Q96KX0 (LYZL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme-like protein 4
Short name=Lysozyme-4

Gene names

Name:	LYZL4
Synonyms:	LYC4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subunit structure	Monomer Probable.
Subcellular location	Secreted Probable.
Tissue specificity	Expressed in testis and epididymis. Ref.1
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.
Caution	Lacks the conserved Asp residue in position 72 essential for activity. Its enzyme activity is therefore unsure.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 146	127	Lysozyme-like protein 4		PRO_0000240638
Sites
	Active site	54	1	By similarity
Amino acid modifications
	Disulfide bond	25 ↔ 144		By similarity
	Disulfide bond	49 ↔ 131		By similarity
	Disulfide bond	84 ↔ 96		By similarity
	Disulfide bond	92 ↔ 110		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96KX0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2A1821ED2153E682	FASTA	146	16,433
	10 20 30 40 50 60 MKASVVLSLL GYLVVPSGAY ILGRCTVAKK LHDGGLDYFE GYSLENWVCL AYFESKFNPM 70 80 90 100 110 120 AIYENTREGY TGFGLFQMRG SDWCGDHGRN RCHMSCSALL NPNLEKTIKC AKTIVKGKEG 130 140 MGAWPTWSRY CQYSDTLARW LDGCKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family." Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L. Biol. Reprod. 73:1064-1071(2005) [PubMed: 16014814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF326749 mRNA. Translation: AAO32946.1. BC016747 mRNA. Translation: AAH16747.1.
IPI	IPI00064892.
RefSeq	NP_653235.1.
UniGene	Hs.234895.
3D structure databases
ProteinModelPortal	Q96KX0.
SMR	Q96KX0. Positions 19-145.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96KX0.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Proteomic databases
PRIDE	Q96KX0.
Genome annotation databases
Ensembl	ENST00000287748; ENSP00000287748; ENSG00000157093; Homo sapiens. [Genome view] ENST00000441172; ENSP00000387897; ENSG00000157093; Homo sapiens. [Genome view]
GeneID	131375.
KEGG	hsa:131375.
UCSC	uc003cle.1. human.
Organism-specific databases
CTD	131375.
GeneCards	GC03M042413.
H-InvDB	HIX0003201.
HGNC	HGNC:28387. LYZL4.
MIM	612750. gene.
PharmGKB	PA134911368.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07822.
HOGENOM	HBG505822.
HOVERGEN	HBG052297.
InParanoid	Q96KX0.
OMA	GRCTVAK.
OrthoDB	EOG9MD0K1.
PhylomeDB	Q96KX0.
Gene expression databases
ArrayExpress	Q96KX0.
Bgee	Q96KX0.
CleanEx	HS_LYZL4.
Genevestigator	Q96KX0.
GermOnline	ENSG00000157093. Homo sapiens.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	82896.
SOURCE	Search...

Entry information

Entry name

LYZL4_HUMAN

Accession

Primary (citable) accession number: Q96KX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 1, 2001
Last modified:	August 10, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.