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Protein

Rho-related GTP-binding protein RhoV

Gene

RHOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45GTPBy similarity8
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoV
Alternative name(s):
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
Wnt-1 responsive Cdc42 homolog 2
Short name:
WRCH-2
Gene namesi
Name:RHOVImported
Synonyms:ARHVImported, WRCH2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104140.6.
HGNCiHGNC:18313. RHOV.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi171177.
OpenTargetsiENSG00000104140.
PharmGKBiPA38313.

Polymorphism and mutation databases

BioMutaiRHOV.
DMDMi74724228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264381 – 236Rho-related GTP-binding protein RhoVAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Lipidationi234S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ96L33.
PaxDbiQ96L33.
PeptideAtlasiQ96L33.
PRIDEiQ96L33.

PTM databases

iPTMnetiQ96L33.
PhosphoSitePlusiQ96L33.

Expressioni

Tissue specificityi

Highly expressed in pancreas, placenta, and fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000104140.
CleanExiHS_RHOV.
ExpressionAtlasiQ96L33. baseline and differential.
GenevisibleiQ96L33. HS.

Organism-specific databases

HPAiHPA053343.

Interactioni

Subunit structurei

Interacts with PAK2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436394EBI-8538631,EBI-713635

Protein-protein interaction databases

BioGridi128110. 1 interactor.
IntActiQ96L33. 2 interactors.
MINTiMINT-7136663.
STRINGi9606.ENSP00000220507.

Structurei

3D structure databases

ProteinModelPortaliQ96L33.
SMRiQ96L33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ96L33.
KOiK07866.
OMAiPPQMDYF.
OrthoDBiEOG091G0E4F.
PhylomeDBiQ96L33.
TreeFamiTF321839.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51420. RHO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96L33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Length:236
Mass (Da):26,217
Last modified:December 1, 2001 - v1
Checksum:i334CEEF501107B91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177K → R in BAB86363 (PubMed:11956592).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079131 mRNA. Translation: BAB86363.1.
AY059636 mRNA. Translation: AAL17966.1.
CH471125 Genomic DNA. Translation: EAW92459.1.
BC105020 mRNA. Translation: AAI05021.1.
BC105022 mRNA. Translation: AAI05023.1.
BC112945 mRNA. Translation: AAI12946.2.
CCDSiCCDS10068.1.
RefSeqiNP_598378.3. NM_133639.3.
UniGeneiHs.447901.

Genome annotation databases

EnsembliENST00000220507; ENSP00000220507; ENSG00000104140.
GeneIDi171177.
KEGGihsa:171177.
UCSCiuc001znd.3. human.

Similar proteinsi

Entry informationi

Entry nameiRHOV_HUMAN
AccessioniPrimary (citable) accession number: Q96L33
Secondary accession number(s): Q2KHQ5, Q8TDW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families