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Protein

60S ribosomal protein L10-like

Gene

RPL10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in compensating for the inactivated X-linked gene during spermatogenesis.1 Publication

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. spermatogenesis Source: UniProtKB
  2. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10-like
Gene namesi
Name:RPL10L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17976. RPL10L.

Subcellular locationi

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: UniProtKB
  2. membrane Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. polysome Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21421460S ribosomal protein L10-likePRO_0000147106Add
BLAST

Proteomic databases

PaxDbiQ96L21.
PeptideAtlasiQ96L21.
PRIDEiQ96L21.

PTM databases

PhosphoSiteiQ96L21.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ96L21.
CleanExiHS_RPL10L.
GenevestigatoriQ96L21.

Organism-specific databases

HPAiHPA011311.

Interactioni

Protein-protein interaction databases

BioGridi126711. 78 interactions.
IntActiQ96L21. 3 interactions.
MINTiMINT-1140193.
STRINGi9606.ENSP00000298283.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00CI1-214[»]
ProteinModelPortaliQ96L21.
SMRiQ96L21. Positions 2-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L10e family.Curated

Phylogenomic databases

eggNOGiCOG0197.
GeneTreeiENSGT00390000003897.
HOGENOMiHOG000223754.
HOVERGENiHBG002287.
InParanoidiQ96L21.
KOiK02866.
OMAiIRCKETN.
OrthoDBiEOG76MK97.
PhylomeDBiQ96L21.
TreeFamiTF300082.

Family and domain databases

Gene3Di3.90.1170.10. 1 hit.
InterProiIPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
SUPFAMiSSF54686. SSF54686. 1 hit.
TIGRFAMsiTIGR00279. L10e. 1 hit.
PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96L21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLGG
60 70 80 90 100
HMVSDEYEQL SSEALEAARI CANKYMVKSC GRDGFHMRVR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNEEHVIE
160 170 180 190 200
ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAKKCL IPDGCGVKYV
210
PSHGPLDKWR VLHS
Length:214
Mass (Da):24,519
Last modified:January 23, 2007 - v3
Checksum:i9119E2F8C40C2E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063605 Genomic DNA. Translation: BAC19833.1.
AB063608 mRNA. Translation: BAC19835.1.
BC014310 mRNA. Translation: AAH14310.1.
BC066312 mRNA. Translation: AAH66312.1.
CCDSiCCDS32071.1.
RefSeqiNP_542784.1. NM_080746.2.
UniGeneiHs.308332.

Genome annotation databases

EnsembliENST00000298283; ENSP00000298283; ENSG00000165496.
GeneIDi140801.
KEGGihsa:140801.
UCSCiuc001wwg.3. human.

Polymorphism databases

DMDMi57013008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063605 Genomic DNA. Translation: BAC19833.1.
AB063608 mRNA. Translation: BAC19835.1.
BC014310 mRNA. Translation: AAH14310.1.
BC066312 mRNA. Translation: AAH66312.1.
CCDSiCCDS32071.1.
RefSeqiNP_542784.1. NM_080746.2.
UniGeneiHs.308332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00CI1-214[»]
ProteinModelPortaliQ96L21.
SMRiQ96L21. Positions 2-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126711. 78 interactions.
IntActiQ96L21. 3 interactions.
MINTiMINT-1140193.
STRINGi9606.ENSP00000298283.

PTM databases

PhosphoSiteiQ96L21.

Polymorphism databases

DMDMi57013008.

Proteomic databases

PaxDbiQ96L21.
PeptideAtlasiQ96L21.
PRIDEiQ96L21.

Protocols and materials databases

DNASUi140801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298283; ENSP00000298283; ENSG00000165496.
GeneIDi140801.
KEGGihsa:140801.
UCSCiuc001wwg.3. human.

Organism-specific databases

CTDi140801.
GeneCardsiGC14M047120.
HGNCiHGNC:17976. RPL10L.
HPAiHPA011311.
neXtProtiNX_Q96L21.
PharmGKBiPA34662.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0197.
GeneTreeiENSGT00390000003897.
HOGENOMiHOG000223754.
HOVERGENiHBG002287.
InParanoidiQ96L21.
KOiK02866.
OMAiIRCKETN.
OrthoDBiEOG76MK97.
PhylomeDBiQ96L21.
TreeFamiTF300082.

Miscellaneous databases

GeneWikiiRPL10L.
GenomeRNAii140801.
NextBioi84401.
PROiQ96L21.

Gene expression databases

BgeeiQ96L21.
CleanExiHS_RPL10L.
GenevestigatoriQ96L21.

Family and domain databases

Gene3Di3.90.1170.10. 1 hit.
InterProiIPR001197. Ribosomal_L10e.
IPR016180. Ribosomal_L10e/L16.
IPR018255. Ribosomal_L10e_CS.
[Graphical view]
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
SUPFAMiSSF54686. SSF54686. 1 hit.
TIGRFAMsiTIGR00279. L10e. 1 hit.
PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes."
    Uechi T., Maeda N., Tanaka T., Kenmochi N.
    Nucleic Acids Res. 30:5369-5375(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL10L_HUMAN
AccessioniPrimary (citable) accession number: Q96L21
Secondary accession number(s): Q8IUD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene has no introns in its coding regions, and therefore was most likely produced by retrotransposition of the original X-linked gene during evolution.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.