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Protein

Lysozyme-like protein 4

Gene

LYZL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity).By similarity

Caution

Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFertilization

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 4
Short name:
Lysozyme-4
Gene namesi
Name:LYZL4
Synonyms:LYC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000157093.8
HGNCiHGNC:28387 LYZL4
MIMi612750 gene
neXtProtiNX_Q96KX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasmic vesicle, Flagellum, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi131375
OpenTargetsiENSG00000157093
PharmGKBiPA134911368

Polymorphism and mutation databases

BioMutaiLYZL4
DMDMi74732223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024063820 – 146Lysozyme-like protein 4Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 144PROSITE-ProRule annotation
Disulfide bondi49 ↔ 131PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96KX0
PeptideAtlasiQ96KX0
PRIDEiQ96KX0

PTM databases

iPTMnetiQ96KX0
PhosphoSitePlusiQ96KX0

Expressioni

Tissue specificityi

Expressed in testis and epididymis.1 Publication

Gene expression databases

BgeeiENSG00000157093
CleanExiHS_LYZL4
ExpressionAtlasiQ96KX0 baseline and differential
GenevisibleiQ96KX0 HS

Organism-specific databases

HPAiHPA038806

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi126277, 1 interactor
STRINGi9606.ENSP00000287748

Structurei

3D structure databases

ProteinModelPortaliQ96KX0
SMRiQ96KX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0QX Eukaryota
ENOG410ZG9G LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiQ96KX0
OMAiYGLFQIR
OrthoDBiEOG091G0R9V
PhylomeDBiQ96KX0
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030062 LYZL4
PANTHERiPTHR11407:SF21 PTHR11407:SF21, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASVVLSLL GYLVVPSGAY ILGRCTVAKK LHDGGLDYFE GYSLENWVCL
60 70 80 90 100
AYFESKFNPM AIYENTREGY TGFGLFQMRG SDWCGDHGRN RCHMSCSALL
110 120 130 140
NPNLEKTIKC AKTIVKGKEG MGAWPTWSRY CQYSDTLARW LDGCKL
Length:146
Mass (Da):16,433
Last modified:December 1, 2001 - v1
Checksum:i2A1821ED2153E682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326749 mRNA Translation: AAO32946.1
AC092048 Genomic DNA No translation available.
BC016747 mRNA Translation: AAH16747.1
CCDSiCCDS2697.1
RefSeqiNP_001291315.1, NM_001304386.1
NP_653235.1, NM_144634.3
XP_016861194.1, XM_017005705.1
XP_016861195.1, XM_017005706.1
UniGeneiHs.234895

Genome annotation databases

EnsembliENST00000287748; ENSP00000287748; ENSG00000157093
ENST00000441172; ENSP00000387897; ENSG00000157093
GeneIDi131375
KEGGihsa:131375
UCSCiuc003cle.4 human

Similar proteinsi

Entry informationi

Entry nameiLYZL4_HUMAN
AccessioniPrimary (citable) accession number: Q96KX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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