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Protein

Lysozyme-like protein 4

Gene

LYZL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157093-MONOMER.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 4
Short name:
Lysozyme-4
Gene namesi
Name:LYZL4
Synonyms:LYC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28387. LYZL4.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi131375.
OpenTargetsiENSG00000157093.
PharmGKBiPA134911368.

Polymorphism and mutation databases

BioMutaiLYZL4.
DMDMi74732223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063820 – 146Lysozyme-like protein 4Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 144PROSITE-ProRule annotation
Disulfide bondi49 ↔ 131PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96KX0.
PeptideAtlasiQ96KX0.
PRIDEiQ96KX0.

PTM databases

iPTMnetiQ96KX0.
PhosphoSitePlusiQ96KX0.

Expressioni

Tissue specificityi

Expressed in testis and epididymis.1 Publication

Gene expression databases

BgeeiENSG00000157093.
CleanExiHS_LYZL4.
ExpressionAtlasiQ96KX0. baseline and differential.
GenevisibleiQ96KX0. HS.

Organism-specific databases

HPAiHPA038806.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi126277. 1 interactor.
STRINGi9606.ENSP00000287748.

Structurei

3D structure databases

ProteinModelPortaliQ96KX0.
SMRiQ96KX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QX. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96KX0.
OMAiYGLFQIR.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ96KX0.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030062. LYZL4.
[Graphical view]
PANTHERiPTHR11407:SF21. PTHR11407:SF21. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASVVLSLL GYLVVPSGAY ILGRCTVAKK LHDGGLDYFE GYSLENWVCL
60 70 80 90 100
AYFESKFNPM AIYENTREGY TGFGLFQMRG SDWCGDHGRN RCHMSCSALL
110 120 130 140
NPNLEKTIKC AKTIVKGKEG MGAWPTWSRY CQYSDTLARW LDGCKL
Length:146
Mass (Da):16,433
Last modified:December 1, 2001 - v1
Checksum:i2A1821ED2153E682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326749 mRNA. Translation: AAO32946.1.
BC016747 mRNA. Translation: AAH16747.1.
CCDSiCCDS2697.1.
RefSeqiNP_001291315.1. NM_001304386.1.
NP_653235.1. NM_144634.3.
XP_016861194.1. XM_017005705.1.
XP_016861195.1. XM_017005706.1.
UniGeneiHs.234895.

Genome annotation databases

EnsembliENST00000287748; ENSP00000287748; ENSG00000157093.
ENST00000441172; ENSP00000387897; ENSG00000157093.
GeneIDi131375.
KEGGihsa:131375.
UCSCiuc003cle.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326749 mRNA. Translation: AAO32946.1.
BC016747 mRNA. Translation: AAH16747.1.
CCDSiCCDS2697.1.
RefSeqiNP_001291315.1. NM_001304386.1.
NP_653235.1. NM_144634.3.
XP_016861194.1. XM_017005705.1.
XP_016861195.1. XM_017005706.1.
UniGeneiHs.234895.

3D structure databases

ProteinModelPortaliQ96KX0.
SMRiQ96KX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126277. 1 interactor.
STRINGi9606.ENSP00000287748.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

PTM databases

iPTMnetiQ96KX0.
PhosphoSitePlusiQ96KX0.

Polymorphism and mutation databases

BioMutaiLYZL4.
DMDMi74732223.

Proteomic databases

PaxDbiQ96KX0.
PeptideAtlasiQ96KX0.
PRIDEiQ96KX0.

Protocols and materials databases

DNASUi131375.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287748; ENSP00000287748; ENSG00000157093.
ENST00000441172; ENSP00000387897; ENSG00000157093.
GeneIDi131375.
KEGGihsa:131375.
UCSCiuc003cle.4. human.

Organism-specific databases

CTDi131375.
DisGeNETi131375.
GeneCardsiLYZL4.
HGNCiHGNC:28387. LYZL4.
HPAiHPA038806.
MIMi612750. gene.
neXtProtiNX_Q96KX0.
OpenTargetsiENSG00000157093.
PharmGKBiPA134911368.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0QX. Eukaryota.
ENOG410ZG9G. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96KX0.
OMAiYGLFQIR.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ96KX0.
TreeFamiTF324882.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157093-MONOMER.

Miscellaneous databases

GenomeRNAii131375.
PROiQ96KX0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157093.
CleanExiHS_LYZL4.
ExpressionAtlasiQ96KX0. baseline and differential.
GenevisibleiQ96KX0. HS.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030062. LYZL4.
[Graphical view]
PANTHERiPTHR11407:SF21. PTHR11407:SF21. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYZL4_HUMAN
AccessioniPrimary (citable) accession number: Q96KX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.