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Q96L34

- MARK4_HUMAN

UniProt

Q96L34 - MARK4_HUMAN

Protein

MAP/microtubule affinity-regulating kinase 4

Gene

MARK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by phosphorylation on Thr-214.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881ATPPROSITE-ProRule annotation
    Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 739ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. gamma-tubulin binding Source: UniProtKB
    3. microtubule binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. protein serine/threonine kinase activity Source: UniProtKB
    6. tau-protein kinase activity Source: UniProtKB
    7. ubiquitin binding Source: UniProtKB

    GO - Biological processi

    1. microtubule bundle formation Source: UniProtKB
    2. microtubule cytoskeleton organization Source: UniProtKB
    3. nervous system development Source: UniProtKB
    4. positive regulation of programmed cell death Source: UniProtKB
    5. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ96L34.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAP/microtubule affinity-regulating kinase 4 (EC:2.7.11.1)
    Alternative name(s):
    MAP/microtubule affinity-regulating kinase-like 1
    Gene namesi
    Name:MARK4
    Synonyms:KIAA1860, MARKL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13538. MARK4.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. microtubule cytoskeleton Source: UniProtKB
    3. microtubule organizing center Source: UniProtKB
    4. neuron projection Source: UniProtKB

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi214 – 2141T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication
    Mutagenesisi214 – 2141T → E: Mimicks phosphorylation state, leading to increased activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA30641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 752752MAP/microtubule affinity-regulating kinase 4PRO_0000086307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei214 – 2141Phosphothreonine; by LKB11 Publication

    Post-translational modificationi

    Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.2 Publications
    Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ96L34.
    PaxDbiQ96L34.
    PRIDEiQ96L34.

    PTM databases

    PhosphoSiteiQ96L34.

    Expressioni

    Tissue specificityi

    Ubiquitous. Isoform 2 is brain-specific.1 Publication

    Gene expression databases

    ArrayExpressiQ96L34.
    BgeeiQ96L34.
    CleanExiHS_MARK4.
    GenevestigatoriQ96L34.

    Organism-specific databases

    HPAiHPA039186.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC42P609532EBI-302319,EBI-81752
    PARD6GQ9BYG42EBI-302319,EBI-295417
    PNMA1Q8ND902EBI-302319,EBI-302345
    PRKCIP417432EBI-302319,EBI-286199
    STK11Q158312EBI-302319,EBI-306838
    TUBG1P232584EBI-302319,EBI-302589
    YWHAHQ049176EBI-302319,EBI-306940

    Protein-protein interaction databases

    BioGridi121760. 40 interactions.
    IntActiQ96L34. 28 interactions.
    MINTiMINT-6425023.
    STRINGi9606.ENSP00000300843.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96L34.
    SMRiQ96L34. Positions 53-369, 653-752.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 310252Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini324 – 36845UBAPROSITE-ProRule annotationAdd
    BLAST
    Domaini703 – 75250KA1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 KA1 (kinase-associated) domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233025.
    HOVERGENiHBG052453.
    InParanoidiQ96L34.
    KOiK08798.
    OMAiDSMSTPN.
    OrthoDBiEOG79CXXX.
    PhylomeDBiQ96L34.
    TreeFamiTF315213.

    Family and domain databases

    Gene3Di3.30.310.80. 1 hit.
    InterProiIPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    [Graphical view]
    PfamiPF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00627. UBA. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view]
    SUPFAMiSSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96L34-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSRTVLAPG NDRNSDTHGT LGSGRSSDKG PSWSSRSLGA RCRNSIASCP    50
    EEQPHVGNYR LLRTIGKGNF AKVKLARHIL TGREVAIKII DKTQLNPSSL 100
    QKLFREVRIM KGLNHPNIVK LFEVIETEKT LYLVMEYASA GEVFDYLVSH 150
    GRMKEKEARA KFRQIVSAVH YCHQKNIVHR DLKAENLLLD AEANIKIADF 200
    GFSNEFTLGS KLDTFCGSPP YAAPELFQGK KYDGPEVDIW SLGVILYTLV 250
    SGSLPFDGHN LKELRERVLR GKYRVPFYMS TDCESILRRF LVLNPAKRCT 300
    LEQIMKDKWI NIGYEGEELK PYTEPEEDFG DTKRIEVMVG MGYTREEIKE 350
    SLTSQKYNEV TATYLLLGRK TEEGGDRGAP GLALARVRAP SDTTNGTSSS 400
    KGTSHSKGQR SSSSTYHRQR RHSDFCGPSP APLHPKRSPT STGEAELKEE 450
    RLPGRKASCS TAGSGSRGLP PSSPMVSSAH NPNKAEIPER RKDSTSTPNN 500
    LPPSMMTRRN TYVCTERPGA ERPSLLPNGK ENSSGTPRVP PASPSSHSLA 550
    PPSGERSRLA RGSTIRSTFH GGQVRDRRAG GGGGGGVQNG PPASPTLAHE 600
    AAPLPAGRPR PTTNLFTKLT SKLTRRVADE PERIGGPEVT SCHLPWDQTE 650
    TAPRLLRFPW SVKLTSSRPP EALMAALRQA TAAARCRCRQ PQPFLLACLH 700
    GGAGGPEPLS HFEVEVCQLP RPGLRGVLFR RVAGTALAFR TLVTRISNDL 750
    EL 752
    Length:752
    Mass (Da):82,520
    Last modified:December 1, 2001 - v1
    Checksum:i4B430FFD2B150E7A
    GO
    Isoform 2 (identifier: Q96L34-2) [UniParc]FASTAAdd to Basket

    Also known as: MARKL1S

    The sequence of this isoform differs from the canonical sequence as follows:
         628-752: ADEPERIGGP...VTRISNDLEL → TLDPSKRQNS...PPGCSDSPGV

    Show »
    Length:688
    Mass (Da):75,321
    Checksum:iA49143B34FDDD086
    GO

    Sequence cautioni

    The sequence BAB47489.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55238.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701F → S in BAB39380. (PubMed:11326310)Curated
    Sequence conflicti70 – 701F → S in BAC03375. (PubMed:11326310)Curated
    Sequence conflicti518 – 5181P → L in BAB55238. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti377 – 3771R → Q.1 Publication
    Corresponds to variant rs35070611 [ dbSNP | Ensembl ].
    VAR_040766
    Natural varianti418 – 4181R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040767

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei628 – 752125ADEPE…NDLEL → TLDPSKRQNSNRCVSGASLP QGSKIRSQTNLRESGDLRSQ VAIYLGIKRKPPPGCSDSPG V in isoform 2. 2 PublicationsVSP_004946Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057448 mRNA. Translation: AAL23683.1.
    AB049127 mRNA. Translation: BAB39380.1.
    AB088047 mRNA. Translation: BAC03375.1.
    AY120867 mRNA. Translation: AAM55491.1.
    AB058763 mRNA. Translation: BAB47489.1. Different initiation.
    AK027619 mRNA. Translation: BAB55238.1. Different initiation.
    AK075272 mRNA. Translation: BAC11510.1.
    CCDSiCCDS12658.1. [Q96L34-2]
    CCDS56097.1. [Q96L34-1]
    RefSeqiNP_001186796.1. NM_001199867.1. [Q96L34-1]
    NP_113605.2. NM_031417.3. [Q96L34-2]
    UniGeneiHs.34314.

    Genome annotation databases

    EnsembliENST00000262891; ENSP00000262891; ENSG00000007047. [Q96L34-1]
    ENST00000300843; ENSP00000300843; ENSG00000007047. [Q96L34-2]
    GeneIDi57787.
    KEGGihsa:57787.
    UCSCiuc002pba.2. human. [Q96L34-2]
    uc002pbb.2. human. [Q96L34-1]

    Polymorphism databases

    DMDMi29840797.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057448 mRNA. Translation: AAL23683.1 .
    AB049127 mRNA. Translation: BAB39380.1 .
    AB088047 mRNA. Translation: BAC03375.1 .
    AY120867 mRNA. Translation: AAM55491.1 .
    AB058763 mRNA. Translation: BAB47489.1 . Different initiation.
    AK027619 mRNA. Translation: BAB55238.1 . Different initiation.
    AK075272 mRNA. Translation: BAC11510.1 .
    CCDSi CCDS12658.1. [Q96L34-2 ]
    CCDS56097.1. [Q96L34-1 ]
    RefSeqi NP_001186796.1. NM_001199867.1. [Q96L34-1 ]
    NP_113605.2. NM_031417.3. [Q96L34-2 ]
    UniGenei Hs.34314.

    3D structure databases

    ProteinModelPortali Q96L34.
    SMRi Q96L34. Positions 53-369, 653-752.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121760. 40 interactions.
    IntActi Q96L34. 28 interactions.
    MINTi MINT-6425023.
    STRINGi 9606.ENSP00000300843.

    Chemistry

    BindingDBi Q96L34.
    ChEMBLi CHEMBL5754.
    GuidetoPHARMACOLOGYi 2100.

    PTM databases

    PhosphoSitei Q96L34.

    Polymorphism databases

    DMDMi 29840797.

    Proteomic databases

    MaxQBi Q96L34.
    PaxDbi Q96L34.
    PRIDEi Q96L34.

    Protocols and materials databases

    DNASUi 57787.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262891 ; ENSP00000262891 ; ENSG00000007047 . [Q96L34-1 ]
    ENST00000300843 ; ENSP00000300843 ; ENSG00000007047 . [Q96L34-2 ]
    GeneIDi 57787.
    KEGGi hsa:57787.
    UCSCi uc002pba.2. human. [Q96L34-2 ]
    uc002pbb.2. human. [Q96L34-1 ]

    Organism-specific databases

    CTDi 57787.
    GeneCardsi GC19P045583.
    HGNCi HGNC:13538. MARK4.
    HPAi HPA039186.
    MIMi 606495. gene.
    neXtProti NX_Q96L34.
    PharmGKBi PA30641.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233025.
    HOVERGENi HBG052453.
    InParanoidi Q96L34.
    KOi K08798.
    OMAi DSMSTPN.
    OrthoDBi EOG79CXXX.
    PhylomeDBi Q96L34.
    TreeFami TF315213.

    Enzyme and pathway databases

    SignaLinki Q96L34.

    Miscellaneous databases

    GeneWikii MARK4.
    GenomeRNAii 57787.
    NextBioi 64721.
    PROi Q96L34.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96L34.
    Bgeei Q96L34.
    CleanExi HS_MARK4.
    Genevestigatori Q96L34.

    Family and domain databases

    Gene3Di 3.30.310.80. 1 hit.
    InterProi IPR028375. KA1/Ssp2_C.
    IPR001772. KA1_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    [Graphical view ]
    Pfami PF02149. KA1. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00627. UBA. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103243. SSF103243. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50032. KA1. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MARK4, homologue of MARK1, MARK2 and MARK3."
      Drewes G., Mandelkow E.M.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis."
      Kato T., Satoh S., Okabe H., Kitahara O., Ono K., Kihara C., Tanaka T., Tsunoda T., Yamaoka Y., Nakamura Y., Furukawa Y.
      Neoplasia 3:4-9(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Neural progenitor-restricted isoform of MARKL1 gene is upregulated by 19q13 amplification in human glioblastoma."
      Beghini A., Magnani I., Roversi G., Piepoli T., DiTerlizzi S., Pollo B., Conti A.M.F., Cowell J.K., Finocchiaro G., Larizza L.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    6. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
      Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G., Alessi D.R.
      EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-214, MUTAGENESIS OF THR-214.
    7. "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains."
      Al-Hakim A.K., Zagorska A., Chapman L., Deak M., Peggie M., Alessi D.R.
      Biochem. J. 411:249-260(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP9X.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-377 AND CYS-418.

    Entry informationi

    Entry nameiMARK4_HUMAN
    AccessioniPrimary (citable) accession number: Q96L34
    Secondary accession number(s): Q8NG37
    , Q96JG7, Q96SQ2, Q9BYD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3