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Q96L21

- RL10L_HUMAN

UniProt

Q96L21 - RL10L_HUMAN

Protein

60S ribosomal protein L10-like

Gene

RPL10L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May play a role in compensating for the inactivated X-linked gene during spermatogenesis.1 Publication

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. spermatogenesis Source: UniProtKB
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L10-like
    Gene namesi
    Name:RPL10L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:17976. RPL10L.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: UniProtKB
    2. membrane Source: UniProtKB
    3. nucleus Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34662.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21421460S ribosomal protein L10-likePRO_0000147106Add
    BLAST

    Proteomic databases

    PaxDbiQ96L21.
    PeptideAtlasiQ96L21.
    PRIDEiQ96L21.

    PTM databases

    PhosphoSiteiQ96L21.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    BgeeiQ96L21.
    CleanExiHS_RPL10L.
    GenevestigatoriQ96L21.

    Organism-specific databases

    HPAiHPA011311.

    Interactioni

    Protein-protein interaction databases

    BioGridi126711. 75 interactions.
    IntActiQ96L21. 3 interactions.
    MINTiMINT-1140193.
    STRINGi9606.ENSP00000298283.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00I1-214[»]
    ProteinModelPortaliQ96L21.
    SMRiQ96L21. Positions 2-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10e family.Curated

    Phylogenomic databases

    eggNOGiCOG0197.
    HOGENOMiHOG000223754.
    HOVERGENiHBG002287.
    InParanoidiQ96L21.
    KOiK02866.
    OMAiMVAKKCL.
    OrthoDBiEOG76MK97.
    PhylomeDBiQ96L21.
    TreeFamiTF300082.

    Family and domain databases

    Gene3Di3.90.1170.10. 1 hit.
    InterProiIPR001197. Ribosomal_L10e.
    IPR016180. Ribosomal_L10e/L16.
    IPR018255. Ribosomal_L10e_CS.
    [Graphical view]
    PfamiPF00252. Ribosomal_L16. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
    SUPFAMiSSF54686. SSF54686. 1 hit.
    TIGRFAMsiTIGR00279. L10e. 1 hit.
    PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96L21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLGG    50
    HMVSDEYEQL SSEALEAARI CANKYMVKSC GRDGFHMRVR LHPFHVIRIN 100
    KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNEEHVIE 150
    ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAKKCL IPDGCGVKYV 200
    PSHGPLDKWR VLHS 214
    Length:214
    Mass (Da):24,519
    Last modified:January 23, 2007 - v3
    Checksum:i9119E2F8C40C2E37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063605 Genomic DNA. Translation: BAC19833.1.
    AB063608 mRNA. Translation: BAC19835.1.
    BC014310 mRNA. Translation: AAH14310.1.
    BC066312 mRNA. Translation: AAH66312.1.
    CCDSiCCDS32071.1.
    RefSeqiNP_542784.1. NM_080746.2.
    UniGeneiHs.308332.

    Genome annotation databases

    EnsembliENST00000298283; ENSP00000298283; ENSG00000165496.
    GeneIDi140801.
    KEGGihsa:140801.
    UCSCiuc001wwg.3. human.

    Polymorphism databases

    DMDMi57013008.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063605 Genomic DNA. Translation: BAC19833.1 .
    AB063608 mRNA. Translation: BAC19835.1 .
    BC014310 mRNA. Translation: AAH14310.1 .
    BC066312 mRNA. Translation: AAH66312.1 .
    CCDSi CCDS32071.1.
    RefSeqi NP_542784.1. NM_080746.2.
    UniGenei Hs.308332.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 I 1-214 [» ]
    ProteinModelPortali Q96L21.
    SMRi Q96L21. Positions 2-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126711. 75 interactions.
    IntActi Q96L21. 3 interactions.
    MINTi MINT-1140193.
    STRINGi 9606.ENSP00000298283.

    PTM databases

    PhosphoSitei Q96L21.

    Polymorphism databases

    DMDMi 57013008.

    Proteomic databases

    PaxDbi Q96L21.
    PeptideAtlasi Q96L21.
    PRIDEi Q96L21.

    Protocols and materials databases

    DNASUi 140801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298283 ; ENSP00000298283 ; ENSG00000165496 .
    GeneIDi 140801.
    KEGGi hsa:140801.
    UCSCi uc001wwg.3. human.

    Organism-specific databases

    CTDi 140801.
    GeneCardsi GC14M047120.
    HGNCi HGNC:17976. RPL10L.
    HPAi HPA011311.
    neXtProti NX_Q96L21.
    PharmGKBi PA34662.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0197.
    HOGENOMi HOG000223754.
    HOVERGENi HBG002287.
    InParanoidi Q96L21.
    KOi K02866.
    OMAi MVAKKCL.
    OrthoDBi EOG76MK97.
    PhylomeDBi Q96L21.
    TreeFami TF300082.

    Miscellaneous databases

    GeneWikii RPL10L.
    GenomeRNAii 140801.
    NextBioi 84401.
    PROi Q96L21.

    Gene expression databases

    Bgeei Q96L21.
    CleanExi HS_RPL10L.
    Genevestigatori Q96L21.

    Family and domain databases

    Gene3Di 3.90.1170.10. 1 hit.
    InterProi IPR001197. Ribosomal_L10e.
    IPR016180. Ribosomal_L10e/L16.
    IPR018255. Ribosomal_L10e_CS.
    [Graphical view ]
    Pfami PF00252. Ribosomal_L16. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005590. Ribosomal_L10. 1 hit.
    SUPFAMi SSF54686. SSF54686. 1 hit.
    TIGRFAMsi TIGR00279. L10e. 1 hit.
    PROSITEi PS01257. RIBOSOMAL_L10E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes."
      Uechi T., Maeda N., Tanaka T., Kenmochi N.
      Nucleic Acids Res. 30:5369-5375(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL10L_HUMAN
    AccessioniPrimary (citable) accession number: Q96L21
    Secondary accession number(s): Q8IUD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3