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Protein

Rho-related GTP-binding protein RhoV

Gene

RHOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.By similarity

Cofactori

Mg2+By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoV
Alternative name(s):
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
Wnt-1 responsive Cdc42 homolog 2
Short name:
WRCH-2
Gene namesi
Name:RHOVImported
Synonyms:ARHVImported, WRCH2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18313. RHOV.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
  • Endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Treatment with TNF activates endosomal but not plasma membrane RHOV.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38313.

Polymorphism and mutation databases

BioMutaiRHOV.
DMDMi74724228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Rho-related GTP-binding protein RhoVPRO_0000326438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineCombined sources
Lipidationi234 – 2341S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ96L33.
PaxDbiQ96L33.
PeptideAtlasiQ96L33.
PRIDEiQ96L33.

PTM databases

iPTMnetiQ96L33.

Expressioni

Tissue specificityi

Highly expressed in pancreas, placenta, and fetal brain.1 Publication

Gene expression databases

BgeeiQ96L33.
CleanExiHS_RHOV.
ExpressionAtlasiQ96L33. baseline and differential.
GenevisibleiQ96L33. HS.

Organism-specific databases

HPAiHPA043713.

Interactioni

Subunit structurei

Interacts with PAK2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436394EBI-8538631,EBI-713635

Protein-protein interaction databases

BioGridi128110. 1 interaction.
IntActiQ96L33. 1 interaction.
MINTiMINT-7136663.
STRINGi9606.ENSP00000220507.

Structurei

3D structure databases

ProteinModelPortaliQ96L33.
SMRiQ96L33. Positions 31-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.By similarity

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ96L33.
KOiK07866.
OMAiYAHTDVF.
OrthoDBiEOG7Z3F56.
PhylomeDBiQ96L33.
TreeFamiTF321839.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS
60 70 80 90 100
YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY
110 120 130 140 150
PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD
160 170 180 190 200
VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS
210 220 230
AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
Length:236
Mass (Da):26,217
Last modified:December 1, 2001 - v1
Checksum:i334CEEF501107B91
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771K → R in BAB86363 (PubMed:11956592).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079131 mRNA. Translation: BAB86363.1.
AY059636 mRNA. Translation: AAL17966.1.
CH471125 Genomic DNA. Translation: EAW92459.1.
BC105020 mRNA. Translation: AAI05021.1.
BC105022 mRNA. Translation: AAI05023.1.
BC112945 mRNA. Translation: AAI12946.2.
CCDSiCCDS10068.1.
RefSeqiNP_598378.3. NM_133639.3.
UniGeneiHs.447901.

Genome annotation databases

EnsembliENST00000220507; ENSP00000220507; ENSG00000104140.
GeneIDi171177.
KEGGihsa:171177.
UCSCiuc001znd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079131 mRNA. Translation: BAB86363.1.
AY059636 mRNA. Translation: AAL17966.1.
CH471125 Genomic DNA. Translation: EAW92459.1.
BC105020 mRNA. Translation: AAI05021.1.
BC105022 mRNA. Translation: AAI05023.1.
BC112945 mRNA. Translation: AAI12946.2.
CCDSiCCDS10068.1.
RefSeqiNP_598378.3. NM_133639.3.
UniGeneiHs.447901.

3D structure databases

ProteinModelPortaliQ96L33.
SMRiQ96L33. Positions 31-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128110. 1 interaction.
IntActiQ96L33. 1 interaction.
MINTiMINT-7136663.
STRINGi9606.ENSP00000220507.

PTM databases

iPTMnetiQ96L33.

Polymorphism and mutation databases

BioMutaiRHOV.
DMDMi74724228.

Proteomic databases

MaxQBiQ96L33.
PaxDbiQ96L33.
PeptideAtlasiQ96L33.
PRIDEiQ96L33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220507; ENSP00000220507; ENSG00000104140.
GeneIDi171177.
KEGGihsa:171177.
UCSCiuc001znd.3. human.

Organism-specific databases

CTDi171177.
GeneCardsiRHOV.
HGNCiHGNC:18313. RHOV.
HPAiHPA043713.
neXtProtiNX_Q96L33.
PharmGKBiPA38313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ96L33.
KOiK07866.
OMAiYAHTDVF.
OrthoDBiEOG7Z3F56.
PhylomeDBiQ96L33.
TreeFamiTF321839.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii171177.
PROiQ96L33.

Gene expression databases

BgeeiQ96L33.
CleanExiHS_RHOV.
ExpressionAtlasiQ96L33. baseline and differential.
GenevisibleiQ96L33. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of WRCH2 on human chromosome 15q15."
    Katoh M.
    Int. J. Oncol. 20:977-982(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The Rho GTPase family: a Racs to Wrchs story."
    Wherlock M., Mellor H.
    J. Cell Sci. 115:239-240(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortexImported and CervixImported.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiRHOV_HUMAN
AccessioniPrimary (citable) accession number: Q96L33
Secondary accession number(s): Q2KHQ5, Q8TDW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.