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Protein

F-actin-capping protein subunit alpha-3

Gene

CAPZA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha-3
Alternative name(s):
CapZ alpha-3
Short name:
CP-alpha-3
Germ cell-specific protein 3
Gene namesi
Name:CAPZA3
Synonyms:CAPAA3, GSG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24205. CAPZA3.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • cortical cytoskeleton Source: Ensembl
  • F-actin capping protein complex Source: InterPro
  • membrane Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990260.

Polymorphism and mutation databases

BioMutaiCAPZA3.
DMDMi20137887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299F-actin-capping protein subunit alpha-3PRO_0000208631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei290 – 2901PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96KX2.
PeptideAtlasiQ96KX2.
PRIDEiQ96KX2.

PTM databases

iPTMnetiQ96KX2.
PhosphoSiteiQ96KX2.

Expressioni

Tissue specificityi

Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region.1 Publication

Gene expression databases

BgeeiENSG00000177938.
CleanExiHS_CAPZA3.
GenevisibleiQ96KX2. HS.

Organism-specific databases

HPAiHPA038688.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000326238.

Structurei

3D structure databases

ProteinModelPortaliQ96KX2.
SMRiQ96KX2. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiQ96KX2.
KOiK10364.
OMAiLNLVMYP.
OrthoDBiEOG091G09AG.
PhylomeDBiQ96KX2.
TreeFamiTF314822.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSVLSRKD KERVIRRLLL QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC
60 70 80 90 100
AGHQHCQKYS VPLCIDGNPV LLSHHNVMGD YRFFDHQSKL SFKYDLLQNQ
110 120 130 140 150
LKDIQSHGII QNEAEYLRVV LLCALKLYVN DHYPKGNCNM LRKTVKSKEY
160 170 180 190 200
LIACIEDHNY ETGECWNGLW KSKWIFQVNP FLTQVTGRIF VQAHFFRCVN
210 220 230 240 250
LHIEISKDLK ESLEIVNQAQ LALSFARLVE EQENKFQAAV LEELQELSNE
260 270 280 290
ALRKILRRDL PVTRTLIDWH RILSDLNLVM YPKLGYVIYS RSVLCNWII
Length:299
Mass (Da):35,025
Last modified:March 27, 2002 - v2
Checksum:iCEE130C8F7397F67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951D → Y in AAH16745 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053259 mRNA. Translation: BAB61901.1.
AK058174 mRNA. Translation: BAB71703.1.
BC016745 mRNA. Translation: AAH16745.1.
CCDSiCCDS8681.1.
RefSeqiNP_201585.1. NM_033328.2.
UniGeneiHs.131288.

Genome annotation databases

EnsembliENST00000317658; ENSP00000326238; ENSG00000177938.
GeneIDi93661.
KEGGihsa:93661.
UCSCiuc001rdy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053259 mRNA. Translation: BAB61901.1.
AK058174 mRNA. Translation: BAB71703.1.
BC016745 mRNA. Translation: AAH16745.1.
CCDSiCCDS8681.1.
RefSeqiNP_201585.1. NM_033328.2.
UniGeneiHs.131288.

3D structure databases

ProteinModelPortaliQ96KX2.
SMRiQ96KX2. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326238.

PTM databases

iPTMnetiQ96KX2.
PhosphoSiteiQ96KX2.

Polymorphism and mutation databases

BioMutaiCAPZA3.
DMDMi20137887.

Proteomic databases

PaxDbiQ96KX2.
PeptideAtlasiQ96KX2.
PRIDEiQ96KX2.

Protocols and materials databases

DNASUi93661.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317658; ENSP00000326238; ENSG00000177938.
GeneIDi93661.
KEGGihsa:93661.
UCSCiuc001rdy.4. human.

Organism-specific databases

CTDi93661.
GeneCardsiCAPZA3.
HGNCiHGNC:24205. CAPZA3.
HPAiHPA038688.
MIMi608722. gene.
neXtProtiNX_Q96KX2.
PharmGKBiPA134990260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0836. Eukaryota.
ENOG410ZAWX. LUCA.
GeneTreeiENSGT00390000006476.
HOGENOMiHOG000036539.
HOVERGENiHBG050810.
InParanoidiQ96KX2.
KOiK10364.
OMAiLNLVMYP.
OrthoDBiEOG091G09AG.
PhylomeDBiQ96KX2.
TreeFamiTF314822.

Miscellaneous databases

GenomeRNAii93661.
PROiQ96KX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177938.
CleanExiHS_CAPZA3.
GenevisibleiQ96KX2. HS.

Family and domain databases

InterProiIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERiPTHR10653. PTHR10653. 1 hit.
PfamiPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSiPR00191. FACTINCAPA.
PROSITEiPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAZA3_HUMAN
AccessioniPrimary (citable) accession number: Q96KX2
Secondary accession number(s): Q969J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.