARLTR VPTSQLQAQG QMQTQAPQPA QVALAKPPVV SVPAAVVSSP GVTTLPMNVA 2950 2960 2970 2980 2990 3000 GISVAIGQPQ KAAGQTVVAQ PVHMQQLLKL KQQAVQQQKA IQPQAAQGPA AVQQKITAQQ 3010 3020 3030 3040 3050 3060 ITTPGAQQKV AYAAQPALKT QFLTTPISQA QKLAGAQQVQ TQIQVAKLPQ VVQQQTPVAS 3070 3080 3090 3100 3110 3120 IQQVASASQQ ASPQTVALTQ ATAAGQQVQM IPAVTATAQV VQQKLIQQQV VTTASAPLQT 3130 3140 3150 3160 PGAPNPAQVP ASSDSPSQQP KLQMRVPAVR LKTPTKPPCQ
	Isoform 2. Checksum: E094F8814F0785C8	FASTA	3,124	339,951
	10 20 30 40 50 60 MHHGTGPQNV QHQLQRSRAC PGSEGEEQPA HPNPPPSPAA PFAPSASPSA PQSPSYQIQQ 70 80 90 100 110 120 LMNRSPATGQ NVNITLQSVG PVVGGNQQIT LAPLPLPSPT SPGFQFSAQP RRFEHGSPSY 130 140 150 160 170 180 IQVTSPLSQQ VQTQSPTQPS PGPGQALQNV RAGAPGPGLG LCSSSPTGGF VDASVLVRQI 190 200 210 220 230 240 SLSPSSGGHF VFQDGSGLTQ IAQGAQVQLQ HPGTPITVRE RRPSQPHTQS GGTIHHLGPQ 250 260 270 280 290 300 SPAAAGGAGL QPLASPSHIT TANLPPQISS IIQGQLVQQQ QVLQGPPLPR PLGFERTPGV 310 320 330 340 350 360 LLPGAGGAAG FGMTSPPPPT SPSRTAVPPG LSSLPLTSVG NTGMKKVPKK LEEIPPASPE 370 380 390 400 410 420 MAQMRKQCLD YHYQEMQALK EVFKEYLIEL FFLQHFQGNM MDFLAFKKKH YAPLQAYLRQ 430 440 450 460 470 480 NDLDIEEEEE EEEEEEEKSE VINDEQQALA GSLVAGAGST VETDLFKRQQ AMPSTGMAEQ 490 500 510 520 530 540 SKRPRLEVGH QGVVFQHPGA DAGVPLQQLM PTAQGGMPPT PQAAQLAGQR QSQQQYDPST 550 560 570 580 590 600 GPPVQNAASL HTPLPQLPGR LPPAGVPTAA LSSALQFAQQ PQVVEAQTQL QIPVKTQQPN 610 620 630 640 650 660 VPIPAPPSSQ LPIPPSQPAQ LALHVPTPGK VQVQASQLSS LPQMVASTRL PVDPAPPCPR 670 680 690 700 710 720 PLPTSSTSSL APVSGSGPGP SPARSSPVNR PSSATNKALS PVTSRTPGVV ASAPTKPQSP 730 740 750 760 770 780 AQNATSSQDS SQDTLTEQIT LENQVHQRIA ELRKAGLWSQ RRLPKLQEAP RPKSHWDYLL 790 800 810 820 830 840 EEMQWMATDF AQERRWKVAA AKKLVRTVVR HHEEKQLREE RGKKEEQSRL RRIAASTARE 850 860 870 880 890 900 IECFWSNIEQ VVEIKLRVEL EEKRKKALNL QKVSRRGKEL RPKGFDALQE SSLDSGMSGR 910 920 930 940 950 960 KRKASISLTD DEVDDEEETI EEEEANEGVV DHQTELSNLA KEAELPLLDL MKLYEGAFLP 970 980 990 1000 1010 1020 SSQWPRPKPD GEDTSGEEDA DDCPGDRESR KDLVLIDSLF IMDQFKAAER MNIGKPNAKD 1030 1040 1050 1060 1070 1080 IADVTAVAEA ILPKGSARVT TSVKFNAPSL LYGALRDYQK IGLDWLAKLY RKNLNGILAD 1090 1100 1110 1120 1130 1140 EAGLGKTVQI IAFFAHLACN EGNWGPHLVV VRSCNILKWE LELKRWCPGL KILSYIGSHR 1150 1160 1170 1180 1190 1200 ELKAKRQEWA EPNSFHVCIT SYTQFFRGLT AFTRVRWKCL VIDEMQRVKG MTERHWEAVF 1210 1220 1230 1240 1250 1260 TLQSQQRLLL IDSPLHNTFL ELWTMVHFLV PGISRPYLSS PLRAPSEESQ DYYHKVVIRL 1270 1280 1290 1300 1310 1320 HRVTQPFILR RTKRDVEKQL TKKYEHVLKC RLSNRQKALY EDVILQPGTQ EALKSGHFVN 1330 1340 1350 1360 1370 1380 VLSILVRLQR ICNHPGLVEP RHPGSSYVAG PLEYPSASLI LKALERDFWK EADLSMFDLI 1390 1400 1410 1420 1430 1440 GLENKITRHE AELLSKKKIP RKLMEEISTS AAPAARPAAA KLKASRLFQP VQYGQKPEGR 1450 1460 1470 1480 1490 1500 TVAFPSTHPP RTAAPTTASA APQGPLRGRP PIATFSANPE AKAAAAPFQT SQASASAPRH 1510 1520 1530 1540 1550 1560 QPASASSTAA SPAHPAKLRA QTTAQASTPG QPPPQPQAPS HAAGQSALPQ RLVLPSQAQA 1570 1580 1590 1600 1610 1620 RLPSGEVVKI AQLASITGPQ SRVAQPETPV TLQFQGSKFT LSHSQLRQLT AGQPLQLQGS 1630 1640 1650 1660 1670 1680 VLQIVSAPGQ PYLRAPGPVV MQTVSQAGAV HGALGSKPPA GGPSPAPLTP QVGVPGRVAV 1690 1700 1710 1720 1730 1740 NALAVGEPGT ASKPASPIGG PTQEEKTRLL KERLDQIYLV NERRCSQAPV YGRDLLRICA 1750 1760 1770 1780 1790 1800 LPSHGRVQWR GSLDGRRGKE AGPAHSYTSS SESPSELMLT LCRCGESLQD VIDRVAFVIP 1810 1820 1830 1840 1850 1860 PVVAAPPSLR VPRPPPLYSH RMRILRQGLR EHAAPYFQQL RQTTAPRLLQ FPELRLVQFD 1870 1880 1890 1900 1910 1920 SGKLEALAIL LQKLKSEGRR VLILSQMILM LDILEMFLNF HYLTYVRIDE NASSEQRQEL 1930 1940 1950 1960 1970 1980 MRSFNRDRRI FCAILSTHSR TTGINLVEAD TVVFYDNDLN PVMDAKAQEW CDRIGRCKDI 1990 2000 2010 2020 2030 2040 HIYRLVSGNS IEEKLLKNGT KDLIREVAAQ GNDYSMAFLT QRTIQELFEV YSPMDDAGFP 2050 2060 2070 2080 2090 2100 VKAEEFVVLS QEPSVTETIA PKIARPFIEA LKSIEYLEED AQKSAQEGVL GPHTDALSSD 2110 2120 2130 2140 2150 2160 SENMPCDEEP SQLEELADFM EQLTPIEKYA LNYLELFHTS IEQEKERNSE DAVMTAVRAW 2170 2180 2190 2200 2210 2220 EFWNLKTLQE REARLRLEQE EAELLTYTRE DAYSMEYVYE DVDGQTEVMP LWTPPTPPQD 2230 2240 2250 2260 2270 2280 DSDIYLDSVM CLMYEATPIP EAKLPPVYVR KERKRHKTDP SAAGRKKKQR HGEAVVPPRS 2290 2300 2310 2320 2330 2340 LFDRATPGLL KIRREGKEQK KNILLKQQVP FAKPLPTFAK PTAEPGQDNP EWLISEDWAL 2350 2360 2370 2380 2390 2400 LQAVKQLLEL PLNLTIVSPA HTPNWDLVSD VVNSCSRIYR SSKQCRNRYE NVIIPREEGK 2410 2420 2430 2440 2450 2460 SKNNRPLRTS QIYAQDENAT HTQLYTSHFD LMKMTAGKRS PPIKPLLGMN PFQKNPKHAS 2470 2480 2490 2500 2510 2520 VLAESGINYD KPLPPIQVAS LRAERIAKEK KALADQQKAQ QPAVAQPPPP QPQPPPPPQQ 2530 2540 2550 2560 2570 2580 PPPPLPQPQA AGSQPPAGPP AVQPQPQPQP QTQPQPVQAP AKAQPAITTG GSAAVLAGTI 2590 2600 2610 2620 2630 2640 KTSVTGTSMP TGAVSGNVIV NTIAGVPAAT FQSINKRLAS PVAPGALTTP GGSAPAQVVH 2650 2660 2670 2680 2690 2700 TQPPPRAVGS PATATPDLVS MATTQGVRAV TSVTASAVVT TNLTPVQTPA RSLVPQVSQA 2710 2720 2730 2740 2750 2760 TGVQLPGKTI TPAHFQLLRQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQT TTTSQVQVPQ 2770 2780 2790 2800 2810 2820 IQGQAQSPAQ IKAVGKLTPE HLIKMQKQKL QMPPQPPPPQ AQSAPPQPTA QVQVQTSQPP 2830 2840 2850 2860 2870 2880 QQQSPQLTTV TAPRPGALLT GTTVANLQVA RLTRVPTSQL QAQGQMQTQA PQPAQVALAK 2890 2900 2910 2920 2930 2940 PPVVSVPAAV VSSPGVTTLP MNVAGISVAI GQPQKAAGQT VVAQPVHMQQ LLKLKQQAVQ 2950 2960 2970 2980 2990 3000 QQKAIQPQAA QGPAAVQQKI TAQQITTPGA QQKVAYAAQP ALKTQFLTTP ISQAQKLAGA 3010 3020 3030 3040 3050 3060 QQVQTQIQVA KLPQVVQQQT PVASIQQVAS ASQQASPQTV ALTQATAAGQ QVQMIPAVTA 3070 3080 3090 3100 3110 3120 TAQVVQQKLI QQQVVTTASA PLQTPGAPNP AQVPASSDSP SQQPKLQMRV PAVRLKTPTK PPCQ
	Isoform 3. Checksum: 39D0F895EE08DBFF	FASTA	3,087	335,934
	10 20 30 40 50 60 MHHGTGPQNV QHQLQRSRAC PGSEGEEQPA HPNPPPSPAA PFAPSASPSA PQSPSYQIQQ 70 80 90 100 110 120 LMNRSPATGQ NVNITLQSVG PVVGGNQQIT LAPLPLPSPT SPGFQFSAQP RRFEHGSPSY 130 140 150 160 170 180 IQVTSPLSQQ VQTQSPTQPS PGPGQALQNV RAGAPGPGLG LCSSSPTGGF VDASVLVRQI 190 200 210 220 230 240 SLSPSSGGHF VFQDGSGLTQ IAQGAQVQLQ HPGTPITVRE RRPSQPHTQS GGTIHHLGPQ 250 260 270 280 290 300 SPAAAGGAGL QPLASPSHIT TANLPPQISS IIQGQLVQQQ QVLQGPPLPR PLGFERTPGV 310 320 330 340 350 360 LLPGAGGAAG FGMTSPPPPT SPSRTAVPPG LSSLPLTSVG NTGMKKVPKK LEEIPPASPE 370 380 390 400 410 420 MAQMRKQCLD YHYQEMQALK EVFKEYLIEL FFLQHFQGNM MDFLAFKKKH YAPLQAYLRQ 430 440 450 460 470 480 NDLDIEEEEE EEEEEEEKSE VINDEQALAG SLVAGAGSTV ETDLFKRQQA MPSTGMAGGM 490 500 510 520 530 540 PPTPQAAQLA GQRQSQQQYD PSTGPPVQNA ASLHTPLPQL PGRLPPAGVP TAALSSALQF 550 560 570 580 590 600 AQQPQVVEAQ TQLQIPVKTQ QPNVPIPAPP SSQLPIPPSQ PAQLALHVPT PGKVQVQASQ 610 620 630 640 650 660 LSSLPQMVAS TRLPVDPAPP CPRPLPTSST SSLAPVSGSG PGPSPARSSP VNRPSSATNK 670 680 690 700 710 720 ALSPVTSRTP GVVASAPTKP QSPAQNATSS QDSSQDTLTE QITLENQVHQ RIAELRKAGL 730 740 750 760 770 780 WSQRRLPKLQ EAPRPKSHWD YLLEEMQWMA TDFAQERRWK VAAAKKLVRT VVRHHEEKQL 790 800 810 820 830 840 REERGKKEEQ SRLRRIAAST AREIECFWSN IEQVVEIKLR VELEEKRKKA LNLQKVSRRG 850 860 870 880 890 900 KELRPKGFDA LQESSLDSGM SGRKRKASIS LTDDEVDDEE ETIEEEEANE GVVDHQTELS 910 920 930 940 950 960 NLAKEAELPL LDLMKLYEGA FLPSSQWPRP KPDGEDTSGE EDADDCPGDR ESRKDLVLID 970 980 990 1000 1010 1020 SLFIMDQFKA AERMNIGKPN AKDIADVTAV AEAILPKGSA RVTTSVKFNA PSLLYGALRD 1030 1040 1050 1060 1070 1080 YQKIGLDWLA KLYRKNLNGI LADEAGLGKT VQIIAFFAHL ACNEGNWGPH LVVVRSCNIL 1090 1100 1110 1120 1130 1140 KWELELKRWC PGLKILSYIG SHRELKAKRQ EWAEPNSFHV CITSYTQFFR GLTAFTRVRW 1150 1160 1170 1180 1190 1200 KCLVIDEMQR VKGMTERHWE AVFTLQSQQR LLLIDSPLHN TFLELWTMVH FLVPGISRPY 1210 1220 1230 1240 1250 1260 LSSPLRAPSE ESQDYYHKVV IRLHRVTQPF ILRRTKRDVE KQLTKKYEHV LKCRLSNRQK 1270 1280 1290 1300 1310 1320 ALYEDVILQP GTQEALKSGH FVNVLSILVR LQRICNHPGL VEPRHPGSSY VAGPLEYPSA 1330 1340 1350 1360 1370 1380 SLILKALERD FWKEADLSMF DLIGLENKIT RHEAELLSKK KIPRKLMEEI STSAAPAARP 1390 1400 1410 1420 1430 1440 AAAKLKASRL FQPVQYGQKP EGRTVAFPST HPPRTAAPTT ASAAPQGPLR GRPPIATFSA 1450 1460 1470 1480 1490 1500 NPEAKAAAAP FQTSQASASA PRHQPASASS TAASPAHPAK LRAQTTAQAS TPGQPPPQPQ 1510 1520 1530 1540 1550 1560 APSHAAGQSA LPQRLVLPSQ AQARLPSGEV VKIAQLASIT GPQSRVAQPE TPVTLQFQGS 1570 1580 1590 1600 1610 1620 KFTLSHSQLR QLTAGQPLQL QGSVLQIVSA PGQPYLRAPG PVVMQTVSQA GAVHGALGSK 1630 1640 1650 1660 1670 1680 PPAGGPSPAP LTPQVGVPGR VAVNALAVGE PGTASKPASP IGGPTQEEKT RLLKERLDQI 1690 1700 1710 1720 1730 1740 YLVNERRCSQ APVYGRDLLR ICALPSHGRV QWRGSLDGRR GKEAGPAHSY TSSSESPSEL 1750 1760 1770 1780 1790 1800 MLTLCRCGES LQDVIDRVAF VIPPVVAAPP SLRVPRPPPL YSHRMRILRQ GLREHAAPYF 1810 1820 1830 1840 1850 1860 QQLRQTTAPR LLQFPELRLV QFDSGKLEAL AILLQKLKSE GRRVLILSQM ILMLDILEMF 1870 1880 1890 1900 1910 1920 LNFHYLTYVR IDENASSEQR QELMRSFNRD RRIFCAILST HSRTTGINLV EADTVVFYDN 1930 1940 1950 1960 1970 1980 DLNPVMDAKA QEWCDRIGRC KDIHIYRLVS GNSIEEKLLK NGTKDLIREV AAQGNDYSMA 1990 2000 2010 2020 2030 2040 FLTQRTIQEL FEVYSPMDDA GFPVKAEEFV VLSQEPSVTE TIAPKIARPF IEALKSIEYL 2050 2060 2070 2080 2090 2100 EEDAQKSAQE GVLGPHTDAL SSDSENMPCD EEPSQLEELA DFMEQLTPIE KYALNYLELF 2110 2120 2130 2140 2150 2160 HTSIEQEKER NSEDAVMTAV RAWEFWNLKT LQEREARLRL EQEEAELLTY TREDAYSMEY 2170 2180 2190 2200 2210 2220 VYEDVDGQTE VMPLWTPPTP PQDDSDIYLD SVMCLMYEAT PIPEAKLPPV YVRKERKRHK 2230 2240 2250 2260 2270 2280 TDPSAAGRKK KQRHGEAVVP PRSLFDRATP GLLKIRREGK EQKKNILLKQ QVPFAKPLPT 2290 2300 2310 2320 2330 2340 FAKPTAEPGQ DNPEWLISED WALLQAVKQL LELPLNLTIV SPAHTPNWDL VSDVVNSCSR 2350 2360 2370 2380 2390 2400 IYRSSKQCRN RYENVIIPRE EGKSKNNRPL RTSQIYAQDE NATHTQLYTS HFDLMKMTAG 2410 2420 2430 2440 2450 2460 KRSPPIKPLL GMNPFQKNPK HASVLAESGI NYDKPLPPIQ VASLRAERIA KEKKALADQQ 2470 2480 2490 2500 2510 2520 KAQQPAVAQP PPPQPQPPPP PQQPPPPLPQ PQAAGSQPPA GPPAVQPQPQ PQPQTQPQPV 2530 2540 2550 2560 2570 2580 QAPAKAQPAI TTGGSAAVLA GTIKTSVTGT SMPTGAVSGN VIVNTIAGVP AATFQSINKR 2590 2600 2610 2620 2630 2640 LASPVAPGAL TTPGGSAPAQ VVHTQPPPRA VGSPATATPD LVSMATTQGV RAVTSVTASA 2650 2660 2670 2680 2690 2700 VVTTNLTPVQ TPARSLVPQV SQATGVQLPG KTITPAHFQL LRQQQQQQQQ QQQQQQQQQQ 2710 2720 2730 2740 2750 2760 QQQQQQQQQQ QQTTTTSQVQ VPQIQGQAQS PAQIKAVGKL TPEHLIKMQK QKLQMPPQPP 2770 2780 2790 2800 2810 2820 PPQAQSAPPQ PTAQVQVQTS QPPQQQSPQL TTVTAPRPGA LLTGTTVANL QVARLTRVPT 2830 2840 2850 2860 2870 2880 SQLQAQGQMQ TQAPQPAQVA LAKPPVVSVP AAVVSSPGVT TLPMNVAGIS VAIGQPQKAA 2890 2900 2910 2920 2930 2940 GQTVVAQPVH MQQLLKLKQQ AVQQQKAIQP QAAQGPAAVQ QKITAQQITT PGAQQKVAYA 2950 2960 2970 2980 2990 3000 AQPALKTQFL TTPISQAQKL AGAQQVQTQI QVAKLPQVVQ QQTPVASIQQ VASASQQASP 3010 3020 3030 3040 3050 3060 QTVALTQATA AGQQVQMIPA VTATAQVVQQ KLIQQQVVTT ASAPLQTPGA PNPAQVPASS 3070 3080 DSPSQQPKLQ MRVPAVRLKT PTKPPCQ
	Isoform 4. Checksum: 627DC4071EF8A035	FASTA	3,043	331,906
	10 20 30 40 50 60 MHHGTGPQNV QHQLQRSRAC PGSEGEEQPA HPNPPPSPAA PFAPSASPSA PQSPSYQIQQ 70 80 90 100 110 120 LMNRSPATGQ NVNITLQSVG PVVGGNQQIT LAPLPLPSPT SPGFQFSAQP RRFEHGSPSY 130 140 150 160 170 180 IQVTSPLSQQ VQTQSPTQPS PGPGQALQNV RAGAPGPGLG LCSSSPTGGF VDASVLVRQI 190 200 210 220 230 240 SLSPSSGGHF VFQDGSGLTQ IAQGAQVQLQ HPGTPITVRE RRPSQPHTQS GGTIHHLGPQ 250 260 270 280 290 300 SPAAAGGAGL QPLASPSHIT TANLPPQISS IIQGQLVQQQ QVLQGPPLPR PLGFERTPGV 310 320 330 340 350 360 LLPGAGGAAG FGMTSPPPPT SPSRTAVPPG LSSLPLTSVG NTGMKKVPKK LEEIPPASPE 370 380 390 400 410 420 MAQMRKQCLD YHYQEMQALK EVFKEYLIEL FFLQHFQGNM MDFLAFKKKH YAPLQAYLRQ 430 440 450 460 470 480 NDLDIEEEEE EEEEEEEKSE VINDEQQALA GSLVAGAGST VETDLFKRQQ AMPSTGMAEQ 490 500 510 520 530 540 SKRPRLEVGH QGVVFQHPGA DAGVPLQQLM PTAQGGMPPT PQAAQLAGQR QSQQQYDPST 550 560 570 580 590 600 GPPVQNAASL HTPLPQLPGR LPPAGVPTAA LSSALQFAQQ PQVVEAQTQL QIPVKTQQPN 610 620 630 640 650 660 VPIPAPPSSQ LPIPPSQPAQ LALHVPTPGK VQVQASQLSS LPQMVASTRL PVDPAPPCPR 670 680 690 700 710 720 PLPTSSTSSL APVSGSGPGP SPARSSPVNR PSSATNKALS PVTSRTPGVV ASAPTKPQSP 730 740 750 760 770 780 AQNATSSQDS SQDTLTEQIT LENQVHQRIA ELRKAGLWSQ RRLPKLQEAP RPKSHWDYLL 790 800 810 820 830 840 EEMQWMATDF AQERRWKVAA AKKLVRTVVR HHEEKQLREE RGKKEEQSRL RRIAASTARE 850 860 870 880 890 900 IECFWSNIEQ VVEIKLRVEL EEKRKKALNL QKVSRRGKEL RPKGFDALQE SSLDSGMSGR 910 920 930 940 950 960 KRKASISLTD DEVDDEEETI EEEEANEGVV DHQTELSNLA KEAELPLLDL MKLYEGAFLP 970 980 990 1000 1010 1020 SSQWPRPKPD GEDTSGEEDA DDCPGDRESR KDLVLIDSLF IMDQFKAAER MNIGKPNAKD 1030 1040 1050 1060 1070 1080 IADVTAVAEA ILPKGSARVT TSVKFNAPSL LYGALRDYQK IGLDWLAKLY RKNLNGILAD 1090 1100 1110 1120 1130 1140 EAGLGKTVQI IAFFAHLACN EGNWGPHLVV VRSCNILKWE LELKRWCPGL KILSYIGSHR 1150 1160 1170 1180 1190 1200 ELKAKRQEWA EPNSFHVCIT SYTQFFRGLT AFTRVRWKCL VIDEMQRVKG MTERHWEAVF 1210 1220 1230 1240 1250 1260 TLQSQQRLLL IDSPLHNTFL ELWTMVHFLV PGISRPYLSS PLRAPSEESQ DYYHKVVIRL 1270 1280 1290 1300 1310 1320 HRVTQPFILR RTKRDVEKQL TKKYEHVLKC RLSNRQKALY EDVILQPGTQ EALKSGHFVN 1330 1340 1350 1360 1370 1380 VLSILVRLQR ICNHPGLVEP RHPGSSYVAG PLEYPSASLI LKALERDFWK EADLSMFDLI 1390 1400 1410 1420 1430 1440 GLENKITRHE AELLSKKKIP RKLMEEISTS AAPAARPAAA KLKASRLFQP VQYGQKPEGR 1450 1460 1470 1480 1490 1500 TVAFPSTHPP RTAAPTTASA APQGPLRGRP PIATFSANPE AKGGEVVKIA QLASITGPQS 1510 1520 1530 1540 1550 1560 RVAQPETPVT LQFQGSKFTL SHSQLRQLTA GQPLQLQGSV LQIVSAPGQP YLRAPGPVVM 1570 1580 1590 1600 1610 1620 QTVSQAGAVH GALGSKPPAG GPSPAPLTPQ VGVPGRVAVN ALAVGEPGTA SKPASPIGGP 1630 1640 1650 1660 1670 1680 TQEEKTRLLK ERLDQIYLVN ERRCSQAPVY GRDLLRICAL PSHGRVQWRG SLDGRRGKEA 1690 1700 1710 1720 1730 1740 GPAHSYTSSS ESPSELMLTL CRCGESLQDV IDRVAFVIPP VVAAPPSLRV PRPPPLYSHR 1750 1760 1770 1780 1790 1800 MRILRQGLRE HAAPYFQQLR QTTAPRLLQF PELRLVQFDS GKLEALAILL QKLKSEGRRV 1810 1820 1830 1840 1850 1860 LILSQMILML DILEMFLNFH YLTYVRIDEN ASSEQRQELM RSFNRDRRIF CAILSTHSRT 1870 1880 1890 1900 1910 1920 TGINLVEADT VVFYDNDLNP VMDAKAQEWC DRIGRCKDIH IYRLVSGNSI EEKLLKNGTK 1930 1940 1950 1960 1970 1980 DLIREVAAQG NDYSMAFLTQ RTIQELFEVY SPMDDAGFPV KAEEFVVLSQ EPSVTETIAP 1990 2000 2010 2020 2030 2040 KIARPFIEAL KSIEYLEEDA QKSAQEGVLG PHTDALSSDS ENMPCDEEPS QLEELADFME 2050 2060 2070 2080 2090 2100 QLTPIEKYAL NYLELFHTSI EQEKERNSED AVMTAVRAWE FWNLKTLQER EARLRLEQEE 2110 2120 2130 2140 2150 2160 AELLTYTRED AYSMEYVYED VDGQTEVMPL WTPPTPPQDD SDIYLDSVMC LMYEATPIPE 2170 2180 2190 2200 2210 2220 AKLPPVYVRK ERKRHKTDPS AAGRKKKQRH GEAVVPPRSL FDRATPGLLK IRREGKEQKK 2230 2240 2250 2260 2270 2280 NILLKQQVPF AKPLPTFAKP TAEPGQDNPE WLISEDWALL QAVKQLLELP LNLTIVSPAH 2290 2300 2310 2320 2330 2340 TPNWDLVSDV VNSCSRIYRS SKQCRNRYEN VIIPREEGKS KNNRPLRTSQ IYAQDENATH 2350 2360 2370 2380 2390 2400 TQLYTSHFDL MKMTAGKRSP PIKPLLGMNP FQKNPKHASV LAESGINYDK PLPPIQVASL 2410 2420 2430 2440 2450 2460 RAERIAKEKK ALADQQKAQQ PAVAQPPPPQ PQPPPPPQQP PPPLPQPQAA GSQPPAGPPA 2470 2480 2490 2500 2510 2520 VQPQPQPQPQ TQPQPVQAPA KAQPAITTGG SAAVLAGTIK TSVTGTSMPT GAVSGNVIVN 2530 2540 2550 2560 2570 2580 TIAGVPAATF QSINKRLASP VAPGALTTPG GSAPAQVVHT QPPPRAVGSP ATATPDLVSM 2590 2600 2610 2620 2630 2640 ATTQGVRAVT SVTASAVVTT NLTPVQTPAR SLVPQVSQAT GVQLPGKTIT PAHFQLLRQQ 2650 2660 2670 2680 2690 2700 QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQTT TTSQVQVPQI QGQAQSPAQI KAVGKLTPEH 2710 2720 2730 2740 2750 2760 LIKMQKQKLQ MPPQPPPPQA QSAPPQPTAQ VQVQTSQPPQ QQSPQLTTVT APRPGALLTG 2770 2780 2790 2800 2810 2820 TTVANLQVAR LTRVPTSQLQ AQGQMQTQAP QPAQVALAKP PVVSVPAAVV SSPGVTTLPM 2830 2840 2850 2860 2870 2880 NVAGISVAIG QPQKAAGQTV VAQPVHMQQL LKLKQQAVQQ QKAIQPQAAQ GPAAVQQKIT 2890 2900 2910 2920 2930 2940 AQQITTPGAQ QKVAYAAQPA LKTQFLTTPI SQAQKLAGAQ QVQTQIQVAK LPQVVQQQTP 2950 2960 2970 2980 2990 3000 VASIQQVASA SQQASPQTVA LTQATAAGQQ VQMIPAVTAT AQVVQQKLIQ QQVVTTASAP 3010 3020 3030 3040 LQTPGAPNPA QVPASSDSPS QQPKLQMRVP AVRLKTPTKP PCQ

References

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[1]	"The p400 complex is an essential E1A transformation target." Fuchs M., Gerber J., Drapkin R., Sif S., Ikura T., Ogryzko V., Lane W.S., Nakatani Y., Livingston D.M. Cell 106:297-307(2001) [PubMed: 11509179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY, ROLE OF EP400-CONTAINING COMPLEXES IN CELLULAR TRANSFORMATION BY ADENOVIRUS E1A PROTEIN, TISSUE SPECIFICITY, INTERACTION WITH TRRAP; RUVBL1 AND RUVBL2.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1847 (ISOFORM 4). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-897 (ISOFORM 3).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-978 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-895 (ISOFORM 3). Tissue: Lymph and Testis.
[6]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2004-3160. Tissue: Brain.
[7]	"cDNAs with long CAG trinucleotide repeats from human brain." Margolis R.L., Abraham M.R., Gatchell S.B., Li S.-H., Kidwai A.S., Breschel T.S., Stine O.C., Callahan C., McInnis M.G., Ross C.A. Hum. Genet. 100:114-122(1997) [PubMed: 9225980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2463-3160. Tissue: Brain.
[8]	"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex." Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W. J. Biol. Chem. 278:42733-42736(2003) [PubMed: 12963728] [Abstract] Cited for: IDENTIFICATION IN NUA4 COMPLEX.
[9]	"The highly conserved and multifunctional NuA4 HAT complex." Doyon Y., Cote J. Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed: 15196461] [Abstract] Cited for: REVIEW ON NUA4 COMPLEX.
[10]	"Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans." Doyon Y., Selleck W., Lane W.S., Tan S., Cote J. Mol. Cell. Biol. 24:1884-1896(2004) [PubMed: 14966270] [Abstract] Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN NUA4 COMPLEX, IDENTIFICATION IN SRCAP-CONTAINING COMPLEX.
[11]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736, MASS SPECTROMETRY. Tissue: Epithelium.
[12]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1547, MASS SPECTROMETRY. Tissue: Epithelium.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314; SER-315; THR-320; SER-941; SER-943; THR-945; SER-1728; SER-1732 AND THR-2814, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY044869 mRNA. Translation: AAK97789.1. AC137590 Genomic DNA. No translation available. AC137632 Genomic DNA. No translation available. AB040931 mRNA. Translation: BAA96022.1. Different initiation. AK096311 mRNA. Translation: BAC04759.1. BC037208 mRNA. Translation: AAH37208.1. Sequence problems. BC064554 mRNA. Translation: AAH64554.1. Sequence problems. AB058721 mRNA. Translation: BAB47447.1. U80743 mRNA. Translation: AAB91441.1. Frameshift.
IPI	IPI00064931. IPI00167535. IPI00783692. IPI00798339.
RefSeq	NP_056224.2.
UniGene	Hs.699245
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96L91. 5 interactions.
PTM databases
PhosphoSite	Q96L91.
Proteomic databases
PRIDE	Q96L91.
Genome annotation databases
Ensembl	ENSG00000183495. Homo sapiens. [Contig view]
GeneID	57634.
KEGG	hsa:57634.
Organism-specific databases
GeneCards	GC12P131000.
H-InvDB	HIX0021564. HIX0023235.
HGNC	HGNC:11958. EP400.
HPA	HPA016704.
MIM	606265. gene.
PharmGKB	PA27808.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96L91.
Gene expression databases
ArrayExpress	Q96L91.
Bgee	Q96L91.
CleanEx	HS_EP400.
GermOnline	ENSG00000183495. Homo sapiens.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR013999. HAS_subgroup. IPR014012. Helicase/SANT-assoc_DNA_bd. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR006562. HSA. IPR017877. MYB-like. IPR001005. SANT_DNA-bd. IPR000330. SNF2_N. [Graphical view]
Pfam	PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00573. HSA. 1 hit. SM00717. SANT. 1 hit. [Graphical view]
PROSITE	PS00690. DEAH_ATP_HELICASE. False negative. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. PS50090. MYB_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	64345.
SOURCE	Search...

Entry information

Entry name

EP400_HUMAN

Accession

Primary (citable) accession number: Q96L91
Secondary accession number(s): O15411 , Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)