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Q96KV6

- BT2A3_HUMAN

UniProt

Q96KV6 - BT2A3_HUMAN

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Protein
Putative butyrophilin subfamily 2 member A3
Gene
BTN2A3P, BTN2A3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative butyrophilin subfamily 2 member A3
Gene namesi
Name:BTN2A3P
Synonyms:BTN2A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:13229. BTN2A3P.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 246219Extracellular Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Reviewed prediction
Add
BLAST
Topological domaini268 – 586319Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 586559Putative butyrophilin subfamily 2 member A3
PRO_0000014531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi50 ↔ 123 By similarity
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KV6.
PRIDEiQ96KV6.

PTM databases

PhosphoSiteiQ96KV6.

Expressioni

Gene expression databases

CleanExiHS_BTN2A3.
GenevestigatoriQ96KV6.

Interactioni

Protein-protein interaction databases

IntActiQ96KV6. 1 interaction.
MINTiMINT-7970691.

Structurei

3D structure databases

ProteinModelPortaliQ96KV6.
SMRiQ96KV6. Positions 27-235, 297-462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 139112Ig-like V-type
Add
BLAST
Domaini281 – 474194B30.2/SPRY
Add
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235790.
HOVERGENiHBG050747.
InParanoidiQ96KV6.
PhylomeDBiQ96KV6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KV6-1 [UniParc]FASTAAdd to Basket

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MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC    50
CLSPEENAED MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK 100
DSRGSVALII HNVTAEDNGI YQCYFQEGRS CNEAILHLVV AGLDSEPVIE 150
MRDHEDGGIQ LECISGGWYP KPLTVWRDPY GEVVPALKEV STPDADSLFM 200
VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP SRSPCVVILP 250
VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN 300
VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA 350
SGKHYLEVDV ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW 400
ALTSLKWILS LEEPLCQVGI FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV 450
PVRPFFSLGS YDSQILICSA FTGASGVTVP EEGWTLHRAG THHSPQNQFP 500
SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL SHPLQTSAPV 550
HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV 586
Length:586
Mass (Da):65,713
Last modified:July 10, 2007 - v2
Checksum:iE320F80CAD074448
GO

Sequence cautioni

The sequence CAC69644.2 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791G → D.
Corresponds to variant rs7745238 [ dbSNP | Ensembl ].
VAR_049830
Natural varianti148 – 1481V → I.
Corresponds to variant rs10946829 [ dbSNP | Ensembl ].
VAR_049831
Natural varianti300 – 3001N → S.
Corresponds to variant rs2893848 [ dbSNP | Ensembl ].
VAR_049832

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL021917 Genomic DNA. Translation: CAC69644.2. Sequence problems.
CH471087 Genomic DNA. Translation: EAW55569.1.
UniGeneiHs.729655.

Genome annotation databases

UCSCiuc011dkl.1. human.

Polymorphism databases

DMDMi152031567.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL021917 Genomic DNA. Translation: CAC69644.2 . Sequence problems.
CH471087 Genomic DNA. Translation: EAW55569.1 .
UniGenei Hs.729655.

3D structure databases

ProteinModelPortali Q96KV6.
SMRi Q96KV6. Positions 27-235, 297-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96KV6. 1 interaction.
MINTi MINT-7970691.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q96KV6.

Polymorphism databases

DMDMi 152031567.

Proteomic databases

PaxDbi Q96KV6.
PRIDEi Q96KV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc011dkl.1. human.

Organism-specific databases

GeneCardsi GC06P026430.
HGNCi HGNC:13229. BTN2A3P.
MIMi 613592. gene.
neXtProti NX_Q96KV6.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235790.
HOVERGENi HBG050747.
InParanoidi Q96KV6.
PhylomeDBi Q96KV6.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

CleanExi HS_BTN2A3.
Genevestigatori Q96KV6.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBT2A3_HUMAN
AccessioniPrimary (citable) accession number: Q96KV6
Secondary accession number(s): A6NEF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 10, 2007
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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