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Protein

Calpain small subunit 2

Gene

CAPNS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi92Calcium 1By similarity1
Metal bindingi94Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi117Calcium 4By similarity1
Metal bindingi132Calcium 2By similarity1
Metal bindingi134Calcium 2By similarity1
Metal bindingi136Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi138Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi143Calcium 2By similarity1
Metal bindingi162Calcium 3By similarity1
Metal bindingi164Calcium 3By similarity1
Metal bindingi166Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi205Calcium 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi88 – 991By similarityAdd BLAST12
Calcium bindingi132 – 1432PROSITE-ProRule annotationBy similarityAdd BLAST12
Calcium bindingi162 – 1733PROSITE-ProRule annotationBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33652-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain small subunit 2
Short name:
CSS2
Alternative name(s):
Calcium-dependent protease small subunit 2
Gene namesi
Name:CAPNS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16371. CAPNS2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Translocates to the plasma membrane upon calcium binding.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256812.
PharmGKBiPA134873146.

Polymorphism and mutation databases

BioMutaiCAPNS2.
DMDMi45476965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737181 – 248Calpain small subunit 2Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei159N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96L46.
MaxQBiQ96L46.
PaxDbiQ96L46.
PeptideAtlasiQ96L46.
PRIDEiQ96L46.

PTM databases

iPTMnetiQ96L46.
PhosphoSitePlusiQ96L46.

Expressioni

Gene expression databases

BgeeiENSG00000256812.
CleanExiHS_CAPNS2.
GenevisibleiQ96L46. HS.

Organism-specific databases

HPAiHPA061317.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.

Protein-protein interaction databases

BioGridi124017. 15 interactors.
IntActiQ96L46. 1 interactor.
STRINGi9606.ENSP00000400882.

Structurei

3D structure databases

ProteinModelPortaliQ96L46.
SMRiQ96L46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 152EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini149 – 184EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini185 – 213EF-hand 3PROSITE-ProRule annotationAdd BLAST29
Domaini214 – 248EF-hand 4PROSITE-ProRule annotationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 43Gly-richAdd BLAST34
Compositional biasi51 – 54Poly-Ala4

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOVERGENiHBG004492.
InParanoidiQ96L46.
KOiK08584.
OMAiFTIESCR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ96L46.
TreeFamiTF314682.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAKALLEG ADRGLGEALG GLFGGGGQRR EGGGRNIGGI VGGIVNFISE
60 70 80 90 100
AAAAQYTPEP PPTQQHFTSV EASESEEVRR FRQQFTQLAG PDMEVGATDL
110 120 130 140 150
MNILNKVLSK HKDLKTDGFS LDTCRSIVSV MDSDTTGKLG FEEFKYLWNN
160 170 180 190 200
IKKWQCVYKQ YDRDHSGSLG SSQLRGALQA AGFQLNEQLY QMIVRRYANE
210 220 230 240
DGDMDFNNFI SCLVRLDAMF RAFKSLDRDR DGLIQVSIKE WLQLTMYS
Length:248
Mass (Da):27,660
Last modified:March 15, 2004 - v2
Checksum:iF40AD8778FF41600
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74E → Q in AAL02241 (PubMed:11853546).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052551 mRNA. Translation: AAL02241.1.
BC005397 mRNA. Translation: AAH05397.1.
BC006000 mRNA. Translation: AAH06000.1.
CCDSiCCDS54010.1.
RefSeqiNP_115706.1. NM_032330.1.
UniGeneiHs.660027.

Genome annotation databases

EnsembliENST00000457326; ENSP00000400882; ENSG00000256812.
GeneIDi84290.
KEGGihsa:84290.
UCSCiuc002eid.2. human.

Cross-referencesi

Web resourcesi

Calpains homepage

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052551 mRNA. Translation: AAL02241.1.
BC005397 mRNA. Translation: AAH05397.1.
BC006000 mRNA. Translation: AAH06000.1.
CCDSiCCDS54010.1.
RefSeqiNP_115706.1. NM_032330.1.
UniGeneiHs.660027.

3D structure databases

ProteinModelPortaliQ96L46.
SMRiQ96L46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124017. 15 interactors.
IntActiQ96L46. 1 interactor.
STRINGi9606.ENSP00000400882.

PTM databases

iPTMnetiQ96L46.
PhosphoSitePlusiQ96L46.

Polymorphism and mutation databases

BioMutaiCAPNS2.
DMDMi45476965.

Proteomic databases

EPDiQ96L46.
MaxQBiQ96L46.
PaxDbiQ96L46.
PeptideAtlasiQ96L46.
PRIDEiQ96L46.

Protocols and materials databases

DNASUi84290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457326; ENSP00000400882; ENSG00000256812.
GeneIDi84290.
KEGGihsa:84290.
UCSCiuc002eid.2. human.

Organism-specific databases

CTDi84290.
GeneCardsiCAPNS2.
HGNCiHGNC:16371. CAPNS2.
HPAiHPA061317.
neXtProtiNX_Q96L46.
OpenTargetsiENSG00000256812.
PharmGKBiPA134873146.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOVERGENiHBG004492.
InParanoidiQ96L46.
KOiK08584.
OMAiFTIESCR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ96L46.
TreeFamiTF314682.

Enzyme and pathway databases

BioCyciZFISH:G66-33652-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Miscellaneous databases

GenomeRNAii84290.
PROiQ96L46.

Gene expression databases

BgeeiENSG00000256812.
CleanExiHS_CAPNS2.
GenevisibleiQ96L46. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPNS2_HUMAN
AccessioniPrimary (citable) accession number: Q96L46
Secondary accession number(s): Q9BPV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.