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Protein

Calpain small subunit 2

Gene

CAPNS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi92 – 921Calcium 1By similarity
Metal bindingi94 – 941Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi117 – 1171Calcium 4By similarity
Metal bindingi132 – 1321Calcium 2By similarity
Metal bindingi134 – 1341Calcium 2By similarity
Metal bindingi136 – 1361Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi138 – 1381Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi143 – 1431Calcium 2By similarity
Metal bindingi162 – 1621Calcium 3By similarity
Metal bindingi164 – 1641Calcium 3By similarity
Metal bindingi166 – 1661Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi205 – 2051Calcium 4By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi88 – 99121By similarityAdd
BLAST
Calcium bindingi132 – 143122PROSITE-ProRule annotationBy similarityAdd
BLAST
Calcium bindingi162 – 173123PROSITE-ProRule annotationBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain small subunit 2
Short name:
CSS2
Alternative name(s):
Calcium-dependent protease small subunit 2
Gene namesi
Name:CAPNS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16371. CAPNS2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Translocates to the plasma membrane upon calcium binding.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873146.

Polymorphism and mutation databases

BioMutaiCAPNS2.
DMDMi45476965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Calpain small subunit 2PRO_0000073718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei159 – 1591N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96L46.
PaxDbiQ96L46.
PRIDEiQ96L46.

PTM databases

iPTMnetiQ96L46.
PhosphoSiteiQ96L46.

Expressioni

Gene expression databases

BgeeiQ96L46.
CleanExiHS_CAPNS2.
GenevisibleiQ96L46. HS.

Organism-specific databases

HPAiHPA061317.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi124017. 15 interactions.
STRINGi9606.ENSP00000400882.

Structurei

3D structure databases

ProteinModelPortaliQ96L46.
SMRiQ96L46. Positions 54-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 15234EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 18436EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini185 – 21329EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini214 – 24835EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 4334Gly-richAdd
BLAST
Compositional biasi51 – 544Poly-Ala

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOVERGENiHBG004492.
InParanoidiQ96L46.
KOiK08584.
OMAiELPHAFQ.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ96L46.
TreeFamiTF314682.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAKALLEG ADRGLGEALG GLFGGGGQRR EGGGRNIGGI VGGIVNFISE
60 70 80 90 100
AAAAQYTPEP PPTQQHFTSV EASESEEVRR FRQQFTQLAG PDMEVGATDL
110 120 130 140 150
MNILNKVLSK HKDLKTDGFS LDTCRSIVSV MDSDTTGKLG FEEFKYLWNN
160 170 180 190 200
IKKWQCVYKQ YDRDHSGSLG SSQLRGALQA AGFQLNEQLY QMIVRRYANE
210 220 230 240
DGDMDFNNFI SCLVRLDAMF RAFKSLDRDR DGLIQVSIKE WLQLTMYS
Length:248
Mass (Da):27,660
Last modified:March 15, 2004 - v2
Checksum:iF40AD8778FF41600
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741E → Q in AAL02241 (PubMed:11853546).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052551 mRNA. Translation: AAL02241.1.
BC005397 mRNA. Translation: AAH05397.1.
BC006000 mRNA. Translation: AAH06000.1.
CCDSiCCDS54010.1.
RefSeqiNP_115706.1. NM_032330.1.
UniGeneiHs.660027.

Genome annotation databases

EnsembliENST00000457326; ENSP00000400882; ENSG00000256812.
GeneIDi84290.
KEGGihsa:84290.
UCSCiuc002eid.2. human.

Cross-referencesi

Web resourcesi

Calpains homepage

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052551 mRNA. Translation: AAL02241.1.
BC005397 mRNA. Translation: AAH05397.1.
BC006000 mRNA. Translation: AAH06000.1.
CCDSiCCDS54010.1.
RefSeqiNP_115706.1. NM_032330.1.
UniGeneiHs.660027.

3D structure databases

ProteinModelPortaliQ96L46.
SMRiQ96L46. Positions 54-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124017. 15 interactions.
STRINGi9606.ENSP00000400882.

PTM databases

iPTMnetiQ96L46.
PhosphoSiteiQ96L46.

Polymorphism and mutation databases

BioMutaiCAPNS2.
DMDMi45476965.

Proteomic databases

EPDiQ96L46.
PaxDbiQ96L46.
PRIDEiQ96L46.

Protocols and materials databases

DNASUi84290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457326; ENSP00000400882; ENSG00000256812.
GeneIDi84290.
KEGGihsa:84290.
UCSCiuc002eid.2. human.

Organism-specific databases

CTDi84290.
GeneCardsiCAPNS2.
HGNCiHGNC:16371. CAPNS2.
HPAiHPA061317.
neXtProtiNX_Q96L46.
PharmGKBiPA134873146.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOVERGENiHBG004492.
InParanoidiQ96L46.
KOiK08584.
OMAiELPHAFQ.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ96L46.
TreeFamiTF314682.

Miscellaneous databases

GenomeRNAii84290.
NextBioi73927.
PROiQ96L46.

Gene expression databases

BgeeiQ96L46.
CleanExiHS_CAPNS2.
GenevisibleiQ96L46. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder carcinoma.

Entry informationi

Entry nameiCPNS2_HUMAN
AccessioniPrimary (citable) accession number: Q96L46
Secondary accession number(s): Q9BPV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: March 16, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.