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Protein

Putative butyrophilin subfamily 2 member A3

Gene

BTN2A3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative butyrophilin subfamily 2 member A3
Gene namesi
Name:BTN2A3P
Synonyms:BTN2A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:13229. BTN2A3P.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 246219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Topological domaini268 – 586319CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 586559Putative butyrophilin subfamily 2 member A3PRO_0000014531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi50 ↔ 123PROSITE-ProRule annotation
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KV6.
PRIDEiQ96KV6.

PTM databases

PhosphoSiteiQ96KV6.

Expressioni

Gene expression databases

CleanExiHS_BTN2A3.
GenevestigatoriQ96KV6.

Interactioni

Protein-protein interaction databases

IntActiQ96KV6. 1 interaction.
MINTiMINT-7970691.

Structurei

3D structure databases

ProteinModelPortaliQ96KV6.
SMRiQ96KV6. Positions 27-235, 297-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 139112Ig-like V-typeAdd
BLAST
Domaini281 – 474194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235790.
HOVERGENiHBG050747.
InParanoidiQ96KV6.
PhylomeDBiQ96KV6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC
60 70 80 90 100
CLSPEENAED MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK
110 120 130 140 150
DSRGSVALII HNVTAEDNGI YQCYFQEGRS CNEAILHLVV AGLDSEPVIE
160 170 180 190 200
MRDHEDGGIQ LECISGGWYP KPLTVWRDPY GEVVPALKEV STPDADSLFM
210 220 230 240 250
VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP SRSPCVVILP
260 270 280 290 300
VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN
310 320 330 340 350
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA
360 370 380 390 400
SGKHYLEVDV ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW
410 420 430 440 450
ALTSLKWILS LEEPLCQVGI FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV
460 470 480 490 500
PVRPFFSLGS YDSQILICSA FTGASGVTVP EEGWTLHRAG THHSPQNQFP
510 520 530 540 550
SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL SHPLQTSAPV
560 570 580
HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV
Length:586
Mass (Da):65,713
Last modified:July 10, 2007 - v2
Checksum:iE320F80CAD074448
GO

Sequence cautioni

The sequence CAC69644.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791G → D.
Corresponds to variant rs7745238 [ dbSNP | Ensembl ].
VAR_049830
Natural varianti148 – 1481V → I.
Corresponds to variant rs10946829 [ dbSNP | Ensembl ].
VAR_049831
Natural varianti300 – 3001N → S.
Corresponds to variant rs2893848 [ dbSNP | Ensembl ].
VAR_049832

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021917 Genomic DNA. Translation: CAC69644.2. Sequence problems.
CH471087 Genomic DNA. Translation: EAW55569.1.
UniGeneiHs.729655.

Genome annotation databases

UCSCiuc011dkl.1. human.

Polymorphism databases

DMDMi152031567.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021917 Genomic DNA. Translation: CAC69644.2. Sequence problems.
CH471087 Genomic DNA. Translation: EAW55569.1.
UniGeneiHs.729655.

3D structure databases

ProteinModelPortaliQ96KV6.
SMRiQ96KV6. Positions 27-235, 297-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96KV6. 1 interaction.
MINTiMINT-7970691.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ96KV6.

Polymorphism databases

DMDMi152031567.

Proteomic databases

PaxDbiQ96KV6.
PRIDEiQ96KV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc011dkl.1. human.

Organism-specific databases

GeneCardsiGC06P026431.
HGNCiHGNC:13229. BTN2A3P.
MIMi613592. gene.
neXtProtiNX_Q96KV6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG235790.
HOVERGENiHBG050747.
InParanoidiQ96KV6.
PhylomeDBiQ96KV6.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiHS_BTN2A3.
GenevestigatoriQ96KV6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBT2A3_HUMAN
AccessioniPrimary (citable) accession number: Q96KV6
Secondary accession number(s): A6NEF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 10, 2007
Last modified: January 7, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.