Q96KV7 (WDR90_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 90

Gene names

Name:	WDR90
Synonyms:	C16orf15, C16orf16, C16orf17, C16orf18, C16orf19, KIAA1924

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1748 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 21 WD repeats.

Sequence caution

The sequence AAK61239.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB67817.1 differs from that shown. Reason: Intron retention. The sequence BAC03575.1 differs from that shown. Reason: Unlikely isoform. Aberrant splicing. The sequence BAC04225.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04225.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAD18654.1 differs from that shown. Reason: Probable cloning artifact. The sequence EAW85775.1 differs from that shown. Reason: Erroneous gene model prediction. Isoform 3: The sequence AAI21187.1 differs from that shown. Reason: Frameshift at position 697. Isoform 5: The sequence AAI21186.1 differs from that shown. Reason: Frameshift at position 697.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96KV7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on partial mRNA and EST data.

Isoform 2 (identifier: Q96KV7-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1401: Missing.
     1402-1437: DDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSK → MLWFGQPGPGGWNRKCLRPFTLPRGQHPQPSYGFPQ
     1629-1672: TQGHLPPSLA...NLCQKQVVEK → VNHAPGTVGG...LPSALGMGRS
     1673-1748: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Ref.1 (BAC04205) sequence differs from that shown at position 252 due to erroneous termination.

Isoform 3 (identifier: Q96KV7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     656-708: EHEGPVSSVC...HTAPVLALAM → GDAVGTLSQL...QVAYPEPWGG
     709-1748: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96KV7-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1401: Missing.
     1402-1437: DDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSK → MLWFGQPGPGGWNRKCLRPFTLPRGQHPQPSYGFPQ
     1580-1627: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q96KV7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     280-280: A → AQ
     656-708: EHEGPVSSVC...HTAPVLALAM → GDAVGTLSQL...QVAYPEPWGG
     709-1748: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1748	1748	WD repeat-containing protein 90		PRO_0000341412
Regions
	Repeat	407 – 450	44	WD 1
	Repeat	452 – 494	43	WD 2
	Repeat	501 – 541	41	WD 3
	Repeat	615 – 654	40	WD 4
	Repeat	656 – 695	40	WD 5
	Repeat	698 – 737	40	WD 6
	Repeat	740 – 779	40	WD 7
	Repeat	782 – 821	40	WD 8
	Repeat	882 – 922	41	WD 9
	Repeat	926 – 964	39	WD 10
	Repeat	969 – 1009	41	WD 11
	Repeat	1156 – 1201	46	WD 12
	Repeat	1204 – 1245	42	WD 13
	Repeat	1247 – 1286	40	WD 14
	Repeat	1298 – 1326	29	WD 15
	Repeat	1327 – 1376	50	WD 16
	Repeat	1433 – 1472	40	WD 17
	Repeat	1475 – 1520	46	WD 18
	Repeat	1523 – 1562	40	WD 19
	Repeat	1568 – 1614	47	WD 20
	Repeat	1715 – 1748	34	WD 21
Amino acid modifications
	Modified residue	241	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 1401	1401	Missing in isoform 2 and isoform 4.		VSP_034290
	Alternative sequence	280	1	A → AQ in isoform 5.		VSP_034294
	Alternative sequence	656 – 708	53	EHEGP…LALAM → GDAVGTLSQLPESLAWMLGR GRPSPRGSAVSRPGSWLHRV PRGQVAYPEPWGG in isoform 3 and isoform 5.		VSP_034298
	Alternative sequence	709 – 1748	1040	Missing in isoform 3 and isoform 5.		VSP_034300
	Alternative sequence	1402 – 1437	36	DDSVD…GHRSK → MLWFGQPGPGGWNRKCLRPF TLPRGQHPQPSYGFPQ in isoform 2 and isoform 4.		VSP_034303
	Alternative sequence	1580 – 1627	48	Missing in isoform 4.		VSP_034306
	Alternative sequence	1629 – 1672	44	TQGHL…QVVEK → VNHAPGTVGGAGTHPPHRSM LRLCRLRATWHPPSLPSALG MGRS in isoform 2.		VSP_041087
	Alternative sequence	1673 – 1748	76	Missing in isoform 2.		VSP_041088
	Natural variant	165	1	S → T. Ref.1 Ref.5 Ref.6 Corresponds to variant rs13337278 [ dbSNP | Ensembl ].		VAR_044060
	Natural variant	250	1	P → L. Ref.5 Corresponds to variant rs11642546 [ dbSNP | Ensembl ].		VAR_044061
	Natural variant	537	1	V → A. Ref.5 Corresponds to variant rs3803697 [ dbSNP | Ensembl ].		VAR_044062
	Natural variant	1001	1	P → T. Ref.1 Corresponds to variant rs4984906 [ dbSNP | Ensembl ].		VAR_044063
	Natural variant	1492	1	R → H. Corresponds to variant rs7190775 [ dbSNP | Ensembl ].		VAR_044064
	Natural variant	1555	1	C → R. Corresponds to variant rs11866949 [ dbSNP | Ensembl ].		VAR_044065
Experimental info
	Sequence conflict	899	1	H → Q in BAD18654. Ref.1
	Sequence conflict	1085	1	P → L in BAD18654. Ref.1
	Sequence conflict	1245	1	S → P in BAC04225. Ref.1
	Sequence conflict	1302	1	E → G in BAC04225. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: B9FC77D5F0FAAD9D	FASTA	1,748	187,437
	10 20 30 40 50 60 MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS 70 80 90 100 110 120 STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL 130 140 150 160 170 180 VLEARTPQRD LVGLAPSGAR WTCLQLDLQD VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS 190 200 210 220 230 240 DLCFEPAISG AQWAKLPVTP MPREMAFPVP KGESWHDRYI HVRFPSESLK VPSKPIEKSC 250 260 270 280 290 300 SPPEAVLLGP GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA SGRAALAPRP FPEVSLSQER 310 320 330 340 350 360 SDASNADGPG FHSLEPWAQL EASDIHTAAA GTHVLTHESA EVPVARTGSC EGFLPDPVLR 370 380 390 400 410 420 LKGVIGFGGH GTRQALWTPD GAAVVYPCHA VIVVLLVDTG EQRFFLGHTD KVSALALDGS 430 440 450 460 470 480 SSLLASAQAR APSVMRLWDF QTGRCLCLFR SPMHVVCSLS FSDSGALLCG VGKDHHGRTM 490 500 510 520 530 540 VVAWGTGQVG LGGEVVVLAK AHTDFDVQAF RVTFFDETRM ASCGQGSVRL WRLRGGVLRS 550 560 570 580 590 600 CPVDLGEHHA LQFTDLAFKQ ARDGCPEPSA AMLFVCSRSG HILEIDCQRM VVRHARRLLP 610 620 630 640 650 660 TRTPGGPHPQ KQTFSSGPGI AISSLSVSPA MCAVGSEDGF LRLWPLDFSS VLLEAEHEGP 670 680 690 700 710 720 VSSVCVSPDG LRVLSATSSG HLGFLDTLSR VYHMLARSHT APVLALAMEQ RRGQLATVSQ 730 740 750 760 770 780 DRTVRIWDLA TLQQLYDFTS SEDAPCAVTF HPTRPTFFCG FSSGAVRSFS LEAAEVLVEH 790 800 810 820 830 840 TCHRGAVTGL TATPDGRLLF SSCSQGSLAQ YSCADPQWHV LRVAADMVCP DAPASPSALA 850 860 870 880 890 900 VSRDGRLLAF VGPSRCTVTV MGSASLDELL RVDIGTLDLA SSRLDSAMAV CFGPAALGHL 910 920 930 940 950 960 LVSTSSNRVV VLDAVSGRII RELPGVHPEP CPSLTLSEDA RFLLIAAGRT IKVWDYATQA 970 980 990 1000 1010 1020 SPGPQVYIGH SEPVQAVAFS PDQQQVLSAG DAVFLWDVLA PTESDQSFPG APPACKTGPG 1030 1040 1050 1060 1070 1080 AGPLEDAASR ASELPRQQVP KPCQASPPRL GVCARPPEGG DGARDTRNSG APRTTYLASC 1090 1100 1110 1120 1130 1140 KAFTPARVSC SPHSAKGTCP PPASGGWLRL KAVVGYSGNG RANMVWRPDT GFFAYTCGRL 1150 1160 1170 1180 1190 1200 VVVEDLHSGA QQHWSGHSAE ISTLALSHSA QVLASASGRS STTAHCQIRV WDVSGGLCQH 1210 1220 1230 1240 1250 1260 LIFPHSTTVL ALAFSPDDRL LVTLGDHDGR TLALWGTATY DLVSSTRLPE PVHGVAFNPW 1270 1280 1290 1300 1310 1320 DAGELTCVGQ GTVTFWLLQQ RGADISLQVR REPVPEAVGA GELTSLCYGA PPLLYCGTSS 1330 1340 1350 1360 1370 1380 GQVCVWDTRA GRCFLSWEAD DGGIGLLLFS GSRLVSGSST GRLRLWAVGA VSELRCKGSG 1390 1400 1410 1420 1430 1440 ASSVFMEHEL VLDGAVVSAS FDDSVDMGVV GTTAGTLWFV SWAEGTSTRL ISGHRSKVNE 1450 1460 1470 1480 1490 1500 VVFSPGESHC ATCSEDGSVR VWALASMELV IQFQVLNQSC LCLAWSPPCC GRPEQQRLAA 1510 1520 1530 1540 1550 1560 GYGDGSLRIF SVSRTAMELK MHPHPVALTT VAFSTDGQTV LSGDKDGLVA VSHPCTGTTF 1570 1580 1590 1600 1610 1620 RVLSDHQGAP ISTICVTCKE CEDLGVEGTD LWLAASGDQR VSVWASDWLR NHCELVDWLS 1630 1640 1650 1660 1670 1680 FPMPATTETQ GHLPPSLAAF CPWDGALLMY VGPGVYKEVI IYNLCQKQVV EKIPLPFFAM 1690 1700 1710 1720 1730 1740 SLSLSPGTHL LAVGFAECML RLVDCAMGTA QDFAGHDNAV HLCRFTPSAR LLFTAARNEI LVWEVPGL
	Isoform 2 [UniParc]. Checksum: 6680E355BF7B99A1	FASTA	271	29,372
	10 20 30 40 50 60 MLWFGQPGPG GWNRKCLRPF TLPRGQHPQP SYGFPQVNEV VFSPGESHCA TCSEDGSVRV 70 80 90 100 110 120 WALASMELVI QFQVLNQSCL CLAWSPPCCG RPEQQRLAAG YGDGSLRIFS VSRTAMELKM 130 140 150 160 170 180 HPHPVALTTV AFSTDGQTVL SGDKDGLVAV SHPCTGTTFR VLSDHQGAPI STICVTCKEC 190 200 210 220 230 240 EDLGVEGTDL WLAASGDQRV SVWASDWLRN HCELVDWLSF PMPATTEVNH APGTVGGAGT 250 260 270 HPPHRSMLRL CRLRATWHPP SLPSALGMGR S
	Isoform 3 [UniParc]. Checksum: A171E6E92EDC81D7	FASTA	708	76,977
	10 20 30 40 50 60 MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS 70 80 90 100 110 120 STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL 130 140 150 160 170 180 VLEARTPQRD LVGLAPSGAR WTCLQLDLQD VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS 190 200 210 220 230 240 DLCFEPAISG AQWAKLPVTP MPREMAFPVP KGESWHDRYI HVRFPSESLK VPSKPIEKSC 250 260 270 280 290 300 SPPEAVLLGP GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA SGRAALAPRP FPEVSLSQER 310 320 330 340 350 360 SDASNADGPG FHSLEPWAQL EASDIHTAAA GTHVLTHESA EVPVARTGSC EGFLPDPVLR 370 380 390 400 410 420 LKGVIGFGGH GTRQALWTPD GAAVVYPCHA VIVVLLVDTG EQRFFLGHTD KVSALALDGS 430 440 450 460 470 480 SSLLASAQAR APSVMRLWDF QTGRCLCLFR SPMHVVCSLS FSDSGALLCG VGKDHHGRTM 490 500 510 520 530 540 VVAWGTGQVG LGGEVVVLAK AHTDFDVQAF RVTFFDETRM ASCGQGSVRL WRLRGGVLRS 550 560 570 580 590 600 CPVDLGEHHA LQFTDLAFKQ ARDGCPEPSA AMLFVCSRSG HILEIDCQRM VVRHARRLLP 610 620 630 640 650 660 TRTPGGPHPQ KQTFSSGPGI AISSLSVSPA MCAVGSEDGF LRLWPLDFSS VLLEAGDAVG 670 680 690 700 TLSQLPESLA WMLGRGRPSP RGSAVSRPGS WLHRVPRGQV AYPEPWGG
	Isoform 4 [UniParc]. Checksum: 48227B6EB6DAC52C	FASTA	299	32,434
	10 20 30 40 50 60 MLWFGQPGPG GWNRKCLRPF TLPRGQHPQP SYGFPQVNEV VFSPGESHCA TCSEDGSVRV 70 80 90 100 110 120 WALASMELVI QFQVLNQSCL CLAWSPPCCG RPEQQRLAAG YGDGSLRIFS VSRTAMELKM 130 140 150 160 170 180 HPHPVALTTV AFSTDGQTVL SGDKDGLVAV SHPCTGTTFR VLSDHQGAPI STICVTCKET 190 200 210 220 230 240 QGHLPPSLAA FCPWDGALLM YVGPGVYKEV IIYNLCQKQV VEKIPLPFFA MSLSLSPGTH 250 260 270 280 290 LLAVGFAECM LRLVDCAMGT AQDFAGHDNA VHLCRFTPSA RLLFTAARNE ILVWEVPGL
	Isoform 5 [UniParc]. Checksum: F65276B3F8EF49A6	FASTA	709	77,106
	10 20 30 40 50 60 MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS 70 80 90 100 110 120 STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL 130 140 150 160 170 180 VLEARTPQRD LVGLAPSGAR WTCLQLDLQD VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS 190 200 210 220 230 240 DLCFEPAISG AQWAKLPVTP MPREMAFPVP KGESWHDRYI HVRFPSESLK VPSKPIEKSC 250 260 270 280 290 300 SPPEAVLLGP GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA QSGRAALAPR PFPEVSLSQE 310 320 330 340 350 360 RSDASNADGP GFHSLEPWAQ LEASDIHTAA AGTHVLTHES AEVPVARTGS CEGFLPDPVL 370 380 390 400 410 420 RLKGVIGFGG HGTRQALWTP DGAAVVYPCH AVIVVLLVDT GEQRFFLGHT DKVSALALDG 430 440 450 460 470 480 SSSLLASAQA RAPSVMRLWD FQTGRCLCLF RSPMHVVCSL SFSDSGALLC GVGKDHHGRT 490 500 510 520 530 540 MVVAWGTGQV GLGGEVVVLA KAHTDFDVQA FRVTFFDETR MASCGQGSVR LWRLRGGVLR 550 560 570 580 590 600 SCPVDLGEHH ALQFTDLAFK QARDGCPEPS AAMLFVCSRS GHILEIDCQR MVVRHARRLL 610 620 630 640 650 660 PTRTPGGPHP QKQTFSSGPG IAISSLSVSP AMCAVGSEDG FLRLWPLDFS SVLLEAGDAV 670 680 690 700 GTLSQLPESL AWMLGRGRPS PRGSAVSRPG SWLHRVPRGQ VAYPEPWGG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-165 AND THR-1001. Tissue: Cerebellum, Thymus and Uterus.
[2]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANTS THR-165; LEU-250 AND ALA-537. Tissue: Brain.
[6]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1138 (ISOFORM 1), VARIANT THR-165. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091062 mRNA. Translation: BAC03575.1. Sequence problems. AK093609 mRNA. Translation: BAC04205.1. Sequence problems. AK093802 mRNA. Translation: BAC04225.1. Sequence problems. AK131510 mRNA. Translation: BAD18654.1. Sequence problems. AE006464 Genomic DNA. Translation: AAK61239.1. Sequence problems. AL022341 Genomic DNA. Translation: CAC79469.1. Z92544 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85775.1. Sequence problems. BC065836 mRNA. Translation: AAH65836.1. BC121185 mRNA. Translation: AAI21186.1. Frameshift. BC121186 mRNA. Translation: AAI21187.1. Frameshift. AB067511 mRNA. Translation: BAB67817.1. Sequence problems.
IPI	IPI00439437. IPI00847889. IPI00895900. IPI00903109. IPI01017969.
RefSeq	NP_660337.3. NM_145294.4.
UniGene	Hs.511903.
3D structure databases
ProteinModelPortal	Q96KV7.
ModBase	Search...
PTM databases
PhosphoSite	Q96KV7.
Polymorphism databases
DMDM	190423649.
Proteomic databases
PaxDb	Q96KV7.
PRIDE	Q96KV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293879; ENSP00000293879; ENSG00000161996. ENST00000315764; ENSP00000322808; ENSG00000161996.
GeneID	197335.
KEGG	hsa:197335.
UCSC	uc002cig.1. human. uc002cii.1. human. uc002cin.1. human.
Organism-specific databases
CTD	197335.
GeneCards	GC16P000699.
H-InvDB	HIX0012659.
HGNC	HGNC:26960. WDR90.
neXtProt	NX_Q96KV7.
PharmGKB	PA145147652.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOVERGEN	HBG108675.
InParanoid	Q96KV7.
Enzyme and pathway databases
SignaLink	Q96KV7.
Gene expression databases
ArrayExpress	Q96KV7.
Bgee	Q96KV7.
CleanEx	HS_WDR90.
Genevestigator	Q96KV7.
Family and domain databases
Gene3D	2.130.10.10. 5 hits.
InterPro	IPR007714. DUF667. IPR021717. Nucleoporin_Nup160. IPR011047. Quinonprotein_ADH-like_supfam. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF05018. DUF667. 1 hit. PF11715. Nup160. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
SMART	SM00320. WD40. 20 hits. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 2 hits. SSF50978. WD40_like. 2 hits.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WDR90. human.
GenomeRNAi	197335.
NextBio	89648.

Entry information

Entry name

WDR90_HUMAN

Accession

Primary (citable) accession number: Q96KV7
Secondary accession number(s): Q0VA87 , Q0VA88, Q6P048, Q6ZMS1, Q6ZTH1, Q8N202, Q8N221, Q8NBB8, Q96PW4, Q96S18

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.