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Q96KV6 (BT2A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative butyrophilin subfamily 2 member A3
Gene names
Name:BTN2A3P
Synonyms:BTN2A3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceUncertain

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 B30.2/SPRY domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Caution

Could be the product of a pseudogene.

Sequence caution

The sequence CAC69644.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 586559Putative butyrophilin subfamily 2 member A3
PRO_0000014531

Regions

Topological domain28 – 246219Extracellular Potential
Transmembrane247 – 26721Helical; Potential
Topological domain268 – 586319Cytoplasmic Potential
Domain28 – 139112Ig-like V-type
Domain281 – 474194B30.2/SPRY

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 123 By similarity

Natural variations

Natural variant791G → D.
Corresponds to variant rs7745238 [ dbSNP | Ensembl ].
VAR_049830
Natural variant1481V → I.
Corresponds to variant rs10946829 [ dbSNP | Ensembl ].
VAR_049831
Natural variant3001N → S.
Corresponds to variant rs2893848 [ dbSNP | Ensembl ].
VAR_049832

Sequences

Sequence LengthMass (Da)Tools
Q96KV6 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: E320F80CAD074448

FASTA58665,713
        10         20         30         40         50         60 
MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC CLSPEENAED 

        70         80         90        100        110        120 
MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK DSRGSVALII HNVTAEDNGI 

       130        140        150        160        170        180 
YQCYFQEGRS CNEAILHLVV AGLDSEPVIE MRDHEDGGIQ LECISGGWYP KPLTVWRDPY 

       190        200        210        220        230        240 
GEVVPALKEV STPDADSLFM VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP 

       250        260        270        280        290        300 
SRSPCVVILP VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN 

       310        320        330        340        350        360 
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA SGKHYLEVDV 

       370        380        390        400        410        420 
ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW ALTSLKWILS LEEPLCQVGI 

       430        440        450        460        470        480 
FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV PVRPFFSLGS YDSQILICSA FTGASGVTVP 

       490        500        510        520        530        540 
EEGWTLHRAG THHSPQNQFP SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL 

       550        560        570        580 
SHPLQTSAPV HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL021917 Genomic DNA. Translation: CAC69644.2. Sequence problems.
CH471087 Genomic DNA. Translation: EAW55569.1.
UniGeneHs.729655.

3D structure databases

ProteinModelPortalQ96KV6.
SMRQ96KV6. Positions 27-235, 297-462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96KV6. 1 interaction.
MINTMINT-7970691.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ96KV6.

Polymorphism databases

DMDM152031567.

Proteomic databases

PaxDbQ96KV6.
PRIDEQ96KV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc011dkl.1. human.

Organism-specific databases

GeneCardsGC06P026430.
HGNCHGNC:13229. BTN2A3P.
MIM613592. gene.
neXtProtNX_Q96KV6.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235790.
HOVERGENHBG050747.
InParanoidQ96KV6.
PhylomeDBQ96KV6.

Gene expression databases

CleanExHS_BTN2A3.
GenevestigatorQ96KV6.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameBT2A3_HUMAN
AccessionPrimary (citable) accession number: Q96KV6
Secondary accession number(s): A6NEF4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 10, 2007
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM