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Protein

F-actin-capping protein subunit alpha-3

Gene

CAPZA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-3
Alternative name(s):
CapZ alpha-3
Short name:
CP-alpha-3
Germ cell-specific protein 3
Gene namesi
Name:CAPZA3
Synonyms:CAPAA3, GSG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000177938.4.
HGNCiHGNC:24205. CAPZA3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177938.
PharmGKBiPA134990260.

Polymorphism and mutation databases

BioMutaiCAPZA3.
DMDMi20137887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002086311 – 299F-actin-capping protein subunit alpha-3Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei290PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96KX2.
PaxDbiQ96KX2.
PeptideAtlasiQ96KX2.
PRIDEiQ96KX2.

PTM databases

iPTMnetiQ96KX2.
PhosphoSitePlusiQ96KX2.

Expressioni

Tissue specificityi

Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region.1 Publication

Gene expression databases

BgeeiENSG00000177938.
CleanExiHS_CAPZA3.
ExpressionAtlasiQ96KX2. baseline and differential.
GenevisibleiQ96KX2. HS.

Organism-specific databases

HPAiHPA038688.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326238.

Structurei

3D structure databases

ProteinModelPortaliQ96KX2.
SMRiQ96KX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiQ96KX2.
KOiK10364.
OMAiLNLVMYP.
OrthoDBiEOG091G09AG.
PhylomeDBiQ96KX2.
TreeFamiTF314822.

Family and domain databases

InterProiView protein in InterPro
IPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiView protein in Pfam
PF01267. F-actin_cap_A. 1 hit.
PRINTSiPR00191. FACTINCAPA.
PROSITEiView protein in PROSITE
PS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96KX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSVLSRKD KERVIRRLLL QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC
60 70 80 90 100
AGHQHCQKYS VPLCIDGNPV LLSHHNVMGD YRFFDHQSKL SFKYDLLQNQ
110 120 130 140 150
LKDIQSHGII QNEAEYLRVV LLCALKLYVN DHYPKGNCNM LRKTVKSKEY
160 170 180 190 200
LIACIEDHNY ETGECWNGLW KSKWIFQVNP FLTQVTGRIF VQAHFFRCVN
210 220 230 240 250
LHIEISKDLK ESLEIVNQAQ LALSFARLVE EQENKFQAAV LEELQELSNE
260 270 280 290
ALRKILRRDL PVTRTLIDWH RILSDLNLVM YPKLGYVIYS RSVLCNWII
Length:299
Mass (Da):35,025
Last modified:March 27, 2002 - v2
Checksum:iCEE130C8F7397F67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95D → Y in AAH16745 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053259 mRNA. Translation: BAB61901.1.
AK058174 mRNA. Translation: BAB71703.1.
BC016745 mRNA. Translation: AAH16745.1.
CCDSiCCDS8681.1.
RefSeqiNP_201585.1. NM_033328.2.
UniGeneiHs.131288.

Genome annotation databases

EnsembliENST00000317658; ENSP00000326238; ENSG00000177938.
GeneIDi93661.
KEGGihsa:93661.
UCSCiuc001rdy.4. human.

Similar proteinsi

Entry informationi

Entry nameiCAZA3_HUMAN
AccessioniPrimary (citable) accession number: Q96KX2
Secondary accession number(s): Q969J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: September 27, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families