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Q96KV6

- BT2A3_HUMAN

UniProt

Q96KV6 - BT2A3_HUMAN

Protein

Putative butyrophilin subfamily 2 member A3

Gene

BTN2A3P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative butyrophilin subfamily 2 member A3
    Gene namesi
    Name:BTN2A3P
    Synonyms:BTN2A3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:13229. BTN2A3P.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 586559Putative butyrophilin subfamily 2 member A3PRO_0000014531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 123PROSITE-ProRule annotation
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96KV6.
    PRIDEiQ96KV6.

    PTM databases

    PhosphoSiteiQ96KV6.

    Expressioni

    Gene expression databases

    CleanExiHS_BTN2A3.
    GenevestigatoriQ96KV6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96KV6. 1 interaction.
    MINTiMINT-7970691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KV6.
    SMRiQ96KV6. Positions 27-235, 297-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 246219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 586319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 139112Ig-like V-typeAdd
    BLAST
    Domaini281 – 474194B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235790.
    HOVERGENiHBG050747.
    InParanoidiQ96KV6.
    PhylomeDBiQ96KV6.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96KV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC    50
    CLSPEENAED MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK 100
    DSRGSVALII HNVTAEDNGI YQCYFQEGRS CNEAILHLVV AGLDSEPVIE 150
    MRDHEDGGIQ LECISGGWYP KPLTVWRDPY GEVVPALKEV STPDADSLFM 200
    VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP SRSPCVVILP 250
    VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN 300
    VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA 350
    SGKHYLEVDV ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW 400
    ALTSLKWILS LEEPLCQVGI FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV 450
    PVRPFFSLGS YDSQILICSA FTGASGVTVP EEGWTLHRAG THHSPQNQFP 500
    SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL SHPLQTSAPV 550
    HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV 586
    Length:586
    Mass (Da):65,713
    Last modified:July 10, 2007 - v2
    Checksum:iE320F80CAD074448
    GO

    Sequence cautioni

    The sequence CAC69644.2 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 791G → D.
    Corresponds to variant rs7745238 [ dbSNP | Ensembl ].
    VAR_049830
    Natural varianti148 – 1481V → I.
    Corresponds to variant rs10946829 [ dbSNP | Ensembl ].
    VAR_049831
    Natural varianti300 – 3001N → S.
    Corresponds to variant rs2893848 [ dbSNP | Ensembl ].
    VAR_049832

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021917 Genomic DNA. Translation: CAC69644.2. Sequence problems.
    CH471087 Genomic DNA. Translation: EAW55569.1.
    UniGeneiHs.729655.

    Genome annotation databases

    UCSCiuc011dkl.1. human.

    Polymorphism databases

    DMDMi152031567.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021917 Genomic DNA. Translation: CAC69644.2 . Sequence problems.
    CH471087 Genomic DNA. Translation: EAW55569.1 .
    UniGenei Hs.729655.

    3D structure databases

    ProteinModelPortali Q96KV6.
    SMRi Q96KV6. Positions 27-235, 297-462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96KV6. 1 interaction.
    MINTi MINT-7970691.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q96KV6.

    Polymorphism databases

    DMDMi 152031567.

    Proteomic databases

    PaxDbi Q96KV6.
    PRIDEi Q96KV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc011dkl.1. human.

    Organism-specific databases

    GeneCardsi GC06P026430.
    HGNCi HGNC:13229. BTN2A3P.
    MIMi 613592. gene.
    neXtProti NX_Q96KV6.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235790.
    HOVERGENi HBG050747.
    InParanoidi Q96KV6.
    PhylomeDBi Q96KV6.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    CleanExi HS_BTN2A3.
    Genevestigatori Q96KV6.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00406. IGv. 1 hit.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiBT2A3_HUMAN
    AccessioniPrimary (citable) accession number: Q96KV6
    Secondary accession number(s): A6NEF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3