Q96L33 (RHOV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoV

Alternative name(s):
CDC42-like GTPase 2
GTP-binding protein-like 2
Rho GTPase-like protein ARHV
Wnt-1 responsive Cdc42 homolog 2
Short name=WRCH-2

Gene names

Name:	RHOV
Synonyms:	ARHV, WRCH2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway By similarity. UniProtKB Q9Z1Y0
Cofactor	Magnesium By similarity. UniProtKB Q7L0Q8
Subunit structure	Interacts with PAK2 By similarity. UniProtKB Q9Z1Y0
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Endosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Treatment with TNF activates endosomal but not plasma membrane RHOV By similarity. UniProtKB Q9Z1Y0
Tissue specificity	Highly expressed in pancreas, placenta, and fetal brain. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rho family. UniProtKB Q9Z1Y0

Ontologies

Keywords
Cellular component	Cell membrane Endosome Membrane
Ligand	GTP-binding Magnesium Metal-binding Nucleotide-binding
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Traceable author statement. Source: Reactome
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Rho-related GTP-binding protein RhoV		PRO_0000326438
Regions
	Nucleotide binding	38 – 45	8	GTP By similarity UniProtKB Q9Z1Y0
	Nucleotide binding	85 – 89	5	GTP By similarity UniProtKB Q7L0Q8
	Nucleotide binding	143 – 146	4	GTP By similarity UniProtKB P61586
Amino acid modifications
	Lipidation	234	1	S-palmitoyl cysteine By similarity UniProtKB Q7L0Q8
Experimental info
	Sequence conflict	177	1	K → R in BAB86363. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96L33 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 334CEEF501107B91	FASTA	236	26,217
	10 20 30 40 50 60 MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY 70 80 90 100 110 120 RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN 130 140 150 160 170 180 ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA 190 200 210 220 230 CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of WRCH2 on human chromosome 15q15." Katoh M. Int. J. Oncol. 20:977-982(2002) [PubMed: 11956592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The Rho GTPase family: a Racs to Wrchs story." Wherlock M., Mellor H. J. Cell Sci. 115:239-240(2002) [PubMed: 11839775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex and Cervix.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB079131 mRNA. Translation: BAB86363.1. AY059636 mRNA. Translation: AAL17966.1. CH471125 Genomic DNA. Translation: EAW92459.1. BC105020 mRNA. Translation: AAI05021.1. BC105022 mRNA. Translation: AAI05023.1. BC112945 mRNA. Translation: AAI12946.2.
IPI	IPI00154827.
RefSeq	NP_598378.3. NM_133639.3.
UniGene	Hs.447901.
3D structure databases
HSSP	HSSP built from PDB template 2C2H based on UniProtKB P60763.
ProteinModelPortal	Q96L33.
SMR	Q96L33. Positions 31-208.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96L33.
Polymorphism databases
DMDM	74724228.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000220507; ENSP00000220507; ENSG00000104140.
GeneID	171177.
KEGG	hsa:171177.
UCSC	uc001znd.1. human.
Organism-specific databases
CTD	171177.
GeneCards	GC15M041164.
H-InvDB	HIX0038068.
HGNC	HGNC:18313. RHOV.
HPA	HPA043713.
neXtProt	NX_Q96L33.
PharmGKB	PA38313.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076971.
HOVERGEN	HBG009351.
InParanoid	Q96L33.
OrthoDB	EOG4255TJ.
PhylomeDB	Q96L33.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q96L33.
Bgee	Q96L33.
CleanEx	HS_RHOV.
Genevestigator	Q96L33.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
KO	K07866.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	89215.

Entry information

Entry name

RHOV_HUMAN

Accession

Primary (citable) accession number: Q96L33
Secondary accession number(s): Q2KHQ5, Q8TDW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.